Polycystic ovary syndrome (PCOS) is a gynecological disease with high incidence of endocrine and metabolic disorders in the reproductive age, its etiology and pathogenesis remain unclear, it may be related to endocrine disorders, insulin resistance, inflammatory factors, intestinal flora, oxidative stress, etc. Traditional Chinese medicine has the unique advantages of high safety and low side effects in the treatment of PCOS, traditional Chinese medicine therapy (traditional Chinese medicine compound, single Chinese medicine, Chinese medicine extract) from the whole, by regulating the above mechanism, effectively improve the endocrine disorders, blood glucose, ovarian function, ovulation status and pregnancy rate of PCOS patients. By collecting literature in recent years, this paper expounded the mechanism of traditional Chinese medicine in the treatment of PCOS in many aspects, aiming to provide theoretical basis for clinical intervention of PCOS by traditional Chinese medicine.

Small cell lung cancer (SCLC) is highly malignant, prone to early recurrence and metastasis, and has a poor prognosis. The median survival for extensive stage SCLC (ES-SCLC) with chemotherapy as the main treatment method is only 8 to 12 months. The combined treatment mode of immunotherapy combined with chemotherapy improved the survival of patients with ES-SCLC to a certain extent than before, but two large-scale clinical studies CASPIAN and IMpower133 only improved the survival of less than 3 months. This article will review the current status and research progress of first-line treatment of ES-SCLC.

Polycystic ovary syndrome (PCOS) with insulin resistance (IR) is a common endocrine disorder that is particularly prevalent in obese patients. With the continuous acceleration of the pace of life, the increasingly diversified lifestyle and the continuous change of living environment, the disease has become one of the important reproductive endocrine diseases affecting the physical and mental health of women at home and abroad. Western medicine mainly treats PCOS with life intervention, hypoglycemic drugs and contraceptives, but the side effects of drugs are relatively large, and the recurrence rate is high after stopping the drug. The treatment principles of traditional medicine for obese PCOS-IR mainly follow the holistic concept and the idea of syndrome differentiation and treatment, aiming at regulating endocrine function and improving metabolic status, so as to achieve the effect of treating both symptoms and root causes, with significant therapeutic effect, small side effects and low overall cost. Based on the medical thoughts of Fu Qing, the feasibility of treating obese PCOS-IR with Fu's Modified Flavor Buzhong Yiqi Decoction was discussed in combination with the records of ancient books and the thoughts of various doctors, so as to provide a new idea for the clinical treatment of obese PCOS-IR patients.

Objective: To explore the application effect of fine intervention in wound nursing of severe diabetes foot. Method: A total of 80 patients with severe diabetes foot who admitted to the First Affiliated Hospital of Xiamen University from January 2023 to January 2024 were selected as the research objects, they were divided into the control group and the observation group according to the principle of randomization, with 40 cases in each group. The control group was given routine nursing during hospitalization, and the observation group was given fine intervention during hospitalization. The clinical indexes, blood glucose indexes, quality of life and nursing satisfaction were compared between two groups. Result: The wound healing time of the observation group was earlier than that of the control group, the visual analogue scale (VAS) score was lower than that of the control group, and the nursing satisfaction was higher than that of the control group, the differences were statistically significant (P<0.05); after intervention, the fasting blood glucose, 2 h postprandial blood glucose and glycosylated hemoglobin in two groups were decreased, and those in the observation group were lower than the control group, the differences were statistically significant (P<0.05); after intervention, the scores of physiological function, psychological function, role and physical function in two groups were increased, and those in the observation group were higher than the control group, the differences were statistically significant (P<0.05). Conclusion: Fine intervention can promote the severe diabetes foot patients' wound healing, relieve pain, reduce blood glucose levels, and improve quality of life and nursing satisfaction.

[Abstract] Objective: To examine the effectiveness of partner-involved care guided by IFSMT theory on pregnant patients with hypertension. Method: A total of 100 patients with pregnancy-induced hypertension admitted to Yangzhou Maternal and Child Care Service Centre from January 2021 to January 2024 were selected as the study objects and divided into experimental group and control group according to random drawing method, with 50 cases in each group. The control group received routine nursing, and the experimental group received partner participation nursing guided by IFSMT theory. Blood pressure level, psychological and emotional [Fear of Childbirth Scale (CAQ) score, Patient Health Questionnaire Depression Scale (PHQ-9) score, 7-item Generalized Anxiety Disorder Scale (GAD-7) score], self-efficacy [General Self-efficacy Scale (GSES) score], self-management ability [Self-Care Health Management Questionnaire (SQHMP) score], and pregnancy outcomes (preterm birth, cesarean section, postpartum hemorrhage, eclampsia, termination of pregnancy) were compared between the two groups. Result: After intervention, the systolic blood pressure, diastolic blood pressure, CAQ, PHQ-9 and GAD-7 scores of the experimental group were lower than those of the control group, with statistical significance (P<0.05). The GSES scores and SQHMP scores of the experimental group were higher than those of the control group, and the differences were statistically significant (P<0.05). The incidence of preterm birth, cesarean section, postpartum hemorrhage, eclampsia and termination of pregnancy in the experimental group was lower than that in the control group, with statistical significance (P<0.05). Conclusion: The partner participation nursing under the guidance of IFSMT theory can significantly improve the blood pressure control, psychological state, self-efficacy and self-management ability of hypertensive patients during pregnancy, and optimize the pregnancy outcome, which is an effective nursing intervention method.

In this paper, the demand status, composition and key points, clinical research status, advantages and disadvantages of maternal and infant continuous nursing based on Internet+multidisciplinary collaboration model are reviewed, and its application progress in maternal and infant continuous nursing is analyzed, it is found that the nursing model is conducive to improving the quality of maternal care and improving the efficiency of maternal and infant nursing services, so as to promote maternal and infant health, it is a nursing method worthy of clinical promotion. It is believed that through further clinical practice and exploration, the multidisciplinary collaborative model of maternal and infant continuous nursing based on Internet+will be more in line with clinical needs and help to improve the overall maternal and infant nursing level in China.

Endometriosis (EMs) is a chronic, estrogen-dependent inflammatory disease, characterized by abnormal endometrioid tissue growth outside the uterus, causing chronic pelvic pain, dysmenorrhea, infertility and soon, seriously jeopardizing the health and fertility of women of childbearing age. In recent years, the incidence of the disease has an obvious upward trend. At present, the specific pathogenesis of EMs is still a hot topic in the field of obstetrics and gynecology. This article reviews the research progress of its pathogenesis, diagnosis and treatment, in order to have a deeper understanding of the disease.

