2025 Volume 23 Issue 22 Published: 05 August 2025
  

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  • Article
    SUN Guobao, CHI Wenyu, SU Wengui, ZHANG Chengrong, ZHU Zengjun
    Abstract ( ) PDF ( ) Knowledge map Save
    Objective: To evaluate the clinical outcomes of modified Holmium Laser Enucleation of the Prostate (HoLEP) with maximum preservation of functional urethra. Method: A retrospective analysis was conducted on 216 patients with benign prostatic hyperplasia (BPH) treated in the hospital from January to December 2024, including 104 cases using modified HoLEP with functional urethral preservation (Group A) and 112 cases using traditional HoLEP (Group B). Assessment indicators included perioperative parameters, effectiveness indicators (IPSS score, QoL score, and PVR 1, 3, and 6 months postoperatively); and safety indicators [incidence of stress urinary incontinence (SUI) immediately after catheter removal and 1, 2, and 4 weeks after operation]. Result: All surgeries were successfully completed, and there were no significant differences in perioperative parameters between the two groups (P>0.05). Group A showed significantly better IPSS scores than Group B at 6 months postoperatively, and the difference was statistically significant (P<0.05). Regarding safety, Group A demonstrated significantly lower incidence of stress urinary incontinence both immediately after catheter removal and 1, 2, and 4 weeks postoperatively compared to Group B, and the differences were statistically significant (P<0.05). Conclusion: The modified HoLEP technique with maximum preservation of functional urethra maintains surgical efficacy while significantly reduces the incidence of postoperative urinary incontinence, demonstrating promising clinical value.
  • Article
    WU Longxiang, XIA Xiaochun, XUE Qiu
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    Objective: To compare the efficacy of proximal gastrectomy and total gastrectomy in the treatment of advanced Siewert type Ⅱ and Ⅲ adenocarcinoma of the esophagogastric junction. Method: A retrospective analysis was conducted on the clinical data of 80 patients with esophagogastric junction adenocarcinoma who received treatment in the hospital from March 2022 to April 2024. Among them, 40 patients underwent proximal gastrectomy, and 40 patients underwent total gastrectomy. The surgical-related indicators, postoperative related indicators and the incidence of postoperative complications between the two groups were compared. Result: The operation time and incision length in the total gastrectomy group were longer than those in the proximal gastrectomy group, P<0.05. There was no statistically significant difference in intraoperative blood loss between the total gastrectomy group and the proximal gastrectomy group (P>0.05). There was no statistically significant difference in the catheterization time and hospital stay between the two groups (P>0.05). The gastric tube drainage volume in the total gastrectomy group was less than that in the proximal gastrectomy group 1 to 3 days after operation, P<0.05. There was no statistically significant difference in postoperative complications such as reflux esophagitis and intestinal obstruction between the two groups (P>0.05). Conclusion: Proximal gastrectomy is superior to total gastrectomy in surgical time, incision length and postoperative drainage volume. There is no difference in complications between total gastrectomy and proximal gastrectomy, and total gastrectomy is more effective for patients with advanced Siewert type Ⅱ and Ⅲ esophagogastric junction adenocarcinoma.
  • Article
    LIU Yanxing
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    Objective: To explore the clinical effect of Fu's subcutaneous needling combined with high-frequency repetitive transcranial magnetic stimulation (rTMS) in the treatment of knee osteoarthritis (KOA). Method: 90 patients with KOA in the hospital from January 2023 to June 2024 were collected and randomly divided into the rTMS group: the Fu's subcutaneous needling group and the combined group, with 30 cases in each gorup by the random number table. The rTMS and Fu's subcutaneous needling groups received rTMS alone and Fu's subcutaneous needling, respectively, and the combined group received both rTMS and Fu's subcutaneous needling for a total of 4 weeks. Visual Analog Scale (VAS), Osteoarthritis Index (WOMAC), Lower Extremity Joint Function Score(Lysholm), 6-minute walk test (6MWT), Tumor Necrosis Factor-α (TNF-α), Interleukin 1 (IL-1) and Interleukin 6 (IL-6) were assessed before and after the intervention. Result: VAS scores, WOMAC scores, TNF-α levels, and IL-1 levels were lower, and Lysholm scores were higher in the three post-intervention groups compared with pre-intervention, and the difference was statistically significant (P<0.05). Compared with the post-intervention rTMS group, Lysholm scores and 6MWT were higher and TNF-α, IL-1 and IL-6 levels were lower in the Fu's subcutaneous needling and combined group, and the difference was statistically significant (P<0.05). Compared with the post-intervention Fu's subcutaneous needling group, the combined group had lower VAS scores, WOMAC scores, TNF-α, IL-1 and IL-6 levels and higher Lysholm scores, and 6MWT, and the difference was statistically significant (P<0.05). Conclusion: Fu's subcutaneous needling combined with high-frequency rTMS can significantly reduce knee pain, improve joint function, enhance walking ability, and inhibit inflammatory response in patients with KOA. It can be widely used in clinical practice.
  • Article
    ZENG Qingxia
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    Objective: To investigate the effects of autologous corneal limbal stem cell transplantation on visual acuity and tear film function in pterygium. Method: 90 patients with pterygium admitted to Putian Ophthalmology Hospital from January 2022 to January 2024 were randomly selected, with 45 patients in each group. The control group underwent pterygium excision surgery, while the study group received autologous corneal stem cell transplantation treatment on the basis of the control group. The clinical efficacy, preoperative and postoperative tear film function indicators [tear secretion test (SIT), tear film rupture time (BUT)], visual function indicators (corneal horizontal curvature, corneal horizontal vertical curvature, refractive error, uncorrected visual acuity), and incidence of postoperative complications between two groups were compared. Result: Compared with the control group, the total effective rate of the study group after surgery was higher (P<0.05). After surgery, both groups had significantly higher levels of SIT and BUT compared to before surgery (P<0.05). Compared with the control group, the study group had higher levels of SIT and BUT after surgery (P<0.05). After surgery, the corneal horizontal curvature, corneal horizontal vertical curvature, and uncorrected visual acuity of both groups were higher than before surgery, while the refractive error was lower than before surgery, with statistically significant difference (P<0.05). Compared with the control group, the study group had higher corneal horizontal curvature, corneal horizontal vertical curvature, and uncorrected visual acuity after surgery, but lower refractive error (P<0.05). There was no significant difference in the incidence of postoperative complications between the two groups (P>0.05). Conclusion: Autologous corneal stem cell transplantation can achieve significant results in the treatment of pterygium patients, helping to promote postoperative visual and tear film function recovery. The surgery is safe and reliable.
  • Article
    LING Rong, LUO Lingling
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    Objective: To explore the effects of early enteral nutrition support based on the theory of fusion transformation on the immune function, nutritional status, and recovery of postoperative gastric cancer patients. Method: A total of 160 patients with gastric cancer admitted to the hospital from April 2022 to April 2024 were selected as the research subjects. They were randomly divided into control group (n=80) and experimental group (n=80) using a random number table method. Patients in the control group received routine nursing intervention, while patients in the observation group received early enteral nutrition support based on the theory of fusion and change on the basis of nursing in the control group. The immune function, nutritional status, and rehabilitation status of the two groups were compared. Result: After intervention, tumor necrosis factor-α (TNF-α), hypersensitive C-reactive protein (hs-CRP), interleukin-2 (IL-2) and interleukin-6 (IL-6) levels of observation group were significantly lower than those in the control group. The difference was statistically significant (P<0.05). The proportion of nutrient-balanced patients in the observation group was significantly higher than that in the control group, and the proportion of severe malnutrition was significantly lower than that in the control patients. The difference was statistically significant (P <0.05). The scores of the health survey (SF-36) were significantly higher than the control group, and the difference was statistically significant (P<0.05). Conclusion: Early enteral nutrition support based on the theory of fusion transformation is significantly more effective in intervening postoperative gastric cancer patients than previous nursing models. The patient's immune function and nutritional status are significantly improved, and their recovery process is effectively promoted.
  • Clinical practice
  • Clinical practice
    DU Mingyan, PENG Jingxia
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    Objective: To study the application of penttone therapy in patients with hyperthyroidism. Method: 120 patients with hyperthyroidism admitted to Linyi Hospital of Traditional Chinese Medicine from June 2021 to June 2024 were divided into conventional group and penttone group, with 60 cases in each group. The routine group performed routine care, and the penttone group received basic treatment. The two groups were cared for 2 months. Before and after nursing care, sleep quality, psychological status, quality of life and nursing adherence were compared by Pittsburgh Sleep Quality Index (PSQI), HAMA, Hamilton Anxiety Scale and Depression Scale (HAMD), World Health Organization quality of survival scale (WHOQOL-BREF), and self-made adherence scale. Result: After the nursing care, the PSQI, HAMA and HAMD scores of the penttone group were lower than those of the conventional group, and the difference was statistically significant (P<0.05). The WHOQOL-BREF score of the pentatonic group was higher than that of the conventional group, and the difference was statistically significant (P<0.05). The total compliance rate of nursing in the five-tone group was higher than the conventional group, and the difference was statistically significant (P<0.05). Conclusion: The application of penttone therapy in the patients with hyperthyroidism can effectively improve the sleep quality, psychological condition, the quality of life and nursing compliance.
