Polycystic ovary syndrome (PCOS) with insulin resistance (IR) is a common endocrine disorder that is particularly prevalent in obese patients. With the continuous acceleration of the pace of life, the increasingly diversified lifestyle and the continuous change of living environment, the disease has become one of the important reproductive endocrine diseases affecting the physical and mental health of women at home and abroad. Western medicine mainly treats PCOS with life intervention, hypoglycemic drugs and contraceptives, but the side effects of drugs are relatively large, and the recurrence rate is high after stopping the drug. The treatment principles of traditional medicine for obese PCOS-IR mainly follow the holistic concept and the idea of syndrome differentiation and treatment, aiming at regulating endocrine function and improving metabolic status, so as to achieve the effect of treating both symptoms and root causes, with significant therapeutic effect, small side effects and low overall cost. Based on the medical thoughts of Fu Qing, the feasibility of treating obese PCOS-IR with Fu's Modified Flavor Buzhong Yiqi Decoction was discussed in combination with the records of ancient books and the thoughts of various doctors, so as to provide a new idea for the clinical treatment of obese PCOS-IR patients.

Rib fracture is one of the most common chest trauma diseases, it can lead to thoracic collapse, pneumothorax, hemothorax and respiratory failure and other complications, serious threat to people's health. At present, there is no definite conclusion on the treatment of rib fracture. Both surgical treatment and conservative treatment have their own advantages. This article reviews the progress in the clinical treatment of rib fracture and provides some basis for clinical diagnosis and treatment.

Objective: To observe the application effect of Qili Qiangxin capsules and dopamine and furosemide pump infusion in patients with acute exacerbation of chronic heart failure. Method: According to the random envelope method, 86 patients with acute onset of chronic heart failure admitted to the First People's Hospital of Kashgar Region from February 2022 to December 2023 were divided into control group (39 cases) and study group (47 cases). Both groups received conventional treatment. The control group was treated with intravenous injection of dopamine and furosemide, while the study group was treated with Qili Qiangxin capsule. Cardiac function, vascular endothelial function, improvement of clinical symptoms, adverse reactions and clinical efficacy were compared between the two groups. Result: The total effective rate, mean arterial pressure, 6-minute walking test (6MWT), left ventricular ejection fraction (LVEF), cardiac output (CO) and nitric oxide (NO) levels in the study group were higher than those in the control group. Left ventricular end-systolic diameter (LVESD), left ventricular end-diastolic diameter (LVEDD), resting heart rate, brain natriuretic peptide (BNP), endothelin-1 (ET-1) levels of study group were lower than those of control group, and the differences were statistically significant (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: Based on the conventional treatment of acute chronic heart failure, Qili Qiangxin capsule combined with dopamine and furosemide pump infusion can effectively alleviate the symptoms of heart failure in patients, improve vascular endothelial function, inhibit ventricular remodeling, restore blood circulation in the venous system, and further improve the heart function of patients, with high safety and practicability.

Objective: To investigate the effect of Celeoxib Capsules combined with Mecobalamine Tablets in the treatment of lumbar disc herniation (LDH) and its influence on lumbar function and pain degree. Method: A total of 92 LDH patients admitted to Zhejiang Provincial People's Hospital Bijie Hospital from May 2020 to October 2023 were selected as the study objects. They were divided into observation group and control group according to random number table method, 46 cases in each group. The control group was given Mecobalamine Tablets, and the observation group was given Celecoxib Capsules on the basis of the control group. The clinical efficacy after treatment, lumbar function and dysfunction condition, pain degree, inflammatory factors before and after treatment and adverse reactions were compared between the two groups. Result: The total effective rate of the observation group was higher than that of the control group, and the difference was statistically significant (P<0.05). After treatment, the score of the Japanese orthopaedic society rating scale (JOA) increased and the score of Oswestry disability index (ODI) decreased in both groups, the JOA score of the observation group was higher than that of the control group, and the ODI score was lower than that of the control group, the differences were statistically significant (P<0.05). After treatment, the visual analogue scale (VAS) score of the two groups decreased, and the VAS score of the observation group was significantly lower than that of the control group, the difference was statistically significant (P<0.05). After treatment, the levels of interleukin-1 (IL-1), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in both groups were decreased, and the levels of IL-1, IL-6 and TNF-α in observation group were lower than those in control group, the differences were statistically significant (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: Celecoxib Capsules and Methylocobalamin Tablets in LDH patients can enhance clinical efficacy, improve lumbar spine function, reduce pain, relieve inflammation reaction, and have a good safety profile.

Objective: To comprehensively analyze the clinical efficacy of using Chifeng Yingyuan acupuncture at Huiyang point in the treatment of female stress urinary incontinence (SUI). Method: 106 female SUI patients admitted to Shenzhen Integrated Traditional Chinese and Western Medicine Hospital from July 2022 to January 2024 were selected as the study objects and randomly divided into a control group (42 cases, electroacupuncture at Huiyang point+pelvic floor muscle training) and an observation group (64 cases, pelvic floor muscle training+red phoenix Yingyuan needle puncture at Huiyang point) using a random number table method. The corresponding datas of the Visual Analog Scale (VAS) scores and the International Consultation on Incontinence Questionnaire-Short Form (ICIQ-SF) questionnaire scores before treatment, after 4 weeks of treatment, and at 4 weeks, 8 weeks, and 12 weeks of follow-up were compared. And the efficacy of the 1-hour urine cushion test between the two groups also were compared. Result: Before treatment, there was no statistically significant difference in the comparison of VAS and ICIQ-SF between the two groups (P>0.05). After 4 weeks of treatment and follow-up at 4 weeks, 8 weeks, and 12 weeks, the VAS and ICIQ-SF in the observation group were lower than those in the control group, and the difference was statistically significant (P<0.05). The total effective rate of the 1-hour urine cushion test in the observation group was higher than that of control group, and the difference was statistically significant (P<0.05). Conclusion: The use of Chifeng Yingyuan acupuncture at Huiyang point in the treatment of female SUI has a positive effect, which can effectively improve the patient's urinary incontinence symptoms and thus enhance overall efficacy.

