Objective: To evaluate the clinical outcomes of modified Holmium Laser Enucleation of the Prostate (HoLEP) with maximum preservation of functional urethra. Method: A retrospective analysis was conducted on 216 patients with benign prostatic hyperplasia (BPH) treated in the hospital from January to December 2024, including 104 cases using modified HoLEP with functional urethral preservation (Group A) and 112 cases using traditional HoLEP (Group B). Assessment indicators included perioperative parameters, effectiveness indicators (IPSS score, QoL score, and PVR 1, 3, and 6 months postoperatively); and safety indicators [incidence of stress urinary incontinence （SUI） immediately after catheter removal and 1, 2, and 4 weeks after operation]. Result: All surgeries were successfully completed, and there were no significant differences in perioperative parameters between the two groups (P>0.05). Group A showed significantly better IPSS scores than Group B at 6 months postoperatively, and the difference was statistically significant (P<0.05). Regarding safety, Group A demonstrated significantly lower incidence of stress urinary incontinence both immediately after catheter removal and 1, 2, and 4 weeks postoperatively compared to Group B, and the differences were statistically significant (P<0.05). Conclusion: The modified HoLEP technique with maximum preservation of functional urethra maintains surgical efficacy while significantly reduces the incidence of postoperative urinary incontinence, demonstrating promising clinical value.

Objective: To compare the efficacy of proximal gastrectomy and total gastrectomy in the treatment of advanced Siewert type Ⅱ and Ⅲ adenocarcinoma of the esophagogastric junction. Method: A retrospective analysis was conducted on the clinical data of 80 patients with esophagogastric junction adenocarcinoma who received treatment in the hospital from March 2022 to April 2024. Among them, 40 patients underwent proximal gastrectomy, and 40 patients underwent total gastrectomy. The surgical-related indicators, postoperative related indicators and the incidence of postoperative complications between the two groups were compared. Result: The operation time and incision length in the total gastrectomy group were longer than those in the proximal gastrectomy group, P<0.05. There was no statistically significant difference in intraoperative blood loss between the total gastrectomy group and the proximal gastrectomy group (P>0.05). There was no statistically significant difference in the catheterization time and hospital stay between the two groups (P>0.05). The gastric tube drainage volume in the total gastrectomy group was less than that in the proximal gastrectomy group 1 to 3 days after operation, P<0.05. There was no statistically significant difference in postoperative complications such as reflux esophagitis and intestinal obstruction between the two groups (P>0.05). Conclusion: Proximal gastrectomy is superior to total gastrectomy in surgical time, incision length and postoperative drainage volume. There is no difference in complications between total gastrectomy and proximal gastrectomy, and total gastrectomy is more effective for patients with advanced Siewert type Ⅱ and Ⅲ esophagogastric junction adenocarcinoma.

Objective: To explore the clinical effect of Fu's subcutaneous needling combined with high-frequency repetitive transcranial magnetic stimulation (rTMS) in the treatment of knee osteoarthritis (KOA). Method: 90 patients with KOA in the hospital from January 2023 to June 2024 were collected and randomly divided into the rTMS group: the Fu's subcutaneous needling group and the combined group, with 30 cases in each gorup by the random number table. The rTMS and Fu's subcutaneous needling groups received rTMS alone and Fu's subcutaneous needling, respectively, and the combined group received both rTMS and Fu's subcutaneous needling for a total of 4 weeks. Visual Analog Scale (VAS), Osteoarthritis Index (WOMAC), Lower Extremity Joint Function Score(Lysholm), 6-minute walk test (6MWT), Tumor Necrosis Factor-α (TNF-α), Interleukin 1 (IL-1) and Interleukin 6 (IL-6) were assessed before and after the intervention. Result: VAS scores, WOMAC scores, TNF-α levels, and IL-1 levels were lower, and Lysholm scores were higher in the three post-intervention groups compared with pre-intervention, and the difference was statistically significant (P<0.05). Compared with the post-intervention rTMS group, Lysholm scores and 6MWT were higher and TNF-α, IL-1 and IL-6 levels were lower in the Fu's subcutaneous needling and combined group, and the difference was statistically significant (P<0.05). Compared with the post-intervention Fu's subcutaneous needling group, the combined group had lower VAS scores, WOMAC scores, TNF-α, IL-1 and IL-6 levels and higher Lysholm scores, and 6MWT, and the difference was statistically significant (P<0.05). Conclusion: Fu's subcutaneous needling combined with high-frequency rTMS can significantly reduce knee pain, improve joint function, enhance walking ability, and inhibit inflammatory response in patients with KOA. It can be widely used in clinical practice.