  • Clinical practice
    LI Liyuan
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    Objective: To explore the clinical effect of Sini Sanjie Decoction combined with leuprelin in the treatment of children with precocious puberty. Method: A comparative analysis trial was carried out in Jinjiang Hospital from January 2022 to June 2024, and 100 female children with precocious puberty were selected during the period. They were randomly divided into the observation group and the control group by using the medical record number table method, with 50 children in both groups. The control group was treated with leuprelin, and the observation group was treated with Sini Sanjietang combined with leuprelin. The clinical effective rate, sex hormone level, ovarian volume, uterine volume, follicle diameter, bone age index, serum factor level and incidence of adverse reactions were compared between the two groups. Result: There was statistically significant difference in the clinical effective rate between the two groups (P<0.05). There was statistically significant difference in sex hormone levels between the two groups (P<0.05). There were statistically significant differences in ovarian volume, uterine volume, follicular diameter and bone age index data between the two groups (P<0.05). The comparison of the serum factor level data of the two groups showed that after treatment, the adiponectin (ADPN) data of the observation group was significantly higher than that of the control group, and the serum neurokinin B (NKB) and insulin-like growth factor 1 (IGF-1) data were significantly lower than those of the control group, with statistically significant difference (P<0.05). Conclusion: For children with precocious puberty, the treatment intervention with Sini Sanjie Decoction combined with leprorelin can achieve relatively ideal results. After the treatment, the sex hormone levels of the children tend to be normal, the ovaries and uterus shrink to varying degrees. The bone age and follicular diameter indicators are similar to those of healthy children, the levels of multiple serum factors improve, with no serious adverse reactions.
  • Clinical practice
    ZHANG Zhen, LUO Yong
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    Objective: To analyze the effect of nanocarbon suspension injection on surgical patients with papillary thyroid carcinoma. Method: 80 patients with papillary thyroid carcinoma admitted to the First People's Hospital of Wanzhou District, Chongqing from February 2021 to December 2023 were selected as the study sample. They were randomly divided into two groups: observation group and control group, with 40 patients in each group. The observation group received treatment with nanocarbon suspension injection during surgery, while the control group received surgical treatment alone. The intraoperative blood loss, intraoperative blood calcium and parathyroid hormone levels, number of lymph node dissections, parathyroid incorrect resection rate, postoperative drainage volume, and incidence of postoperative complications were compared between the two groups. Result: The intraoperative blood calcium (4.24±0.62) mmol/L, parathyroid hormone (32.13±2.08) pg/ml, and lymph node dissection number (7.39±1.02) in the observation group were higher than those in the control group (2.29±0.37) mmol/L, (29.15±1.74) pg/ml, and (5.42±0.85), respectively. The intraoperative bleeding volume (8.35 ±2.08) mL, postoperative drainage volume (31.93±2.28) mL, parathyroid misplacement rate 0.00%, and postoperative complication rate 2.50% in the observation group were all lower than those in the control group (13.19±2.14) mL, (42.07±2.52) mL, 12.50%, and 15.00%, respectively (P<0.05). Conclusion: Nanocarbon suspension injection has numerous benefits for patients undergoing surgery for papillary thyroid carcinoma. It can not only prevent the accidental removal of parathyroid tissue, thereby preventing a decrease in blood calcium and parathyroid hormone levels, but also increase the number of lymph node dissections and reduce the risk of postoperative complications.
  • Clinical practice
    LI Yunguang, XIONG Liang
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    Objective: To investigate the effect of minimally invasive internal fixation surgery in the patients with thoracolumbar fracture and influence for stability. Method: 98 patients with thoracolumbar fracture from October 2023 to October 2024 were divided into two groups by random number table, with 49 patients in each group. The control group were treated with traditional open invasive internal fixation surgery of pedicle screws, and the observation group were treated with minimally invasive internal fixation surgery of pedicle screws. Then the total excellent and good rates, operation indexes (incision length, intraoperative blood loss, operative time and postoperative hospitalization time), waist and lower limbs pain (VAS score), functional state of waist and back (ODI score) and stability indexes (posterior Cobb angle, spinal canal occupancy rate and anterior vertebral compression rate) before and after the operation of two groups were compared. Result: The total excellent and good rates of two groups were compared, the difference was not statistically significant (P>0.05). The incision length of observation group was significantly shorter than that of control group, the intraoperative blood loss was significantly less than that of control group, the operative time and postoperative hospitalization time were significantly shorter than those of control group (P<0.05). The waist and lower limbs scores of two groups before the operation were compared, the differences were not statistically significant (P>0.05). The waist and lower limbs scores of observation group at 1st week and 3rd month after the operation were significantly lower than those of control group (P<0.05). The stability indexes of two groups before and after the operation were compared, and the differences were not statistically significant (P>0.05). Conclusion: The effect of minimally invasive internal fixation surgery in the patients with thoracolumbar fracture are not significantly different from those of traditional open surgery. Its operation indexes are relatively better, and can effectively control the postoperative pain.
  • Clinical practice
    WANG Xiaorong
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    Objective: To explore the application effects of active hypothermia prevention combined with inhalation aromatherapy on patients undergoing hip arthroplasty. Method: A total of 86 patients undergoing hip arthroplasty at Hai'an City Hospital from January 2023 to November 2024 were selected and randomly divided into an observation group (n=43) and a control group (n=43). The control group received standard surgical room care, while the observation group was additionally given active hypothermia prevention and inhalation aromatherapy. Comparisons were made between the two groups regarding physiological stress indicators, anxiety and depression levels (SAS and SDS scores), intraoperative temperature stability, recovery and extubation times, comfort levels, and incidence of complications. Result: After the intervention, the observation group showed significantly better physiological stress indicators, intraoperative temperature stability, SAS and SDS scores, and recovery and extubation times compared to the control group. Furthermore, the observation group reported higher comfort levels and a lower incidence of complications, with statistically significant differences (P<0.05). Conclusion: Active hypothermia prevention combined with inhalation aromatherapy can effectively reduce physiological and psychological stress in patients undergoing hip arthroplasty, maintain stable body temperature, promote postoperative recovery, decrease the incidence of complications, and enhance surgical comfort.
  • Clinical practice
    MA Jide
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    Objective: To study and analyze the effects of negative pressure closed drainage (VSD) and perfusion irrigation on patients with lower limb bone infection and inflammation indexes. Method: 60 patients with lower limb bone infection admitted to the hospital from June 2020 to June 2024 were studied. They were randomly divided into drainage group (n=30) and irrigation group (n=30) by envelope method. The drainage group was treated with VSD, and the irrigation group was treated with conventional lavage. The clinical efficacy, rehabilitation process, inflammatory factor levels and complications were compared between the two groups. Result: The total effective rate of drainage group was higher than that of irrigation group (P<0.05). The infection control time, wound healing time, antibiotic use days and hospitalization days in the drainage group were shorter than those in the irrigation group. The frequency of dressing change was less than that of washing group (P<0.05). After treatment, the serum interleukin-6 (IL-6), interleukin-8 (IL-8), tumor necrosis factor-α (TNF-α) and white blood cell count (WBC) in both groups were lower than before treatment, and the drainage group was lower than the irrigation group (P<0.05). The total incidence of drainage group was lower than that of irrigation group (P<0.05). Conclusion: VSD is better than perfusion irrigation in the treatment of lower limb bone infection, and can improve the level of inflammatory indicators and reduce the risk of complications.
  • Clinical practice
    FAN Guozhen
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    Objective: To explore the effect of immediate implant restoration on the restoration effect and pain of patients with tooth defect. Method: 62 patients (62 teeth) with tooth defect admitted to Jingtai Hospital of Traditional Chinese Medicine from January 2022 to June 2024 were selected. All patients were divided into delayed group (31 cases) and immediate group (31 cases) by random number table method. The delayed group was treated with delayed implant restoration, and the immediate group was treated with immediate implant restoration. The restoration effect, ISQ value, pain score, pain factor levels and periodontal indexes before and after treatment were observed and compared between the two groups. Result: There was no significant difference in the restoration effect and ISQ value between the two groups (P>0.05). After treatment, pain score, levels of pain factors and periodontal indicators in the immediate group were lower than those in the delayed group, and the differences were statistically significant (P<0.05). Conclusion: Compared with delayed implant restoration, immediate implant restoration in the treatment of tooth defect can help to reduce the level of pain factors and pain symptoms, and improve the periodontal indexes of patients.
