Objective: To assess the therapeutic response of tongue acupuncture in patients with post-stroke dysphagia (PSD). Method: Medical records of PSD patients consecutively admitted to Yangjiang Hospital of Traditional Chinese Medicine between October 2021 and December 2022 were retrospectively analyzed. Eighty patients meeting the inclusion criteria were enrolled. Participants were stratified into a control group (n=40) and a tongue acupuncture group (n=40) based on the specific therapeutic regimen received. The control group was given rehabilitation therapy, while the treatment group was combined with tongue acupuncture. The differences in Water Swallowing Test (WST) grades and Standardized Swallowing Assessment (SSA) scores were compared. The therapeutic outcomes and adverse events were documented following the intervention period. Result: Baseline equivalence in WST grades and SSA scores was observed, demonstrated no significant intergroup differences (P>0.05). Post-therapy, the tongue acupuncture cohort demonstrated greater WST improvement, lower SSA scores, and higher clinical efficacy rates versus controls, differences were statistically significant (P<0.05). No adverse events occurred in either group. Conclusion: Tongue acupuncture combined with rehabilitation achieves superior dysphagia mitigation in PSD compared to rehabilitation alone, with sustained short-term effects observed at 3-month follow-up and an optimal safety trajectory.

Objective: To investigate the effect of fenelidone for diabetic nephropathy combined with heart failure on patients. Method: 107 patients with diabetic nephropathy combined with chronic heart failure admitted to Putian Ninety-five Hospital from July 2022 to December 2024 were selected as the study subjects, and were randomly divided into 53 cases in the observation group and 54 cases in the control group using the lottery method. The control group was treated with metformin hydrochloride tablets with valsartan capsules, and the observation group was treated with combined fenetylline on the basis of the control group for 2 months. The efficacy, cardiac enzymes and urine microalbumin, and quality of life of the two groups were compared, and the incidence of adverse reactions was counted. Result: After treatment, the total effective rate of the observation group was higher than that of the control group, and the difference was statistically significant (P<0.05). After treatment, the indicators of cardiac enzymes and 24-h urinary microalbumin excretion rate decreased significantly in both groups, and compared with the control group, troponin I (cTnI), N-terminal B-type natriuretic peptide precursor (NT-proBNP), free fatty acid (FFA), and 24-h urinary microalbumin excretion rate in the observation group were lower, and the difference was statistically significant (P<0.05). The scores of all dimensions of quality of life in both groups increased after treatment compared with those before treatment, and compared with the control group, the observation group had higher scores in the physical domain, emotional domain, and other domains, and the difference was statistically significant (P<0.05). The difference in the incidence of adverse reactions between the two groups was not statistically significant (P>0.05). Conclusion: The adjuvant treatment of diabetic nephropathy combined with chronic heart failure can effectively improve the cardiac enzymes, urinary microalbumin excretion rate, and play a protective role in the recovery of cardiac and renal function, with good therapeutic effects and few adverse reactions, and high safety.

Lumbar disc herniation (LDH) is a common condition in clinical practice, particularly in orthopedics, often causing lower back and leg pain and affecting patients' quality of life. Traditional Chinese medicine acupuncture has been shown to be effective in treating LDH patients, offering advantages such as simplicity, convenience, affordability and reliability, and plays an irreplaceable role in treatment. The article reviews relevant literature on the mechanisms of action of acupuncture in the treatment of LDH over the past five years and summarizes the findings. The results indicate that acupuncture treatment for LDH is closely associated with multiple mechanisms of action, including reducing inflammation levels, improving bone metabolism, improving serum differential metabolite levels, regulating neurotransmitters, enhancing nerve conduction velocity, and improving blood rheology.

Objective: To explore the clinical value of pearl eye drops combined with polyvinyl alcohol eye drops in the treatment of dry eye syndrome. Method: 112 patients with dry eye disease who were diagnosed and treated in Ezhou Aier Eye Hospital from December 2023 to October 2024 were randomly divided into two groups. The control group (56 cases and 112 eyes) were treated with polyvinyl alcohol eye drops, and the experimental group (56 cases and 112 eyes) were treated with pearl eye drops and polyvinyl alcohol eye drops. After 2 weeks of treatment, compared the overall efficacy, disease-related indicators, tear inflammatory factors and drug safety. Result: After treatment, comparisons between the experimental group and the control group showed that the total effective rate was higher in the experimental group, the Schirmer Tear Secretion Test (SIT) and the average tear film break-up time (BUT) were both longer in the experimental group, the Ocular Surface Disease Index (OSDI) was lower in the experimental group, the concentrations of interleukin-1 β (IL-1β), tumor necrosis factor -α (TNF-α), and interleukin-6 (IL-6) in the tear fluid were lower in the experimental group, with statistically significant difference (P<0.05). The difference in adverse reaction rates did not reach statistical significance (P>0.05). Conclusion: Pearl eye drops combined with polyvinyl alcohol eye drops in the treatment of dry eye syndrome can play positive synergistic effect. It is conducive to the improvement of the disease. And it can reduce the expression of inflammatory factors in tears, with good safety.

Objective: To explore the effectiveness of mind mapping health education in patients with colorectal cancer with temporary colostomy. Method: 130 patients with colorectal cancer with temporary enterostomy admitted to Jianyang First Hospital in Nanping City from June 2020 to June 2024 were selected the subjects, and were randomly into the study and the control group, 65 cases in group. The control received conventional rehabilitation nursing care, and the study group used thinking guide health education, and both groups received nursing care for a period of 12 weeks . Before and after the intervention, self-care ability, survival quality, peristoma skin status, awareness and complications were compared between the two groups. Result: After 12 weeks of intervention, erosion, discoloration, and tissue proliferation scores lower in study group compared the control, and difference was statisically sigifiant (P<0.05). The quality of cancer survival scores in the 3 domains of symptomatic domain, functional domain and general health status were elevated in study group compared the control group, the difference was statistcally signifcant (P<0.05). The scores the dimensions of self-care ability the study increased mpared with the trol group, and the diffence was statiscally signcant (P<0.05). Knowledge scores the 3 dimensions of complication recognition, stoma replacement, and precautions were elevated in the study compared with control group, difference was stastically signcant (P<0.05). The complicon rate of the study group was lwer than that of the control, and the difference was stastically signifnt (P<0.05). Conclusion: Mind mapping health education can better improve the quality of cancer survival and peristoma skin status of colorectal cancer patients with temporary colostomy, improve self-care ability and knowledge.