Objective: To investigate the effects of autologous corneal limbal stem cell transplantation on visual acuity and tear film function in pterygium. Method: 90 patients with pterygium admitted to Putian Ophthalmology Hospital from January 2022 to January 2024 were randomly selected, with 45 patients in each group. The control group underwent pterygium excision surgery, while the study group received autologous corneal stem cell transplantation treatment on the basis of the control group. The clinical efficacy, preoperative and postoperative tear film function indicators [tear secretion test (SIT), tear film rupture time (BUT)], visual function indicators (corneal horizontal curvature, corneal horizontal vertical curvature, refractive error, uncorrected visual acuity), and incidence of postoperative complications between two groups were compared. Result: Compared with the control group, the total effective rate of the study group after surgery was higher (P<0.05). After surgery, both groups had significantly higher levels of SIT and BUT compared to before surgery (P<0.05). Compared with the control group, the study group had higher levels of SIT and BUT after surgery (P<0.05). After surgery, the corneal horizontal curvature, corneal horizontal vertical curvature, and uncorrected visual acuity of both groups were higher than before surgery, while the refractive error was lower than before surgery, with statistically significant difference (P<0.05). Compared with the control group, the study group had higher corneal horizontal curvature, corneal horizontal vertical curvature, and uncorrected visual acuity after surgery, but lower refractive error (P<0.05). There was no significant difference in the incidence of postoperative complications between the two groups (P>0.05). Conclusion: Autologous corneal stem cell transplantation can achieve significant results in the treatment of pterygium patients, helping to promote postoperative visual and tear film function recovery. The surgery is safe and reliable.

Objective: To explore the effects of early enteral nutrition support based on the theory of fusion transformation on the immune function, nutritional status, and recovery of postoperative gastric cancer patients. Method: A total of 160 patients with gastric cancer admitted to the hospital from April 2022 to April 2024 were selected as the research subjects. They were randomly divided into control group (n=80) and experimental group (n=80) using a random number table method. Patients in the control group received routine nursing intervention, while patients in the observation group received early enteral nutrition support based on the theory of fusion and change on the basis of nursing in the control group. The immune function, nutritional status, and rehabilitation status of the two groups were compared. Result: After intervention, tumor necrosis factor-α (TNF-α), hypersensitive C-reactive protein (hs-CRP), interleukin-2 (IL-2) and interleukin-6 (IL-6) levels of observation group were significantly lower than those in the control group. The difference was statistically significant (P<0.05). The proportion of nutrient-balanced patients in the observation group was significantly higher than that in the control group, and the proportion of severe malnutrition was significantly lower than that in the control patients. The difference was statistically significant (P <0.05). The scores of the health survey (SF-36) were significantly higher than the control group, and the difference was statistically significant (P<0.05). Conclusion: Early enteral nutrition support based on the theory of fusion transformation is significantly more effective in intervening postoperative gastric cancer patients than previous nursing models. The patient's immune function and nutritional status are significantly improved, and their recovery process is effectively promoted.

Objective: To study the application of penttone therapy in patients with hyperthyroidism. Method: 120 patients with hyperthyroidism admitted to Linyi Hospital of Traditional Chinese Medicine from June 2021 to June 2024 were divided into conventional group and penttone group, with 60 cases in each group. The routine group performed routine care, and the penttone group received basic treatment. The two groups were cared for 2 months. Before and after nursing care, sleep quality, psychological status, quality of life and nursing adherence were compared by Pittsburgh Sleep Quality Index (PSQI), HAMA, Hamilton Anxiety Scale and Depression Scale (HAMD), World Health Organization quality of survival scale (WHOQOL-BREF), and self-made adherence scale. Result: After the nursing care, the PSQI, HAMA and HAMD scores of the penttone group were lower than those of the conventional group, and the difference was statistically significant (P<0.05). The WHOQOL-BREF score of the pentatonic group was higher than that of the conventional group, and the difference was statistically significant (P<0.05). The total compliance rate of nursing in the five-tone group was higher than the conventional group, and the difference was statistically significant (P<0.05). Conclusion: The application of penttone therapy in the patients with hyperthyroidism can effectively improve the sleep quality， psychological condition, the quality of life and nursing compliance.