Chronic kidney disease is a major disease that endangers human health because of its high prevalence rate, poor awareness rate and high treatment cost. Renal anemia is a common complication of chronic kidney disease, and chronic kidney disease can also cause many cardiopulmonary complications, which has a serious impact on the quality of life and prognosis of patients with chronic kidney disease. The article reviews the effects of chronic kidney disease and renal anemia on cardiopulmonary function, focusing on the cardiovascular disease (CVD)and pulmonary diseases caused by them, such as chronic kidney disease caused by heart failure, ischemic cardiomyopathy, obstructive sleep apnea hypopnea syndrome, pulmonary hypertension and other diseases, renal anemia caused by heart failure, coronary heart disease and other diseases were analyzed, and the possible mechanism of action was discussed. At the same time, integrated analysis of the current research status and research gaps, found that the effects of renal anemia on cardiopulmonary function and the specific mechanism of related studies are still few, pointing out the direction of future research.

Objective: To observe the application effect of Qili Qiangxin capsules and dopamine and furosemide pump infusion in patients with acute exacerbation of chronic heart failure. Method: According to the random envelope method, 86 patients with acute onset of chronic heart failure admitted to the First People's Hospital of Kashgar Region from February 2022 to December 2023 were divided into control group (39 cases) and study group (47 cases). Both groups received conventional treatment. The control group was treated with intravenous injection of dopamine and furosemide, while the study group was treated with Qili Qiangxin capsule. Cardiac function, vascular endothelial function, improvement of clinical symptoms, adverse reactions and clinical efficacy were compared between the two groups. Result: The total effective rate, mean arterial pressure, 6-minute walking test (6MWT), left ventricular ejection fraction (LVEF), cardiac output (CO) and nitric oxide (NO) levels in the study group were higher than those in the control group. Left ventricular end-systolic diameter (LVESD), left ventricular end-diastolic diameter (LVEDD), resting heart rate, brain natriuretic peptide (BNP), endothelin-1 (ET-1) levels of study group were lower than those of control group, and the differences were statistically significant (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: Based on the conventional treatment of acute chronic heart failure, Qili Qiangxin capsule combined with dopamine and furosemide pump infusion can effectively alleviate the symptoms of heart failure in patients, improve vascular endothelial function, inhibit ventricular remodeling, restore blood circulation in the venous system, and further improve the heart function of patients, with high safety and practicability.

Objective: To comprehensively analyze the clinical efficacy of using Chifeng Yingyuan acupuncture at Huiyang point in the treatment of female stress urinary incontinence (SUI). Method: 106 female SUI patients admitted to Shenzhen Integrated Traditional Chinese and Western Medicine Hospital from July 2022 to January 2024 were selected as the study objects and randomly divided into a control group (42 cases, electroacupuncture at Huiyang point+pelvic floor muscle training) and an observation group (64 cases, pelvic floor muscle training+red phoenix Yingyuan needle puncture at Huiyang point) using a random number table method. The corresponding datas of the Visual Analog Scale (VAS) scores and the International Consultation on Incontinence Questionnaire-Short Form (ICIQ-SF) questionnaire scores before treatment, after 4 weeks of treatment, and at 4 weeks, 8 weeks, and 12 weeks of follow-up were compared. And the efficacy of the 1-hour urine cushion test between the two groups also were compared. Result: Before treatment, there was no statistically significant difference in the comparison of VAS and ICIQ-SF between the two groups (P>0.05). After 4 weeks of treatment and follow-up at 4 weeks, 8 weeks, and 12 weeks, the VAS and ICIQ-SF in the observation group were lower than those in the control group, and the difference was statistically significant (P<0.05). The total effective rate of the 1-hour urine cushion test in the observation group was higher than that of control group, and the difference was statistically significant (P<0.05). Conclusion: The use of Chifeng Yingyuan acupuncture at Huiyang point in the treatment of female SUI has a positive effect, which can effectively improve the patient's urinary incontinence symptoms and thus enhance overall efficacy.

Coronary artery disease (CAD) is a common disease that endangers human health. Due to the rapid development of China's economy, people's living standards have also improved from food and clothing to a well-off level, the proportion of high-calorie diets such as cholesterol in the dietary structure has increased, and the psychological pressure of life and work has increased, so that the incidence of coronary heart disease is also increasing. As an important pathological basis of cardiovascular diseases, more and more doctors and scholars have paid attention to atherosclerosis (AS) and conducted a lot of research on its prevention and treatment. The pathogenesis of AS mainly includes inflammatory response, oxidative stress, vascular endothelial damage, lipid metabolism disorders, etc., and for the pathogenesis of AS, traditional Chinese medicine mainly relies on the effects of antioxidant stress, anti-inflammatory response, improvement of lipid metabolism, and adjustment of vascular endothelium. A large number of studies have shown that traditional Chinese medicine (TCM) has a significant advantage in the prevention and treatment of coronary atherosclerosis, with multiple pathways, multiple targets and few toxic side effects. The article summarizes the literature and research in the past five years to further explore the pathogenesis of coronary atherosclerosis and the role of traditional Chinese medicine in its prevention and treatment, so as to provide new ideas and directions for the prevention and treatment of coronary atherosclerotic heart disease.

Objective: To explore the clinical effect of acupuncture embedding at pressing points and whole knee three-step and nine methods for knee osteoarthritis (KOA) patients with liver and kidney deficiency. Method: A total of 80 KOA patients with liver and kidney deficiency syndrome who were admitted to Xifeng County Traditional Chinese Medicine Hospital from January 2023 to January 2024 were selected as the study objects and randomly divided into the study group and the control group, with 40 cases in each group. The study group was treated with acupoint acupuncture combined with whole knee three-step and nine methods, while the control group was treated with conventional western medicine. The clinical efficacy, knee joint function, pain level, quality of life, inflammatory factors in both groups were compared. Result: The total effective rate of the study group was higher than that of the control group, and the difference was statistically significant (P<0.05). After treatment, the University of Western Ontario and McMaster University Osteoarthritis Index (WOMAC) scores decreased in both groups, and the study group was lower than the control group, and the difference was statistically significant (P<0.05). After treatment, the scores of visual analogue scale (VAS) and knee osteoarthritis Quality of Life Scale (QOL-KOA) decreased in both groups, and the study group was lower than the control group, and the difference was statistically significant (P<0.05). After treatment, the levels of interleukin-1β (IL-1β) and interleukin-6 (IL-6) in the two groups were decreased, and the levels in the study group were lower than those in the control group, and the difference was statistically significant (P<0.05). Conclusion: In patients with KOA with hepatorenal insufficiency, the combination of acupoint acupuncture and whole knee three-step and nine methods can improve clinical efficacy, better reduce pain, improve knee joint function, and enhance quality of life. The mechanism of action is related to the regulation of IL-1β and IL-6 levels.