Chronic kidney disease is a major disease that endangers human health because of its high prevalence rate, poor awareness rate and high treatment cost. Renal anemia is a common complication of chronic kidney disease, and chronic kidney disease can also cause many cardiopulmonary complications, which has a serious impact on the quality of life and prognosis of patients with chronic kidney disease. The article reviews the effects of chronic kidney disease and renal anemia on cardiopulmonary function, focusing on the cardiovascular disease (CVD)and pulmonary diseases caused by them, such as chronic kidney disease caused by heart failure, ischemic cardiomyopathy, obstructive sleep apnea hypopnea syndrome, pulmonary hypertension and other diseases, renal anemia caused by heart failure, coronary heart disease and other diseases were analyzed, and the possible mechanism of action was discussed. At the same time, integrated analysis of the current research status and research gaps, found that the effects of renal anemia on cardiopulmonary function and the specific mechanism of related studies are still few, pointing out the direction of future research.

Coronary artery disease (CAD) is a common disease that endangers human health. Due to the rapid development of China's economy, people's living standards have also improved from food and clothing to a well-off level, the proportion of high-calorie diets such as cholesterol in the dietary structure has increased, and the psychological pressure of life and work has increased, so that the incidence of coronary heart disease is also increasing. As an important pathological basis of cardiovascular diseases, more and more doctors and scholars have paid attention to atherosclerosis (AS) and conducted a lot of research on its prevention and treatment. The pathogenesis of AS mainly includes inflammatory response, oxidative stress, vascular endothelial damage, lipid metabolism disorders, etc., and for the pathogenesis of AS, traditional Chinese medicine mainly relies on the effects of antioxidant stress, anti-inflammatory response, improvement of lipid metabolism, and adjustment of vascular endothelium. A large number of studies have shown that traditional Chinese medicine (TCM) has a significant advantage in the prevention and treatment of coronary atherosclerosis, with multiple pathways, multiple targets and few toxic side effects. The article summarizes the literature and research in the past five years to further explore the pathogenesis of coronary atherosclerosis and the role of traditional Chinese medicine in its prevention and treatment, so as to provide new ideas and directions for the prevention and treatment of coronary atherosclerotic heart disease.

Small cell lung cancer (SCLC) is highly malignant, prone to early recurrence and metastasis, and has a poor prognosis. The median survival for extensive stage SCLC (ES-SCLC) with chemotherapy as the main treatment method is only 8 to 12 months. The combined treatment mode of immunotherapy combined with chemotherapy improved the survival of patients with ES-SCLC to a certain extent than before, but two large-scale clinical studies CASPIAN and IMpower133 only improved the survival of less than 3 months. This article will review the current status and research progress of first-line treatment of ES-SCLC.

Objective: To explore the clinical effect of acupuncture embedding at pressing points and whole knee three-step and nine methods for knee osteoarthritis (KOA) patients with liver and kidney deficiency. Method: A total of 80 KOA patients with liver and kidney deficiency syndrome who were admitted to Xifeng County Traditional Chinese Medicine Hospital from January 2023 to January 2024 were selected as the study objects and randomly divided into the study group and the control group, with 40 cases in each group. The study group was treated with acupoint acupuncture combined with whole knee three-step and nine methods, while the control group was treated with conventional western medicine. The clinical efficacy, knee joint function, pain level, quality of life, inflammatory factors in both groups were compared. Result: The total effective rate of the study group was higher than that of the control group, and the difference was statistically significant (P<0.05). After treatment, the University of Western Ontario and McMaster University Osteoarthritis Index (WOMAC) scores decreased in both groups, and the study group was lower than the control group, and the difference was statistically significant (P<0.05). After treatment, the scores of visual analogue scale (VAS) and knee osteoarthritis Quality of Life Scale (QOL-KOA) decreased in both groups, and the study group was lower than the control group, and the difference was statistically significant (P<0.05). After treatment, the levels of interleukin-1β (IL-1β) and interleukin-6 (IL-6) in the two groups were decreased, and the levels in the study group were lower than those in the control group, and the difference was statistically significant (P<0.05). Conclusion: In patients with KOA with hepatorenal insufficiency, the combination of acupoint acupuncture and whole knee three-step and nine methods can improve clinical efficacy, better reduce pain, improve knee joint function, and enhance quality of life. The mechanism of action is related to the regulation of IL-1β and IL-6 levels.

Menopausal syndromes (MPS) associated with menopause significantly affect the quality of life and physical and mental health of middle-aged and older women. At present, modern medicine takes menopausal hormone therapy as the only treatment plan, but there are many contraindications and risks in clinical use. Traditional Chinese medicine has a variety of treatment methods, and the treatment through syndrome differentiation has remarkable curative effect. By summarizing the relevant literature in the past three years, the author discusses the achievements of traditional Chinese medicine in sleep disorders, abnormal uterine bleeding, anxiety and depression, sweat syndrome, etc, so as to provide a more effective and safer method for the treatment of menopausal syndrome.

Cancer pain (abbreviated as cancer pain) has become one of the most common complications in cancer patients. While causing pain symptoms in cancer patients, it also can cause serious damage to their quality of life. The application of the three-step analgesic regimen in cancer pain patients not only has risks but also certain limitations. Using traditional Chinese medicine treatment programs has a positive effect on improving the analgesic effect of patients, and the common programs included oral administration and external treatment, acupuncture and moxibustion moxibustion, and Chinese medicine, which have been widely used in the treatment of cancer pain patients, and have achieved significant results. However, the application of traditional Chinese medicine treatment plans in cancer pain patients must be based on a deep understanding of the pathological mechanisms of cancer pain itself, in order to ensure the safety and effectiveness of traditional Chinese medicine treatment plans in cancer pain treatment. This article provides a brief review of traditional Chinese medicine plans and their implementation effects for cancer pain.