Objective: To investigate the efficacy of combined administration of diquafosol sodium and cyclosporine in the treatment of dry eye disease. Method: A total of 110 patients with dry eye treated in our hospital from January 2022 to December 2023 were selected as cases and divided into two groups with 55 cases each by random number table method. The conventional group received cyclosporine eye drops, and the experimental group received desquafoxol sodium eye drops + cyclosporine eye drops. The treatment effect was compared. Result: After treatment, the effective rate, Schirmer test result and BUT value, disease symptom score and inflammatory factor level of the experimental group were better than those of the conventional group, with statistically significant difference (P<0.05). Conclusion: Diquafoxol sodium eye drops combined with cyclosporine eye drops have outstanding efficacy in the treatment of dry eye, which can effectively improve eye function and reduce disease symptoms, and reduce inflammation, and is worth promoting.

Dexamethasone is a synthetic long-acting glucocorticoid, a fluorinated derivative of prednisolone, with anti-inflammatory, antitoxic, anti-immune and antishock effects, excitation of the central nervous system, affecting the hematopoietic system, promoting the secretion of gastric acid, inhibiting the pineal gland's secretion of melatonin, and decreasing iodine ion uptake by the thyroid gland, which has been widely used in clinical practice. For unexplained fever and osteoarthritic pain, it has the effect of temporarily reducing fever and alleviating pain, which is favored by clinicians, especially in the primary health care institutions is a large number of applications, and even reached the point of abuse. The article found that dexamethasone would have adverse reactions such as ergotism, hypokalemic paralysis, anaphylactic shock, mental abnormality, perineal itching, urinary incontinence, acanthosis nigricans, epilepsy, gastric perforation, and femoral head necrosis in clinical application, which would cause unnecessary pain to patients. These adverse reactions occurring in the clinical application of dexamethasone in recent years are now analyzed and summarized to provide reference for future clinical application.

Objective: To investigate the effect of limaprost in the treatment of patients with lumbar spinal stenosis and influence for gait parameters. Method: 80 patients with lumbar spinal stenosis diagnosed and treated in 910th Hospital of the Joint Service Support Force of the Chinese People's Liberation Army from November 2023 to August 2024 were grouped by random number table. 40 cases of the control group were treated with routine treatment for lumbar spinal stenosis, and 40 cases of the observation group were treated with limaprost on the treatment of control group. Then the total effective rates for limaprost, lower back and leg pain situation [Visual Analogue Scale (VAS)], disease state [Chinese swiss spinal stenosis questionnaire (CSSS scale)] and gait parameters [routine gait indexes (step speed, step frequency and stride length) and gait symmetry indexes (stance phase and bipedal support phase)] of two groups before and after the treatment were compared. Result: The total effective rate for limaprost of observation group was significantly higher than that of control group. The lower back and leg VAS score, CSSS score and gait symmetry indexes of observation group 4 and 8 weeks after the treatment were significantly lower than those of control group. The routine gait indexes were all significantly higher than those of control group, and the differences were statistically significant (P<0.05). Conclusion: The effect of limaprost in the treatment of patients with lumbar spinal stenosis is better, and it can effectively control the lower backand leg pain, and improve the gait parameters. So its application value in the patients with lumbar spinal stenosis is higher.

Objective: To study the efficacy of tirofiban in non-endovascular treatment of patients with wake ischemic stroke. Method: A total of 100 patients with wake ischemic stroke who received non-endovascular treatment in Xinyi People's Hospital from January 2023 to December 2024 were selected and divided into a control group and an experimental group, with 50 cases in each group, based on whether tirofiban was used for non-endovascular treatment after admission for wake ischemic stroke. The control group received conventional treatment, while the experimental group was treated with tirofiban in addition. The therapeutic effects and hematocrit, platelet count, platelet ratio, fibrinogen, NIHSS, mRS And ADL scores of the two groups were compared. Result: The effective rate of treatment in the experimental group was higher than that in the control group, and the difference was statistically significant (P<0.05). There was no statistically significant difference in hematocrit, platelet count, platelet ratio, fibrinogen level, NIHSS, mRS And ADL score between the two groups before treatment (P>0.05). After treatment, the hematocrit, platelet count, platelet ratio, fibrinogen level, NIHSS and mRS Score of both groups decreased, and those of the experimental group were lower than those of the control group. The ADL score of both groups increased, and that of the experimental group was higher than that of the control group (P<0.05). Conclusion: Tirofiban in the treatment of patients with ischemic stroke after awakening who received non-endovascular treatment is helpful to improve the rheological indicators of blood flow and neurological function of patients, and to enhance the mRS, ADL scores and therapeutic effects.

Objective: To explore the effect of metoprolol succinate sustained-release tablets in patients with coronary heart disease (CHD) after percutaneous coronary intervention (PCI). Method: A total of 201 CHD patients treated with PCI in Enshi Huiyi Rheumatology Hospital from February 2022 to February 2024 were selected and divided into two groups by random number table method, group B (n=100) received conventional drug treatment, and group A (n=101) was treated with metoprolol succinate extended-release tablets on the basis of group B. The clinical efficacy, cardiac function, hemodynamics, myocardial enzymes, and major adverse cardiovascular events in the two groups were observed. Result: The total effective rate of group A was higher than that of group B, and the difference was statistically significant (P<0.05). After 6 months of treatment, the left ventricular ejection fraction and 6-minute walk test in the two groups increased compared with the time of admission and were higher in group A than in group B, the left ventricular end-diastolic diameter and left ventricular end-systolic inner diameter in the two groups decreased compared with those at admission, and group A was lower than that in group B, the mean left atrial pressure, mean pulmonary artery pressure, and mean mitral valve pressure in the two groups decreased compared with the time of admission, and group A was lower than group B, the incidence of recurrent angina and heart failure in group A were significantly lower than those in group B，with statistically significant differences (P<0.05). There were no significant differences in the incidence of stent restenosis, stroke, and sudden cardiac death between the two groups (P>0.05).Conclusion: The application of metoprolol succinate sustained-release tablets in CHD patients undergoing PCI can improve hemodynamics and myocardial enzyme levels, promote the recovery of cardiac function, reduce the incidence of recurrent angina and heart failure, and improve clinical efficacy.

Objective: To elucidate the specific process and efficacy of acupoint application combined with ear-patch therapy in the treatment of COPD combined with cough. Method: From December 2023 to January 2025, 80 patients of COPD complicated with cough participated in this study from Nanning Traditional Chinese Medicine Hospital. According to the principle of randomization, patients were classified into control group and test group, with 40 cases in each group. The control group received general medication and nursing from the department, while the test group received acupuncture point application combined with ear-patch therapy. Compare the CCS scores , lung capacity, cough severity and cough related quality of life between two groups. Result: After applying acupoint patches combined with ear-patch therapy to treat cough, the test group showed clearly better on the CCS and VAS scales, lung capacity and cough related quality of life compared to the control group. Conclusion: The combination of acupoint application and plaster therapy effectively improves cough symptoms, lung capacity and cough related quality of life in COPD patients with cough.

