Gastroesophageal reflux disease (GERD) is a common chronic digestive disorder characterized by symptoms such as reflux, heartburn, bloating, belching, and chest pain, which can lead to severe complications like esophageal adenocarcinoma. With the ongoing social and economic development and lifestyle changes, the prevalence of GERD continues to rise, particularly in Asian countries. Although proton pump inhibitors (PPIs) are considered as the first-line treatment, monotherapy presents limitations, such as incomplete symptom relief and long-term safety concerns. Therefore, recent treatment strategies have gradually shifted towards diversification and personalization. The study summarizes the latest advances in GERD treatment, including the use of acid-suppressing agents, prokinetics, mucosal protectants, reflux inhibitors, and neuromodulators, as well as non-pharmacological interventions such as endoscopic and surgical therapies. Additionally, the treatment characteristics for special populations, including children, the elderly, and pregnant women, are discussed. By optimizing combination therapy and individualized approaches, the clinical outcomes for GERD patients and their quality of life are expected to improve further.

Objective: To explore the impact of adenoidectomy on nasal inflammation control and Th1/Th2 cell balance in children with adenoid hypertrophy and allergic rhinitis (AR). Method: 100 children with adenoid hypertrophy combined with allergic rhinitis who were treated at Puning People's Hospital from June 2022 to June 2024 were selected and randomly divided into a control group (treated with drugs, n=50) and an observation group (treated with drugs plus adenoidectomy, n=50) according to the random number table method. The control of rhinitis in the two groups, the levels of inflammatory factors [tumor necrosis factor-α (TNF-α), leukocyte mediators (IL)-4, IL-6, interferon-γ(INF-γ)] before and after treatment, and the occurrence of adverse reactions were compared. Result: The total effective rate of treatment in the observation group was higher than that in the control group, and the difference was statistically significant (P<0.05). After treatment in both groups, the levels of TNF-α, IL-4 and IL-6 decreased, and those in the observation group were lower than those in the control group. The level of INF-γ increased in both groups, and that in the observation group was higher than that in the control group. The differences were statistically significant (P<0.05). The occurrence of adverse reactions in the observation group was higher than that in the control group, but the difference was not statistically significant (P>0.05). Conclusion: Adenoidectomy can effectively increase the total effective rate of treatment for children with adenoid hypertrophy accompanied by AR, reduce the levels of inflammatory factors, and subsequently regulate the Th1/Th2 cell balance, with high safety.

Nervous tinnitus, as one of the most common clinical tinnitus symptoms, causes serious damage to the patient's physical and mental health and quality of life. At present, there is a lack of effective therapeutic drugs for nervous tinnitus in clinical practice, acupuncture have good effects and safety in the treatment of nervous tinnitus, and the methods of acupuncture in the treatment of nervous tinnitus are becoming more and more abundant, under the guidance of traditional Chinese medicine theory, it can effectively reduce the severity of symptoms, ensure the therapeutic effect, and play a positive role in improving physical and mental health. This article is a brief summary of the etiology and pathogenesis of nervous tinnitus and the methods of acupuncture treatment of nervous tinnitus, hoping to provide an effective reference for the treatment of neural tinnitus.

Objective: To assess the therapeutic response of tongue acupuncture in patients with post-stroke dysphagia (PSD). Method: Medical records of PSD patients consecutively admitted to Yangjiang Hospital of Traditional Chinese Medicine between October 2021 and December 2022 were retrospectively analyzed. Eighty patients meeting the inclusion criteria were enrolled. Participants were stratified into a control group (n=40) and a tongue acupuncture group (n=40) based on the specific therapeutic regimen received. The control group was given rehabilitation therapy, while the treatment group was combined with tongue acupuncture. The differences in Water Swallowing Test (WST) grades and Standardized Swallowing Assessment (SSA) scores were compared. The therapeutic outcomes and adverse events were documented following the intervention period. Result: Baseline equivalence in WST grades and SSA scores was observed, demonstrated no significant intergroup differences (P>0.05). Post-therapy, the tongue acupuncture cohort demonstrated greater WST improvement, lower SSA scores, and higher clinical efficacy rates versus controls, differences were statistically significant (P<0.05). No adverse events occurred in either group. Conclusion: Tongue acupuncture combined with rehabilitation achieves superior dysphagia mitigation in PSD compared to rehabilitation alone, with sustained short-term effects observed at 3-month follow-up and an optimal safety trajectory.

Objective: To investigate the clinical effect of Montelukast sodium combined with Yupingfeng granules in the treatment of allergic rhinitis in children. Method: A cohort of 100 pediatric patients diagnosed with allergic rhinitis was enrolled from Yangjiang Maternal and Child Health Hospital from April 2023 to April 2024. Participants were randomly allocated via a random number table into two groups (n=50 each): control group receiving 0.9% saline nasal irrigation combined with montelukast sodium monotherapy, and research group receiving 0.9% saline nasal irrigation plus a combined regimen of montelukast sodium and Yupingfeng granules. Treatment efficacy and safety were evaluated by comparative analysis of Traditional Chinese Medicine (TCM) syndrome scores, inflammatory cytokine levels, and immunoglobulin profiles before and after the intervention period. Result: Baseline assessments indicated comparable TCM syndrome scores and serum levels of interleukin-6 (IL-6), interleukin-17 (IL-17), interleukin-23 (IL-23), immunoglobulin A (IgA), immunoglobulin G (IgG), and immunoglobulin E (IgE) between groups (P>0.05). After treatment, the syndrome score of the study group was significantly lower than that of the control group, and the concentration of pro-inflammatory factors was also lower than that of the control group. The immune function of the study group was significantly improved, manifested as an increase in IgA and IgG levels compared with the control group, while IgE decreased. The difference was statistically significant (P<0.05). The total clinical effective rate of the study group was significantly higher than that of the control group, and the difference was statistically significant (P<0.05). Moreover, no drug-related serious adverse events occurred in either group. Conclusion: The adjunctive use of Yupingfeng granules with montelukast sodium significantly enhances therapeutic outcomes in pediatric allergic rhinitis. This synergistic approach effectively alleviates nasal symptoms (rhinorrhea, congestion) through concurrent suppression of inflammatory mediators and bidirectional immunomodulation, without increasing drug-related risks.

Objective: To study the effect of sodium-glucose cotransporter 2 (SGLT2) inhibitors combined with angiotensin-converting enzyme inhibitors (ACEI)/angiotensin II receptor antagonists (ARB) in the treatment of type 2 diabetic nephropathy. Method: A total of 102 patients with type 2 diabetic nephropathy admitted to the Department of Nephrology of Rugao Hospital of Traditional Chinese Medicine from January 2021 to January 2023 were selected as the research subjects and divided into the control group (n=52) and the study group (n=50) according to the random number table method. The control group was treated with ACEI/ARB alone, while the study group was treated with SGLT2 inhibitor combined with ACEI/ARB. The clinical efficacy, biochemical indicators [24-hour urine protein, serum creatinine (Scr), estimated glomerular filtration rate (eGFR)] and the incidence of adverse reactions were compared between the two groups. Result: The total effective rate of the study group was higher than that of the control group, and the difference was statistically significant (P<0.05). After the treatment, the 24-hour urine protein in both groups decreased, and the 24-hour urine protein in the study group was lower than that in the control group, with statistically significant differences (P<0.05). After the treatment, the Scr in both groups increased, and the difference was statistically significant (P<0.05). After treatment, there was no statistically significant difference in Scr between the two groups (P>0.05). After the treatment, the eGFR of both groups increased, and that of the study group was higher than that of the control group, with statistically significant differences (P<0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: SGLT2 inhibitors combined with ACEI/ARB in the treatment of patients with type 2 diabetic nephropathy can effectively reduce proteinuria, improve renal function, and have good safety.