This article reviews the application and possible mechanisms of traditional Chinese medicine sensitization acupoint therapy in the treatment of depression syndrome. Based on the guidance of meridian theory, sensitize acupoints to adjust the circulation of qi and blood and the function of organs, in order to alleviate the symptoms of depression syndrome. By restoring the balance of the body, sensitization acupoint therapy can reduce symptoms, improve mental state, and be combined with medication, psychotherapy, and other treatments to enhance therapeutic effects. The mechanism of sensitization acupoint therapy for depression syndrome may involve multiple aspects, including neurobiology, immune regulation, inflammatory response, psychological and psychosomatic regulation, etc. In addition, the selection and application of sensitization acupoint therapy are guided by the theory of meridians, which restores the body's balance by adjusting the circulation of meridians. In summary, this article aims to gain a deeper understanding of the application and mechanism of sensitization acupoint therapy for depression syndrome, provide scientific basis for clinical treatment, and improve treatment effectiveness.

Objective: To study and analyze the minimally invasive advantages of intussusception transparent dilation channel in the protection of neurological function and improvement of prognosis in hypertensive intracerebral hemorrhage. Method: 90 patients with hypertensive cerebral hemorrhage admitted to Sihong Hospital from August 2021 to July 2023 were selected as the study objects, and were divided into control group and study group according to different treatment plans, with 45 cases in each group. The control group underwent traditional craniotomy, while the study group underwent intussusception transparent dilatation. Surgical indicators, cerebral blood flow parameters, serum inflammatory factors, neurological function indicators and Glasgow prognostic score (GOS) were compared between the two groups. Result: After treatment, the operation time and intraoperative blood loss in the study group were significantly lower than those in the control group, and the difference was statistically significant (P<0.05). After treatment, the hematoma clearance rate of the study group was significantly higher than that of the control group, and the difference was statistically significant (P<0.05). After treatment, the average blood flow and average blood flow velocity in the study group were significantly higher than those in the control group, with statistical significance (P<0.05). After treatment, the peripheral resistance of the study group was significantly lower than that of the control group, the difference was statistically significant (P<0.05). After treatment, the levels of serum inflammatory factors [interleukin-6 (IL-6), tumor necrosis factor-α(TNF-α) and hypersensitive C-reactive protein (hs-CRP)] in the study group were lower than those in the control group, and the difference was statistically significant (P<0.05). After treatment, the levels of neuron-specific enolase (NSE), neuropeptide Y (NPY) and brain-derived neurotrophic factor (BDNF) in the study group were significantly lower than those in the control group, and the difference was statistically significant (P<0.05). Six months after surgery, GOS prognostic score in the study group was significantly higher than that in the control group, with statistical significance (P<0.05). Conclusion: The treatment of hypertensive intracerebral hemorrhage by intusception hyaline dilation can effectively shorten the operation time, reduce the amount of intraoperative blood loss, regulate inflammatory factors, protect nerve function and improve prognosis. In this way, it can provide patients with more effective and suitable treatment and surgical options in clinical practice, and improve the survival rate and postoperative quality of life of patients.

Objective: To explore the efficacy of mirtazapine plus duloxetine and its effect on sleep quality in elderly patients with depression. Method: 100 elderly depression patients admitted to the hospital from January 2021 to January 2023 were selected as the study objects and devided into the control group and the observation group, with 50 cases in each group. The cases of control group were treated with oral duloxetine and the observation group were treated with mirtazapine. All of them were evaluated after 6 weeks of treatment. The depressive symptoms, clinical efficacy, serum indicators, sleep quality, and adverse effects were compared. Result: The total response rate in observation group was higher than that of the control group (P <0.05). Pre-treatment depressive symptoms, serum indicators, and sleep quality were compared between the two groups (P> 0.05). After treatment, the scores of HAMD of observation group were lower than those of the control group.Compared with the control group, the norepinephrine (NE), serotonin (5-HT) of the observation group were higher in observation group , while the PSQI was lower (P<0.05). And there were no differences in the comparison of adverse reaction of the two groups (P>0.05). Conclusion: Mirtazapine combined with duloxetine in elderly patients with depression can reduce depressive symptoms, regulate serum indicators, promote the improvement of sleep quality, and have high safety, which can be further promoted in clinical practice.

Objective: To observe the effect of Levofloxacin Hydrochloride Ear Drops combined with Dexamethasone in the treatment of acute suppurative otitis media (ASOM). Method: A total of 100 patients with ASOM admitted to the Second People's Hospital of Jiuquan City from May 2019 to May 2023 were selected. According to the random envelope method, they were divided into control group and experimental group, with 50 cases in each group. The control group was given Levofloxacin Hydrochloride Ear Drops, and the experimental group was given Levofloxacin Hydrochloride Ear Drops combined with Dexamethasone. The clinical efficacy, inflammatory factors, hearing threshold before and after treatment, symptom resolution time and adverse reactions of the two groups were compared. Result: The total effective rate of experimental group was higher than that of control group, and the difference was statistically significant (P<0.05). After treatment, the level of interleukin-8 (IL-8), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and hearing threshold in both groups decreased, the levels of TNF-α, IL-6, IL-8 and hearing threshold in experimental group were lower than those in control group, and the differences were statistically significant (P<0.05). The regression time of ear pain, pus discharge, ear blockage, fever in experimental group were earlier than those in control group, and the difference was statistically significant (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: Levofloxacin Hydrochloride Ear Drops combined with Dexamethasone in the treatment of APOM patients can further improve the efficacy, promote the regression of symptoms, improve inflammatory reaction and hearing sensitivity, and have good safety.