This article reviews the application and possible mechanisms of traditional Chinese medicine sensitization acupoint therapy in the treatment of depression syndrome. Based on the guidance of meridian theory, sensitize acupoints to adjust the circulation of qi and blood and the function of organs, in order to alleviate the symptoms of depression syndrome. By restoring the balance of the body, sensitization acupoint therapy can reduce symptoms, improve mental state, and be combined with medication, psychotherapy, and other treatments to enhance therapeutic effects. The mechanism of sensitization acupoint therapy for depression syndrome may involve multiple aspects, including neurobiology, immune regulation, inflammatory response, psychological and psychosomatic regulation, etc. In addition, the selection and application of sensitization acupoint therapy are guided by the theory of meridians, which restores the body's balance by adjusting the circulation of meridians. In summary, this article aims to gain a deeper understanding of the application and mechanism of sensitization acupoint therapy for depression syndrome, provide scientific basis for clinical treatment, and improve treatment effectiveness.

Objective: To study and analyze the minimally invasive advantages of intussusception transparent dilation channel in the protection of neurological function and improvement of prognosis in hypertensive intracerebral hemorrhage. Method: 90 patients with hypertensive cerebral hemorrhage admitted to Sihong Hospital from August 2021 to July 2023 were selected as the study objects, and were divided into control group and study group according to different treatment plans, with 45 cases in each group. The control group underwent traditional craniotomy, while the study group underwent intussusception transparent dilatation. Surgical indicators, cerebral blood flow parameters, serum inflammatory factors, neurological function indicators and Glasgow prognostic score (GOS) were compared between the two groups. Result: After treatment, the operation time and intraoperative blood loss in the study group were significantly lower than those in the control group, and the difference was statistically significant (P<0.05). After treatment, the hematoma clearance rate of the study group was significantly higher than that of the control group, and the difference was statistically significant (P<0.05). After treatment, the average blood flow and average blood flow velocity in the study group were significantly higher than those in the control group, with statistical significance (P<0.05). After treatment, the peripheral resistance of the study group was significantly lower than that of the control group, the difference was statistically significant (P<0.05). After treatment, the levels of serum inflammatory factors [interleukin-6 (IL-6), tumor necrosis factor-α(TNF-α) and hypersensitive C-reactive protein (hs-CRP)] in the study group were lower than those in the control group, and the difference was statistically significant (P<0.05). After treatment, the levels of neuron-specific enolase (NSE), neuropeptide Y (NPY) and brain-derived neurotrophic factor (BDNF) in the study group were significantly lower than those in the control group, and the difference was statistically significant (P<0.05). Six months after surgery, GOS prognostic score in the study group was significantly higher than that in the control group, with statistical significance (P<0.05). Conclusion: The treatment of hypertensive intracerebral hemorrhage by intusception hyaline dilation can effectively shorten the operation time, reduce the amount of intraoperative blood loss, regulate inflammatory factors, protect nerve function and improve prognosis. In this way, it can provide patients with more effective and suitable treatment and surgical options in clinical practice, and improve the survival rate and postoperative quality of life of patients.

Objective: To explore the clinical effect and safety of Guizhi Fuling Pills in the treatment of uterine fibroids. Method: A total of 80 patients with uterine fibroids who admitted to Quanzhou Quangang District Hospital from February 2022 to August 2023 were selected as the study objects, the patients were divided into the control group and the observation group by random number table method, 40 cases in each group. The control group was treated with Mifepristone, and the observation group was treated with Guizhi Fuling Pills on the basis of the control group. The sex hormone levels, blood viscosity, uterine fibroids volume and adverse reactions were compared between two groups. Result: After treatment, the levels of follicle stimulating hormone, estradiol, progesterone, whole blood viscosity and plasma viscosity in two groups were lower than those before treatment, and those in the observation group were lower than the control group, the differences were statistically significant (P<0.05); after treatment, the uterine fibroids volume in two groups were smaller than those before treatment, and that in the observation group was smaller than that in the control group, the differences were statistically significant (P<0.05); there was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: Guizhi Fuling Pills in the treatment of uterine fibroids can effectively improve the level of sex hormones and blood viscosity, reduce the uterine fibroids volume, and has high safety.

Objective: To evaluate the effectiveness of combined treatment with Pediatric Chiqiao Clearing Granules and oseltamivir phosphate in shortening the symptom relief time for children with influenza A, so as to provide a more scientific medication basis for clinical treatment of children with influenza A. Method: A total of 88 children with influenza A admitted to Funing County People's Hospital from July 2021 to July 2023 were selected as the study objects. They were randomly divided into a control group and an observation group using the envelope drawing method, with 44 cases in each group. The control group was treated with oseltamivir phosphate, while the observation group was treated with Pediatric Chiqiao Clearing Granules and oseltamivir phosphate. The symptom relief times (runny nose, cough, fever, pharyngeal congestion, tonsil enlargement, viral conversion) and levels of inflammatory factors before and after treatment [C-reactive protein (CRP), tumor necrosis factor alpha (TNF-α) levels, neutrophil to lymphocyte ratio (NLR), interferon-gamma (IFN-γ), serum amyloid A (SAA)] and symptom scores were compared between the two groups. Result: The symptoms of runny nose, cough, fever, pharyngeal congestion, swollen tonsils and virus turning negative in the observation group were relieved in a shorter time than those in the control group, and the difference was statistically significant (P<0.05). After treatment, the levels of CRP, TNF-α, NLR, IFN-γ, SAA and other inflammatory factors and symptom scores in the observation group were lower than those in the control group, with statistical significance (P<0.05). Conclusion: Treating children with influenza A with Pediatric Chiqiao Clearing Granules combined with oseltamivir phosphate can effectively shorten their symptom relief time and reduce the level of inflammatory factors and improve the score of symptoms, which provides an important scientific basis for the clinical treatment of influenza A.