Objective: To explore the application effect of dragon pot moxibustion in patients with lumbar disc herniation (LDH). Method: A total of 100 LDH patients admitted to the Department of Traditional Chinese Medicine of Deyang People's Hospital were selected as the research objects from April 2023 to April 2024. They were divided into two groups by random number table method, group A with 50 cases and group B with 50 cases. Group A was treated with routine treatment and rehabilitation nursing, group B was treated with dragon pot moxibustion nursing intervention on the basis of group A. Pain degree, lumbar function, mental state and nursing satisfaction were compared between the two groups. Result: After 2 weeks of intervention, visual analogue scale (VAS) scores in both groups were lower than those before intervention, and VAS score in group B was lower than that in group A, the differences were statistically significant (P<0.05). Japanese Orthopaedic Association evaluation treatment (JOA) scores and Oswestry disability index (ODI) scores in both groups were better than those before intervention, and JOA scores and ODI scores in group B were better than those in group A, the differences were statistically significant (P<0.05). The scores of self-rating anxiety scale (SAS) and self-rating depression scale (SDS) in both groups were lower than those before intervention, and the scores of SAS and SDS in group B were lower than those in group A, the differences were statistically significant (P<0.05). The total nursing satisfaction of group B was 92.00%, which was higher than 74.00% of group A, the difference was statistically significant (P<0.05). Conclusion: The nursing intervention of dragon pot moxibustion can effectively reduce the pain symptoms of LDH patients, promote the recovery of lumbar spine, and improve their psychological state and nursing satisfaction.

Objective: To observe the efficacy of Shenshuaining combined with compound alpha ketoacid tablets in the treatment of patients with chronic renal failure. Method: 82 patients with chronic renal failure admitted to Yongtai County Hospital from August 2022 to August 2024 were randomly divided into a control group and a test group using the envelope method. The control group was treated with oral compound alpha ketoacid tablets, while the test group was treated with Shenshuaining in addition. The clinical efficacy and drug side effects of two groups, as well as the renal function indicators, renal fibrosis indicators, and micro inflammation indicators before and after treatment were compared. The total effective rate of the experimental group (95.12%) was significantly higher than that of the control group (78.05%), and the difference was statistically significant (P<0.05). After 30 days of treatment, the levels of BUN, Scr, and Cys-C in both groups decreased significantly, with the experimental group showing a more significant decrease. The eGFR levels were significantly increased, with the experimental group showing a more significant increase, and the difference was statistically significant (P<0.05). After 30 days of treatment, the levels of TIMP-1, CTGF, FN, TNF-α, and IL-6 in both groups decreased significantly. The experimental group showed a more significant decrease, and the difference was statistically significant (P<0.05). There was no significant difference in the incidence of drug side effects between the experimental group (7.32%) and the control group (4.88%), and the difference was not statistically significant (P>0.05). Conclusion: The combination therapy of oral administration of Shenshuaining and compound alpha ketoacid tablets in patients with chronic renal failure has significant therapeutic effects, significantly improving renal function indicators, renal fibrosis indicators, and micro inflammatory indicators, with low drug side effects.

Objective: To explore the effect of warm palace plaster combined with traditional Chinese medicine characteristic nursing on pain, dysmenorrhea symptoms, and sleep quality in patients with dysmenorrhea. Method: According to the random number table method, 102 patients with dysmenorrhea who visited Songzi Traditional Chinese Medicine Hospital from May 2023 to May 2024 were divided into a warm uterine patch group (n=51) and a traditional Chinese medicine group (n=51). The warm palace patch group received warm palace patch intervention. The traditional Chinese medicine group added traditional Chinese medicine characteristic nursing (separated moxibustion and finger acupoint nursing intervention). After 6 treatment courses (1 menstrual cycle as 1 treatment course), the pain level, Traditional Chinese Medicine symptom score, dysmenorrhea symptoms, and sleep quality of the two groups were compared. Result: The VAS scores of the two groups before intervention were compared, and there was no significant difference (P>0.05). After 6 courses of intervention, the VAS scores of the third course and the sixth course of intervention in the two groups were lower than those before intervention, with statistically significant difference (P<0.05). The TCM symptom score of TCM group was lower than that of warm palace patch group, and the difference was statistically significant (P<0.05). The CMSS score of TCM group was lower than that of warm palace patch Group, and the difference was statistically significant (P<0.05). The PSQI of TCM group was lower than that of warm palace patch group, and the difference was statistically significant (P<0.05). Conclusion: Traditional Chinese medicine characteristic nursing combined with warm uterus patches can alleviate the pain of dysmenorrhea patients, and improve dysmenorrhea symptoms and sleep quality.

Objective: To investigate the effect of Weisu Granules based on four joint program in the treatment of gastric mucosal lesions in patients with Helicobacter pylori (HP) infection complicated with atrophic gastritis. Method: A total of 90 patients with HP infection complicated with atrophic gastritis admitted to Wuxue Hospital of Traditional Chinese Medicine from April 2022 to April 2023 were selected as the research objects. They were divided into the Western medicine group, the traditional Chinese medicine group and the integrated traditional Chinese and Western medicine group according to the random number table method, with 30 cases in each group. The Western medicine group was treated with the quadruple therapy, the traditional Chinese medicine group was treated with Weisu Granules, and the integrated traditional Chinese and Western medicine group was treated with the quadruple therapy combined with Weisu Granules. The levels of gastrin (GAS), motilin (MTL), and gastrin-17 (G-17), as well as the TCM syndrome scores were compared among the three groups. Levels of inflammatory factors [C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α)]. Result: After treatment, the GAS and MTL in the integrated traditional Chinese and Western medicine group were lower than those in the Western medicine group and the traditional Chinese medicine group, while the G-17 level was higher than that in the Western medicine group and the traditional Chinese medicine group, and the differences were statistically significant (P<0.05). The TCM syndrome scores (belching, acid reflux, abdominal distension and abdominal pain) in the integrated Chinese and Western medicine group were lower than those in the Western medicine group and the traditional Chinese medicine group, and the difference was statistically significant (P<0.05). The levels of CRP, IL-6 and TNF-α in the integrated traditional Chinese and Western medicine group were lower than those in the Western medicine group and the traditional Chinese medicine group, and the difference was statistically significant (P<0.05). Conclusion: Gaisu Granules have a significant effect in the treatment of patients with HP infection complicated with atrophic gastritis. It can improve the clinical gastric discomfort symptoms of patients, effectively regulate the levels of gastrointestinal hormones, promote the repair of gastric mucosa, and reduce the inflammatory response.