Objective: To explore the effect of Moluodan combined with quadruple therapy in the treatment of Helicobacter pylori (Hp)-related chronic atrophic gastritis (CAG). Method: A total of 96 patients with Hp-related CAG admitted to the Second Affiliated Hospital of Fujian Medical University from March 2022 to February 2023 were selected as the research objects. They were divided into control group (n=48) and observation group (n=48) according to the random number table method. The control group was given quadruple therapy, and the observation group was given Moluodan combined with quadruple therapy. The clinical efficacy, Hp-negative rate, traditional Chinese medicine syndrome score, quality of life instruments for chronic diseases-chronic gastritis (QLICD-CG) score and serum levels of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin-1β (IL-1β), pepsinogen Ⅰ (PG-Ⅰ), pepsinogen Ⅱ (PG-Ⅱ) and ghrelin levels were compared between the two groups. Result: The total clinical effective rate of the observation group was 95.83%, higher than 83.33% of the control group, and the difference was statistically significant (P<0.05). The Hp-negative rate in the observation group was 100.00%, which was higher than 93.75% in the control group, but there was no statistically significant (P>0.05). After treatment, the traditional Chinese medicine syndrome score of the observation group was lower than that of the control group, and the QLICD-CG score was higher than that of the control group, the differences were statistically significant (P<0.05). After treatment, the serum levels of TNF-α, IL-6 and IL-1β in the observation group were lower than those in the control group, and the differences were statistically significant (P<0.05). After treatment, the levels of serum PG-Ⅰ and ghrelin in the observation group were higher than those in the control group, and the differences were statistically significant (P<0.05). Conclusion: Moluodan combined with quadruple therapy is effective in the treatment of Hp-related CAG, which can effectively inhibit inflammatory response, regulate PGⅠ and ghrelin levels, and improve clinical symptoms and quality of life of patients.

Endometriosis (EMs) is a chronic, estrogen-dependent inflammatory disease, characterized by abnormal endometrioid tissue growth outside the uterus, causing chronic pelvic pain, dysmenorrhea, infertility and soon, seriously jeopardizing the health and fertility of women of childbearing age. In recent years, the incidence of the disease has an obvious upward trend. At present, the specific pathogenesis of EMs is still a hot topic in the field of obstetrics and gynecology. This article reviews the research progress of its pathogenesis, diagnosis and treatment, in order to have a deeper understanding of the disease.

The scoliosis scientific training method (SEAS) originated at the Italian scoliosis treatment center. The principle is based on patient active self-correction (ASC) and spinal stability training. In 2011, the Society on Scoliosis Orthopaedic and Rehabilitation Treatment (SOSORT) officially included physiotherapy scoliosis specific exercises (PSSE) into conservative scoliosis therapy, and SEAS therapy was one of the specific scoliosis training. Because of its early creation time, relatively perfect theoretical system and wide clinical application, it has been accepted by more and more spinal correction centers. In this paper, the origin, basic concepts, theoretical principles, stability training and application of SEAS in the clinical treatment of idiopathic scoliosis (IS) are systematically described.

Preeclampsia is a common obstetric disease leading to severe maternal and maternal complications, and its etiology and pathogenesis have not been defined. Placental ischemia and hypoxia is one of the most important pathophysiological mechanisms. The maternal-fetal interface recruits many immune cells, and the innate immunity and adaptive immunity jointly participate in the immune tolerance at the maternal-fetal interface, and regulate the immune response through immune cells, cytokines, etc. The break of immune tolerance and immune imbalance cause abnormal inflammation, which causes the insufficient trophoblast cell invasion and the disorder of spiral artery remodeling, leading to placental ischemia and hypoxia. Interleukin-9 (IL-9) and interleukin-27 (IL-27) are recently discovered immune cytokines, which are involved in the immune regulation and other pathological mechanisms of preeclampsia. This article mainly summarized the latest research progress on the immune mechanism and related immune factors of preeclampsia in recent years.

Degenerative lumbar spondylolisthesis (DS), also known as pseudospondylolisthesis, refers to the gradual occurrence of spondylolisthesis without isthmus rupture, caused by intervertebral disc degeneration, joint wear, and pathological changes in soft tissue. The most common manifestation is pain in the waist and legs, which is more common in middle-aged and elderly women. This article mainly reviews other comprehensive treatments such as traditional Chinese medicine manipulation, traditional Chinese medicine acupuncture and moxibustion treatment, acupotomy, traditional Chinese medicine treatment, cupping, scraping, etc., as well as traditional Chinese medicine comprehensive treatment and its mechanism of action, providing a reference for traditional Chinese medicine treatment of DS.

Proliferative diabetic retinopathy (PDR) is a complex and dangerous ocular complication caused by diabetes mellitus, often resulting in severe visual impairment. For patients with PDR, pars plana vitrectomy (PPV) is the preferred treatment method to maintain the patient's visual function and quality of life by eliminating intraocular neovascularization (NH), correcting vitreous hemorrage (VH) and preventing retinal detachment (RD). In recent years, with the continuous development and application of minimally invasive pars plana vitrectomy (MIVS), wide-angle viewing system (WAVS), digital assistance system (DAS), retinal photocoagulation and anti-vascular endothelial growth factor (VEGF) therapies, PPV not only significantly improves the vision of PDR patients but also achieves long-term anatomical stability. Consequently, PPV has become one of the important techniques for the effective treatment of diabetic patients. This review will provide a comprehensive overview of the application of PPV in PDR.