Objective: To explore the clinical effect of Sini Sanjie Decoction combined with leuprelin in the treatment of children with precocious puberty. Method: A comparative analysis trial was carried out in Jinjiang Hospital from January 2022 to June 2024, and 100 female children with precocious puberty were selected during the period. They were randomly divided into the observation group and the control group by using the medical record number table method, with 50 children in both groups. The control group was treated with leuprelin, and the observation group was treated with Sini Sanjietang combined with leuprelin. The clinical effective rate, sex hormone level, ovarian volume, uterine volume, follicle diameter, bone age index, serum factor level and incidence of adverse reactions were compared between the two groups. Result: There was statistically significant difference in the clinical effective rate between the two groups (P<0.05). There was statistically significant difference in sex hormone levels between the two groups (P<0.05). There were statistically significant differences in ovarian volume, uterine volume, follicular diameter and bone age index data between the two groups (P<0.05). The comparison of the serum factor level data of the two groups showed that after treatment, the adiponectin (ADPN) data of the observation group was significantly higher than that of the control group, and the serum neurokinin B (NKB) and insulin-like growth factor 1 (IGF-1) data were significantly lower than those of the control group, with statistically significant difference (P<0.05). Conclusion: For children with precocious puberty, the treatment intervention with Sini Sanjie Decoction combined with leprorelin can achieve relatively ideal results. After the treatment, the sex hormone levels of the children tend to be normal, the ovaries and uterus shrink to varying degrees. The bone age and follicular diameter indicators are similar to those of healthy children, the levels of multiple serum factors improve, with no serious adverse reactions.

Objective: To analyze the effect of nanocarbon suspension injection on surgical patients with papillary thyroid carcinoma. Method: 80 patients with papillary thyroid carcinoma admitted to the First People's Hospital of Wanzhou District, Chongqing from February 2021 to December 2023 were selected as the study sample. They were randomly divided into two groups: observation group and control group, with 40 patients in each group. The observation group received treatment with nanocarbon suspension injection during surgery, while the control group received surgical treatment alone. The intraoperative blood loss, intraoperative blood calcium and parathyroid hormone levels, number of lymph node dissections, parathyroid incorrect resection rate, postoperative drainage volume, and incidence of postoperative complications were compared between the two groups. Result: The intraoperative blood calcium (4.24±0.62) mmol/L, parathyroid hormone (32.13±2.08) pg/ml, and lymph node dissection number (7.39±1.02) in the observation group were higher than those in the control group (2.29±0.37) mmol/L, (29.15±1.74) pg/ml, and (5.42±0.85), respectively. The intraoperative bleeding volume (8.35 ±2.08) mL, postoperative drainage volume (31.93±2.28) mL, parathyroid misplacement rate 0.00%, and postoperative complication rate 2.50% in the observation group were all lower than those in the control group (13.19±2.14) mL, (42.07±2.52) mL, 12.50%, and 15.00%, respectively (P<0.05). Conclusion: Nanocarbon suspension injection has numerous benefits for patients undergoing surgery for papillary thyroid carcinoma. It can not only prevent the accidental removal of parathyroid tissue, thereby preventing a decrease in blood calcium and parathyroid hormone levels, but also increase the number of lymph node dissections and reduce the risk of postoperative complications.

Objective: To investigate the effect of minimally invasive internal fixation surgery in the patients with thoracolumbar fracture and influence for stability. Method: 98 patients with thoracolumbar fracture from October 2023 to October 2024 were divided into two groups by random number table, with 49 patients in each group. The control group were treated with traditional open invasive internal fixation surgery of pedicle screws, and the observation group were treated with minimally invasive internal fixation surgery of pedicle screws. Then the total excellent and good rates, operation indexes (incision length, intraoperative blood loss, operative time and postoperative hospitalization time), waist and lower limbs pain (VAS score), functional state of waist and back (ODI score) and stability indexes (posterior Cobb angle, spinal canal occupancy rate and anterior vertebral compression rate) before and after the operation of two groups were compared. Result: The total excellent and good rates of two groups were compared, the difference was not statistically significant (P>0.05). The incision length of observation group was significantly shorter than that of control group, the intraoperative blood loss was significantly less than that of control group, the operative time and postoperative hospitalization time were significantly shorter than those of control group (P<0.05). The waist and lower limbs scores of two groups before the operation were compared, the differences were not statistically significant (P>0.05). The waist and lower limbs scores of observation group at 1st week and 3rd month after the operation were significantly lower than those of control group (P<0.05). The stability indexes of two groups before and after the operation were compared, and the differences were not statistically significant (P>0.05). Conclusion: The effect of minimally invasive internal fixation surgery in the patients with thoracolumbar fracture are not significantly different from those of traditional open surgery. Its operation indexes are relatively better, and can effectively control the postoperative pain.