Objective: To investigate the efficacy of teprenone capsule combined with magnesium aluminum carbonate in the treatment of gastroduodenal ulcer and its effect on the healing of gastric mucosa. Method: 78 cases of gastroduodenal ulcer patients admitted to the First Hospital Affiliated to the School of Medicine of Zhejiang University from October 2022 to October 2024 were selected as the study subjects, and they were divided into the control group and the observation group according to the different medication regimens, with 39 cases in each group. The control group was treated with magnesium aluminum carbonate, and the observation group was treated with teprenone capsule combined with magnesium aluminum carbonate, and both groups continued treatment for 2 weeks. The clinical efficacy, symptom relief time, gastrointestinal hormone level changes and gastric mucosa healing were compared between the two groups. Result: After treatment, the total effective rate of treatment of the observation group was higher than that of the control group, and the difference was statistically significant (P<0.05). The time to relieve abdominal pain, abdominal distension, acid reflux, belching and other symptoms in the observation group was shorter than that in the control group, and the difference was statistically significant (P<0.05). Serum pepsinogen I (PG I), pepsinogen II (PG II) and gastrin-17 (G-17) levels were lower in the observation group than in the control group, and the difference was statistically significant (P<0.05). The gastric mucosa healing score of the observation group was lower than that of the control group, and the difference was statistically significant (P<0.05). Conclusion: Teprenone capsule combined with magnesium aluminum carbonate is effective in the treatment of gastroduodenal ulcer, which can shorten the time of symptomatic relief, improve the patient's gastrointestinal hormone level, and improve the quality of gastric mucosal healing.

Cardiac amyloidosis (CA) is a toxic infiltrative cardiomyopathy caused by the deposition of amyloid fibers formed by the misfolding of amyloid proteins in the extracellular matrix of cardiomyocytes. CA can lead to thickening of the biventricular wall, concentric ventricular remodeling, low cardiac output, and various arrhythmias, ultimately develop into refractory heart failure. In recent years, with the gradual understanding of the pathophysiological process of amyloid fiber formation, the pathogenesis of CA, and the continuous development of imaging examination technology, we have gained updated understanding of the diagnosis and treatment of CA. This present paper summarizes the research progress of CA.

Objective: To observe the clinical effect of Eucalyptol, Limonene and Pinene Enteric Capsules adjuvant Tiotropium Bromide in the treatment of elderly patients with bronchial asthma. Method: A total of 72 elderly patients with bronchial asthma admitted to Yellow River Sanmenxia Hospital from January 2022 to July 2024 were selected and they were divided into two groups according to the random number table method. The control group (n=36) was treated with Tiotropium Bromide, and the combined group (n=36) was additionally treated with Eucalyptol, Limonene and Pinene Enteric Capsules on the basis of the control group, treatment for 14 d. The lung function, levels of eosinophilic granulocyte (EOS), eosinophilic cationic protein (ECP) in induced sputum and serum inflammatory factors before and after treatment, and the occurrence of adverse reactions during treatment between the two groups. Result: After treatment, forced expiratory volume in one second (FEV1), forced vital capacity (FVC), FEV1/FVC and peak expiratory flow rate (PEF) of the two groups were higher than before treatment, and the indexes in the combined group were higher than those in the control group, the differences were statistically significant (P<0.05). After treatment, the levels of EOS and ECP in induced sputum of the two groups were lower than those before treatment, and the levels in the combined group were lower than those in the control group, the differences were statistically significant (P<0.05). After treatment, the levels of tumor necrosis factor-α (TNF-α), interleukin-8 (IL-8), interleukin-10 (IL-10) and interleukin-18 (IL-18) in the two groups were lower than those before treatment, and the levels in the combined group were lower than those in the control group, the differences were statistically significant (P<0.05). During treatment, the incidence of nausea and vomiting, rash and other adverse reactions in the combined group was 8.33%, which was not statistically significant compared with 16.67% in the control group (χ2=1.143, P=0.285). Conclusion: Eucalyptol, Limonene and Pinene Enteric Capsules adjuvant Tiotropium Bromide is safe and effective in the treatment elderly patients with bronchial asthma, which can improve lung function, reduce sputum EOS, and regulate the level of inflammatory factors.

Objective: To investigate the effect of fenelidone for diabetic nephropathy combined with heart failure on patients. Method: 107 patients with diabetic nephropathy combined with chronic heart failure admitted to Putian Ninety-five Hospital from July 2022 to December 2024 were selected as the study subjects, and were randomly divided into 53 cases in the observation group and 54 cases in the control group using the lottery method. The control group was treated with metformin hydrochloride tablets with valsartan capsules, and the observation group was treated with combined fenetylline on the basis of the control group for 2 months. The efficacy, cardiac enzymes and urine microalbumin, and quality of life of the two groups were compared, and the incidence of adverse reactions was counted. Result: After treatment, the total effective rate of the observation group was higher than that of the control group, and the difference was statistically significant (P<0.05). After treatment, the indicators of cardiac enzymes and 24-h urinary microalbumin excretion rate decreased significantly in both groups, and compared with the control group, troponin I (cTnI), N-terminal B-type natriuretic peptide precursor (NT-proBNP), free fatty acid (FFA), and 24-h urinary microalbumin excretion rate in the observation group were lower, and the difference was statistically significant (P<0.05). The scores of all dimensions of quality of life in both groups increased after treatment compared with those before treatment, and compared with the control group, the observation group had higher scores in the physical domain, emotional domain, and other domains, and the difference was statistically significant (P<0.05). The difference in the incidence of adverse reactions between the two groups was not statistically significant (P>0.05). Conclusion: The adjuvant treatment of diabetic nephropathy combined with chronic heart failure can effectively improve the cardiac enzymes, urinary microalbumin excretion rate, and play a protective role in the recovery of cardiac and renal function, with good therapeutic effects and few adverse reactions, and high safety.

Objective: To investigate the effect of nasal endoscopic surgery in the treatment of chronic sinusitis (CRS). Method: A total of 78 patients with CRS who admitted to Dehua County Hospital from April 2021 to April 2024 were selected as the research objects, the two-color ball method was divided into the traditional group (traditional surgery) and the nasal endoscopy group (nasal endoscopic surgery), 39 cases in each group. The curative effect, symptoms and signs, inflammatory factors, nasal mucociliary clearance function, operation time, operation bleeding volume and complications were compared between two groups. Result: Compared with the traditional group, the total effective rate of the nasal endoscopy group was higher, the operation time was shorter, the operation bleeding volume was less, and the complication rate was lower, the differences were statistically significant (P<0.05). There were no significant differences in the symptom and sign score, inflammatory factors and nasal mucociliary clearance function between two groups (P>0.05); compared with the traditional group, the scores of symptoms and signs (nasal congestion, nasal itching, runny nose, sneezing), inflammatory factors [interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), high-sensitivity C-reactive protein (hs-CRP)] in the nasal endoscopy group were lower at 4 weeks after operation, and the nasal mucociliary clearance function indexes (saccharin clearance time, mucociliary clearance rate, mucociliary clearance rate) were better, the differences were statistically significant (P<0.05). Conclusion: Compared with traditional surgical treatment for CRS, nasal endoscopic surgery can not only shorten the operation time, reduce operation bleeding volume, better improve symptoms and signs, promote inflammation relief, but also help reduce the occurrence of complications, improve clinical effect, and promote the improvement of nasal mucus cilia clearance function in patients.