  • Clinical practice
    HAN Jiaqi, YU Hongyan
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    Objective: To investigate the nursing effectiveness of the wireless ultra-high-definition laparoscopic system in hepatobiliary surgery. Method: 65 patients who underwent laparoscopic surgery in Armed Police Anhui Provincial Corps Hospital of the Chinese People's Armed Police Force from June 2023 to January 2024 were selected and divided into observation group and control group using an odd-even grouping method, with 33 and 32 patients, respectively. The control group underwent laparoscopic surgery using traditional laparoscopic instruments, while the observation group underwent laparoscopic surgery using a wireless ultra-high-definition laparoscopic system. Multiple perioperative indicators were compared between the two groups, including surgery duration, length of hospital stay, time for item preparation, time for laparoscopic system connection, and usage cost. Additionally, the satisfaction of medical staff was assessed, and the incidence of complications, including incision infection, intra-abdominal abscess, postoperative bleeding, pancreatic fistula, and biliary fistula, was recorded. Result: The observation group was lower than the control group in terms of operation time, connection time of the laparoscopic system and usage cost, and the difference was statistically significant (P<0.05). The satisfaction rate of medical staff in the observation group was higher than that in the control group, and the difference was statistically significant (P<0.05). The incidence of complications in the observation group was lower than that in the control group, and the difference was statistically significant (P<0.05). Conclusion: Compared with the traditional system, the wireless ultra-high-definition laparoscopic system can improve preoperative preparation efficiency, reduce costs, and enhance the satisfaction of medical staff, with lower complication rate.
  • Clinical practice
    LIU Jie, FU Dunkai, LIU Gang, XIE Chao, LIU Qiang, DU Xiaoping
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    Objective: To compare the clinical efficacy of artificial hemiarthroplasty and proximal femoral nail (PFNA) fixation for Evans type Id intertrochanteric fractures in elderly patients. Method: A retrospective analysis was conducted on the relevant data of 72 elderly patients with Evans type Id intertrochanteric fractures of the femur admitted to Shishou People's Hospital from January 2018 to January 2024. According to the surgical method, they were divided into observation group and control group, with 36 cases in each group. The observation group underwent artificial hemiarthroplasty, while the control group underwent PFNA internal fixation. The surgical time, perioperative blood loss, Harris hip joint function score, and patient satisfaction were compared between the two groups. Result: Both groups were followed up for 6~12 months. No complications, such as incision infection, prosthetic failure, or internal fixation failure, were observed. Operation time, blood loss, hip joint function and patient satisfaction, the artificial hemiarthroplasty of observation group were better than the PFNA group, and the difference is statistically significant (P<0.05). Conclusion: Artificial hemiarthroplasty for the treatment of intertrochanteric type Id fractures of the femur in elderly patients has shorter time and less perioperative blood loss compared to the PFNA internal fixation. It is simple to operate and has significant efficacy. Postoperatively, it allows patients to get out bed early, improve their quality of life, and achieve high patient satisfaction.
  • Clinical practice
    CAO Qihua, YU Huaying
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    Objective: To explore the application of thirteen acupuncture points for regulating menstruation and assisting pregnancy combined with active immunotherapy in patients with unexplained recurrent miscarriage (URSA). Method: 118 patients with URSA admitted to Macheng Maternal and Child Health Hospital from January 2023 to January 2024 were randomly divided into a combination group (n=59) and an immunization group (n=59) using a random number table method. The immunization group received active lymphocyte immunotherapy, while the combination group received thirteen injections of menstrual regulation and pregnancy assistance therapy on this basis. The clinical efficacy of two groups, including ovarian function, immune function [CD3+, CD4+/CD8+, blocking antibody conversion rate] before and after 10 weeks of treatment were compared, and the occurrence of adverse reactions was compared. Result: The total effective rate of the combination group was higher than that of the immunization group, and the difference was statistically significant (P<0.05). After 10 weeks of treatment, the levels of antral follicle count (AFC), and anti Mullerian hormone (AMH) increased in both groups, while the levels of follicle stimulating hormone (FSH), CD3+ and CD4+/CD8+ lymphocytes percentages decreased in both groups, with the combination group showing a more significant increase, and the differences were statistically significant (P<0.05). The conversion rate of blocked antibodies in the combination group was higher than that in the immunization group, and the difference was statistically significant (P<0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: The combination of thirteen injections of menstrual regulation assisted pregnancy and active immunotherapy has significant therapeutic effects in patients with URSA. It can effectively improve their ovarian and immune functions, and increase the conversion rate of blocking antibodies to positive. It has good safety.
  • Medical technology and clinical
  • Medical technology and clinical
    HU Yang, XU Bo, ZHANG Aodan, CHEN Haichen
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    Objective: To explore the clinical efficacy and safety of ultrasound-guided injection of Pingyangmycin in the treatment of pediatric lymphangioma. Method: A prospective analysis was conducted on the clinical data of 70 pediatric lymphangioma patients admitted to Xiamen Maternal and Child Health Hospita from January 2021 to December 2023. According to the treatment method, they were divided into two groups: the Pingyangmycin group (35 cases) and the control group (35 cases). The Pingyangmycin group was treated with ultrasound-guided injection of Pingyangmycin, while the control group was treated with surgical resection. The treatment efficacy, incidence of complications, length of hospital stay, and expenses were compared between two groups. Result: The treatment effect score of the Pingyangmycin group was similar to that of the control group, and the difference was not statistically significant (P>0.05). The incidence of complications in the Pingyangmycin group was significantly lower than the control group (P<0.05). The average hospitalization time of the Pingyangmycin group was significantly shorter than the control group (P<0.05). The average cost of the Pingyangmycin group was significantly lower than the control group (P<0.05). Conclusion: Ultrasound guided injection of Pingyangmycin in the treatment of pediatric lymphangioma has the advantages of good therapeutic effect, fewer complications, short hospital stay, and low cost. It is a safe and effective treatment method.
  • Medical technology and clinical
    ZHANG Jianfeng
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    Objective: To explore the diagnostic value of serum anti cyclic citrullinated peptide (CCP), soluble interleukin-2 receptor (sIL-2R), and rheumatoid factor (RF) in rheumatoid arthritis (RA). Method: 70 patients with RA treated in the hospital from August 2021 to August 2024 were selected as the observation group, and another 70 healthy individuals who underwent physical examination were selected as the control group. The levels of CCP, sIL-2R, and RF were detected in both groups, and the diagnostic efficacy of CCP, sIL-2R and RF detection alone and in combination was analyzed. Result: The levels of CCP, sIL-2R and RF in the observation group were higher than those in the control group, and the difference was statistically significant (P<0.05). CCP sensitivity, accuracy and accuracy was 78.57%, 90.00% and 84.29%. sIL-2R sensitivity, accuracy and accuracy was 77.14%, 85.71% and 81.43%. RF sensitivity, accuracy and accuracy was 80.00%, 84.29% and 82.14%. Combined diagnostic sensitivity, accuracy and accuracy was 95.71%, 90.00% and 92.86%. The sensitivity and accuracy of CCP, sIL-2R and RF detected separately were lower than those in the combined diagnosis, and the difference was statistically significant (P<0.05). There was no statistically significant difference in the specificity of CCP, sIL-2R, RF and the specificity of combined diagnosis (P>0.05). Conclusion: CCP, sIL-2R and RF levels are abnormally high in RA patients, and the combined diagnosis of RA has high efficacy and can accurately differentiate RA.