Objective: Evaluating the therapeutic efficacy of recombinant human epidermal growth factor (rhEGF) in synergistic combination with sodium hyaluronate for the management of post-phacoemulsification dry eye (PKPD). Method: The clinical cases of 100 PKPD patients admitted to Fuzhou First General Hospital across from September 2022 to September 2024 were selected. The study adopted the random number table method for grouping. The observation group and the control group each included 50 patients. The control group was patients treated with sodium hyaluronate eye dreps while the intervention group was treated with rhEGF on the basis of controll group. Tear film stability, the condition of corneal epithelial defect, condition, tear secretion, response rate and adverse reaction were assessed. Result: The control group exhibited significantly longer duration of ocular dryness, burning sensation, eye pain, and photophobia symptoms compared to the observation group, with statistically significant differences (P<0.05). Pretreatment assessments showed no significant intergroup differences in tear film stability, corneal epithelial defect status, disease severity, or tear secretion function (P>0.05). Post-treatment evaluations revealed significantly greater reductions in Ocular Surface Disease Index (OSDI) and fluorescein staining (FL) scores, along with more substantial improvements in Schirmer's test (SIt) and tear film breakup time (BUT) in the observation group versus controls (P<0.05). Efficacy analysis demonstrated a significantly higher treatment response rate in the observation group (98.00%) compared to the control group (86.00%) (P<0.05). Safety assessment indicated no statistically significant difference in the incidence of local reactions including eyelid itching, conjunctival congestion, and ocular redness between groups (P>0.05). Conclusion: The dual-action mechanism of rhEGF and sodium hyaluronate promotes more rapid clinical symptom abatement in affected patients, alleviate the condition, repair corneal epithelial defects, enhance tear secretion function, prolong tear film break-up time, and has good therapeutic effect and high safety.

Objective: To investigate the effects of ultrasound-guided dual nerve block technology on analgesia, motor function preservation, and postoperative recovery in ankle surgery patients. Method: A total of 80 patients undergoing ankle surgery at Xinhui District Hospital of Traditional Chinese Medicine in Jiangmen City, Guangdong Province from April to November 2024 were selected as subjects. The study was divided into experimental and control groups using equalized sequential matching. Equalized sequential matching was applied, with 40 cases in the control group receiving combined spinal-epidural anesthesia and 40 cases in the experimental group receiving ultrasound-guided popliteal popliteal nerve block combined with obturator block. The effectiveness of the control anesthesia protocol during surgical treatment was evaluated. Result: Analysis of heart rate, systolic blood pressure, diastolic blood pressure, and oxygen saturation levels showed no significant differences across time periods. Systolic and diastolic blood pressure remained unchanged before anesthesia initiation and at the end of surgery. However, the experimental group exhibited higher blood pressure at the start of surgery and 30 minutes post-surgery compared to the control group, with statistically significant difference (P<0.05). No significant difference was observed at 1 h postoperative, but statistically significant differences (P<0.05) were found at 12 h and 24 h postoperative, indicating better analgesia outcomes. The experimental group also demonstrated superior nerve block efficacy compared to the control group (P<0.05). Conclusion: During ankle surgery, implementing ultrasound-guided popliteal popliteal nerve block combined with obturator block ensures reliable anesthesia blockade, maintains stable circulatory status, and delivers high-quality analgesia.

Acute coronary syndrome (ACS) is one of the most common cardiovascular diseases, and percutaneous coronary intervention (PCI) is one of the main modalities that can improve the prognosis of ACS patients. Serum uric acid (UA) is closely related to cardiovascular disease. The article reviews the domestic and international literature on uric acid and adverse cardiovascular events (MACEs) in order to describe the mechanism of cardiovascular effects of UA, its relationship with the occurrence of MACEs after PCI, and related therapeutic strategies.

Objective: To investigate the effect of combined treatment of finerenone and dapagliflozin on patients with diabetic nephropathy (DN). Method: 100 DN patients treated in Beijing Shijingshan Hospital from February 2022 to February 2024 were taken as the subjects. All cases were assigned to control group (n=50 cases, treated with dapagliflozin) and observation group (n=50 cases, treated with dapagliflozin and finerenone) by random numerical table. The glucose metabolism indicators, inflammatory factors, renal function indicators, quality of life and adverse reactions in both groups were compared. Result: After 4 weeks of treatment, the observation group had lower glucose metabolism indicators, tumor necrosis factor - α (TNF - α), interleukin-1 β (IL-1 β), interleukin-6 (IL-6), high-sensitivity C-reactive protein (hs-CRP), serum creatinine (Scr), blood urea nitrogen (BUN), and 24-hour urinary protein quantity (24hUPE) levels compared to the control group. The estimated glomerular filtration rate (eGFR) level and 36-Item Short-Form Health Survey (SF-36) score in the observation group were higher compared with the control group (P<0.05). The comparison of the incidence of adverse reactions in both groups showed no statistically significant difference(P>0.05). Conclusion: The combination of finerenone and dapagliflozin has significant therapeutic effect in DN patients, which can effectively regulate glucose metabolism indicators, reduce inflammatory levels, improve renal function, and enhance the quality of life, with relatively high safety.

Objective: To compare the effects of mometasone furoate nasal spray combined with clarithromycin and eustachian tube blowing on children with acute secretory otitis media (ASOM). Method: A total of 118 children with ASOM admitted to the Women and Children's Medical Center Affiliated to Guangzhou Medical University from January 2020 to December 2024 were selected. The cases were divided into control and observation groups by random number table method, with an average of 59 cases. The clinical efficacy, symptom relief time, the changes in inflammatory factors [C-reactive protein (CRP), procalcitonin (PCT), interleukin-8 (IL-8), interleukin-1 β (IL-1 β)] indicators before and after treatment, the changes in audiological indicators [air conduction valve (AC), bone conduction valve (BC), air bone conduction difference (ABG)] before and after treatment, and the hearing conditions (average speech frequency, static sound straightness, ear peak pressure) before and after treatment were compared. The incidence of adverse reactions was statistically analyzed. Result: The total effective rate of the observation group was higher than that of the control group, while the relief time of ear pain, ear blockage, middle ear effusion and tinnitus in the observation group was all lower than that in the control group. After treatment, the average auditory valve levels of CRP, PCT, IL-8, IL-1β and speech frequency in both groups decreased, AC and ABG significantly decreased, static sound straightness and peak ear pressure values increased, and the observation group was better. The differences were statistically significant (P<0.05). After treatment, there were no significant changes in BC between or within the two groups, and no safety incidents occurred. The differences were not statistically significant (P>0.05). Conclusion: On the basis of conventional clarithromycin combined with eustachian tube inflation treatment, the treatment of children with ASOM by adding mometasone furoate nasal spray has significant effect, which can promote the relief of clinical symptoms, reduce the degree of inflammatory reaction, improve their hearing status, and has high safety.