Objective: To explore the mechanism of psychological resilience, fear of cancer recurrence, perceived social support and post-traumatic growth on fear of cancer recurrence in young and middle-aged patients with breast cancer after operation, and to provide scientific theoretical basis and guidance for the formulation of intervention strategies and clinical health education of fear of cancer recurrence in young and middle-aged patients with breast cancer after operation. Method: A total of 220 young and middle-aged patients with breast cancer after operation who re-visited in the Outpatient Department of Breast Surgery of Deyang City People's Hospital from May to December 2023 were selected as the research objects, a cross-sectional study was conducted using the fear of cancer recurrence scale, post-traumatic growth scale, psychological resilience scale and perceived social support scale. The correlation between psychological resilience, fear of cancer recurrence, perceived social support and post-traumatic growth in young and middle-aged breast cancer patients was analyzed, AMOS 23.0 was used to construct a mediating effect model to verify its mediating effect. Result: A total of 213 young and middle-aged patients with breast cancer after operation completed the study. The score of fear of cancer recurrence was (38.49±4.72) points, which was negatively correlated with psychological resilience, posttraumatic growth and perceived social support (P<0.05), perceived social support and post-traumatic growth played a chain mediating role between resilience and fear of cancer recurrence in young and middle-aged patients with breast cancer after operation, the chain mediating effect was -0.103, accounting for 13.0% of the total effect, and the total mediating effect was -0.467, accounting for 58.9% of the total effect. Conclusion: It is suggested that medical staff should pay attention to the relationship among four factors, starting from improving psychological resilience, so as to improve the level of perceived social support, so that they can recover from adversity as soon as possible, improve the level of post-traumatic growth, and then reduce their fear of cancer recurrence.

Objective: To investigate the effect and the changes of serum sex hormone and neurotransmitter levels of Anshen Dingzhi Pills combined with Estazolam in the treatment of patients with perimenopausal insomnia (PI). Method: A total of 100 patients with PI who treated in the Second People's Hospital of Macheng City from June 2023 to June 2024 were prospectively selected, and they were randomly divided into the control group and the observation group, with 50 cases in each group. The control group was treated with Estazolam, and the observation group was treated with Anshen Dingzhi Pills combined with Estazolam. The sleep quality, therapeutic effect, serum sex hormones, neurotransmitters and adverse reactions were compared between two groups. Result: After treatment, the Pittsburgh sleep quality index (PSQI) scores, follicle stimulating hormone (FSH), luteinizing hormone (LH) and noradrenaline (NE) in two groups decreased, and those in the observation group were lower, the levels of estradiol (E2), 5-hydroxyindoleacetic acid (5-HIAA) and 5-hydroxytryptamine (5-HT) in two groups increased, and those in the observation group were higher, the differences were statistically significant (P<0.05); there were no significant difference in the total effective rate and the incidence of adverse reactions between two groups (P>0.05). Conclusion: Anshen Dingzhi Pills combined with Esazolam in the treatment of patients with PI can regulate the levels of serum sex hormones and neurotransmitters, and improve insomnia.

Objective: To investigate the effect of laparoscopic surgery on acute intestinal obstruction and the influencing factors of poor prognosis. Method: The clinical data of 80 patients with acute intestinal obstruction admitted to Anhai Hospital of Jinjiang from January 2021 to June 2022 were retrospectively analyzed. All patients received conservative treatment after onset, and laparoscopic surgery was performed after 24 h without remission. The treatment and the changes of inflammatory factors and oxidative stress factors before and after operation were analyzed. Then, all patients were followed up for 1 year and divided into good prognosis group and poor prognosis group according to the prognosis. Compared with their general clinical conditions, logistic regression model was established to analyze the influencing factors of poor prognosis. Result: Two out of 80 patients underwent conversion to open abdominal treatment. The surgical time was (87.34±5.25) minutes, the intraoperative blood loss was (50.25±6.34) mL, the postoperative exhaust time was (31.24±2.77) h, the gastric tube removal time was (3.42±0.42) d, and the hospital stay was (9.34±1.23) d. The total effective rate of 78 patients treated was 91.03% (71/78), of which 34 were significantly improved, 37 were effective, and 7 were ineffective. The incidence of complications was 14.10% (11/78), including 2 cases of intestinal fistula, 7 cases of residual abdominal abscess, and 2 cases of incision infection. The levels of interleukin-10 (IL-10) and superoxide dismutase (SOD) in all patients at 7 d after surgery were higher than before and 1 d after surgery, interleukin-6 (IL-6), C-reactive protein (CRP), and malondialdehyde (MDA) were lower than those before and 1 d after surgery, and the differences were statistically significant (P<0.05). There was no significant difference in gender, body mass index (BMI), combined underlying diseases, history of abdominal surgery, preoperative anemia, preoperative fever, preoperative blood in the stool, and preoperative SOD and MAD levels between the good prognosis group and the poor prognosis group (P>0.05). The age, the proportion of progressive abdominal pain before surgery, the levels of IL-10, IL-6 and CRP before surgery of the poor prognosis group were higher than those of the good prognosis group, and the differences were statistically significant (P<0.05). Age, progressive exacerbation of abdominal pain, IL-10, IL-6 and CRP levels were the independent factors influencing the prognosis of acute intestinal obstruction (P<0.05). Conclusion: The total effective rate of laparoscopic surgery for acute intestinal obstruction patients after 24 h of conservative treatment is relatively high. The prognosis can be influenced by the patient's age, progressive worsening of preoperative abdominal pain, and preoperative levels of IL-10, IL-6, and CRP. Therefore, clinical practice should closely monitor the above indicators of patients in the early stage, clarify the indications for this treatment method, and further improve the patient's poor prognosis.

Objective: To explore the clinical value of pearl eye drops combined with polyvinyl alcohol eye drops in the treatment of dry eye syndrome. Method: 112 patients with dry eye disease who were diagnosed and treated in Ezhou Aier Eye Hospital from December 2023 to October 2024 were randomly divided into two groups. The control group (56 cases and 112 eyes) were treated with polyvinyl alcohol eye drops, and the experimental group (56 cases and 112 eyes) were treated with pearl eye drops and polyvinyl alcohol eye drops. After 2 weeks of treatment, compared the overall efficacy, disease-related indicators, tear inflammatory factors and drug safety. Result: After treatment, comparisons between the experimental group and the control group showed that the total effective rate was higher in the experimental group, the Schirmer Tear Secretion Test (SIT) and the average tear film break-up time (BUT) were both longer in the experimental group, the Ocular Surface Disease Index (OSDI) was lower in the experimental group, the concentrations of interleukin-1 β (IL-1β), tumor necrosis factor -α (TNF-α), and interleukin-6 (IL-6) in the tear fluid were lower in the experimental group, with statistically significant difference (P<0.05). The difference in adverse reaction rates did not reach statistical significance (P>0.05). Conclusion: Pearl eye drops combined with polyvinyl alcohol eye drops in the treatment of dry eye syndrome can play positive synergistic effect. It is conducive to the improvement of the disease. And it can reduce the expression of inflammatory factors in tears, with good safety.