  • Medical technology and clinical
    WANG Li, DING Jiaying
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    Objective: To explore the effects of interferon α-2b combined with lactic acid bacteria vaginal capsules and laser treatment on vaginal microecology and immune function in patients with cervicitis complicated with human papillomavirus (HPV) infection. Method: 80 patients diagnosed with cervicitis and HPV who visited Fuding Maternal and Child Health Hospital from March 2023 to April 2024 were selected and finally included in the study. All the research subjects were divided into two groups by the method of random number table. Among the 40 cases in the control group, the treatment plan adopted was laser therapy combined with vaginal administration of interferon α-2b. The 40 cases in the observation group, on the basis of the medication of the control group, added the intervention method of vaginal administration of lactic acid bacteria capsules. Each group received a medication intervention lasting for 3 months. The therapeutic effects of the two groups, the changes of vaginal microecology and immune function indicators before and after treatment were compared. The differences in adverse reactions that occurred during the treatment process were recorded. Result: In terms of the therapeutic effect, the total effective rate of clinical treatment in the observation group was higher than that in the control group, and the difference was statistically significant (P<0.05). After 3 months of treatment, in terms of various indicators such as the pH value of vaginal secretions, Nugent score, and CD8+ level, the observation group was significantly lower than the control group, and the difference was statistically significant (P<0.05). However, in terms of the levels of CD4+ and CD4+/CD8+ indicators, the observation group was higher than the control group, and the difference was statistically significant (P<0.05). There was no statistically significant difference in adverse reactions between the two groups (P>0.05). Conclusion: Interferon α-2b, lactic acid bacteria vaginal capsules combined with laser intervention for cervicitis with HPV infection are beneficial for regulating vaginal microecology and improving peripheral immune function, but there are few adverse reactions during the treatment period.
  • Medical technology and clinical
    XU Shiru, KONG Xiangbing, MA Baoling
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    Objective: To analyze the role and value of transvaginal color Doppler ultrasound (transvaginal color Doppler ultrasound) in the clinical differential diagnosis of ectopic pregnancy rupture and ovarian corpus luteum rupture. Method: Patients with ruptured ectopic pregnancy and ruptured corpus luteum of the ovary admitted to Taishan Maternal and Child Health Hospital from May 2022 to May 2024 were selected as the research subjects, with 62 cases and 53 cases respectively. All patients underwent vaginal color Doppler ultrasound examination. The color Doppler ultrasound indicators, blood flow characteristics, diagnostic efficacy and consistency of pathological diagnosis of patients with different diseases were compared and calculated. Result: The ovarian volume, depth of the fluid dark area and diameter of the abnormal echo area in ruptured corpus luteum of the ovary were higher than those in ruptured ectopic pregnancy, and the difference was statistically significant (P<0.05). The comparison of blood flow signal patterns in patients with the two diseases showed statistically significant difference (P<0.05). In the images of ruptured ectopic pregnancy, point-like and strip-like blood flow signals were mainly found, while in the images of ruptured corpus luteum of the ovary, there were more circular blood flow signals. Among the efficacy indicators of vaginal color Doppler ultrasound in the differential diagnosis of the two lesions, the accuracy was 95.65%, the sensitivity was 94.34%, the specificity was 96.77%, the positive predictive value was 96.15%, and the negative predictive value was 95.24%, and it had extremely high consistency with the pathological diagnosis (Kappa=0.912, P<0.05). Conclusion: The application of vaginal ultrasound in clinical examination and differential diagnosis of ectopic pregnancy rupture and ovarian corpus luteum rupture is accurate and effective. It has good application results.
  • Modern nursing
  • Modern nursing
    LIN Juan, JIANG Jiali, JIANG Yan, LIN Yinglan, CHEN Suyu
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    Objective: To analyze the impact of FMEA caring on patients undergoing endoscopic colorectal polypectomy. Method: 110 cases who accepted endoscopic colorectal polypectomy in the hospital from June to December 2023 were stochasticly assigned to the study group and the control group, with 55 cases in each group. The control group accepted general clinical care, while the study group received FMEA based care. The intestinal cleaning effect, complications, negative emotions, comfort and quality of life were compared between them. Result: After receiving FMEA based care, the observation group showed clearly better intestinal cleanliness, negative emotions, comfort, and quality of life compared to the control group, with fewer complications. The differences were statistically significant (P<0.05). Conclusion: Implementing FMEA based nursing care for patients undergoing endoscopic colorectal polypectomy can effectively improve intestinal cleansing efficacy, comfort, and quality of life, and reduce complications.
  • Modern nursing
    WU Cuiping, ZHOU Wenjing, SUN Xiujuan
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    Objective: To explore the clinical effect of high-quality nursing combined with integrated psychological nursing on patients undergoing radical surgery for endometrial cancer. Method: A total of 100 patients who underwent radical surgery for endometrial cancer in the hospital from April 2023 and June 2024 were selected as the study sample. The patients were randomly allocated to the control group and the observation group, with 50 patients in each group. The control group was administered routine nursing intervention, whereas the observation group received high-quality nursing integrated with comprehensive psychological nursing in addition to the routine nursing measures. Clinical indicators, self-care ability, quality of life, and complication rates were compared between the two groups. Result: Compared with the control group, patients in the observation group showed significant reductions in surgical duration, intraoperative blood loss, and length of hospital stay (P<0.05). Patients in the observation group exhibited notably higher self-care ability and quality of life scores compared to those in the control group(P<0.05). The observation group had a notably lower incidence of postoperative complications compared to the control group (P<0.05). Conclusion: The application of high-quality nursing combined with integrated psychological nursing in patients undergoing radical surgery for endometrial cancer can improve clinical treatment outcomes and is worthy of promotion..
  • Modern nursing
    CHEN Liling, JIANG Lifen
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    Objective: To analyze the significance of using pressure antithrombotic pumps and comprehensive nursing interventions during the nursing period for postoperative patients with cerebral hemorrhage, and to study the impact of this approach on deep vein thrombosis in the lower limbs. Method: The sample subjects included in the study were 100 patients with cerebral hemorrhage admitted to the First Affiliated Hospital of Xiamen University from December 2021 to December 2023. They were randomly divided into two groups using a random number table. The study group and the control group were named as the two groups, with 50 patients in each group. They were provided with pressure antithrombotic pump+comprehensive nursing intervention and conventional nursing intervention respectively, and the differences between the two groups were compared. Result: A comparative analysis of deep vein thrombosis in the lower limbs between the two groups showed that the study group had a lower incidence (P<0.05). The comparative analysis of daily living abilities between two groups found that there was no significant difference between the two groups before nursing (P>0.05). After nursing care, the level of this indicator in the study group patients was higher (P<0.05). Comparative analysis of patient satisfaction between two groups showed that the study group had a higher satisfaction rate (P<0.05). Comparative analysis of the circumference and average blood flow velocity of the affected calf between two groups was conducted. Before nursing, there was no significant difference in this indicator between the two groups of patients (P>0.05). After nursing care, the improvement effect of this indicator in the study group patients was better (P<0.05). A comparative analysis of the quality of life between two groups of patients showed no difference before nursing (P>0.05). After nursing care, the research group was higher (P<0.05). Conclusion: In the treatment of patients with cerebral hemorrhage, the use of pressure antithrombotic pumps and comprehensive nursing methods can reduce the risk of deep vein thrombosis and improve the quality of life and living standards of patients. The patient was very satisfied and achieved good therapeutic effects.
  • Modern nursing
    ZENG Qiumei, CHEN Qiaoling, ZHANG Kaizhen
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    Objective: To explore the effect of empathy and refined nursing on the psychological state and self-efficacy of primary mothers. Method: 360 primipara cases admitted from January to June 2023 were divided into control group and study group by random computer method. The control group received routine care, and the study group added empathy care and refined care. Negative emotions, self-efficacy, self-care ability, and nursing satisfaction were compared between the two groups. Result: After the nursing care, the scores both groups decreased (P<0.05). The negative emotion scores of the study group was lower, difference was statistically significant (P<0.05). After the nursing care, scores of both groups increased. The self-efficacy score higher, difference was statistically significant (P<0.05). After the nursing care, the scores of both groups increased. The score of self-care ability higher, difference was statistically significant (P<0.05). The nursing satisfaction also significantly higher, and the difference was statistically significant (P<0.05). Conclusion: Empic nursing combined with fine nursing can effectively alleviate the negative mood of primary mothers; and improve self-efficacy, self-care ability and nursing satisfaction.
  • Modern nursing
    LU Xingyan
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    Objective: To analyze the effects of hyperbaric oxygen physiotherapy and rehabilitation combined with structural nursing on the rehabilitation of patients after hypertensive cerebral hemorrhage. Method: A total of 86 patients with hypertensive cerebral hemorrhage who were hospitalized in the hyperbaric oxygen department of Anshun People's Hospital from March 2022 to January 2024 were studied. All patients received surgical treatment and were divided into two groups according to the principle of randomization and double blindness. The observation group (43 cases) received postoperative hyperbaric oxygen physiotherapy and rehabilitation combined with structural nursing, while the control group (43 cases) received postoperative hyperbaric oxygen physiotherapy and rehabilitation combined with conventional nursing. Microcirculation, neuropublic fuction, psychological state, selfcare ability and quality of life before and after nursing were compared. Result: After nursing, CP level and HHI score, ESCA score and SS-QOL score were higher in the observation group, while Dr, Wv level and NIHSS and CIPQ-R score were lower (P<0.05). Conclusion: Hyperbaric oxygen physiotherapy and rehabilitation combined with structural nursing can improve the microcirculation function, reduce the neurological function defect, improve the psychological state, and effectively improve the self-care ability and quality of life of patients with hypertensive cerebral hemorrhage after surgery.