Meniscus injury is a common knee joint disease. As a common sports injury, it often leads to symptoms such as knee joint pain and limited movement, seriously affecting patients' daily life and athletic ability. This literature reviews the latest research progress in the treatment of meniscus injury with both traditional Chinese and Western medicine. The exploration of treatment methods has always been a hot topic in the field of orthopedics. In recent years, significant progress has been made in the clinical application of integrated traditional Chinese and Western medicine in the treatment of meniscus injuries. This article explores the advantages and clinical application prospects of different treatment methods, aiming to provide references for clinical treatment.

Objective: To assess the clinical outcomes of cholangioscopy-assisted percutaneous transhepatic approaches in managing complex intrahepatic bile duct stones. Method: 104 patients with complex intrahepatic bile duct stones admitted to the First Hospital of Sanming City, Fujian Province, from July 2019 to July 2024 were selected as the study subjects, and were divided into the control group (received traditional open surgery treatmen) and the observation group (percutaneous transhepatic choledochoscopy treatment) using the random number table method, with 52 cases in each group. A comparative assessment was performed between groups regarding perioperative parameters, immunological profiles, hepatic function markers, and postoperative complications. Result: In comparison with the control group, the observation group exhibited shorter durations in terms of operation time, intraoperative bleeding volume, postoperative fasting period, postoperative defecation recovery time, and hospital stay. Meanwhile, the stone clearance rate of the observation group was notably higher (P<0.05). After surgery, the levels of CD3+, CD4+, CD8+, CD4+/CD8+, alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin and direct bilirubin showed lower values in contrast to those recorded in the control group (P<0.05). In terms of the complication rate, the observation group presented a lower figure as opposed to the control group (P<0.05). Conclusion: Percutaneous transhepatic cholangioscopy for the treatment of complex intrahepatic bile duct stones can shorten the operative time, reduce intraoperative bleeding, accelerate postoperative recovery, increase the rate of stone removal, improve immune and liver functions, and reduce the complication rate.

Objective: To investigate the effect of keratoplasty on corneal function and visual acuity recovery in adolescent myopic patients. Method: The data of 120 adolescent myopia patients (186 eyes) who underwent visual acuity examination and correction at the First Affiliated Hospital of Xiamen University from July 2021 to January 2024 were retrospectively analyzed, and based on the different correction methods, they were divided into the control group (59 cases and 91 eyes wearing conventional myopia spectacles), and the plasmapheresis group (61 cases and 95 eyes wearing keratoplasty lenses continuously for 6 months). Corneal function and visual acuity were examined before, 1 week, 1 month, 3 months, and 6 months after lens wear and the number of corneal endothelial cells, corneal refractive error, intraocular pressure length, ocular axis, corneal thickness, anterior and posterior surface high-order aberration, and naked-eye visual acuity (UCVA) were compared between the two groups. Result: Corneal refraction, axial length, and corneal thickness were significantly reduced in both groups at 1 week, 1 month, 3 months, and 6 months after wearing the lenses, and the refraction was higher in the plastic lens group than in the control group at all time points, and the axial length and corneal thickness were lower than those in the control group, and the difference was statistically significant (P<0.05). The anterior surface high-order aberration was higher than that before lens wear in both groups at 1 week, 1 month, 3 months, and 6 months after lens wear, and the anterior surface high-order aberration was higher in the plastigraphy group than that in the control group at all time points, and the difference was statistically significant (P<0.05). The UCVA (logMA) of the plastic lens group was better than that of the control group at 1 week, 1 month, 3 months, and 6 months after lens wear, and the difference was statistically significant (P<0.05). Pearson's parametric correlation analysis showed that corneal refraction, corneal thickness, and ocular axis length were positively correlated with naked-eye distance visual acuity (UDVA), and anterior surface higher-order aberrations were negatively correlated with UDVA in myopia patients at 6 months after lens wear (P<0.05). Conclusion: The recovery of corneal function and visual acuity is most obvious 1 week after keratoplasty in adolescent myopic patients, while continuous wearing of keratoplasty lenses for 6 months can effectively improve patients' corneal function and naked-eye visual acuity.

Objective: To analyze the effect of labetalol-based comprehensive treatment on gestational hypertension (PIH) patients in high-altitude areas. Method: A total of 84 PIH patients admitted to Qinghai Women and Children's Hospital from July 2023 to November 2024 were enrolled in this study and randomly divided into two groups, with 42 cases each. The control group received conventional antihypertensive treatment, while the experimental group was treated with labetalol-based comprehensive treatment. Both groups were treated for 14 days. The hypertension levels, pregnancy outcomes, biochemical test indicators, and clinical efficacy rates of the two groups were analyzed and compared. Result: Before treatment, both groups had high blood pressure levels. At 1 to 3 months post-treatment, blood pressure levels in both groups showed a downward trend, with the experimental group exhibiting lower diastolic/systolic blood pressure parameters compared to the control group, and the difference was statistically significant (P<0.05). The experimental group had fewer cases and a lower proportion of adverse pregnancy outcomes, with a statistically significant difference (P<0.05). No statistically significant difference was observed in blood biochemical indicators between the two groups before treatment (P>0.05). After treatment, the experimental group showed superior blood biochemical test results, with three indicator levels lower than those of the control group, and the difference was statistically significant (P<0.05). In the labetalol-based experimental group, the condition of PIH patients was effectively controlled, and the total efficacy rate was higher than that of the control group, with a statistically significant difference (P<0.05). Conclusion: Labetalol-based comprehensive treatment plays a significant role in controlling PIH symptoms, effectively reducing blood pressure, protecting vital organ functions, and improving maternal pregnancy outcomes.

Objective: To explore the impact of Cognitive Behavioral Therapy for Insomnia (CBT-I) combined with vagal nerve stimulation on the sleep quality of patients with anxiety-related insomnia during the perioperative period. Method: The study included 92 patients with anxiety-related insomnia treated in the First People's Hospital of Huai'an from June to October 2024. Patients were randomly divided using a drawing method, with odd numbers assigned to the control group (n=46) and even numbers to the observation group (n=46). The control group received standard care, while the observation group underwent CBT-I combined with VNS. The clinical efficacy, psychological state before and after 1 weeks of treatment [Generalized Anxiety Disorder Scale (GAD-7) and Patient Health Questionnaire (PHQ-9)], sleep quality [Pittsburgh Sleep Quality Index (PSQI)], and insomnia severity [Insomnia Severity Index (ISI)] were compared between the two groups. Result: After treatment, the total efficacy rate in the observation group was higher than in the control group. Scores for GAD-7 and PHQ-9 were lower in the observation group. Scores across all dimensions of the PSQI were lower in the observation group. ISI scores were lower in the observation group, with statistically significant difference (P<0.05). Conclusion: CBT-I combined with VNS significantly improves sleep quality and psychological state in patients with anxiety-related insomnia during the perioperative period. The treatment efficacy is higher than that of CBT-I alone, showing significant improvements in anxiety, depression, and the severity of insomnia.