Objective: To analyze the value of cardiac color Doppler ultrasound combined with carotid artery ultrasound in the early diagnosis of coronary heart disease. Method: A total of 100 patients with suspected coronary heart disease were selected from Nanping First Hospital Affiliated to Fujian Medical University from April 2021 to April 2024. All patients underwent cardiac color Doppler ultrasonography and carotid ultrasonography, and coronary artery angiography was used as the gold standard. The patients were divided into coronary heart disease group (group A, n=62) and non-coronary heart disease group (group B, n=38). Intima-media thickness (IMT) of the carotid artery, myocardial work index (Tei index) and plaque score were compared between the two groups to evaluate the consistency and diagnostic efficacy of the two diagnostic methods with the gold standard. Result: The IMT of the carotid artery, Tei index and plaque score in group A were higher than those in group B, and the differences were statistically significant (P<0.05). The consistency of cardiac color Doppler ultrasound and carotid artery ultrasound with gold standard were medium (Kappa=0.595, 0.514, P<0.05). The combination diagnosis was in good agreement with the gold standard (Kappa=0.915, P<0.05). The diagnostic efficiency of combined diagnosis was higher than that of cardiac color Doppler ultrasound and carotid artery ultrasound, the differences were statistically significant (P<0.05). Conclusion: The combination of cardiac color Doppler ultrasonography and carotid ultrasonography has significant value in the early diagnosis of coronary heart disease, and its diagnostic consistency and efficacy are better than that of single ultrasonography.

Objective: To analyze the effect evaluation of acupuncture at Dong's unique acupoint on pain mediators and lumbar vertebral function in patients with lumbar disc herniation. Method: 97 patients with lumbar disc herniation admitted to the Acupuncture and Moxibustion Department of the Rehabilitation Hospital Affiliated to Fujian University of Chinese Medicine from March 2022 to February 2023 were selected as the study objects, and randomly divided into the control group (48 cases) and the study group (49 cases). The control group was given rehabilitation training combined with traditional Chinese medicine treatment, and the study group was given additional acupuncture treatment at Dong's unique acupoint. The therapeutic effect of the two groups was compared after 4 courses of treatment. Result: The lumbar function score of the study group was (22.07±1.98), which was significantly higher than that of the control group, and the difference was statistically significant (P<0.05). The scores of the main complaint pain scale and lumbar dysfunction index in the study group were (3.47±0.32) points and (22.81±2.05) points, which were significantly lower than those in the control group, with statistical significance (P<0.05). The levels of serotonin (468.72±43.08) ng/L and substance P (178.26±15.19) ng/mL in the study group were significantly lower than those in the control group, with statistical significance (P<0.05). The total effective rate of the control group was 77.08% (37/48) and that of the study group was 93.88% (46/49), which was significantly higher than that of the control group, and the difference was statistically significant (P<0.05). Conclusion: Acupuncture at Dong's uniqe acupoint is beneficial to relieve the pain degree of patients with lumbar disc herniation, improve the function of lumbar spine and treatment effect, and then reduce the expression of pain mediators, which has a good clinical treatment effect.

Objective: To investigate the effect of Spleen Aminopeptide Oral Lyophilized Powder in the treatment of children with bronchial asthma. Method: A total of 100 children who were diagnosed as bronchial asthma in Maternal and Child Health Hospital of Xiaogan from January 2022 to March 2024 were divided into groups according to the random number table. Fifty cases of control group were treated with routine treatment for bronchial asthma. Fifty cases of observation group were treated with Spleen Aminopeptide Oral Lyophilized Powder on the basis of control group. The total effective rates for bronchial asthma, disappearance time of asthma related symptoms and signs included wheezing, difficulty breathing and wheezing sounds, immune state (CD3+,CD4+ and CD4+/CD8+), airway hyperresponsiveness state [minimum cumulative dose (Dmin) and linear slope of the Grs decreaced (SGRs)] and allergic reaction related blood indexes [eosinophilic cationic protein (ECP), eotaxin and eosinophil (EOS)] before and after the treatment were compared. Result: The total effective rate for bronchial asthma of observation group was 94.00%, which was significantly higher than 78.00% of control group, the disappearance time of wheezing, difficulty breathing and wheezing sounds were significantly shorter than those of control group, the immune state and Dmin of observation group after the treatment were significantly higher than the levels of control group, the SGRs and allergic reaction related blood indexes were significantly lower than the levels of control group, the immune state and Dmin of two groups after the treatment were significantly higher than those before the treatment, the SGRs and allergic reaction related blood indexes were significantly lower than those before the treatment, the differences were statistically significant (P<0.05). Conclusion: The application effect of Spleen Aminopeptide Oral Lyophilized Powder in children with bronchial asthma is better, and it can significantly improve the airway hyperresponsiveness and expression of allergic reaction related blood indexes of children.

Objective: To compare the application effect and safety of Ciprofol and Propofol combined with Remifentanil anesthesia respectively in patients undergoing painless gastroscopy examination. Method: A total of 120 patients undergoing painless gastroscopy who admitted to Jingzhou Third People's Hospital from January to June 2024 were selected, they were randomly divided into the control group and the observation group, with 60 cases in each group. The control group was anesthetized with Propofol combined with Remifentanil, and the observation group was anesthetized with Ciprofol combined with Remifentanil. The recovery, vital signs, stress response and adverse reactions were compared between two groups. Result: The spontaneous breathing recovery time, eye opening time and orientation recovery time of the observation group were shorter than those of the control group, and the incidence of adverse reactions was lower than that of the control group, the differences were statistically significant (P<0.05); the heart rate (HR) and mean arterial pressure (MAP) at the endoscope was inserted (T1), at the end of the examination (T2) in the observation group were higher than those in the control group, and the levels of norepinephrine (NE), cortisol (Cor) and epinephrine (E) were lower than those in the control group, the differences were statistically significant (P<0.05). Conclusion: The Ciprofol combined with Remifentanil can more effectively stabilize the vital signs of patients undergoing painless gastroscopy examination, control stress reactions, help patients recover quickly, and have fewer adverse reactions.

Objective: To investigate the effect of Sacubitril Valsartan Combined with Spironolactone in the treatment of patients with chronic heart failure. Method: A prospective study was conducted to select 82 CHF patients admitted to Liyang People's Hospital from April 2022 to February 2024. They were randomly divided into two groups by random number table method, with 41 patients in each group. Both groups received routine anti heart failure and Spironolactone treatment, with the control group receiving Valsartan treatment and the observation group receiving Sacubitril Valsartan treatment. The efficacy after 12 weeks of treatment was evaluated. Result: The total clinical effective rate of the observation group was 90.24%, which was higher than 68.29% of the control group, and the difference was statistically significant (P<0.05). After treatment, the left ventricular ejection fraction in the observation group was higher than that in the control group, and the left ventricular end diastolic diameter, left ventricular end systolic thickness, end diastolic interventricular septum thickness, end diastolic left ventricular posterior wall thickness, left ventricular mass index, serum amino terminal brain natriuretic peptide precursor (NT-proBNP) and aldosterone levels, Minnesota Heart failure quality of life scale (MLHFQ) score were lower than those in the control group, the incidence of major adverse cardiovascular events (MACE) was lower than that in the control group, and the differences were statistically significant (P<0.05). There was no total significant difference in the incidence of adverse reactions in the two groups (P>0.05). Conclusion: The combination of Sacubitril Valsartan combined with Spironolactone can effectively inhibit left ventricular remodeling in CHF patients, regulate serum NT-proBNP levels, improve cardiac function and quality of life, and reduce the occurrence of MACE.