Objective: To investigate the effect of eucalyptol, limonene and pinene enteric soft capsule combined with budesonide nasal spray on patients with chronic sinusitis. Method: A total of 94 patients with chronic sinusitis admitted to the First Hospital of Sanming City from January 2020 to December 2022 were selected as the study objects. They were divided into study group (n=47) and control group (n=47) by random number table method. 5 cases in the control group were lost to follow-up, 2 cases were lost to study follow-up, and 45 cases in the final study group and 42 cases in the control group. Patients in both groups were given nasal endoscopic surgery, the control group was given budesonide nasal spray intervention after surgery, and the study group was given eucalyptus, limonene pinene enteric soft capsules on the basis of the control group. Nasal mucociliary transport velocity and function score [Nasal mucosal structure (Lund-Mackay) score, Sinusoidal Outcomes Test-20 (SNOT-20) score] were compared between the two groups. Result: After treatment, the levels of inflammatory factors, Lund-Mackay score, SNOT-20 score of the study group were lower, the nasal mucociliary transmission speed was faster, 1 year after the end of the treatment, the total clinical effective rate of the study group was higher, and the difference was statistically significant (P<0.05). Conclusion: Eucalyptol, limonene and pinene enteric soft capsule combined with budesonide nasal spray can effectively relieve the inflammation level of chronic sinusitis, improve the clinical symptoms of patients, improve the nasal mucociliary transmission speed, and improve the therapeutic effect.

After conventional treatment, stroke patients are often accompanied by different degrees of dysfunction, among which muscle spasm is one of the main causes of limb movement disorders. Therefore, continuous, safe and effective control of muscle spasm has a positive effect on the recovery of limb function in stroke patients. This article analyzes recent literature on extracorporeal shock wave therapy in the treatment of post-stroke muscle spasms and finds that extracorporeal shock wave therapy has a definite effect in the treatment of this disease. Its mechanism of action may be related to regulating motor nerve excitability and promoting endothelial nitric oxide synthesis. However, there is currently no consensus on the optimal treatment interval and optimal treatment parameters for extracorporeal shock wave therapy of this disease, and further research and exploration are needed in clinical practice to better guide its clinical application.

Objective: To study the clinical effect of Escitalopram Oxalate combined with Sodium Valproate in the treatment of patients with bipolar disorder (BD) manic episode. Method: A total of 76 BD manic episode patients admitted to Xiamen Fifth Hospital from July 2022 to July 2023 were selected as the study objects and divided into two groups according to random number table method, with 38 cases in each group. The control group was treated with Sodium Valproate, and the observation group was treated with Escitalopram Oxalate combined with Sodium Valproate. The clinical efficacy, Bech-Rafaelsen mania rating scale (BRMS) score, social dysfunction screening scale (SDSS) score, positive and negative symptom scale (PANSS) score, cognitive function [Wisconsin card classification test (WCST), trail-making test (TMT)], neurotransmitter [serum triiodothyronine (T3), brain-derived neuronutrition factor (BDNF), 5-hydroxytryptamine (5-HT)] and the occurrence of adverse reactions between the two groups were compared. Result: The total clinical effective rate of the observation group was higher than that of the control group, the difference was statistically significant (P<0.05). Before treatment, there were no significant differences in symptoms, function, cognitive function and neurotransmitter between the two groups (P>0.05). After treatment, BRMS score, SDSS score, PANSS score, number of persistent errors, number of erroneous responses, TMT-A, TMT-B in observation group were lower than those in control group, and the number of completed classification, number of correct responses, T3, BDNF, 5-HT were higher than those in control group, the differences were statistically significant (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: Escitalopram Oxalate combined with Sodium Valproate in the treatment of BD manic episode can improve the neurological function of patients, alleviate clinical symptoms, and enhance the cognitive and social functions of patients, with accurate efficacy and high safety.

Combined with a large number of current clinical data, it can be known that the incidence of systemic lupus erythematosus (SLE) is mostly for women of reproductive age, and SLE is an autoimmune system disease involving multiple internal organs of the human body. At present, the exact etiology of SLE is not clear, but it can be known from relevant research literature that integrated Chinese and western medicine treatment plays a certain role in SLE. This paper summarized relevant studies on the pathogenesis of SLE, traditional Chinese medicine treatment (syndrome differentiation treatment, stage treatment, single prescription treatment), western medicine treatment, and integrated Chinese and western medicine treatment. It is expected to provide valuable reference for clinical treatment.

Objective: To explore the clinical efficacy of Budesonide, Glycopyrronium Bromide and Formoterol Fumarate Inhalation Aerosol combined with Acetylcysteine Effervescent Tablets in the treatment of acute exacerbation of chronic obstructive pulmonary disease. Method: A total of 88 patients with acute exacerbation of chronic obstructive pulmonary disease admitted to the First People's Hospital of Xiaogan City from January to October 2023 were selected. According to random number table method, they were divided into routine group and observation group, 44 cases in each group. The routine group was given Budesonide, Glycopyrronium Bromide and Formoterol Fumarate Inhalation Aerosol, and the observation group was given Acetylcysteine Effervescent Tablets on the basis of control group. The pulmonary function, airway remodeling indexes before and after treatment and clinical efficacy of the two groups were compared. Result: After treatment, forced vital capacity (FVC), maximum peak expiratory flow rate (PEF) and forced expiratory volume in the first second (FEV1)/FVC% in both groups were increased, and FVC, PEF and FEV1/FVC% in the observation group were higher than those in the routine group, the differences were statistically significant (P<0.05). The total effective rate of the observation group was higher than that of the routine group, and the difference was statistically significant (P<0.05). After treatment, the ratio of airway wall thickness to outer diameter (TDR) and airway area to total cross-sectional area (WA) were decreased in both groups, and the TDR and WA in the observation group were lower than those in the routine group, the differences were statistically significant (P<0.05). Conclusion: In the acute exacerbation of chronic obstructive pulmonary disease, Budesonide, Glycopyrronium Bromide and Formoterol Fumarate Inhalation Aerosol combined with Acetylcysteine Effervescent Tablets can significantly improve lung function and resist airway remodeling.