  • Modern nursing
    YAN Xiaorun, WANG Hongtai, WU Shanshan, CAI Lianzhu, WU Xiaoping
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    Objective: To explore the improvement effect of psychological nursing combined with early rehabilitation therapy based on mindfulness based cognitive therapy (MBCT) on negative emotions in elderly patients with old myocardial infarction (OMI) and its preventive effect on myocardial infarction recurrence. Method: 170 elderly OMI patients admitted to the hospital from May 2022 to August 2023 were selected and divided into different groups based on nursing methods, with 85 patients in each group. The control group (May to December 2022) received routine care and early rehabilitation treatment, while the observation group (January to August 2023) received MBCT based psychological care. The psychological state, stress coping strategies and changes in sleep quality of two groups were compared before and after nursing care. The patients were followed up for one year to observe the recurrence rate of myocardial infarction in both groups. Result: After the intervention, the SDS and SAS scores in both groups decreased significantly compared to before the intervention (P<0.05), while the observation group showed a greater decrease, which was significantly different from the control group (P<0.05). After intervention, the PC score significantly increased and the NC score significantly decreased in both groups (P<0.05), while the observation group showed a significantly greater increase/decrease than the control group (P<0.05). Compared with before intervention, the PSQI scores of both groups were significantly lower after intervention, and the PSQI scores of the observation group were significantly lower than those of the control group (P<0.05). The one-year recurrence rate of myocardial infarction in the observation group was significantly lower than that in the control group (P<0.05). Conclusion: MBCT based psychological nursing can improve the negative emotions of elderly OMI patients, encourage them to choose positive coping strategies, improve their sleep quality, and prevent the recurrence of myocardial infarction.
  • Modern nursing
    LIU Jinhong, ZUO Yibei
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    Objective: To explore the effect of nursing mode combined with simple respiratory function exercise in patients with lung cancer undergoing chemotherapy. Method: 86 patients with lung cancer treated with chemotherapy in the hospital were selected from February 2023 to March 2024. They were divided into experimental group and reference group according to envelope method. The reference group was treated with routine nursing intervention, and the experimental group was treated with no-vomiting ward nursing mode combined with simple respiratory function exercise intervention. Pulmonary function index, Functional living indexemesis (FLIE) scale score and dyspnea scale (Modified Medical Research Council, mMRC score and 6-minute walkingdistance (6MWD) level were used to observe adverse reactions in both groups. Result: After intervention, Forced vital capacity (FVC), Force Expiratory Volume in 1 second (FEV1), Peak Expiratory Flow, PEF levels were higher than those in the reference group, and the difference was statistically significant (P<0.05). After intervention, nausea score and vomiting score of experimental group were higher than those of reference group, and the difference was statistically significant (P<0.05). After intervention, the mMRC score of experimental group was lower than that of reference group, and the 6MWD score was higher than that of reference group, with statistically significant difference (P<0.05). The incidence of adverse reactions in test group was lower than that in reference group, with statistically significant difference (P<0.05). Conclusion: The nursing mode combined with simple respiratory function exercise can improve lung function level, reduce nausea and vomiting symptoms, improve lung symptoms, promote exercise endurance, and reduce adverse reactions in patients with lung cancer chemotherapy.
  • Modern nursing
    LU Yanghua, HUANG Sujing
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    Objective: To explore the effect of warm palace plaster combined with traditional Chinese medicine characteristic nursing on pain, dysmenorrhea symptoms, and sleep quality in patients with dysmenorrhea. Method: According to the random number table method, 102 patients with dysmenorrhea who visited Songzi Traditional Chinese Medicine Hospital from May 2023 to May 2024 were divided into a warm uterine patch group (n=51) and a traditional Chinese medicine group (n=51). The warm palace patch group received warm palace patch intervention. The traditional Chinese medicine group added traditional Chinese medicine characteristic nursing (separated moxibustion and finger acupoint nursing intervention). After 6 treatment courses (1 menstrual cycle as 1 treatment course), the pain level, Traditional Chinese Medicine symptom score, dysmenorrhea symptoms, and sleep quality of the two groups were compared. Result: The VAS scores of the two groups before intervention were compared, and there was no significant difference (P>0.05). After 6 courses of intervention, the VAS scores of the third course and the sixth course of intervention in the two groups were lower than those before intervention, with statistically significant difference (P<0.05). The TCM symptom score of TCM group was lower than that of warm palace patch group, and the difference was statistically significant (P<0.05). The CMSS score of TCM group was lower than that of warm palace patch Group, and the difference was statistically significant (P<0.05). The PSQI of TCM group was lower than that of warm palace patch group, and the difference was statistically significant (P<0.05). Conclusion: Traditional Chinese medicine characteristic nursing combined with warm uterus patches can alleviate the pain of dysmenorrhea patients, and improve dysmenorrhea symptoms and sleep quality.
  • Modern nursing
    GUO Qiumei, WANG Jia
    Abstract ( ) PDF ( ) Knowledge map Save
    Objective: To explore situation, risk factors and nursing countermeasures of lung infection in neonates with noninvasive positive pressure assisted ventilation in neonatal intensive care unit (NICU). Method: A total of 104 neonates undergoing non-invasive assisted ventilation in NICU of Xiamen Fifth Hospital from July 2021 and July 2024 were retrospectively enrolled as the research objects. According to presence or absence of lung infection, they were divided into positive group (n=32) and negative group (n=72). The clinical data of all neonates were collected, and risk factors of lung infection were analyzed by binary logistic regression analysis. Result: Among 104 NICU neonates after noninvasive positive pressure assisted ventilation, there were 32 cases with lung infection and 72 cases without infection, and the incidence of lung infection was 30.77%. There were significant differences in general data (birth weight, maternal gestational hypertension, maternal gestational diabetes mellitus, primary lung diseases, mechanical ventilation time, duration of sedatives use, times of sputum aspiration, nutritional support modes, early use of antibiotics) between positive group and negative group, and the differences were statistically significant (P<0.05). There was no significant difference in gender, gestational age, delivery modes or Apgar score (P>0.05). Binary Logistic regression analysis showed that birth weight <2 500 g , primary lung diseases , mechanical ventilation time≥5 h , sputum aspiration≥5 times and early non-use of antibiotics were independent risk factors of lung infection in NICU neonates after noninvasive positive pressure assisted ventilation (P<0.05). Conclusion: Low birth weight, primary lung diseases, mechanical ventilation time≥5 d, sputum aspiration≥5 times and early non-use of antibiotics are risk factors of lung infection in NICU neonates after noninvasive positive pressure assisted ventilation. Clinically, it is necessary to pay attention to high-risk children, take cluster intervention countermeasures, shorten unnecessary ventilation time, reduce frequency of sputum aspiration, and decrease the risk of of lung infection.
  • Experience
  • Experience
    HONG Rongqing, LI Shengju, GUAN Jinzhen, FENG Liya
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    Objective: To explore the therapeutic effect of Xiaoxuming Decoction combined with Chinese medicine scalding on hemisensory disorder after stroke based on the theory of “Six Differentiation”. Method: 100 post-stroke hemiplegia patients Yangjiang City Hospital of Traditional Chinese Medicine from May 2022 to May 2024 were selected. According to the randomized table method, they were divided into treatment group and control group, with 50 cases in each group. Two groups received conventional medical treatment and rehabilitation training. The control group received traditional Chinese medicine scalding treatment, and the treatment group in the control group based on the theory of “six meridians” small life-supporting soup treatment. The control group was treated with herbal medicine and scalding, while the treatment group was treated with Xiaoxuming Decoction based on the theory of “Six Differentiation”. Comparison of the two groups before and after treatment: changes in Chinese medicine symptom score, anxiety [Hamilton Anxiety Scale (HAMA)], sensory impairment [Sensory Impairment Rating Scale (Improved Fugl-Meyer and Lindmark Scale)], neurological impairment [National Institutes of Health Stroke Scale (NIHSS)], activities of daily living (Barthel Index), electromyographic integral of biceps and triceps brachii (IEMG) with root-mean-square (RMS) values, and central nerve-specific protein beta (S100β) levels were compared. Result: After treatment, the scores for sensory loss or disappearance, hemiplegia, dizziness or vertigo, and shortness of breath and fatigue decreased in both groups. The treatment group had lower scores than the control group, with statistically significant differences (P<0.05). After treatment, the NIHSS scores and HAMA scores in both groups were lower than before treatment, with the treatment group showing a greater reduction. Meanwhile, the MBI scores, Fugl-Meyer scores, and Lindmark scores in both groups were higher than before treatment, with the treatment group showing a greater increase. These differences were statistically significant (P<0.05). After treatment, the biceps brachii RMS, biceps brachii IEMG, triceps brachii RMS, and triceps brachii IEMG were all lower in both groups, with the treatment group showing a lower value, and the difference was statistically significant (P<0.05). After treatment, the S-100β levels in both groups were lower than before treatment, with the treatment group showing a lower value, and the difference was statistically significant (P<0.05). Conclusion: Based on the theory of “Six Differentiation”, the application of Xiaoxuming Decoction combined with Chinese medicine scalding treatment can significantly reduce hemisensory disorders after stroke, reduce the degree of anxiety and nerve function damage of patients, improve the activities of daily living of patients, alleviate the symptoms of muscle spasm after stroke, and promote the recovery of nerve function of patients.