Objective: To investigate the effect of Eucalyptol, Limonene and Pinene Enteric Capsules combined with nasal endoscopic surgery on patients with chronic sinusitis. Method: A total of 92 patients with chronic sinusitis admitted to the Otorhinolaryngology Head and Neck Surgery Department of Macheng People's Hospital from January 2022 to March 2024 were selected and divided into experimental group and control group using the double-blind method, 46 cases in each group. The control group underwent nasal endoscopic surgery, while the experimental group received Eucalyptol, Limonene and Pinene Enteric Capsules combined with nasal endoscopic surgery. The postoperative nasal mucosa recovery, inflammatory factors, and adverse reactions were compared between the two groups. Result: The disappearance time of mucociliary edema in experimental group was shorter than that in control group, and the mucociliary transport rate (MTR) and mucociliary clearance (MCC) in experimental group were higher than those in control group, the differences were statistically significant (P<0.05). After 3 months of treatment, interleukin-6 (IL-6), interleukin-1β (IL-1β) and C-reactive protein (CRP) decreased in both groups compared with

Postoperative insomnia is a common postoperative complication of surgery. At present, there is no clear definition of postoperative insomnia in clinic. Combining theories related to insomnia and postoperative sleep disorders, postoperative insomnia is caused by surgical trauma, anesthetics, pain and other factors such as sleep disorders and daytime cognitive dysfunction. Modern medicine mainly adopts drug therapy as an intervention method for postoperative insomnia. At the same time, the field of traditional Chinese medicine in the exploration of non-drug treatment methods have also achieved significant results. The aim of this paper is to summarize the prevention and treatment of postoperative insomnia with traditional Chinese medicine and western medicine.

Objective: To analyze the role and value of transvaginal color Doppler ultrasound (transvaginal color Doppler ultrasound) in the clinical differential diagnosis of ectopic pregnancy rupture and ovarian corpus luteum rupture. Method: Patients with ruptured ectopic pregnancy and ruptured corpus luteum of the ovary admitted to Taishan Maternal and Child Health Hospital from May 2022 to May 2024 were selected as the research subjects, with 62 cases and 53 cases respectively. All patients underwent vaginal color Doppler ultrasound examination. The color Doppler ultrasound indicators, blood flow characteristics, diagnostic efficacy and consistency of pathological diagnosis of patients with different diseases were compared and calculated. Result: The ovarian volume, depth of the fluid dark area and diameter of the abnormal echo area in ruptured corpus luteum of the ovary were higher than those in ruptured ectopic pregnancy, and the difference was statistically significant (P<0.05). The comparison of blood flow signal patterns in patients with the two diseases showed statistically significant difference (P<0.05). In the images of ruptured ectopic pregnancy, point-like and strip-like blood flow signals were mainly found, while in the images of ruptured corpus luteum of the ovary, there were more circular blood flow signals. Among the efficacy indicators of vaginal color Doppler ultrasound in the differential diagnosis of the two lesions, the accuracy was 95.65%, the sensitivity was 94.34%, the specificity was 96.77%, the positive predictive value was 96.15%, and the negative predictive value was 95.24%, and it had extremely high consistency with the pathological diagnosis (Kappa=0.912, P<0.05). Conclusion: The application of vaginal ultrasound in clinical examination and differential diagnosis of ectopic pregnancy rupture and ovarian corpus luteum rupture is accurate and effective. It has good application results.

Pyogenic liver abscess (PLA) refers to the abscess formed by the local inflammation, liquefaction and pus accumulation of liver tissue caused by pyogenic bacteria invading the liver through various ways such as hepatic artery, portal vein and biliary tract. In recent years, changes in its pathogenesis, etiology and clinical manifestations have posed new challenges for the diagnosis and treatment of this disease. With the advancements in imaging techniques and laboratory medicine, the detection rate and diagnostic accuracy of early-stage PLA have significantly improved. Concurrently, the development of interventional therapy and the extensive use of antibiotics have introduced new transformations in the clinical management of PLA. Although most cases can be cured through interventional therapy combined with antibiotics, surgical intervention remains necessary for certain patients. Therefore, several unresolved issues persist in the diagnosis and treatment of PLA, warranting further in-depth research.

Objective: To explore the clinical efficacy of the combination of Fuyang Huaji Formula and Tislelizumab in the treatment of non-small cell lung cancer (NSCLC). Method: Eighty patients with NSCLC treated in Honghu Traditional Chinese Medicine Hospital from March 2022 to December 2023 were selected and divided into study group (n=40) and control group (n=40) by random number table method. The control group was treated with Tislelizumab, and the study group was treated with Fuyang Huaji Formula combined with Tislelizumab. The clinical efficacy, traditional Chinese medicine symptom score, tumor markers [squamous cell carcinoma antigen (SCC), carbohydrate antigen 199 (CA199), carbohydrate antigen 125 (CA125)], cellular immune function [T lymphocyte subsets (CD3+, CD4+, CD8+)] and incidence of adverse reactions were compared between the two groups. Result: The objective response rate (ORR) and disease control rate (DCR) of the study group were higher than those of the control group, and the differences were statistically significant (P<0.05). The scores of traditional Chinese medicine symptoms of the two groups decreased after treatment, and the study group was lower than the control group, the differences were statistically significant (P<0.05). After treatment, the levels of SCC, CA199 and CA125 decreased in the two groups, and the levels in the study group were lower than those in the control group, the differences were statistically significant (P<0.05). After treatment, CD3+ and CD4+ increased and CD8+ decreased in the two groups, the CD3+ and CD4+ in the study group were higher than those in the control group, and CD8+ was lower, the differences were statistically significant (P<0.05). The incidence of adverse reactions in the study group was 15.00% (6/40), which was lower than 40.00% (16/40) in the control group, and the difference was statistically significant (P<0.05). Conclusion: The combination of Fuyang Huaji Formula and Tislelizumab in the treatment of NSCLC patients can improve clinical efficacy, reduce traditional Chinese medicine syndrome scores and tumor marker levels, improve cellular immune function, and reduce the occurrence of adverse reactions.

Objective: To investigate the clinical effect of Zopiclone and Alprazolam on elderly patients with insomnia in the community. Method: 70 elderly insomnia patients treated in the Chronic Disease Hospital of Shandong Province from September 2023 to September 2024 were selected for this study. The patients were randomly assigned into control group receiving Alprazolam, and an observation group receiving both Alprazolam and Zopiclone, with 35 each group. Clinical efficacy, sleep quality (PSQI), cognitive function (MMSE), treatment satisfaction, and adverse drug reactions between the two groups were compared. Result: After treatment, the observation group showed significant improvements in PSQI and MMSE scores compared to the control group. The clinical efficacy and treatment satisfaction were also significantly higher in the observation group, with statistically significant differences (P<0.05). There was no statistically significant difference in adverse drug reactions between the two groups (P>0.05). Conclusion:.The combination of Zopiclone and Alprazolam effectively improves sleep quality, cognitive function, and psychological status in elderly insomnia patients, and enhances treatment satisfaction.