Objective: To analyze the clinical effect of Lianhua Qingwen Capsules combined with Oseltamivir in the treatment of patients with influenza. Method: A total of 84 patients with influenza who admitted to the 63750 Team Hospital of the Chinese People's Liberation Army from March 2023 to March 2024 were selected as the research objects, the patients were divided into the control group (n=42) and the observation group (n=42) by random number table method. The control group was treated with Oseltamivir Phosphate, the observation group was treated with Oseltamivir Phosphate combined with Lianhua Qingwen Capsules, two groups were treated for 5 d. The improvement of clinical symptoms, traditional Chinese medicine symptom score, C-reactive protein (CRP), clinical efficacy and adverse reactions were compared between two groups. Result: The disappearance times of fever, sore throat, cough and muscle acid in the observation group were shorter than those in the control group, and the differences were statistically significant (P<0.05); the main symptoms, secondary symptoms, total scores and CRP levels in the observation group after treatment were lower than those in the control group, and the differences were statistically significant (P<0.05); the total effective rate of the observation group was higher than that of the control group, and the difference was statistically significant (P<0.05); the total incidence of adverse drug reactions in the observation group was lower than that in the control group, but there was no significant difference between two groups (P>0.05). Conclusion: Lianhua Qingwen Capsules combined with Oseltamivir in the treatment of influenza can effectively accelerate the improvement of clinical symptoms, improve the inflammation control effect and treatment effect, and will not increase the adverse drug reactions, with good effectiveness and safety.

Objective: To analyze the clinical diagnostic efficacy of EB virus NA1-IgA combined with VCA-IgA detection on patients with nasopharyngeal carcinoma. Method: Blood samples of 783 patients undergoing nasopharyngeal carcinoma two items (EB virus NA1-IgA and VCA-IgA) routine were retrospectively analyzed from January 1, 2021 to July 26, 2023 in the inpatient and outpatient of Hechi People's Hospital. All samples were detected by EB virus NA1-IgA and VCA-IgA. The detection rate of nasopharyngeal carcinoma in NA1-IgA and VCA-IgA and its combined positive was compared. The diagnosis condition of nasopharyngeal carcinoma by NA1-IgA and VCA-IgA combination was analyzed. Result: Among the 783 patients, 155 cases (19.80%) were NA1-IgA positive, 114 cases (14.56%) were VCA-IgA positive, and 85 cases (10.86%) were both NA1-IgA and VCA-IgA positive. The detection rate of nasopharyngeal carcinoma in NA1-IgA and VCA-IgA positive patients was significantly higher than that in NA1-IgA and VCA-IgA alone positive patients, and the differences were statistically significant (P<0.05). The sensitivity, specificity and accuracy of NA1-IgA combined with VCA-IgA in diagnosis of nasopharyngeal carcinoma were 98.67% (74/75), 90.00% (9/10) and 97.65% (83/85) respectively. Conclusion: The combined detection of EB virus NA1-IgA and VCA-IgA has high clinical diagnostic efficacy in patients with nasopharyngeal carcinoma.

Objective: To analyze the effect of five elements music therapy combined with time acupoint application on essential hypertension patients with liver-Yang hyperactivity syndrome. Method: A total of 80 patients with essential hypertension with liver-Yang hyperactivity syndrome treated in Qidong Hospital of Traditional Chinese Medicine from March 2023 to March 2024 were selected. They were divided into control group and observation group according to random number table method, with 40 cases in each group. The control group received conventional treatment, and the observation group received five elements music therapy combined with time acupoint application on the basis of the control group. Blood pressure, Chinese medicine symptom score, psychological symptoms and quality of life before and after treatment were compared. Result: After treatment, diastolic blood pressure (DBP) and systolic blood pressure (SBP) in both groups were decreased, and SBP and DBP in observation group were lower than those in control group, the differences were statistically significant (P<0.05). After treatment, the scores of vertigo and headache, facial hot, impatience and irritability, tinnitus and insomnia in both groups were reduced, and the scores of vertigo and headache, facial hot, impatience and irritability, tinnitus and insomnia in the observation group were lower than those in the control group, the differences were statistically significant (P<0.05). After treatment, the Hamilton anxiety scale (HAMA), Hamilton depression scale (HAMD) score of the two groups was decreased, and the HAMA and HAHD score of the observation group was lower than that of the control group, the differences were statistically significant (P<0.05). After treatment, mental health, social function, emotional function, physical function, vitality, physical pain, physiological function and overall health scores of both groups were increased, and mental health, social function, emotional function, physical function, vitality, physical pain, physiological function and overall health scores of the observation group were higher than those of the control group, the differences were statistically significant (P<0.05). Conclusion: Five elements music therapy combined with time acupoint application can effectively reduce the blood pressure of essential hypertension of liver-Yang hyperactivity syndrome and improve the quality of life.

Objective: To investigate the influence and factors of plateau environmental on health status of body, it provides a scientific basis for formulating health prevention strategies and improving the sub-health status of the population in the plateau area. Method: A total of 1 213 healthy people in Tibet from December 7 to 14, 2021 were selected as the survey subjects, the questionnaire survey was conducted, and the Pittsburgh sleep quality index (PSQI) was used to evaluate the sleep quality, and the influencing factors of the health status of different people in the plateau area were preliminarily analyzed. Result: There were significant differences in the incidence of dizziness and headache among different genders, time of entering Tibet, age, education level and "drunk oxygen" (P<0.05); there were significant differences in the incidence of palpitation and chest tightness among the subjects in each group (P<0.05); there were statistically significant differences in the incidence of nausea and vomiting among the subjects with different time of entering Tibet and age (P<0.05); there were statistically significant differences in the incidence of fatigue among subjects with different gender, age, education level and "drunk oxygen" (P<0.05). There were statistically significant differences in the incidence of anxiety and irritability among subjects of different ages (P<0.05); there were statistically significant differences in the incidence of nasal bleeding and gingival bleeding among the subjects with different "drunk oxygen" (P<0.05). There were statistically significant differences in the incidence of polycythemia among subjects with different gender, education level and "drunk oxygen" (P<0.05); there were significant differences in the incidence of hypertension/heart disease among subjects with different ages, nationality, educational levels and "drunk oxygen" (P<0.05); there were statistically significant differences in the incidence of digestive system diseases among different nationalities (P<0.05); there were statistically significant differences in the incidence of neuroendocrine diseases among subjects with different gender, age, nationality, culture and "drunk oxygen" (P<0.05). There were statistically significant differences in PSQI scores among people of different genders, time of entering Tibet, ages and education levels (P<0.05). The results of regression analysis showed that sleep quality was affected by the time of entering Tibet, age, nationality and education level (P<0.01). Conclusion: The factors such as the time of entering Tibet, age, nationality and education level can have a significant impact on the acute altitude sickness, health status and sleep quality of the population in the plateau area. The results of the study provide a scientific basis for further elucidating the occurrence of acute altitude sickness, maintaining the health of the population in the plateau area, improving the quality of life, and formulating protective measures.