  • Experience
    ZHANG Yue
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    Objective: To investigate the clinical effect of Zopiclone and Alprazolam on elderly patients with insomnia in the community. Method: 70 elderly insomnia patients treated in the Chronic Disease Hospital of Shandong Province from September 2023 to September 2024 were selected for this study. The patients were randomly assigned into control group receiving Alprazolam, and an observation group receiving both Alprazolam and Zopiclone, with 35 each group. Clinical efficacy, sleep quality (PSQI), cognitive function (MMSE), treatment satisfaction, and adverse drug reactions between the two groups were compared. Result: After treatment, the observation group showed significant improvements in PSQI and MMSE scores compared to the control group. The clinical efficacy and treatment satisfaction were also significantly higher in the observation group, with statistically significant differences (P<0.05). There was no statistically significant difference in adverse drug reactions between the two groups (P>0.05). Conclusion:.The combination of Zopiclone and Alprazolam effectively improves sleep quality, cognitive function, and psychological status in elderly insomnia patients, and enhances treatment satisfaction.
  • Experience
    LI Zheng, WEI Wei, LI Wankui, WEN Huiting
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    Objective: To analyze the effect of magnesium sulfate and labetalol in the treatment of Gestational hypertension (GH). Method: 70 GH patients were randomly selected from the the hospital from January 2019 to November 2024, and they were divided into group A (35 cases, magnesium sulfate) and group B (35 cases, magnesium sulfate + Labetalol) by random number table method. The effects of the two groups were compared. Result: After treatment, the test indexes of group B [interleukin-6 (IL-6), hypersensitive C-reactive protein (hs-CRP), tumor necrosis factor (TNF-α), nitric oxide (NO), angioendothelin-1 (ET-1), calcitonin gene-related peptide (CGRP)], Blood pressure [Systolic blood pressure (SBP), diastolic blood pressure (DBP)], renal function indicators [creatinine (Scr), urea nitrogen (BUN), blood β2-microglobulin (β2-MG), parathyroid hormone (PTH), 24 h urinary protein quantity (24hrUprV)] were better than group A, and the difference was statistically significant (P<0.05). The effective rate of treatment in group B was higher than that in group A, the difference was statistically significant (P<0.05). The incidence of adverse reactions in group B was higher than that in group A, the difference was not statistically significant (P>0.05). The incidence of adverse pregnancy outcome in group B was lower than that in group A, and the difference was statistically significant (P<0.05). Conclusion: The combined use of magnesium sulfate and labetalol in the treatment of GH patients can better improve clinical symptoms and renal function, improve the effect of hypotension, and reduce the risk of adverse pregnancy outcomes, with significant effect and high safety.
  • Experience
    KANG Zhiqun
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    Objective: To explore the effect of methylprednisolone sodium succinate in the treatment of refractory mycoplasma pneumoniae pneumonia (RMPP). Method: A total of 76 children with RMPP admitted to Putian Children's Hospital were divided into three groups from July 2022 to March 2024 according to the random number table method, with 38 cases in each group. The control group was treated with azithromycin, and the observation group was additionally treated with intravenous drip of methylprednisolone sodium succinate. Both groups were treated continuously for 2 treatment courses. The therapeutic effect, symptom improvement time, inflammatory factors, lung function, immune function and adverse reactions were compared between the two groups. Result: After treatment with methylprednisolone sodium succinate, the total effective rate of observation group was higher than that of control group, the symptom improvement time was shorter than that of control group. The levels of inflammatory factors, immunoglobulin A (IgA) and immunoglobulin M (IgM) were lower than those of control group, and the levels of lung function index and immunoglobulin G (IgG) were higher than those of control group, with statistically significant (P<0.05). There was no difference in adverse reactions between the two groups (P>0.05). Conclusion: The combined treatment with methylprednisolone sodium succinate in children with RMPP has significant effect. It can improve the level of inflammatory factors in the body, promote the recovery of children's immune function, and improve lung function, with high drug safety in clinical application, and is worthy of promotion.
  • Experience
    WANG Qingyang
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    Objective: To investigate the anesthetic effects of different doses of propofol combined with alfentanil in laparoscopic cholecystectomy and their impact on postoperative pain. Method: 84 patients scheduled for laparoscopic cholecystectomy in the hospital from December 2022 to December 2024 were enrolled and randomly divided into Group A, Group B, and Group C all combined with 20 μg/kg alfentanil for anesthesia induction. Hemodynamic parameters, postoperative NRS pain scores, recovery time, anesthetic efficacy, and adverse reactions were compared among the three groups. Result: The excellent and good anesthesia rate in Group B was significantly higher than in Groups A and C. 12 hours after operation, Group B exhibited the lowest NRS scores, while Group C had the highest scores. Group B maintained this advantage at 24 hours postoperatively. The spontaneous respiration recovery time in Group B was shorter than in Group C, and the incidence of complications in Group B was lower. Immediately before and after intubation, the MAP and HR levels in Group B were higher than in Group C, with statistically significant differences (P<0.05). No significant differences were observed between Groups A and B (P>0.05). Conclusion: The combination of 2 mg/kg propofol with alfentanil optimizes anesthetic efficacy in laparoscopic cholecystectomy stabilizes intraoperative hemodynamics, significantly alleviates early postoperative pain, and reduces postoperative complications.
  • Experience
    ZHANG Lei, WEI Baohua
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    Objective: To study the clinical efficacy of escitalopram combined with risperidone in the treatment of schizophrenia with depression. Method: From July 2023 to December 2024, 100 inpatients with schizophrenia and depression were recruited and randomly allocated to control or observation group, with 50 patients in each group. The observation group received treatment with escitalopram combined with risperidone, while the control group was treated with escitalopram alone. After treatment, outcomes, such as clinical effectiveness, psychiatric symptom severity, depression levels, and adverse effects, were analyzed across both groups. Result: The total effective rate was significantly higher in the observation group than the control group (P<0.05). The scores of the Positive and Negative Symptom Scale (PANSS), the Hamilton Depression Scale (CDSS), the scores of scales such as psychosocial, psychodynamic and side effects in the Schizophrenia Quality of Life Scale (SQLS) and the score of the Therapeutic Adverse Events Checklist (TESS) in the observation group were significantly lower thanthe control group (P<0.05). Conclusion: Escitalopram combined with risperidone can significantly improve clinical efficacy, alleviate psychiatric symptoms, and reduce depression in patients with schizophrenia and depression. Additionally, it is superior to escitalopram alone in minimizing adverse reactions, indicating its high clinical application value.
  • Experience
    CHEN Yan, WU Weixian
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    Objective: To investigate the effects of cyclopofol on hemodynamics and postoperative delirium (POD) in elderly patients undergoing laparoscopic cholecystectomy. Method: 95 patients who underwent laparoscopic cholecystectomy in Changshu Second People's Hospital from January 2021 to August 2024 were randomly divided into Group A (n=47, induced and maintained with propofol anesthesia) and Group B (n=48, induced and maintained with propofol anesthesia). Hemodynamic indicators, including mean arterial pressure (MAP) and heart rate (HR), at the time of entry (T0), intubation (T1), establishment of pneumoperitoneum through skin incision (T2), and completion of surgery (T3), and the quality of recovery, POD and incidence of adverse reactions were compared between the two groups. Results: At time points T1 to T3, both groups had higher levels of MAP and HR than at time point T0, while group B had lower levels of various indicators than group A, with statistically significant differences (P<0.05). The recovery time of spontaneous breathing, awakening time, POD, injection pain during induction period, and incidence of postoperative hypotension in group B were all lower than those in group A, and the difference was statistically significant (P<0.05). Conclusion: The application of cyclosporine in elderly patients undergoing laparoscopic cholecystectomy is effective in stabilizing hemodynamics and improving the quality of patient recovery, with a lower incidence of POD.