Objective: To observe the effect of Total Glucosides of White Paeony Capsules combined with Methotrexate in the treatment of patients with rheumatoid arthritis. Method: A total of 71 patients with rheumatoid arthritis who admitted to the Bengbu Hospital of Shanghai General Hospital from January 2021 to September 2023 were selected as the research objects, the patients were divided into the study group (n=36) and the control group (n=35) according to the random number table method. The control group was given Methotrexate treatment, while the study group was given Total Glucosides of White Paeony Capsules, the therapeutic effect, immune function, traditional Chinese medicine symptom score, inflammatory factors, bone metabolism and adverse reactions were compared between two groups. Result: The total effective rate of treatment in the study group was higher than that in the control group, the difference was statistically significant (P<0.05). After treatment, the levels of CD3⁺, CD4⁺, N-terminal middle osteocalcin (N-MID), total type Ⅰ collagen amino terminal extension peptide (T-PⅠNP) and bone alkaline phosphatase (BALP) in two groups were higher than those before treatment, and the scores of traditional Chinese medicine symptoms and the levels of CD8⁺, β-crosslaps (β-CTX), interleukin-6 (IL-6), erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were lower than those before treatment, and those in the study group were better than those in the control group, the differences were statistically significant (P<0.05). The incidence of adverse reactions in the study group was higher than that in the control group, but the difference was not statistically significant (P>0.05). Conclusion: Total Glucosides of White Paeony Capsules combined with Methotrexate in the treatment of rheumatoid arthritis can significantly alleviate the stimulation of joint inflammation, improve the immune function and bone metabolism, promote the improvement of clinical symptoms, and have high safety and practicability.

Objective: To explore the effect of Xiangsha Liujunzi Decoction combined with Omeprazole in the treatment of chronic gastritis. Method: A total of 129 patients with chronic gastritis were selected in Datian General Hospital from January 2021 to September 2023 for grouping study. The patients were divided into control group (n=64) and study group (n=65) by random number table method. Both groups used with routine treatment. The control group was treated with Omeprazole, and the study group was treated with Xiangsha Liujunzi Decoction based on the control group. The clinical efficacy, adverse drug reaction, traditional Chinese medicine syndrome score, C-reactive protein level and gastric motility were compared. Result: The clinical efficacy of the study group was higher than that of the control group (P<0.05). There was no significant difference in the incidence of adverse drug reactions between the two groups (P>0.05). After treatment, the scores of epigastric pain, acid reflux, bloating of traditional Chinese medicine symptoms in the study group were lower than those in the control group, and the differences were statistically significant (P<0.05). After treatment, the C-reactive protein level in the study group was lower than that in the control group, and the difference was statistically significant (P<0.05). After treatment, the gastric emptying time of the study group was shorter than that of the control group, and the frequency of gastric antrum contraction and amplitude of gastric antrum contraction were lower than that of the control group, and the differences were statistically significant (P<0.05). Conclusion: Xiangsha Liujunzi Decoction combined with Omeprazole has a remarkable effect in the treatment of chronic gastritis, which can improve traditional Chinese medicine symptom score, C-reactive protein level and gastric motility, and does not increase the adverse reactions.

Nowadays, antibiotics are widely used all over the world. Due to factors such as non-standard application and management, related side effects, gradual expansion of application scope and antibiotic residue in the body, researchers have paid more and more attention to the impact of antibiotic exposure on human health, and the correlation with allergic diseases such as allergic rhinitis has become a focus. Infants, in particular, are particularly vulnerable to antibiotics in the early stages of life. The gut microbiome hypothesis has recently emerged as a link between antibiotic exposure and disease development. Probiotics are expected to regulate the immune response of patients with allergic rhinitis, establish a more balanced intestinal flora, so as to reduce patients' allergic symptoms and even prevent allergies, which is one of the popular adjuvant treatment strategies for allergic rhinitis. Therefore, to explore the correlation between antibiotic exposure in early life and allergic rhinitis, optimize antibiotic use and management, and conduct precise intervention in the critical period of the whole life cycle has important practical significance for the primary prevention of allergic rhinitis and improve the quality of life of patients. This article discusses the effect of antibiotic exposure in early life on allergic rhinitis in children and related problems.

Among the more common post-anesthesia complications in surgical patients, the incidence of perioperative neurocognitive impairment is high, which has a direct impact on the postoperative quality of life of patients. So far, the cause and mechanism of perioperative neurocognitive impairment have not been unified and clear. Among them, propofol is a commonly used anesthetic drug for surgical patients, and many studies have shown that propofol can cause perioperative neurocognitive disorders in patients. This article integrates the research of many experts and scholars and the practice data of clinical medical staff, discusses the related mechanism of perioperative neurocognitive impairment caused by propofol, and forms a review for reference.

This paper reviewed the related concepts and assessment tools of fear of disease progression in diabetic patients, and introduced the influencing factors and intervention measures of fear of disease progression, in order to improve the medical staff's attention to fear of disease progression in diabetic patients, and provide reference for further relevant research.