Gout is a group of diseases caused by high blood uric acid deposition in the joints and tissues causing a variety of damage, with strong heterogeneity, severe cases can be complicated by cardiovascular and cerebrovascular diseases, renal failure, and ultimately may be life-threatening. In recent years, clinical trials have found that Chinese medicine has obvious advantages in the treatment of gouty arthritis, which can not only reduce clinical symptoms, but also reduce blood uric acid, and achieve the effect of treating both symptoms and root causes. This article collects the dialectical thoughts of ancient and modern doctors on gout, and then summarizes Simiao San, Xuanbi Decoction, White Tiger and Guizhi Decoction. The research progress of the four classic prescriptions of Guizhi Shaoyao Zhimu Decoction in the field of gout is expected to further clarify the dialectical logic of TCM treatment of gout and provide new ideas for clinical diagnosis and treatment.

Lumbar disc herniation (LDH) is a common condition in clinical practice, particularly in orthopedics, often causing lower back and leg pain and affecting patients' quality of life. Traditional Chinese medicine acupuncture has been shown to be effective in treating LDH patients, offering advantages such as simplicity, convenience, affordability and reliability, and plays an irreplaceable role in treatment. The article reviews relevant literature on the mechanisms of action of acupuncture in the treatment of LDH over the past five years and summarizes the findings. The results indicate that acupuncture treatment for LDH is closely associated with multiple mechanisms of action, including reducing inflammation levels, improving bone metabolism, improving serum differential metabolite levels, regulating neurotransmitters, enhancing nerve conduction velocity, and improving blood rheology.

Objective: To investigate the effect of Tislelizumab combined with Docetaxel second-line treatment on short-term efficacy and tumor markers in patients with advanced non-small cell lung cancer (NSCLC). Method: A total of 81 patients with advanced NSCLC who admitted to Nantong University Affiliated Cancer Hospital from January 2020 to October 2023 were selected as the research objects, all patients were divided into the observation group (n=40) and the control group (n=41) by odd-even grouping method. The control group was treated with single-agent Docetaxel as the second-line treatment, and the observation group was treated with Tislelizumab combined with Docetaxel second-line treatment, the treatment time was 2 cycles (6 weeks). The short-term efficacy, tumor markers [cytokeratin 19 fragment antigen 21 (CYFRA21-1), glycoprotein antigen 125 (CA125), carcinoembryonic antigen (CEA), squamous cell carcinoma antigen (SCC)] and inflammatory response [neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), systemic immune inflammation index (SII)] before and after treatment, incidence of adverse reactions and prognosis were compared between two groups. Result: The disease control rate of the observation group was higher than that of the control group, and the difference was statistically significant (P<0.05); after treatment, the CYFRA21-1, CA125, CEA, SCC, NLR, PLR and SII in two groups were lower than those before treatment, and those in the observation group were lower than the control group, the differences were statistically significant (P<0.05); there was no significant difference in the incidence of adverse reactions between two groups during treatment (P>0.05); the 1-year survival rate of the observation group was 80.00% (32/40), which was higher than 58.54% (24/41) of the control group, and the difference was statistically significant (P<0.05). Conclusion: Tislelizumab combined with Docetaxel second-line treatment in the treatment of patients with advanced NSCLC is more effective, reducing tumor marker levels and inflammatory factor levels, and improve patient survival rates.

Objective: The effects of traditional Chinese medicine enema and external application of mirnitus on patients with acute pancreatitis were compared. Method: 60 patients with acute pancreatitis admitted to the Second People's Hospital Affiliated to Fujian University of Traditional Chinese Medicine from January 2023 to September 2024 were selected as the research objects. They were divided into the control group and the observation group by the random number table method, with 30 cases in each group. Both groups received routine care. The control group was given enema with traditional Chinese medicine, while the observation group was treated with external application of mirnitus. The syndrome of TCM, symptom recovery time and intra-abdominal pressure before and after the intervention in the two groups were compared. Result: Before the intervention, there was no statistically significant difference in the TCM syndrome scores between the two groups (P>0.05). After the intervention, the syndrome TCM of the patients all decreased, and the decrease in the observation group was higher than that in the control group, with statistically significant differences (P<0.05). The pain relief time, the disappearance time of abdominal distension and the cessation time of nausea and vomiting in the observation group were all shorter than those in the control group, and the differences were statistically significant (P<0.05). Before the intervention, there was no statistically significant difference in intra-abdominal pressure between the two groups (P>0.05). After 3 and 7 days of intervention, the intra-abdominal pressure of the patients gradually decreased, and the observation group was lower than the control group, and the difference was statistically significant (P<0.05). Conclusion: Enema with traditional Chinese medicine and external application of mirnitus can shorten the symptom recovery time of patients with acute pancreatitis, improve the TCM syndrome score and reduce intra-abdominal pressure.

Objective: To investigate the clinical effect of traditional Chinese medicine colon dialysis with Wenpi Decoction in the treatment of patients with stage 3 and stage 4 chronic kidney disease (CKD). Method: A total of 82 patients with stage 3 and stage 4 CKD who admitted to the Department of Nephrology, the First People's Hospital of Suining from April 2020 to April 2023 were included, they were divided into the treatment group (n=42) and the control group (n=40) according to whether they received traditional Chinese medicine colon dialysis with Wenpi Decoction. Both groups were given basic treatment of western medicine, and the treatment group was treated with traditional Chinese medicine colon dialysis with Wenpi Decoction. The renal function and electrolyte, traditional Chinese medicine symptom score and adverse reactions were compared between two groups. Result: After 5 courses and 10 courses of treatment, the serum creatinine (Scr) and blood urea nitrogen (BUN) in two groups were lower than those before treatment, and those in the treatment group were lower than those in the control group, the differences were statistically significant (P<0.05); after treatment, the traditional Chinese medicine symptom scores of two groups were lower than those before treatment, and that in the treatment group was lower than that in the control group, the differences were statistically significant (P<0.001). In the treatment group, 2 cases (4.8%) had mild diarrhea discomfort after treatment, which was relieved after symptomatic treatment, there were no adverse reactions in the control group. Conclusion: Traditional Chinese medicine colon dialysis with Wenpi Decoction in the treatment of patients with stage 3 and stage 4 CKD can improve renal function, reduce traditional Chinese medicine syndrome score, so as to improve the quality of life.