Objective: To observe the effect of Metformin combined with Letrozole Tablets on polycystic ovary syndrome (PCOS) patients. Method: A total of 100 PCOS patients admitted to the First Affiliated Hospital of Suzhou University from January 2022 to December 2023 were selected as the study objects. They were divided into Letrozole group and combined group according to random number table method, with 50 cases in each group. Letrozole group was given Letrozole Tablets, and combined group was given Metformin Hydrochloride Tablets on the basis of Letrozole group. The clinical efficacy after treatment, related indexes and sex hormone indexes before and after treatment were compared between the two groups. Result: After treatment, the total effective rate of combined group was higher than that of Letrozole group, and the difference was statistically significant (P<0.05). After treatment, endometrial thickness increased and bilateral ovarian volume decreased in both groups, the endometrial thickness in combined group was higher than that in Letrozole group, and bilateral ovarian volume was lower than that in Letrozole group, the differences were statistically significant (P<0.05). After treatment, testosterone (T), anti-Mullerian hormone (AMH), dehydroepiandrosterone sulfate (DHEA-S) levels were decreased in both groups, the levels of T, AMH and DHEA-S in combined group were lower than those in Letrozole group, and the differences were statistically significant (P<0.05). Conclusion: Metformin combined with Letrozole Tablets can reduce the levels of serum T, AMH and DHEA-S in PCOS patients, improve the ovarian volume and endometrial thickness, and improve the therapeutic effect.

The main clinical manifestation of the third lumbar transverse process syndrome (TLTPS) is chronic pain caused by acute or chronic injury, especially the tenderness at the third lumbar transverse process, in this paper, we collected and summarized the relevant literatures about the treatment and the analysis of the curative effect of the TLTPS in recent 3 years, so as to provide more effective treatment for the clinician.

Cough variant asthma (CVA) is a special type of asthma in which chronic cough is the main or only clinical manifestation. In recent years, the incidence of CVA continues to rise, affecting people's normal daily life. Conventional western medicine treatment can only temporarily relieve its symptoms, but can not be completely cured, resulting in the recurrence of the disease, the overall effect is not good. Chinese medicine treatment of CVA has rich experience and a long history. In this paper, the etiology and pathogenesis of CVA, syndrome differentiation and Chinese medicine treatment are discussed to provide theoretical basis for community treatment.

Objective: To investigate the significance of urinary α1 microglobulin (α1-MG), urinary β2 microglobulin (β2-MG) and urinary microalbumin/creatinine ratio (ACR) combined detection in early-stage diabetic nephropathy (EDN). Method: A total of 208 patients with type 2 diabetes who were hospitalized in Yancheng Hospital of Traditional Chinese Medicine from November 2022 to December 2023 were selected as the study objects. According to the 24-hour urinary albumin ejection rate (UAER), the patients were divided into diabetes mellitus (DM) group, EDN group and clinical diabetic nephropathy (DN) group. These three groups are study groups. Another 43 healthy subjects in Yancheng Hospital of Traditional Chinese Medicine were selected as control group. The differences in urine α1-MG, β2-MG and ACR detection results between the two groups were compared, and the differences in urine α1-MG, β2-MG and ACR detection results between the study group were compared, and receiver operating curve (ROC) was drawn to analyze the diagnostic significance of 3 indicators alone and combined detection in early kidney injury in diabetic patients. Result: Urinary α1-MG, β2-MG and ACR levels in study group were higher than those in control group, urinary α1-MG, β2-MG and ACR levels in EDN group were significantly higher than those in DM group, and the three indexes in DN group were significantly higher than those in EDN group, and the differences were statistically significant (P<0.05). ROC curve showed that the AUC of α1-MG, β2-MG and ACR alone and combined detection in predicting early kidney injury in type 2 diabetes mellitus were 0.833, 0.870, 0.981 and 0.993, respectively, and the combined detection had a higher predictive value (P<0.05). Conclusion: Urine α1-MG, β2-MG and ACR combined detection has high clinical value in early diagnosis of diabetic nephropathy.

Objective: To investigate the effect of Weichun capsule combined with quadruple therapy on Helicobacter pylori (Hp)-positive chronic atrophic gastritis. Method: A total of 120 patients with Hp-positive chronic atrophic gastritis admitted to Chun 'an County Traditional Chinese Medicine Hospital from October 2022 to December 2023 were selected as the study objects and randomly divided into control group and observation group, with 60 cases in each group. The control group was treated with quadruple therapy, while the observation group was treated with Weifuchun capsule combined with quadruple therapy. The clinical effect, the degree of clinical symptoms, laboratory test indexes and the results of Hp negative conversion were compared between the two groups. Result: The total effective rate, Hp negative conversion rate and the levels of pepsinogen Ⅰ (PG-Ⅰ), PG-Ⅰ / PG-Ⅱ and G17 in the observation group were higher than those in the control group, while the scores of TCM symptoms and PG-Ⅱlevels in the observation group were lower than those in the control group, with statistical significance (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: Weifuchun capsule combined with quadruple therapy is effective in the treatment of Hp-positive chronic atrophic gastritis, which can not only increase the negative conversion rate of Hp, but also improve clinical symptoms and serum pepsinogen and G17 levels more effectively.

Objective: To investigate the effect of oral four vitamins combined with Iodine Glycerin in the treatment of oral ulcer. Method: A total of 94 patients with oral ulcer who admitted to Qianxinan Autonomous Prefecture Hospital of Traditional Chinese Medicine from June 2022 to June 2023 were selected as the research objects, they were divided into the control group and the observation group by random number table method, with 47 cases in each group. The control group was treated with Iodine Glycerin, and the observation group was treated with four vitamins on the basis of the control group, the efficacy, epidermal growth factor, immune indexes and inflammatory factors were compared between two groups. Result: The total effective rate of the observation group was higher than that of the control group, and the difference was statistically significant (P<0.05); after 30 d of treatment, the epidermal growth factor, CD3+, CD4+ and CD4+/CD8+ in two groups were higher than those before treatment, and those in the observation group were higher than those in the control group, the differences were statistically significant (P<0.05); after 30 d of treatment, the levels of interleukin-1 (IL-1), interleukin-8 (IL-8), interleukin-17 (IL-17) and tumor necrosis factor-α (TNF-α) in two groups were lower than those before treatment, and those in the observation group were lower than those in the control group, the differences were statistically significant (P<0.05). Conclusion: Oral four vitamins combined with Iodine Glycerin is effective in the treatment of oral ulcer, which can increase epidermal growth factor, improve immune function and reduce inflammatory response.