Objective: To study the effect of evidence-based pain care on postoperative patients with mixed hemorrhoids. Method: 160 cases of mixed hemorrhoids patients who attended Bijie Hospital of Zhejiang Provincial People's Hospital from October 2023 to October 2024 were selected and divided into two groups of 80 cases each according to the random number table method. The control group used conventional postoperative care, and the observation group used evidence-based pain care on the basis of conventional care. Consecutively followed up for 4 weeks, the pain level, anal margin edema level, defecation, anal function, postoperative recovery time and nursing satisfaction were compared between the two groups. Result: The observation group had lower pain, edema, defecation, and anal function scores than the control group, shorter postoperative recovery time, and higher nursing satisfaction scores in all categories than the control group, and the difference was statistically significant (P<0.05). Conclusion: Evidence-based pain care can effectively reduce traumatic pain and edema in postoperative patients with mixed hemorrhoids, accelerate postoperative recovery, improve anal function, and obtain higher nursing satisfaction.

Objective: To compare the therapeutic effects of laparoscopic resection and open abdominal surgery on patients with uterine fibroids (UF). Method: 68 patients with uterine fibroids admitted to the Gaochun People's Hospital in Nanjing from January 2022 to June 2024 were selected and divided into group B (n=34, treated with open abdominal surgery) and group A (n=34, treated with laparoscopic resection) according to different surgical methods. Compare two groups of surgical indicators, Visual Analog Scale (VAS) scores, Generic Quality of Life Inventory (GQOLI-74) scores, and incidence of complications. Result: The surgical indicators in group A were superior to those in group B, and the difference was statistically significant (P<0.05)； The postoperative pain level in group A was lower than that in group B, and the difference was statistically significant (P<0.05)； The postoperative quality of life in group A was higher than that in group B, and the difference was statistically significant (P<0.05)； The incidence of complications in group A was lower than that in group B, and the difference was statistically significant (P<0.05).Conclusion: Compared with open surgery abdominal, laparoscopic resection is more effective in treating patients with uterine fibroids, which can further reduce pain, improve quality of life, and prevent postoperative complications.

Chronic respiratory diseases are a major contributor to the global burden of disease, and although awareness of these diseases has increased and traditional treatment options have greatly reduced mortality from the diseases, there are still limitations in treatment strategies and new treatment options still need to be sought. The intake of appropriate amounts of vitamin D has a multifaceted positive impact on the body's ability to maintain good health and may reduce morbidity and mortality from respiratory diseases. The aim of the article is to systematically review the relationship between chronic respiratory diseases and vitamin D, and to explore whether vitamin D could be a new adjunctive treatment option for chronic respiratory diseases.

Objective: To explore the clinical efficacy and safety of different hysteroscopic surgical schemes for the treatment of endometrial polyps. Method: 100 patients with endometrial polyps admitted to Fujian Funeng Group General Hospital from January 2019 to January 2024 were selected, and they were divided into 49 cases of control group (treated with hysteroscopic resection) and 51 cases of observation group (treated with hysteroscopic cold knife resection) according to different treatment methods. The changes in preoperative and postoperative menstrual symptom scores, endometrial indicators, surgery related indicators, and incidence of complications were compared. Result: The operation time, blood loss and incidence of complications in the observation group were all lower than those in the control group, and the difference was statistically significant (P<0.05). 6 months after operation, the menstrual symptom scores, endometrial thickness, pulsatility index (PI), and resistance index (RI) of both groups showed a downward trend compared with those before the operation. Moreover, compared with the control group in the same period, the menstrual symptom scores, endometrial thickness, PI and RI of the observation group were lower, and the differences were statistically significant (P<0.05). There was no statistically significant difference in the hospital stay between the observation group and the control group (P>0.05). Conclusion: Both hysteroscopic resection and hysteroscopic cold knife resection have good polypectomy effects on endometrial polyps. It can reduce the risk of postoperative recurrence. However, compared with hysteroscopic resection, hysteroscopic cold knife resection has more advantages in improving surgical efficiency, improving patients' menstrual symptoms, and promoting endometrial recovery. It has better security.

Objective: To compare the differences between percutaneous microballoon compression and radiofrequency thermocoagulation in the treatment of primary trigeminal neuralgia. Method: A retrospective review of clinical data from 86 patients with primary trigeminal neuralgia admitted to Yancheng NO.1 People's Hospital between August 2019 and August 2023 was conducted, and the patients were divided into two groups based on treatment modality: the balloon group and the radiofrequency group, with 43 patients in each group. The balloon group received percutaneous microballoon compression therapy, while the radiofrequency group received radiofrequency thermal coagulation therapy. The clinical efficacy, pain levels, recurrence rates, and incidence of complications were compared between the two groups. Result: After 3 months postoperatively, there was no statistically significant difference in the overall clinical efficacy rate between the two groups (P>0.05). Compared with 1 month postoperatively, the visual analog scale scores were higher in both groups at 3 months postoperatively, with a statistically significant difference (P<0.05). The recurrence rate was higher in the radiofrequency group than in the balloon group, but the difference was not statistically significant (P>0.05). The incidence of facial numbness and masseter muscle weakness was lower in the radiofrequency group than in the balloon group, while the incidence of corneal discomfort was higher in the radiofrequency group than in the balloon group, and both differences were statistically significant (P<0.05). There was no statistically significant difference in the incidence of oral herpes between the two groups (P>0.05). Conclusion: Microballoon compression and radiofrequency thermocoagulation are similar in their effectiveness in treating patients with primary trigeminal neuralgia. Both procedures result in similar pain relief and recurrence rates one year after surgery. However, percutaneous microballoon compression has a lower incidence of complications such as facial numbness and masseter muscle weakness, but a higher incidence of corneal discomfort.