Objective: To explore the application effects of active hypothermia prevention combined with inhalation aromatherapy on patients undergoing hip arthroplasty. Method: A total of 86 patients undergoing hip arthroplasty at Hai'an City Hospital from January 2023 to November 2024 were selected and randomly divided into an observation group (n=43) and a control group (n=43). The control group received standard surgical room care, while the observation group was additionally given active hypothermia prevention and inhalation aromatherapy. Comparisons were made between the two groups regarding physiological stress indicators, anxiety and depression levels (SAS and SDS scores), intraoperative temperature stability, recovery and extubation times, comfort levels, and incidence of complications. Result: After the intervention, the observation group showed significantly better physiological stress indicators, intraoperative temperature stability, SAS and SDS scores, and recovery and extubation times compared to the control group. Furthermore, the observation group reported higher comfort levels and a lower incidence of complications, with statistically significant differences (P<0.05). Conclusion: Active hypothermia prevention combined with inhalation aromatherapy can effectively reduce physiological and psychological stress in patients undergoing hip arthroplasty, maintain stable body temperature, promote postoperative recovery, decrease the incidence of complications, and enhance surgical comfort.

Objective: To explore the impact of elderly case management based on the Omaha System on the occurrence of adverse events such as falls and pressure ulcers in dementia patients, as well as its effect on improving daily living abilities, quality of life and cognitive function. Method: A total of 60 dementia patients admitted to Longyan Third Hospital from October 2023 to October 2024 were selected. The patients were randomly assigned to two groups, each consisting of 30 individuals. The control group received routine care, while the observation group implemented elderly case management based on the Omaha System. Both groups were evaluated for daily living abilities, quality of life, cognitive function, and the occurrence rate of adverse events before and after the intervention. Result: After 3 months of intervention, the observation group had significantly higher scores in the activity of daily living scale (ADL), quality of life-Alzheimer's disease (QOL-AD), and mini-mental state examination (MMSE) compared to the control group, the incidence of falls, and pressure ulcers was lower in the observation group compared to the control group, the difference was statistically significant (P<0.05). Conclusion: Omaha System-based geriatric case management can significantly improve the activities of daily living, quality of life, and cognitive function of dementia patients, while reducing the incidence of adverse events such as falls and pressure ulcers. This intervention strategy provides an effective management model for improving the quality of life and reducing complications in dementia patients.

Objective: To investigate the relationship between glycated hemoglobin (HbA1C) levels and carotid plaque stability and carotid blood flow in patients with type 2 diabetes mellitus (T2DM). Method: 100 cases of T2DM patients admitted to Putian No. 1 Hospital from January 2022 to December 2023 were selected as the study subjects, and were divided into <7.0% group (32 cases), ≥7.0% and <8.5% group (48 cases), and ≥8.5% group (20 cases) based on the HbA1C level. All patients had their blood collected to test the levels of glycemic and lipid metabolism indexes, and carotid ultrasonography was carried out to clarify the carotid intima-media thickness (IMT), plaque score, and unstable plaque, and to determine the carotid blood flow parameters, including resistance to obstruction (RI), diastolic blood flow velocity (EDV), and peak systolic flow velocity (PSV). Result: Fasting glucose (FPG), total cholesterol (TC), triacylglycerol (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) were higher in the ≥8.5% group than in the ≥7.0% and <8.5% group, and in the <7.0% group, and the difference was statistically significant (P<0.05). IMT, plaque score, and carotid RI were higher in the ≥8.5% group than in the ≥7.0% and <8.5% group and <7.0% group, and EDV and PSV were lower than in the ≥7.0% and <8.5% group and <7.0% group, and the differences were statistically significant (P<0.05). The incidence of unstable plaques in the ≥8.5% group was higher than that in the ≥7.0% and <8.5% and <7.0% groups, and the difference was statistically significant (P<0.05). Conclusion: HbA1C levels in T2DM patients are closely related to carotid plaque stability and carotid blood flow, and the higher the HbA1C level, the higher the risk of arteriopathy, which needs to be highly emphasized clinically and appropriate preventive and curative measures need to be taken.