Objective: To explore the therapeutic effect of Methylprednone Sodium Succinate on hyperthermia in children with adenovirus pneumonia and its effects on inflammatory indexes and lymphocyte subsets. Method: A total of 80 children with adenovirus pneumonia and hyperthermia diagnosed and treated in Xuzhou Mining Group General Hospital from January 2022 to December 2023 were selected. They were divided into two groups by random number table method, with 40 cases in each group. The control group received conventional symptomatic treatment, and the observation group was treated with Methylprednisolone Sodium Succinate. The course of treatment was 7 d. The levels of inflammatory indicators [WBC, procalcitonin (PCT), C-reactive protein (CRP)] and lymphocyte subsets (CD3+, CD4+, CD4+/CD8+) before and after treatment were compared between the two groups, and the treatment efficiency and the incidence of adverse reactions were analyzed. Result: After treatment, the levels of CRP, PCT and WBC in the observation group were lower than those in the control group, and the difference was statistically significant (P<0.05). After treatment, the levels of CD3+, CD4+ and CD4+/CD8+ in the observation group were higher than those in the control group, and the differences were statistically significant (P<0.05). Compared with the control group, the time of fever reduction, cough relief and lung moist rales disappearance in the observation group were shorter, and the difference was statistically significant (P<0.05). No adverse reactions occurred in both groups during treatment. Conclusion: Methylprednisolone Sodium Succinate is effective in the treatment of hyperthermia in children with adenovirus pneumonia, which is helpful to reduce inflammatory response, enhance the immune capacity of the body, promote the improvement of symptoms, and has a high safety.

Objective: To evaluate and analyze the differences in efficacy between the treatment regimen of cefoperazone sodium and sulbactam sodium injection combined with moxifloxacin hydrochloride and sodium chloride injection for the treatment of severe pneumonia and the single drug treatment of cefoperazone sodium and sulbactam sodium injection. Method: 80 patients with severe pneumonia admitted to the Left Wing Houqi People's Hospital of Horqin from September 2022 to August 2023 were selected as the study objects, and were divided into control group and observation group by random number table method. Both groups were given cefoperazone sodium and sulbactam sodium for injection, and the observation group was given moxifloxacin hydrochloride and sodium chloride injection. Both groups were given continuous administration for 14 days. The results of the subjective evaluation of the efficacy, the time for cough and other symptoms to disappear, the changes in the levels of three inflammatory factors before and after treatment, and the occurrence of adverse reactions during treatment were compared between the two groups. Result: The total effective rate in the observation group was higher than that in the control group, and the difference was statistically significant (P<0.05). The time of cough disappearance, temperature return to normal and discomfort disappearance in the observation group were shorter than those in the control group, and the difference was statistically significant (P<0.05). Before treatment, the levels of C-reactive protein, procalcitonin and white blood cell count were higher in 2 groups, and there was no statistical significance (P>0.05). After treatment, C-reactive protein, procalcitonin and white blood cell count levels in both groups were decreased, and the observation group was lower than the control group, and the difference was statistically significant (P<0.05). There was no significant difference in the total incidence of adverse reactions between the observation group and the control group (P>0.05). Conclusion: In the treatment of severe pneumonia, the combination of cefoperazone sodium and sulbactam sodium for injection and moxifloxacin hydrochloride and sodium chloride injection can achieve better clinical efficacy than the single drug regimen of cefoperazone sodium and sulbactam sodium for injection.

Objective: To investigate the effect of the combination of ulinastatin and somatostatin in patients with acute pancreatitis (AP). Method: A total of 100 AP patients admitted to Bijie Hospital of Zhejiang Provincial People's Hospital from January 2023 to January 2024 were selected as the study objects and divided into control group and observation group by random number table method, with 50 cases in each group. The control group was treated with somatostatin for injection, and the observation group was treated with ulinastatin for injection on the basis of the control group. The clinical efficacy, intestinal barrier function indexes, inflammatory factors and adverse reactions were compared between the two groups. Result: The total effective rate of observation group was higher than that of control group, and the difference was statistically significant (P<0.05). After treatment, the levels of D-lactic acid (D-Lac), endotoxin (ET), diamine oxidase (DAO), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and hypersensitive C-reactive protein (hs-CRP) in observation group were lower than those in control group, and the differences were statistically significant (P<0.05). There was no significant difference in adverse reactions between the two groups (P>0.05). Conclusion: Ulinastatin combined with somatostatin can enhance the therapeutic effect, improve the intestinal mucosal barrier function and reduce the inflammatory response in AP patients, and the drug has high safety.

Objective: To explore the clinical effect of electrical stimulation combined with muscle fascia massage in the treatment of pelvic floor muscle high tension pain. Method: A total of 82 patients with pelvic floor muscle high tension pain who treated in the Department of Obstetrics and Gynecology of Yunfu People's Hospital from March 2023 to August 2024 were selected, they were divided into the electrical stimulation group and the comprehensive group according to the random lottery method, with 41 cases in each group. The electrical stimulation group was treated with electrical stimulation, and the comprehensive group was treated with muscle fascia massage on the basis of the electrical stimulation group, both groups were treated for 4 weeks. The pain degree [visual analogue scale (VAS)], pelvic floor function, clinical efficacy and pain recurrence were compared between two groups. Result: After 4 weeks of treatment, the VAS score and pre-rest and post-rest muscular electricity values of two groups were lower than those before treatment, and those in the comprehensive group were lower than those in the electrical stimulation group, the differences were statistically significant (P<0.05); after 4 weeks of treatment, the total effective rate of the comprehensive group was 90.24%, which was higher than 60.98% of the electrical stimulation group, and the difference was statistically significant (P<0.05); at 3 months of follow-up after treatment, the recurrence rate of pain in the comprehensive group was 5.41%, which was lower than the 28.00% in the electrical stimulation group, and the difference was statistically significant (P<0.05). Conclusion: Electrical stimulation combined with muscle fascia massage for pelvic floor muscle high tension pain can effectively improve the degree of pain, promote the recovery of pelvic floor function, improve the therapeutic effect and reduce recurrence.

Objective: To investigate the effectiveness of azithromycin in conjunction with Montelukast sodium for treating mycoplasma pneumoniae pneumonia in children. Method: A total of 100 pediatric patients diagnosed with mycoplasma pneumoniae pneumonia, who were treated in the hospital from May 2022 to March 2024 were chosen as study subjects. These patients were randomly divided into two groups, with 50 patients in each group. The control group received azithromycin alone, whereas the study group was given a combination of azithromycin and Montelukast sodium. The outcomes measured included treatment efficacy, lung function parameters [such as peak time ratio (t-PTEF/t-E), tidal volume (V-T), mid-inspiratory flow rate to mid-expiratory flow rate ratio (MTIF/MTEF), forced vital capacity (FVC), maximum peak expiratory flow rate (PEF), and forced expiratory volume in one second (FEV1)], inflammatory markers [C-reactive protein (CRP), procalcitonin (PCT), and erythrocyte sedimentation rate (ESR)], duration of symptom resolution (cough, wheezing, rales, and fever), and the occurrence of adverse effects (dizziness, nausea, vomiting, abdominal pain, and diarrhea) of two groups were compared. Result: The overall effectiveness in the study group was notably superior to that in the control group (P<0.05). After treatment, both groups showed improvements in lung function, but the study group exhibited better results (P<0.05). Both groups experienced a reduction in inflammatory marker levels compared to pre-treatment, but the study group had a more pronounced decrease (P<0.05). The study group also had a shorter symptom resolution time than the control group (P<0.05). Additionally, the incidence of adverse reactions was lower in the study group, with statistically significant difference (P<0.05). Conclusion: The combination of azithromycin and Montelukast sodium is effective in treating mycoplasma pneumonia in children, contributing to improving lung function, reducing inflammation, and accelarting clinical symptom improvement, with high therapeutic safety.