Objective: To explore the impact of refined care based on early warning scores for children on the nursing outcomes of pediatric patients with pneumonia admitted to the emergency department for observation. Method: A retrospective analysis was conducted on the medical records of 80 pediatric pneumonia patients admitted to Quanzhou Children's Hospital from May to October 2023. The patients were divided into two groups based on different nursing approaches, with 40 cases in each group. The control group received routine care based on early warning scores, while the observation group received specialized care based on early warning scores. The early warning assessment scores (PEWS), observation time, prognosis, and family satisfaction of the two groups of children were evaluated. Result: After nursing care, compared with the control group, the observation group had lower PEWS scores and shorter observation times, with statistically significant differences (P<0.05). The number of cases admitted to the PICU in the observation group was lower than that in the control group, while the number of outpatient follow-up cases was higher than that in the control group, with statistically significant differences (P<0.05). Family members in the observation group reported higher satisfaction with nursing care than those in the control group, with statistically significant differences (P<0.05). Conclusion: In the clinical treatment of pediatric pneumonia patients in the emergency department, the use of refined nursing care based on early warning scores can effectively shorten the observation time of patients, improve their prognosis, and increase the satisfaction of their families with the nursing care, thereby achieving significant nursing outcomes.

Objective: To observe the effect of Cameron's timely theoretical rehabilitation exercises combined with first-perspective multifaceted evangelism in patients undergoing hip arthroplasty for femoral neck fracture. Method: 94 patients with femoral neck fracture who underwent hip arthroplasty treatment in Putian First Hospital from July 2023 to June 2024 were selected as the study subjects, and were divided into experimental group and control group by coin-flip method, with 47 cases in each group. The control group followed the conventional rehabilitation mode of hip arthroplasty for femoral neck fracture to carry out nursing activities, and the experimental group added Cameron's timely theoretical rehabilitation exercise combined with the first perspective multivariate missionary intervention. The indicators of the two groups after the intervention were compared. Result: The TSK-11 score of the experimental group was lower than that of the control group, the rehabilitation exercise adherence score was higher than that of the control group, the rehabilitation effect indexes were better than that of the control group, and the complication rate was lower than that of the control group, and the difference was statistically significant (P<0.05). Conclusion: The use of Cameron's timely theory of rehabilitation exercise combined with the first perspective multivariate missionary intervention for hip arthroplasty patients with femoral neck fracture can reduce the patients' fear of exercise, improve the patients' adherence to rehabilitation exercise, optimize the patients' rehabilitation effect, and reduce the incidence of complications.

Objective: To investigate the effect of penehyclidine hydrochloride combined with atropine in the treatment of acute organophosphorus pesticide poisoning (ADPP). Method: 60 patients with ADPP who received treatment in the Longyan Second Hospital were included in the study. They were treated from January 2021 to December 2023 and grouped according to the order of admission. The first 30 patients were treated with penehyclidine hydrochloride as control group. The latter 30 patients received penehyclidine hydrochloride combined with atropine as the observation group. The recovery index, myocardial enzyme spectrum, liver function and the improvement of inflammatory reaction were compared between the two groups. Result: After treatment, the indicators of recovery in the observation group were better than those in the control group (P<0.05) The indexes of myocardial enzyme spectrum and AST level in the two groups were significantly lower the observation group (P<0.05). Conclusion: The combination therapy of penehyclidine hydrochloride and atropine in patients with ADPP can effectively shorten the recovery time, reduce the impact on myocardial enzyme spectrum and liver function, and improve the inflammatory reaction state, which has significant clinical application value.

Objective: To discuss the application effect of whole-process nursing based on fine nursing concept on children during bronchoscopy. Method: Totally 96 children who received bronchoscopy at Haicang Hospital in Xiamen were selected from October 2022 to September 2023, and were randomly divided into control group (n=48, routine nursing) and observation group (n=48, whole-process nursing based on fine nursing concept). The clinical data and occurrence of bronchoscopy complications, negative emotions [Modified Yale Preoperative Anxiety Scale (m-YPAS) score, Screen for Child Anxiety Related Emotional Disorder (SCARED) score] before and after nursing, compliance of children, and satisfaction evaluation of family members of children with nursing work were compared between groups. Result: Compared with the two groups, the incidence of complications of bronchoscopy and negative emotions after nursing in the observation group were lower, and the compliance rate and nursing satisfaction of children's family members were higher, the differences were statistically significant (P<0.05). Conclusion: Whole-process nursing based on fine nursing concept during bronchoscopy can reduce the incidence rates of complications, improve the negative emotions of children, and enhance the compliance of children and nursing work satisfaction of family members.

Objective: To observe the results of early thoracoscopic surgery in the treatment of tuberculous pyothorax. Method: The data of 60 cases of tuberculous pyothorax patients admitted to Longyan Second Hospital from January 2021 to December 2023 were retrospectively analyzed and divided into two groups according to the timing of thoracoscopic surgery. Those who were operated in the early stage were the study group, and those who were operated in the late stage of the disease were the control group. Lung function indexes and blood oxygen indexes were compared between the two groups before and after the operation, and the time of disappearance of relevant symptoms, postoperative complications and recurrence rate of the patients were counted. Result: After the treatment the lung function indexes and blood oxygen indexes of the two groups were higher than before the treatment, and the research group was higher than the control group, the duration of chest tightness, dyspnea, chest pain, malaise, night sweats and low fever of the research group was shorter than that of the control group, and the rate of postoperative complications and recurrence rate of the research group were lower than that of the control group, and the difference was statistically significant (P<0.05). Conclusion: In the thoracoscopic surgical treatment of patients with tuberculous pyothorax, early surgery is ideal for improving lung function, elevating the body's oxygen saturation, shortening the duration of related symptoms, and reducing complications and recurrence.

Objective: To explore the therapeutic effect of pelvic floor formula based on the theory of tonifying Qi and promoting elevation combined with biofeedback electrical stimulation on female patients with mild to moderate stress urinary incontinence (SUI) of Qi deficiency type. Method: 60 female patients with mild to moderate SUI of Qi deficiency type were selected, all of whom were admitted to Fujian University of Traditional Chinese Medicine Affiliated Rehabilitation Hospital from July 2024 to February 2025. They were randomly divided into three groups according to the random number table method. Group A (20 cases) was treated with pelvic floor formula, Group B (20 cases) was treated with pelvic floor formula combined with biofeedback electrical stimulation, and Group C (20 cases) was treated with biofeedback electrical stimulation. Pelvic floor electromyography, quality of life (ICI-O-SF), symptom scores, clinical efficacy, and adverse reactions of the three groups were compared. Result: After treatment, the pelvic floor electromyography values in the fast muscle stage and the slow muscle stage in group B were respectively higher than those in group A and group C. The ICI-O-SF score and syndrome score of group B were lower than those of group A and group C, and the difference was statistically significant (P<0.05). The total effective rate of treatment in group B was higher than that in group A and group C, and the difference was statistically significant (P<0.05). No obvious adverse reactions occurred in all three groups during the treatment period. Conclusion: Pelvic floor formula combined with biofeedback electrical stimulation based on the theory of tonifying Qi and promoting elevation has a definite therapeutic effect on mild to moderate SUI patients with qi deficiency. It can effectively improve pelvic floor muscle strength, alleviate urinary incontinence symptoms, and improve quality of life. It is relatively safe.