  • Experience
    HU Zhinan, JIANG Siting
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    Objective: To investigate the effectiveness of azithromycin in conjunction with Montelukast sodium for treating mycoplasma pneumoniae pneumonia in children. Method: A total of 100 pediatric patients diagnosed with mycoplasma pneumoniae pneumonia, who were treated in the hospital from May 2022 to March 2024 were chosen as study subjects. These patients were randomly divided into two groups, with 50 patients in each group. The control group received azithromycin alone, whereas the study group was given a combination of azithromycin and Montelukast sodium. The outcomes measured included treatment efficacy, lung function parameters [such as peak time ratio (t-PTEF/t-E), tidal volume (V-T), mid-inspiratory flow rate to mid-expiratory flow rate ratio (MTIF/MTEF), forced vital capacity (FVC), maximum peak expiratory flow rate (PEF), and forced expiratory volume in one second (FEV1)], inflammatory markers [C-reactive protein (CRP), procalcitonin (PCT), and erythrocyte sedimentation rate (ESR)], duration of symptom resolution (cough, wheezing, rales, and fever), and the occurrence of adverse effects (dizziness, nausea, vomiting, abdominal pain, and diarrhea) of two groups were compared. Result: The overall effectiveness in the study group was notably superior to that in the control group (P<0.05). After treatment, both groups showed improvements in lung function, but the study group exhibited better results (P<0.05). Both groups experienced a reduction in inflammatory marker levels compared to pre-treatment, but the study group had a more pronounced decrease (P<0.05). The study group also had a shorter symptom resolution time than the control group (P<0.05). Additionally, the incidence of adverse reactions was lower in the study group, with statistically significant difference (P<0.05). Conclusion: The combination of azithromycin and Montelukast sodium is effective in treating mycoplasma pneumonia in children, contributing to improving lung function, reducing inflammation, and accelarting clinical symptom improvement, with high therapeutic safety.
  • Experience
    CHEN Hailan
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    Objective: To investigate the therapeutic effects of semaglutide combined with insulin glargine in patients with early diabetic nephropathy. Method: A total of 126 patients with early diabetic nephropathy admitted to Hai'an Traditional Chinese Medicine Hospital from March 2021 to May 2024 were selected and randomly divided into observation group (n=63) and control group (n=63) using a random number table method. The control group received treatment with insulin glargine, while the observation group received additional treatment with semaglutide on top of the base regimen. The clinical efficacy, renal function indices, glycemic control indices, pancreatic β-cell function indices, and renal fibrosis factors were compared between the two groups. Result: Upon completion of the treatment, patients in the observation group exhibited superior improvements in overall effective clinical efficacy, renal function, glycemic control indices, pancreatic β-cell function, and levels of renal fibrosis factors compared to the control group, with statistically significant difference (P<0.05). Conclusion: The combination of semaglutide and insulin glargine significantly improves blood glucose levels and pancreatic β-cell function in patients with early diabetic nephropathy, and reduces renal fibrosis factors, so as to renal protection and enhance clinical efficacy.
  • Experience
    LUO Huiling, HE Siyun, ZHANG Ying, ZHAO Guoyan, CHEN Xingyu, XU Chengxu, LIU Xiaoli
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    Objective: To investigate the clinical efficacy of ipratropium bromide in patients with acute exacerbation of bronchial asthma (BA). Method: From January 2023 to June 2024, 100 patients with acute onset of BA admitted to the Second People's Hospital of Lanzhou were enrolled. The patients were divided into the control group (treated with budesonoid) and the observation group (treated with ipratropium bromide on this basis) by palpation. The symptom improvement time, clinical effect, air trapping index, pulmonary ventilation function and safety were compared between the two groups. Result: Compared with the control group, the improvement time of clinical symptoms in the observation group was shorter, the total effective rate of treatment, pH value, partial pressure of blood oxygen (PaO2), the levels of FEV1, FEV1/FVC and PEF were higher, and the partial pressure of carbon dioxide (PaCO2) was lower, and the difference was statistically significant (P<0.05). There was no significant difference in the incidence of mild headache, abnormal liver function and abnormal gastrointestinal function between the two groups(P>0.05). Conclusion: The application of ipratropium bromide in the treatment of acute attack of BA can shorten the improvement time of clinical symptoms with good curative effect, and improves pulmonary ventilation function and air trapping index with good safety.
  • Synthetic medicine
  • Synthetic medicine
    WU Shihao, REN Lanxian
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    Objective: To investigate the clinical effect of Montelukast sodium combined with Yupingfeng granules in the treatment of allergic rhinitis in children. Method: A cohort of 100 pediatric patients diagnosed with allergic rhinitis was enrolled from Yangjiang Maternal and Child Health Hospital from April 2023 to April 2024. Participants were randomly allocated via a random number table into two groups (n=50 each): control group receiving 0.9% saline nasal irrigation combined with montelukast sodium monotherapy, and research group receiving 0.9% saline nasal irrigation plus a combined regimen of montelukast sodium and Yupingfeng granules. Treatment efficacy and safety were evaluated by comparative analysis of Traditional Chinese Medicine (TCM) syndrome scores, inflammatory cytokine levels, and immunoglobulin profiles before and after the intervention period. Result: Baseline assessments indicated comparable TCM syndrome scores and serum levels of interleukin-6 (IL-6), interleukin-17 (IL-17), interleukin-23 (IL-23), immunoglobulin A (IgA), immunoglobulin G (IgG), and immunoglobulin E (IgE) between groups (P>0.05). After treatment, the syndrome score of the study group was significantly lower than that of the control group, and the concentration of pro-inflammatory factors was also lower than that of the control group. The immune function of the study group was significantly improved, manifested as an increase in IgA and IgG levels compared with the control group, while IgE decreased. The difference was statistically significant (P<0.05). The total clinical effective rate of the study group was significantly higher than that of the control group, and the difference was statistically significant (P<0.05). Moreover, no drug-related serious adverse events occurred in either group. Conclusion: The adjunctive use of Yupingfeng granules with montelukast sodium significantly enhances therapeutic outcomes in pediatric allergic rhinitis. This synergistic approach effectively alleviates nasal symptoms (rhinorrhea, congestion) through concurrent suppression of inflammatory mediators and bidirectional immunomodulation, without increasing drug-related risks.
  • Synthetic medicine
    LI Fangfang, SUN Lijing
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    Objective: To study the efficacy of Lactobacillus vaginal capsule combined with clotrimazole vaginal suppository in the treatment of mycotic vaginitis and the effect on vaginal environment. Method: 82 patients with mycotic vaginitis admitted to Shijingshan Teaching Hospital, Capital Medical University, Beijing Shijingshan Hospital from April 2023 to June 2024 were divided into two groups by random number table method, including control group (treated with clotrimazole vaginal suppository, 41 cases) and observation group (treated with lactobacillus vaginal capsule on the basis of observation group, 41 cases). The inflammation, vaginal environment, efficacy and adverse reactions were compared between the two groups. Result: Before treatment, no significant differences were observed in the levels of inflammatory mediators or the vaginal environment between the two groups (P>0.05). After treatment, the observation group exhibited a greater reduction in C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor (TNF-α), vaginal secretion pH, and acetylglucosaminase compared to the control group (P<0.05). Additionally, the observation group experienced a more pronounced increase in vaginal hydrogen peroxide levels than the control group, with statistically significant difference (P<0.05). The treatment effectiveness rate was higher in the observation group than in the control group, with statistically significant difference (P<0.05). However, there were no significant differences between the two groups in the overall incidence of vulvar swelling, loss of appetite, and rash (P>0.05). Conclusion: The combination of Lactobacillus vaginal capsule and clotrimazole vaginal suppository in the treatment of mycotic vaginitis can alleviate the inflammatory response of patients, and improve and maintain the vaginal environment, with good efficacy, high safety.
  • Synthetic medicine
    HONG Fuxin, HONG Qilin
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    Objective: To observe the effect of intravenous thrombolysis with alteplase in the treatment of acute mild ischemic stroke. Method: 56 patients with acute mild ischemic stroke [National Institutes of Health Stroke Scale (NIHSS) ≤5 points, onset time ≤4.5 h] who were hospitalized in Jinnan Branch of Jinjiang Hospital from January 2021 to August 2024, and received intravenous thrombolysis with alteplase were selected as the observation group. Another 60 patients with non-intravenous thrombolytic acute mild ischemic stroke (NIHSS score ≤5 points, onset time ≤36 h) who were hospitalized during the same period were randomly selected as the control group. The NIHSS and modified Rankin Scale (mRS) scores of the patients before treatment, 1 d, 3 d, and 7 d after treatment, as well as the adverse reactions. Result: After treatment, NIHSS scores in the observation group 1 d, 3 d and 7 d after operation were significantly lower than those before treatment at (P<0.05), and each score was lower than that in the control group at the same period (P<0.05). The mRS score of the observation group was also significantly improved 1 d, 3 d and 7 d after treatment (all P<0.05), which was better than that of the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: Intravenous thrombolysis with alteplase in the treatment of acute mild ischemic stroke can improve the severity of neurological impairment in a short time.