Objective: To explore the application effect of family-integrated care (FICare) in senile weakened patients with severe pneumonia. Method: A total of 113 senile weakened patients with severe pneumonia were selected from the 900th Hospital of Joint Logistics Support Force, PLA from June 2022 to June 2023. They were randomly divided into control group (n=55) and observation group (n=58). The control group was treated with routine nursing, and the observation group was treated with FICare based on the control group. Lung function, self-efficacy, quality of life before and at 3 months of nursing and family satisfaction were compared between the two groups. Result: At 3 months of nursing, the forced lung capacity (FVC), the percentage of forced expiratory volume in the first second to the expected value (FEV1%pred) and peak respiratory flow rate (PEF) of the two groups were increased, and the FVC, FEV1%pred and PEF of the observation group were higher than those of the control group, the differences were statistically significant (P<0.05). At 3 months of nursing, the general self-efficacy scale (GSES) score of both groups increased, and the GSES score of the observation group was higher than that of the control group, the difference was statistically significant (P<0.05). At 3 months of nursing, the physiological, psychological, environmental and social scores of the two groups were increased, and the physiological, psychological, environmental and social scores in the observation group were higher than those of the control group, the differences were statistically significant (P<0.05). The total satisfaction of family members in the observation group was higher than that in the control group, and the difference was statistically significant (P<0.05). Conclusion: FICare can effectively improve lung function, self-efficacy and quality of life in senile weakened patients with severe pneumonia, and the nursing satisfaction of family members is higher.

Congenital muscular torticollis (CMT) is a common pediatric disease. In recent years, the incidence of this disease has been on the rise, and most parents of children choose to avoid taking the risk of surgery through TCM treatment. Massage treatment of children with muscular torticollis has the advantages of significant efficacy, high safety, less side effects, children and parents are easy to accept. Its treatment methods can be divided into massage, acupuncture and Chinese medicine treatment three, which can be used alone, as well as can be used in a variety of methods, but its efficacy evaluation criteria are still insufficient. This review summarizes the clinical research progress of massage therapy CMT, aiming to summarize the situation of massage therapy CMT and explore the clinical research progress of massage therapy CMT.

Sepsis associated acute kidney injury (SA-AKI) is characterized by significantly high morbidity and mortality, and it is urgent to further explore effective strategies to promote the progress of research and practice in this field. At present, the clinical understanding of the diagnosis and treatment of SA-AKI is still insufficient, which makes most patients have developed acute kidney injury (AKI) at the time of treatment, leading to poor prognosis. Therefore, early identification of SA-AKI is particularly important for implementing targeted treatment and improving patient outcomes. This article will focus on the pathophysiological mechanism, early novel biomarkers and corresponding treatment of SA-AKI, hoping to provide a useful reference for clinical research.

Objective: To explore the impact of personalized nursing based on Caprini risk assessment on the incidence of deep venous thrombosis (DVT) in elderly patients with lower limb fractures. Method: A total of 80 elderly patients with lower limb fractures in Quanzhou Orthopedic-Traumatological Hospital from February to December 2023 were selected as the study subjects. The patients were divided into control group (n=40) and observation group (n=40) by random number table method. The control group received routine nursing intervention, while the observation group received personalized nursing based on Caprini risk assessment on the basis of routine nursing intervention. The differences in thigh circumference, incidence of DVT, and satisfaction between two groups of lower limbs were compared between the two groups. Result: Before surgery, there were no significant difference in thigh circumference between the two groups of lower limbs (P>0.05). At 3 d after surgery, 7 d after surgery and before discharge, the thigh circumference in the observation group were better than those in the control group , the differences were statistically significant (P<0.05). There were 1 case of DVT occurred in the observation group, with an incidence rate of 2.50%; there were 6 cases of DVT in the control group, with an incidence rate of 15.00%, and there was no statistically significant in the incidence of DVT between the two groups (P<0.05). The total satisfaction of the observation group was higher than that of the control group, the difference was statistically significant (P<0.05). Conclusion: Personalized nursing based on Caprini risk assessment can reduce the risk of DVT in elderly patients with lower limb fractures and improve patient satisfaction.

Objective: To investigate the clinical effect of combined administration of voronolazone and esomeprazole in patients with refractory gastroesophageal reflux (GERD) positive helicobacter pylori (Hp). Method: A total of 80 patients with Hp-positive refractory GERD treated in Dongtai People's Hospital from January 2021 to October 2023 were selected as the study objects, and grouped according to treatment differences, with 40 cases in each group. Patients in both groups received basic intervention. The control group was treated with esomeprazole, while the study group was treated with Vonolazine fumarate tables on the basis of control group. The levels of gastrointestinal hormones, inflammatory factors, adverse reactions and clinical efficacy of the two groups were compared. Result: Before treatment, there was no significant difference in gastrointestinal hormone levels between the two groups (P>0.05). After treatment, VIP in the study group was lower than that before treatment, and lower than that in control group, with statistically significance (P>0.05). After treatment, gastrin and motilin in study group were higher than that before treatment, with statistical significance (P<0.05). Before treatment, there was no significant difference in the levels of inflammatory factors between the two groups (P>0.05). After treatment, CRP, C-creative protein, interleukin-6 and TNF-α in the study group were lower than those before treatment and lower than those in control group, and the difference was statistically significant (P<0.05). After treatment, the incidence of abdominal pain, diarrhea, nausea and vomiting in the study group was lower than that in the control group, and the difference was statistically significant (P<0.05). After treatment, the total effective rate of the study group was higher than that of the control group, and the difference was statistically significant (P<0.05). Conclusion: Venolazan combined with esomeprazole can improve the level of gastrointestinal hormones and inflammatory factors in patients with Hp-positive refractory gastroesophageal reflux disease, thus improving the clinical effect of patients with high safety.

Insulin resistance is one of the important risk factors for stroke. The triglyceride-glucose (TyG) index is a simple and reliable index for assessing insulin resistance. TyG index combined with body measurement indicators, long-term level and variation trajectory of TyG index are related to the occurrence, development and prognosis of stroke, it has potential value in optimizing the risk stratification of stroke in the general population and predicting the prognosis of stroke patients. Therefore, this paper reviewed the research on the correlation between TyG index and its related indexes and stroke, and discusses the predictive value of TyG index for stroke, so as to provide reference for its application in screening high-risk stroke population and evaluating the prognosis of stroke patients.