Objective: To investigate the effect of dopamine combined with phentolamine in the treatment of children with pneumonia complicated with heart failure. Method: A total of 86 children with pneumonia complicated with heart failure admitted to the First Hospital of Hanbin District of Ankang from June 2022 to September 2024 were selected as the study objects. And they were divided into two groups according to the random number table method, with 43 cases in each group. The control group was treated with phentolamine, while the observation group was treated with dopamine. The effective rate, clinical indicators, improvement of myocardial enzymes and adverse reactions were compared between the two groups. Result: The effective rate of the observation group was higher than control group, and the difference was significant (P<0.05). The heart rate recovery time, respiratory recovery time, heart failure correction time, hospitalization time in observation group were shorter than those in control group, and the differences were statistically significant (P<0.05). After treatment, the levels of CK-MB, LDH, CK in the observation group were lower than those in control group, and the differences were statistically significant (P<0.05). Compared with the control group, the incidence of adverse reactions in the observation group was lower, the difference was significant (P<0.05). Conclusion: For children with pneumonia complicated with heart failure, the combination of phentolamine and dopamine can effectively improve the clinical efficacy, shorten the recovery time of the disease, promote the improvement of heart failure symptoms, reduce the level of myocardial enzyme spectrum indicators, and reduce the risk of adverse reactions.

Objective: To analyze the effects of two ventilation modes, namely synchronous intermittent mandatory ventilation (SIMV) + volume guarantee (VG) and pressure support ventilation (PSV) +VG, on the clinical indicators and inflammatory mediators of neonatal respiratory failure (NRF). Method: A total of 100 children with NRF admitted to Qingyang Maternal and Child Health Hospital from January 2023 to December 2024 were selected as the research subjects and randomly divided into a control group and a study group, with 50 cases in each group. The control group used the SIMV+VG mode, while the study group used the PSV+VG mode. The levels of arterial partial pressure of oxygen (PaO²), arterial partial pressure of carbon dioxide (PaCO²), oxygenation index (OI), respiratory index (RI), inflammatory mediators [C-reactive protein (CRP), procalcitonin (PCT), and neutrophil percentage (NEUT %)], and ventilation indicators [mechanical ventilation time, weaning duration and extubation failure rate] and complications were compared between the two groups before and after treatment. Result: There were statistically significant differences in PaO², PaCO², OI and RI between the two groups after treatment (P<0.05). After treatment, the levels of CRP, PCT and NEUT % in the study group were lower than those in the control group, the weaning duration in the study group was shorter than that in the control group, and the extubation failure rate in the study group was lower than that in the control group. The differences were statistically significant (P<0.05). There was no statistically significant difference in the mechanical ventilation time and the total incidence of complications between the two groups (P>0.05). Conclusion: Compared with the SIMV+VG mode, the PSV+VG mode intervention for children with NRF can effectively improve oxygenation indicators, down-regulate the levels of inflammatory mediators, shorten the weaning time, reduce the risk of weaning failure, and does not increase the risk of complications. It is safe and feasible.

Objective: To observe the effect of Xanthium sibiricum powder combined with modified Yupingfeng powder and triamcinolone acetonide nasal spray in the treatment of Weibiao Bugu Type Rhinitis with lung qi deficiency and coldness and unstable exterior defense. Method: A total of 80 patients with Weibiao Bugu Type Rhinitis of lung qi deficiency, cold and weak exterior defense type admitted to the outpatient department of outpatient service of Sanming Hospital of Integrated Traditional Chinese and Western Medicine affiliated to Fujian University of traditional Chinese Medicine from February to October 2024 were selected and randomly divided into the experimental group (Cangerzi San combined with Yupingfeng San modified + triamcinolone acetonide Nasal spray, group A) and the control group (triamcinolone acetonide nasal spray, group B), with 40 cases in each group. The treatment course for both groups was one month. Group A completed the study with 34 cases, and Group B completed the study with 38 cases. Nasal Symptom Score (TNSS), Nasal Conjunctivitis Quality of Life Questionnaire (RQLQ), and TCM Syndrome Score were used to record the scores of patients when they evaluated themselves in the past 6 months and at the end of the treatment course.Blood samples were drawn to detect interleukin-10 (IL-10) and CD4+CD25+Foxp3+ regulatory T cells (T cells, CD4+CD25+Foxp3+Treg) before and one month after the treatment of the patients. Result: Compared within the same group of indicators, TNSS, RQLQ, and TCM syndrome score all decreased after treatment, while IL-10 and CD4+CD25+Foxp3+Treg increased after treatment, and the differences were statistically significant (P<0.05). After treatment, when comparing the same indicators between groups, the RQLQ and TCM syndrome score in group A were lower than those in group B. The IL-10 and CD4+CD25+Foxp3+Treg in group A were higher than those in group B, and the differences were statistically significant (P<0.05). The effective rate was 91.18% in group A and 71.05% in group B, and the difference was statistically significant (P<0.05). Conclusion: The combination of Cangerzi San and modified Yupingfeng San with triamcinolone acetonide nasal spray is superior to the use of nasal spray alone in improving the clinical symptoms of AR patients with lung qi deficiency and coldness and unstable exterior defense. Both treatment plans are effective.

Objective: To evaluate the efficacy of a precision intercostal nerve block for postoperative analgesia in single-port television-assisted thoracoscopic surgery. Method: 100 patients who underwent single-hole TV-assisted thoracoscopic surgery in the Affiliated Hospital of Qinghai University from January 2022 to January 2023 were selected as the study subjects, and randomly divided into the precise intercostal nerve block (PINB) group and the local infiltration anesthesia (LIA) group, with 50 cases in each group. Pain levels were assessed in the patients' quiet state and deep breathing state in the post-anesthesia recovery room (PACU) (T1), 1 h after leaving the PACU (T2), 4 h (T3), 12 h (T4), and 24 h (T5). The quality of patients' postoperative recovery was assessed at the T5 time point using the 40-item Quality of Recovery Rating Scale (QoR-40). The number of patient controlled intravenous analgesia (PCIA) pump presses and the number of remedial analgesia were recorded for each postoperative period. The time of the first remedial analgesia, patient agitation during awakening, delayed awakening, chills, and the occurrence of adverse reactions such as postoperative nausea and vomiting (PONV), dizziness, skin itching, and hypoxemia during the 24 h postoperative period were recorded. Result: The visual analog scale (VAS) scores at the T2 time point during deep breathing were lower in the PINB group than in the LIA group, and the difference was statistically significant (P<0.05). The VAS at rest and at the T3 time point during deep breathing was lower in the PINB group than in the LIA group, and the difference was statistically significant (P<0.05). The scores of comfort category and pain category in QoR-40 in PINB group were higher than that in LIA group at 24 h after operation, and the difference was statistically significant (P<0.05). The number of PCIA presses and the number of remedial analgesia in PINB group in the time period of T1~T3 was less than that in LIA group, and the difference was statistically significant (P<0.05). The time of the first remedial analgesia in PINB group was shorter than that in LIA group, and the difference was statistically significant (P<0.05). Conclusion: Precision intercostal nerve block provides excellent postoperative analgesia with a high degree of safety in patients undergoing single-port television-assisted thoracoscopic surgery.