  • Synthetic medicine
    DAI Siqin, CHEN Bifang
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    Objective: To explore the effect of PERMA on patients with secondary epilepsy after cerebral infarction. Method: 90 patients with secondary epilepsy after cerebral infarction treated in the hospital from August 2023 to August 2024 were selected and randomly divided into control group (n=44) and study group (n=46) using a random number table method. The control group received routine nursing care, while the study group received PERMA intervention mode on the basis of the control group. The hope level, psychological resilience, post-traumatic growth, coping style, and neurological function level of the two groups were compared. Result: After intervention, the scores of hope level, psychological resilience, post-traumatic growth and coping dimension in the research group were higher, while the neurological function scores of the patients in the research group were lower (P<0.05). Conclusion: The PERMA intervention model can improve the psychological resilience and hope level scores of patients with secondary epilepsy after cerebral infarction, promote their post-traumatic growth, and change their coping strategies, which can help improve their neurological function levels.
  • Synthetic medicine
    WANG Wei, ZHAO Fenglin
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    Objective: To analyze the clinical efficacy of Qi injection in the treatment of dilated cardiomyopathy and its impact on patients' cardiac function. Method: 100 patients with dilated cardiomyopathy admitted to Youyang County People's Hospital in Chongqing from February 2023 to February 2024 were selected as the study sample. According to different treatment methods, they were divided into control group (50 cases) and observation group (50 cases). The control group received intravenous infusion of sodium phosphocreatine, while the observation group received intravenous infusion of Huangqi injection in addition to sodium phosphocreatine. The treatment effects of the two groups were compared. Result: After treatment, the total effective rate of the observation group was higher than the control group. The heart function grade IV rate and adverse reaction rate in the observation group were lower than those in the control group, with statistically significant difference (P<0.05). Conclusion: Huangqi injection has high clinical efficacy and safety in treating patients with dilated cardiomyopathy, and can improve their cardiac function.
  • Synthetic medicine
    YUE Mingjia
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    Objective: To analyze the efficacy and safety of antiplatelet therapy in patients with coronary heart disease. Method: 100 eligible coronary heart disease patients who received treatment in the Second People's Hospital of Tongren City from September 2024 to March 2025. The study subjects were randomly divided into an observation group and a control group, with 50 patients in each group. Patients were usually treated with beta blockers, calcium channel inhibitors, and statins as standard therapy based on their condition. On this basis, patients in the control group were treated with aspirin as a therapeutic drug, with a frequency of once a day and a dosage of 100 mL per dose. The observation group patients received clopidogrel combination therapy on the basis of the original treatment, with a dosage of 75 mL per session, while maintaining a daily medication frequency. The coagulation function, cardiac function, serum levels, and related adverse reactions of two groups of patients before and after receiving medication treatment were compared. Result: After treatment, the levels of activated partial thromboplastin time (APTT), prothrombin time (PT), and left ventricular ejection fraction (LVEF) in the observation group were higher than those in the control group, and the difference was statistically significant (P<0.05). The incidences of fibrinogen (FIB), brain natriuretic peptide (BNP), left ventricular end-diastolic diameter (LVEDD), left ventricular end-systolic diameter (LVESD), high-sensitivity C-reactive protein (hs-CRP), soluble CD40 ligand (sCD40L), and adverse reactions were lower than those in the control group, and the differences were statistically significant (P<0.05). Conclusion: In the treatment of coronary heart disease, the combination of aspirin and clopidogrel shows better efficacy than using aspirin alone. After the combination therapy, the patient's coagulation mechanism, cardiac function, and serum biochemical indicators were significantly improved, and the incidence of adverse events was effectively managed.
  • Synthetic medicine
    CHEN Jinzhu, LIU Qiuxia, CHEN Shaoxia, LIU Yanhua, HONG Congying, LIU Lijing
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    Objective: To investigate the impact of health belief education combined with positive psychological suggestion on postoperative health beliefs, compliance with breathing exercises and pulmonary function recovery in patients undergoing surgery for early lung cancer (LC). Method: 104 patients with early LC who underwent surgery in the Affiliated Hospital of Putian University from October 2023 to August 2024 were selected and assigned to the A group (n=52) and the B group (n=52) using a table of random numbers. The former received routine care, and the latter received health belief education combined with positive psychological suggestion on the basis of routine nursing. Postoperative health beliefs, compliance with breathing exercises and pulmonary function recovery were compared between the two groups. Result: After the intervention, the health belief scores of susceptibility, severity, benefits, barriers, health motivation, and self-efficacy in Group B were higher than those of pre-intervention and Group A, with statistically significant differences (P<0.05). After intervention, the respiratory exercise compliance scores of Group B were higher than those of pre-intervention and Group A in adherence, precautionary adherence, and proactive advice-seeking, with statistically significant difference (P<0.05). After intervention, the lung function scores of Group B in Vital Capacity (VC), Forced Vital Capacity (FVC), Forced Expiratory Volume in One Second as a Percentage of the Predicted Value(FEV1), and FEV1/FVC were significantly higher than those of pre-intervention and Group A, and the differences were statistically significant (P<0.05). Conclusion: Health belief education combined with positive psychological suggestion can enhance postoperative health beliefs and compliance with breathing exercises in patients undergoing surgery for early LC, and promote pulmonary function recovery.
  • Synthetic medicine
    LIU Yan, YU Weina, MO Qingqing
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    Objective: To explore the influence of cognitive behavioral therapy (CBT) based emotional management on cerebral infarction patients, so as to provide scientific and effective nursing strategies. Method: This study enrolled 90 patients with acute cerebral infarction admitted to the Department of Neurology , the First Affiliated Hospital of Bengbu Medical University from March 2021 to February 2024..They were randomly divided into experimental group and conventional group, with 45 cases in each group. Patients in the conventional group received routine nursing intervention, and those in the experimental group received CBT-based emotional management on the basis of routine nursing intervention. The psychological state, quality of life, sleep quality and neurological function damage of the two groups were observed and compared. Result: Before intervention, there were no statistically significant differences in Hamilton Depression Scale (HAMD) scores, Hamilton Anxiety Scale (HAMA) scores, or National Institutes of Health Stroke Scale (NIHSS) scores between the two groups (P>0.05). After intervention, the experimental group showed significantly greater improvements in HAMD, HAMA, and NIHSS scores compared to the conventional group (P<0.05). Before intervention, when comparing the scores of each dimension of quality of life between the two groups, there was no statistically significant difference (P>0.05). After intervention, the experimental group showed better scores in all dimensions of quality of life, and the quality of life scores of both groups were significantly improved compared with those before the intervention, with statistically significant difference (P<0.05). Before intervention, there was no statistically significant difference in the Pittsburgh Sleep Quality Index (PSQI) scores of the two groups (P>0.05). After the intervention, the PSQI score of the experimental group was significantly lower than that of the conventional group. Moreover, the PSQI scores of both groups showed a downward trend compared with those before the intervention, and the difference was statistically significant (P<0.05). Conclusion: The application of emotion management based on CBT in patients with cerebral infarction can effectively improve neurological function, reduce levels of depression and anxiety, enhance sleep quality, and promote quality of life.
  • Review
  • Review
    CHEN Yu, FAN Baoxin, GONG Changrong, LIU Jinjing
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    Fear of disease progression is common in elderly heart failure patients due to the long duration of the disease and the ease of disease recurrence. In addition, the decline in physical function, physiological and psychological tolerance, clinical symptoms, uncertainty about future health status, and the complexity and long-term nature of treatment are common factors that lead to the fear of disease progression in elderly patients. The aim of this study is to review the current situation of fear of disease progression and its influencing factors in elderly heart failure patients, in order to provide theoretical support and evidence-based basis for clinical practice.
  • Review
    LIN Shuai, ZHANG Yong, WANG Dalong, SU Sisi, LIU Jia
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    The study briefly reviews the related trials of remazolam in painless gastroenteroscopy conducted by PubMed and CNKI. It is found that remazolam has significant sedative effect, less respiratory depression, less circulation impact and fewer adverse reactions compared with propofol and other drugs, and the adverse reactions are relatively less. However, the onset time, call response time and wake time are relatively prolonged.
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