Objective: To explore the effect of Moluodan combined with Rabeprazole in the treatment of elderly chronic atrophic gastritis. Method: A total of 90 elderly patients with chronic atrophic gastritis who treated in Qichun County People's Hospital from February 2022 to February 2023 were selected as the research objects, they were divided into the study group and the reference group according to the envelope method, with 45 cases in each group. The reference group was treated with Rabeprazole-based conventional therapy, and the study group was treated with Moluodan on the basis of the reference group. The gastrointestinal hormones, serum inflammatory factors, clinical efficacy and adverse reactions were compared between two groups. Result: After treatment, the levels of gastrin (GAS), motilin (MTL) and serum inflammatory factors in two groups were improved compared with those before treatment, the levels of GAS, serum interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and high-sensitivity C-reactive protein (hs-CRP) in the study group were lower than those in the reference group, while the level of MTL was higher than that in the reference group, and the differences were statistically significant (P<0.05); the total clinical effective rate of the study group was 95.56%, which was higher than 82.22% of the reference group, the incidence of adverse reactions in the study group was 8.89%, which was lower than 24.44% in the reference group, the differences were statistically significant (P<0.05). Conclusion: The combined treatment of Moluodan and Rabeprazole for elderly patients with chronic atrophic gastritis can significantly improve the levels of serum gastrointestinal hormones and inflammatory factors, thereby improving clinical efficacy and controlling adverse reactions.

Objective: To observe the effect of Jianpi Shengxue Granules combined with Ferrous Succinate in the treatment of patients with iron deficiency anemia during pregnancy. Method: A total of 128 patients with iron deficiency anemia during pregnancy treated in Jintai Hospital in Baoji City from January to December 2023 were selected. They were divided into control group (n=64) and observation group (n=64) according to random number table method. The control group was treated with Ferrous Succinate, and the observation group was treated with Jianpi Shengxue Granules on the basis of the control group. The clinical efficacy, blood biochemical and iron metabolism indexes before and after medication, pregnancy outcome and adverse reactions were compared between the two groups. Result: The total effective rate of the observation group was higher than that of the control group, and the difference was statistically significant (P<0.05). After treatment, red blood cell count (RBC), mean red blood cell hemoglobin concentration (MCHC), hematocrit (HCT) and hemoglobin (Hb) levels in both groups were increased, and RBC, MCHC, HCT and Hb levels in observation group were higher than those in control group, the differences were statistically significant (P<0.05). After treatment, the levels of ferritin (SF), transferrin (TRF), iron concentration (SI) and iron regulating hormone (HEPC) in both groups were increased, and the levels of SF, TRF, SI and HEPC in observation group were higher than those in control group, the differences were statistically significant (P<0.05). The incidences of preterm birth, cesarean section, puerperal infection, postpartum hemorrhage, low birth weight infants and neonatal asphyxia in observation group were lower than those in control group, and the differences were statistically significant (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: The application of Ferrous Succinate combined with Jianpi Shengxue Granules in the treatment of iron-deficiency anemia in pregnancy can effectively regulate iron metabolism, improve blood biochemical indexes, reduce adverse pregnancy outcomes, with definite clinical effect and drug safety.

Objective: To explore the clinical effect of Montmorillonite Powder combined with Bifidobacterium Tetravalent Live Bacteria in the treatment of acute gastroenteritis (AGE). Method: A total of 60 patients with AGE who admitted to the Department of Emergency Medicine of Jiangyin People's Hospital from March 2023 to May 2024 were selected as the research objects, they were divided into the control group and the study group according to the random number table method, with 30 cases in each group. Two groups were given symptomatic treatment such as bed rest, rehydration, correction of electrolyte, etc, the control group was given oral Montmorillonite Powder, and the study group was given oral Bifidobacterium Tetravalent Live Bacteria Tablets on the basis of the control group, two groups were treated for 3 d. The remission times of clinical symptoms (diarrhea, abdominal pain, nausea and vomiting), curative effect, stool frequency, stool trait score, immune function (CD4+, CD8+ and CD4+/CD8+) were compared between two groups. Result: The remission times of diarrhea, abdominal pain, nausea and vomiting in the study group were earlier than those in the control group, the total effective rate was higher than that in the control group, the differences were statistically significant (P<0.05); the stool frequency in the study group after treatment was less than that in the control group, the stool trait score was lower than that in the control group, and CD4+ and CD4+/CD8+ were higher than those in the control group, the differences were statistically significant (P<0.05). Conclusion: Montmorillonite Powder combined with Bifidobacterium Tetravalent Live Bacteria can shorten clinical symptoms relief time, improve therapeutic effects, reduce stool frequency and stool trait scores, and improve immune function in AGE patients.

Objective: To investigate and compare the influence of laparoscopic, transabdominal and transvaginal hysterectomy for postoperative life quality and sexual life quality of patients. Method: A total of 180 patients with hysterectomy in People's Hospital of Xintai City from June 2022 to June 2023 were divided into group A, group B and group C by the method of random number table, 60 cases in each group. The group A were treated with laparoscopic hysterectomy, the group B were treated with transabdominal hysterectomy, the group C were treated with transvaginal hysterectomy. Then the operation time, blood loss, exhaust time, hospitalization time, complications rates, life quality [World Health Organization Quality of life brief (WHOQOL-BREF scale)] and sexual life quality (sexual life quality questionnaire for women) before operation and 3 months and 6 months after operation of three groups were compared. Result: The operation time of group A was significantly longer than those of group B and group C, the blood loss of group A and group C was significantly less than that of group B, the exhaust time and hospitalization time were significantly shorter than that of group B, the differences were statistically significant (P<0.05). The complications rates of three groups were compared, the differences were not statistically significant (P>0.05). The WHOQOL-BRE scale and sexual life quality questionnaire for women of three groups at before operation and 6 months after operation were compared, the differences were not statistically significant (P>0.05). The WHOQOL-BRE scale and sexual life quality questionnaire for women of group A and group C at 3 months after operation were significantly higher than those of group B, the differences were statistically significant (P<0.05). Conclusion: The short-term adverse influence of laparoscopic and transvaginal hysterectomy for postoperative life quality and sexual life quality of patients are smaller than those of transabdominal hysterectomy, while the differences of long-term adverse influence are not significant.