Objective: To investigate the clinical effects of floating needle reperfusion therapy in the treatment of cervicogenic vertigo. Method: 100 cases of patients with cervicogenic vertigo admitted to Guangzhou Dongsheng Hospital from June 2022 to June 2023 were selected as the study subjects, and were randomly divided into an observation group and a control group, with 50 cases in each group. Patients in the control group received warm needle intervention, and patients in the observation group received floating needle reperfusion therapy intervention. At the end of the treatment course, the treatment effect of the patients was evaluated using the Cervical Vertigo Symptom and Function Assessment Scale, and the Visual Analogu Scale (VAS) and carotid Doppler examination results of the two groups were compared. Result: There were 8 cases of ineffective treatment in the patients in the observation group and 22 cases of ineffective treatment in the patients in the control group. The total effective rate of the observation group was higher than that of the control group, and the difference was statistically significant (P<0.05). After the intervention, the pain level of patients in the observation group was lower than that of the control group, and the difference was statistically significant (P<0.05). After intervention, the PSV and EDV levels of patients in both groups were lower than those before treatment, and the observation group were lower than the control group, and the difference was statistically significant (P<0.05). Conclusion: Floating needle reperfusion therapy for cervicogenic vertigo can effectively improve the clinical symptoms of patients, and the therapeutic effect is clear. Compared with the traditional warm needle, floating needle re-infusion therapy can relieve patients' pain better and improve the problem of insufficient cerebral blood supply.

Objective: To explore and analyze the clinical effect of Dapagliflozin Tablets combined with Sacubitril Valsartan Sodium Tablets in patients with heart failure. Method: A total of 70 patients with heart failure admitted to the Youyang County People's Hospital of Chongqing from March 2022 to March 2023 were selected to carry out the clinical practice study. The patients were divided into odd-even groups by odd-even number method, and the single number was included in the control group (treated with Sacubitril Valsartan Sodium Tablets), and the even-number group was included in the observation group (treated with Dapagliflozin Tablets and Sacubitril Valsartan Sodium Tablets), with 35 cases in each group. The cardiac function indexes [brain natriuretic peptide (BNP), left ventricular end-diastolic diameter (LVEDD), left ventricular end-systolic diameter (LVESD), left ventricular ejection fraction (LVEF)], neuroendocrine hormones [noreadrenaline (NE), angiotensin Ⅱ (AngⅡ)] before and after treatment and the total effective rate of treatment were compared between the two groups. Result: Before treatment, there were no significant differences in cardiac function indexes and neuroendocrine hormone levels between the two groups (P>0.05). After treatment, BNP, LVEDD, LVESD, NE and AngⅡ in the observation group were lower than those in the control group, and LVEF was higher than that in the control group, the differences were statistically significant (P<0.05). The total effective rate of the observation group was 97.14%, higher than 82.86% of the control group, and the difference was statistically significant (P<0.05). Conclusion: Patients with heart failure were treated with Dagaglizin Tablets combined with Sacubitril Valsartan Sodium Tablets for good therapeutic effect.

Cough variant asthma (CVA) is a special type of asthma in which chronic cough is the main or only clinical manifestation. In recent years, the incidence of CVA continues to rise, affecting people's normal daily life. Conventional western medicine treatment can only temporarily relieve its symptoms, but can not be completely cured, resulting in the recurrence of the disease, the overall effect is not good. Chinese medicine treatment of CVA has rich experience and a long history. In this paper, the etiology and pathogenesis of CVA, syndrome differentiation and Chinese medicine treatment are discussed to provide theoretical basis for community treatment.

Objective: To explore the effect of Sijunzi decoction in the treatment of chronic gastritis. Method: A total of 86 patients with chronic gastritis admitted to Taining County Traditional Chinese Medicine Hospital of Traditional Chinese Medicine from May 2019 to April 2023 were selected and divided into two groups by random number table method, with 43 cases in each group. The conventional group was treated with quadruple therapy, while the traditional Chinese medicine group was treated with Sijunzi decoction on the basis of quadruple therapy. The clinical efficacy, gastric mucosal secretion function, intestinal flora structure and adverse reactions of the two groups were compared. Result: The effective rate of treatment in the traditional Chinese medicine group was higher than that in the conventional group, and the difference was statistically significant (P<0.05). The levels of gastrin (GAS), nitric oxide (NO), and gastric mucosal prostaglandin 2 (PGE2) in the traditional Chinese medicine group were higher than those in the conventional group, and the differences were statistically significant (P<0.05). The content of various bacterial phyla in the traditional Chinese medicine group was higher than that in the conventional group, and the difference was statistically significant (P<0.05). The incidence of nausea or vomiting in the traditional Chinese medicine group was lower than that in the conventional group, and the difference was statistically significant (P<0.05). There was no statistically significant difference in the comparison of other adverse reactions (P>0.05). Conclusion: Sijunzi decoction is effective in chronic gastritis patients, and it can enhance the regulation of intestinal flora abundance in patients, so as to promote the recovery of gastric mucosal secretion function, with relatively few adverse reactions and high drug safety.

Epilepsy is a chronic brain disease caused by abnormal discharge of brain neurons, which is characterized by recurrent, episodic and transient central nervous system dysfunction, which can not only induce migraines, anxiety disorders and other diseases, but also lead to psychological and social dysfunction in patients, seriously affecting the physical and mental health of patients. The pathogenic factors of epilepsy are many and complex, but its pathogenic mechanism has not been fully clarified, which may be related to abnormal discharge of brain neurons and abnormal activity of cerebral cortex. The treatment period of epilepsy is long and difficult, and the effect is not good for drug-resistant epilepsy and generalized tonic epilepsy. Nitric oxide (NO), as a diatomic gas, widely exists in the human body and can be involved in regulating the basic activities of the human body. NO is obviously correlated with epilepsy and has a bidirectional regulatory effect, so NO can be used to treat epilepsy, but adverse reactions may occur in the treatment process, and its clinical effect needs to be further optimized. This article reviewed the relationship between NO and the pathogenesis of epilepsy in order to provide new ideas for clinical diagnosis and treatment.