Objective: To investigate the effectiveness of integrated nursing care combined with rehabilitation training in patients with aseptic necrosis of the femoral head. Method: A total of 100 patients with aseptic necrosis of the femoral head admitted to Rugao Traditional Chinese Medicine Hospital from March 2021 to October 2024 were selected and divided into a control group (50 cases, conventional nursing) and an observation group (50 cases, comprehensive nursing combined with rehabilitation training based on the control group) using a random number table method. The Harris Hip Score, SF-36 score, HAMA score, HAMD score, complication rate, and patient satisfaction were compared between the two groups before and after intervention. Result: After nursing intervention, the Harris hip function score, nursing satisfaction score, and SF-36 score were higher in the observation group than in the control group, while the HAMA and HAMD scores were lower in the observation group than in the control group (P<0.05). Conclusion: The application of comprehensive nursing combined with rehabilitation training in patients with aseptic necrosis of the femoral head can effectively improve hip joint function, enhance patients' quality of life, alleviate anxiety and depression, and increase patient satisfaction.

Objective: To investigate the prophylactic effect of the application of a plantar pump after femoral artery puncture intervention on lower extremity deep vein thrombosis (DVT) and its hemodynamic impact. Method: 196 patients who underwent femoral artery puncture intervention in the Second Affiliated Hospital of Shandong First Medical University from January 2020 to January 2025 were selected as the study subjects, and were randomly divided into observation group (n=98) and control group (n=98).The observation group used the plantar pump to promote blood circulation in the lower limbs after surgery, while the control group did not carry out this intervention. The clinical effect of the plantar pump was analyzed by comparing the incidence of postoperative DVT, hemodynamic changes, and patient comfort between the two groups. Result: In the experimental group, the incidence of lower limb venous thrombosis was significantly less than that in the control group after undergoing surgery, and this difference was statistically significant (P<0.05). In the control group, two cases developed lower limb oedema, and three cases felt discomfort after standing activities. Prior to clinical intervention, there was no significant difference between the two groups in terms of haemorheological parameters and coagulation function (P>0.05). On the first day after the intervention treatment, the partial thromboplastin time and prothrombin time of the two groups of patients did not show any significant changes, and there was no statistically significant difference between the two groups (P>0.05). In the observation group, platelet counts decreased, fibrinogen decreased, and plasma viscosity levels showed a downward trend, and this difference reached statistical significance when compared with the control samples (P<0.05). The concentration of D-dimer generally increased after the operation, but in the patients in the observation group, this increase was lower than that in the control group, and the difference between the two groups was statistically significant (P<0.05). The lower limb venous blood flow velocity in the observation group was significantly higher compared to the control group, and this difference was also statistically significant (P<0.05). Compared with the control sample, these indicators in the observation group showed significant improvement, and the satisfaction of the observation group increased, and the difference was statistically significant (P<0.05). Conclusion: The plantar pump as an adjunctive therapy is effective in preventing lower extremity DVT after femoral artery puncture interventions.

Objective: Observation of the surgical effect of ultrasound-guided percutaneous microwave ablation in the clinical treatment of benign thyroid nodules. Method: 284 patients with benign thyroid nodules from Shenzhen Hengsheng Hospital from July 2021 to July 2024 were selected as the study subjects. The grouping method was envelope randomization. The control group (142 cases) underwent conventional endoscopic unilateral thyroidectomy, while the study group (142 cases) underwent ultrasound-guided percutaneous microwave ablation. The clinical efficacy of the two groups was compared. Result: The appearance satisfaction, postoperative free triiodothyronine (FT3) levels, free tetraiodothyronine (FT4) levels and total thyroxine (TT4) levels of the study group were all higher than those of the control group, with significant difference (P<0.05). The postoperative thyroid stimulating hormone (TSH) levels, adrenocorticotropic hormone (ACTH) levels, aldosterone (ALD) levels, cortisol (Cor) levels, total white blood cell count (WBC) levels, tumor necrosis factor-α (TNF-α) levels, C-reactive protein (CRP) levels, and pain index (VAS) scores of the study group were all lower than those of the control group, with significant difference (P<0.05). The improvement of perioperative indicators in the research group was better than that in the control group, with significant difference (P<0.05). Postoperative complications are comparable between the two groups with no signigicant difference (P>0.05). Conclusion: Ultrasound guided percutaneous microwave ablation for the treatment of benign thyroid nodules can promote postoperative appearance satisfaction, reduce thyroid function damage, alleviate postoperative traumatic stress and inflammatory reactions, improve rehabilitation efficiency, and improve prognosis.

Objective: Exploring the efficacy of combination therapy with aripiprazole and lithium carbonate in patients with schizophrenia. Method: 80 patients with schizophrenia admitted to the Third Hospital of Nanping City from January 2023 to May 2024 were selected as the study objects and randomly divided into an observation group (40 cases, treated with aripiprazole combined with lithium carbonate) and a control group (40 cases, treated with aripiprazole). The mental symptoms, neurotransmitters [dopamine (DA), norepinephrine (NE)], aggressive behaviors, quality of life and adverse reactions of the two groups were compared. Result: After 12 weeks of treatment, the observation group had lower scores in all dimensions and total scores of the Positive and Negative Symptom Scale, as well as lower scores in the Revised Explicit Aggressive Behavior Scale (MOAS) and DA compared to the control group. The NE level and Activities of Daily Living (ADL) score were higher in the observation group than in the control group, and the differences were statistically significant (P<0.05). There was no statistically significant difference in adverse reactions between the two groups (P>0.05). Conclusion: The combination of aripiprazole and lithium carbonate can not only regulate the neurotransmitter metabolism levels of patients with schizophrenia, but also alleviate their mental symptoms and aggressive behavior, while helping to improve their quality of life, with acceptable safety.