Objective: To explore the high risk factors and protective measures for recurrence after endoscopic submucosal dissection (ESD) in patients with esophageal cancer. Method: A total of 82 patients with esophageal cancer admitted to Xiamen Traditional Chinese Medicine Hospital from January 2020 to December 2022. The general information of all patients was collected. All patients received ESD treatment and underwent 1-year follow-up. According to the recurrence situation, they was divided into recurrence group and non recurrence group. The grouping situation was analyzed. The general information between the recurrent group and the non recurrent group was compared. The factors that affect the recurrence of esophageal cancer patients after ESD surgery was analyzed. Result: Out of 82 patients, a total of 12 recurred, with a recurrence rate of 14.63% (12/82), and were included in the recurrence group; and 70 cases without recurrence were included in the non recurrence group. The proportion of severe intraoperative adhesions, postoperative complications of vascular tumor thrombus coindition, lesion diameter ≥3 cm, tumor infiltration depth T1b, incomplete lesion resection, and no postoperative participation in chemotherapy in the recurrence group were all higher than those in the non recurrence group, and the differences were statistically significant (P<0.05). Multiple factors analysis showed that severe adhesion during surgery, postoperative complications of vascular tumor thrombus coindition, lesion diameter ≥3 cm, tumor infiltration depth T1b, incomplete resection of the lesion, and failure to participate in chemotherapy after surgery were high-risk factors for ESD recurrence in esophageal cancer patients (P<0.05). Conclusion: The recurrence of esophageal cancer patients after ESD surgery is closely related to severe adhesion during surgery, postoperative complications of vascular tumor thrombus coindition, lesion diameter ≥3 cm, tumor infiltration depth T1b, incomplete lesion resection, and failure to participate in chemotherapy after surgery. Therefore, it is necessary to attach great importance to targeted intervention measures, improve intervention measures as much as possible, and reduce the risk of postoperative recurrence.

Objective: To investigate the efficacy and safety of Mirabegron in the early application after transurethral holmium laser enucleation of prostate (HoLEP) for benign prostatic hyperplasia (BPH) with overactive bladder (OAB). Method: Seventy-two patients with BPH and OAB who admitted to Wujin Hospital Affiliated to Jiangsu University from January 2020 to January 2022 were selected as the study objects, they were randomly divided into two groups, all patients were underwent HoLEP under general anesthesia, thirty-six patients in the observation group was given Mirabegron Sustained-release Tablets, thirty-six patients in the control group were not given drug treatment, and three patients in the observation group withdrew from the study due to the novel coronavirus epidemic. The incidence of complications, overactive bladder symptom score (OABSS), quality of life (QOL), international prostate symptom score (IPSS), maximum urinary flow rate (Qmax), residual urine volume (PVR) and adverse drug reactions were compared between two groups. Result: At 4 weeks after operation, the QOL scores, voiding symptom IPSS (V-IPSS), total IPSS (T-IPSS), maximum urinary flow rate (Qmax) and residual urine volume (PVR) of two groups were improved compared with those before operation, and the differences were statistically significant (P<0.05); the OABSS score and urine storage symptom IPSS (S-IPSS) score of the control group at 4 weeks after operation were lower than those before operation, but the difference was not statistically significant (P>0.05); the OABSS score and S-IPSS score of the observation group at 4 weeks after operation were lower than those before operation and those of the control group after operation, and the differences were statistically significant (P<0.05); the QOL score and T-IPSS score of the observation group at 4 weeks after operation were lower than those of the control group, and the differences were statistically significant (P<0.05); however, there were no significant differences in the V-IPSS score, Qmax and PVR between two groups at 4 weeks after operation (P>0.05). There were 2 cases (6.1%) of constipation in the observation group during oral administration of Mirabegron, and 1 case (2.8%) of constipation in the control group, there was no significant difference between two groups (P>0.05). Conclusion: Early application of Mirabegron after HoLEP can further alleviate lower urinary tract symptoms in patients with BPH and OAB without affecting urinary function.

Acute kidney injury (AKI) is a global problem, affecting millions of patients worldwide, and over the past few decades, many research results have improved our understanding of AKI, standardizing the diagnostic criteria for AKI and influencing subsequent clinical treatment in Kidney Diseases: Improving Global Outcomes (KDIGO) in 2012. Glutamine (GLN) is a non-essential amino acid that is abundant in healthy humans, and previous studies have shown that GLN supplementation can be used to prevent new infections in uninfected patients or subsequent infections in critically ill patients who have already been infected, and is part of the clinical nutritional supplement regimen and recommended immunosuppressive individuals. With the continuous updating of AKI treatment guidelines and the in-depth exploration of GLN metabolism, more and more researchers have found that GLN plays a non-ignorable protective role in clinical AKI and critically ill patients. This review introduces the possible protective mechanism and clinical reference of GLN metabolism in the occurrence of AKI diseases, so as to provide a reference for better treatment of AKI patients. It can effectively protect the renal function of AKI patients, alleviate the disease symptoms and improve the prognosis of the disease.

Objective: To investigate the application effect of total hip arthroplasty (THA) and hemiarthroplasty (HA) under direct anterior approach (DAA) pathway in the treatment of elderly femoral neck fracture (FNF). Method: A total of 70 patients with FNF who admitted to the Department of Orthopedics, Nanjing First Hospital, Nanjing Medical University from January 2020 to January 2023 were selected as the research objects, the patients were divided into the treatment group 1 (HA) and the treatment group 2 (THA) based on the random number table method, with 35 cases in each group. The perioperative indexes, muscle tissue injury, bone metabolism and long-term hip function were compared between two groups. Result: The operation time of the treatment group 2 was longer than that of the treatment group 1, and the intraoperative blood loss and postoperative drainage volume were more than those of the treatment group 1, the differences were statistically significant (P<0.05); however, there were no significant differences in the time of first ambulation, the incidence of postoperative complications, the rate of central fixation of femoral prosthesis and the time of postoperative hospitalization between two groups (P>0.05). At 3 d after operation, the creatine kinase (CK) and C-reactive protein (CRP) in two groups were higher than those before operation, and those in the treatment group 2 were higher than those in the treatment group 1, the differences were statistically significant (P<0.05); at 3 months after operation, the N-terminal propeptide of type Ⅰ precollagen (PⅠNP) and C-terminal telopeptides of type Ⅰ collagen (CTX) in two groups were lower than those before operation, and the bone-specific alkaline phosphatase (BAP) were higher than those before operation, the difference was statistically significant (P<0.05); however, there were no significant differences in the PⅠNP, CTX and BALP between two groups at 3 months after operation (P>0.05). At 5 months, 8 months and 12 months after operation, the Harris scores of two groups were higher than those at 3 months after operation, and those in the treatment group 2 were higher than those in the treatment group 1, the differences were statistically significant (P<0.05). Conclusion: Both THA and HA under DAA pathway have good therapeutic effects, and HA has advantages in perioperative indicators, and it is suitable for patients with poor physical conditions; THA has more advantages in recovery of long-term hip function, and it is suitable for patients with high mobility needs.