Objective: To evaluate the effectiveness of combined treatment with Pediatric Chiqiao Clearing Granules and oseltamivir phosphate in shortening the symptom relief time for children with influenza A, so as to provide a more scientific medication basis for clinical treatment of children with influenza A. Method: A total of 88 children with influenza A admitted to Funing County People's Hospital from July 2021 to July 2023 were selected as the study objects. They were randomly divided into a control group and an observation group using the envelope drawing method, with 44 cases in each group. The control group was treated with oseltamivir phosphate, while the observation group was treated with Pediatric Chiqiao Clearing Granules and oseltamivir phosphate. The symptom relief times (runny nose, cough, fever, pharyngeal congestion, tonsil enlargement, viral conversion) and levels of inflammatory factors before and after treatment [C-reactive protein (CRP), tumor necrosis factor alpha (TNF-α) levels, neutrophil to lymphocyte ratio (NLR), interferon-gamma (IFN-γ), serum amyloid A (SAA)] and symptom scores were compared between the two groups. Result: The symptoms of runny nose, cough, fever, pharyngeal congestion, swollen tonsils and virus turning negative in the observation group were relieved in a shorter time than those in the control group, and the difference was statistically significant (P<0.05). After treatment, the levels of CRP, TNF-α, NLR, IFN-γ, SAA and other inflammatory factors and symptom scores in the observation group were lower than those in the control group, with statistical significance (P<0.05). Conclusion: Treating children with influenza A with Pediatric Chiqiao Clearing Granules combined with oseltamivir phosphate can effectively shorten their symptom relief time and reduce the level of inflammatory factors and improve the score of symptoms, which provides an important scientific basis for the clinical treatment of influenza A.

Objective: To explore the clinical effect of Vitamin D Calcium Chewable Tablets combined with Recombinant Human Growth Hormone (rhGH) in the treatment of growth hormone deficiency (GHD) in children. Method: Seventy-two children with GHD who admitted to Shishi City Hospital from January 2022 to December 2023 were selected by objective sampling method, the patients were randomly divided into the control group and the observation group according to the random number table method, with 36 cases in each group. The control group was treated with rhGH, and the observation group was treated with Vitamin D Calcium Chewable Tablets combined with rhGH, the Vitamin D related indexes {25-hydroxyvitamin D3 [25-(OH)D3], 1, 25-dihydroxyvitamin D3 (1, 25-(OH)2D3]}, physical related indexes [height standard deviation score (HtSDS), height growth rate, bone age], bone metabolism indexes [alkaline phosphatase (BAP), type Ⅰ collagen C terminal peptide (ⅠCTP), osteocalcin], thyroid function [free triiodothyronine (FT3), free tetraiodothyronine (FT4), thyroid stimulating hormone (TSH)], growth factors [insulin-like growth factor-1 (IGF-1), insulin-like growth factor binding protein-3 (IGFBP-3)] and clinical effects were compared between two groups. Result: Before treatment, there were no significant differences in the Vitamin D related indexes, physical related indexes, bone metabolism indexes, thyroid function and growth factors between two groups (P>0.05); after treatment, the levels of 25-(OH)D3, 1,25-(OH)2D3, BAP, ⅠCTP, osteocalcin, FT3, FT4, IGF-1, IGFBP-3, HtSDS, height growth rate and bone age in two groups were higher than those before treatment, the TSH levels were lower than those before treatment, and those in the observation group were better than those in the control group, the differences were statistically significant (P<0.05). The total clinical effective rate of the observation group was 94.44%, which was higher than 77.78% of the control group, and the difference was statistically significant (P<0.05). Conclusion: Vitamin D Calcium Chewable Tablets combined with rhGH has a definite clinical effect in the tratment of GHD in children, compared with rhGH alone, which can better improve the Vitamin D related indexes, physical related indexes, bone metabolism indexes, thyroid function and growth factors of children, and it can also effectively improve the therapeutic effect.

Objective: To observe the effect of Yanning syrup combined with interferon treatment on the recovery of inflammation and symptoms in children with acute upper respiratory tract infections. Method: 120 cases of children with acute upper respiratory tract infections admitted to Union Jiangbei Hospital of Huazhong University of Science and Technology from December 2021 to December 2023 were selected as the study subjects, and were divided into a study group and a control group according to the method of randomized number table, with 60 cases in each group. The children in the control group were treated with interferon, while the children in the study group were treated with inflammatory syrup on the basis of the control group, and the clinical efficacy of the two regimens was compared. Result: The total effective rate of treatment and the levels of CD3⁺ and CD4⁺ of the children in the study group were higher than those of the control group, the TCM evidence points and the levels of CD8⁺, total white blood cells (WBC), neutrophils and C-reactive protein (CRP) were lower than those of the control group, and the time to stop coughing, the time to relief of nasal congestion and the time to abate fever were shorter than those of the control group, and the differences were statistically significant (P<0.05). Conclusion: Yanning syrup combined with interferon is more effective in the treatment of acute upper respiratory tract infections, which can significantly alleviate the clinical symptoms of children, reduce the respiratory tract inflammatory stimulation, improve the immune function, and improve the therapeutic utility.

Cardiovascular disease (CVD) is a common geriatric disease, mainly characterized by changes in the heart and blood vessels, including weakened heart function, vascular stenosis and blockage. CVD often worsens progressively and has a poor prognosis, posing a serious threat to health. Frailty is also a type of elderly syndrome, which mainly manifests as insufficient physiological reserve functions in the human body. When facing diseases, the resistance decreases, making it more prone to stress and exacerbating existing diseases. CVD combined with frailty is very common in the elderly population. Current research has found that there are multiple high-risk factors for the onset of both diseases, and there are common pathways for their pathogenesis. This article collects relevant literature both domestical and international on the elderly cardiovascular disease combined with frailty, and provides a review.