Objective: To investigate the effect of ultra-early tracheal intubation on clinical outcomes in patients with traumatic brain injury (TBI). Method: The clinical data of 94 patients with severe TBI admitted by Xingtan Hospital of Shunde Hospital of Southern Medical University to General Hospital from January 2022 to May 2024 were retrospectively analyzed. The propensity matching scoring method was applied to divide them into conventional group (given conventional tracheal intubation according to the condition) and ultra-early group (performed ultra-early tracheal intubation) according to the timing of tracheal intubation, with 47 cases in each group. The blood gas analysis indexes [arterial blood partial pressure of carbon dioxide (PaCO₂), partial pressure of oxygen (PaO₂), and oxygen saturation (SaO₂)], optic nerve sheath diameter (ONSD), clinical indexes (duration of mechanical ventilation, length of hospitalization, and incidence of aspiration pneumonia), and clinical outcomes were compared between the two groups at the time of admission and after intubation. Result: After intubation, SaO₂ and PaO₂ increased and PaCO₂ and ONSD decreased in both groups, and SaO₂ and PaO₂ were higher in the ultra-early group than in the conventional group, and PaCO₂ and ONSD were lower than in the conventional group, and the difference was statistically significant (P<0.05). The duration of mechanical ventilation and hospitalization in the ultra-early group was shorter than that in the conventional group, and the incidence of aspiration pneumonia was lower than that in the conventional group, with statistically significant differences (P<0.05). The incidence of good prognosis in the ultra-early group was higher than that in the conventional group, and the difference was statistically significant (P<0.05). Conclusion: Ultra-early tracheal intubation effectively improves oxygenation, shortens hospitalization time, and reduces the risk of aspiration pneumonia in patients with severe TBI, contributing to an improved patient prognosis.

Objective: To explore the impact of internet+health management on glycemic control and quality of survival in diabetes mellitus in young and middle-aged adults. Method: 110 cases of young and middle-aged diabetic patients who received consultation and treatment at the No. 90 Hospital of the People's Liberation Army Joint Command and Security Forces from April 2021 to April 2024 were selected as the study subjects, and were divided into a control group (n=55, implementing the traditional management method) and an experimental group (n=55, implementing the Internet+health management on the basis of the control group) according to the randomized throw method. The blood glucose control (fasting blood glucose (FBG), postprandial blood glucose (2 hPG), glycosylated hemoglobin (HbA1c)), quality of life scores, self-management scores and nursing satisfaction of the two groups were compared. Result: After the intervention, FBG and 2 hPG of both groups were lower than that of the same group before the intervention and the experimental group was lower than that of the control group, and the difference was statistically significant (P<0.05). After the intervention, the quality of life scores and self-management scores of both groups were higher than those of the same group before the intervention and the experimental group was higher than that of the control group, with statistically significant differences (P<0.05). The HbA1c levels of both groups were lower than before the intervention, and the difference was not statistically significant (P>0.05). The total satisfaction of the experimental group was higher than that of the control group, and the difference was statistically significant (P<0.05). Conclusion: Internet + health management model can effectively control blood glucose, improve quality of life and enhance self-management ability of young and middle-aged diabetic patients with high satisfaction.

Objective: To investigate the efficacy and effect on renal function and microinflammatory status of flavored Fangji Huangqi Tang in the treatment of primary nephrotic syndrome (PNS). Method: 106 PNS patients admitted to the First Hospital of Zhangzhou Gulei Port Economic Development Zone from August 2021 to August 2024 were selected as the study subjects, and were divided into the control group (n=52) and the observation group (n=54) according to the treatment plan. The control group was treated symptomatically with conventional drugs, and the observation group was treated on the basis of symptomatic conventional drugs combined with flavored Fangji Huangqi Tang. Result: The total effective rate of the observation group was higher than that of the control group, and the difference was statistically significant (P<0.05). In 3 months of treatment, all TCM symptom scores, renal function indexes and microinflammatory state indexes of the observation group were lower than those of the control group, and the difference was statistically significant (P<0.05). The difference in the incidence of adverse drug reactions between the two groups was not statistically significant (P>0.05). Conclusion: The treatment of PNS with flavored Fangji Huangqi Tang can improve the clinical efficacy, alleviate the clinical symptoms of patients, improve the renal function and the microinflammatory state of the organism, and has a good safety profile.

Objective: To investigate the effects of milrinone (MIL) adjuvant therapy on plasma B-type natriuretic peptide (BNP), amino-terminal B-type natriuretic peptide precursor (NT-proBNP) levels and cardiac function in patients with chronic heart failure (CHF). Method: A random number table method was used to divide 165 chronic heart failure patients admitted to the First People's Hospital of Qujing City from January 2023 to March 2024 into a control group (82 cases, conventional treatment of chronic heart failure) and an experimental group (83 cases, MIL treatment added on the basis of conventional treatment), all treated for 7 d. The treatment effects, plasma levels of BNP and NT-proBNP, cardiac function levels [left atrial end-diastolic diameter (LADd), left ventricular end-diastolic internal diameter (LVEDd), cardiac output (CO), and output per beat (SV)] and myocardial remodeling levels [left ventricular myocardial mass index (LVMI), left ventricular posterior wall thickness (LVPWT), and interventricular septal thickness (IVST )] were observed and compared. Result: The treatment efficiency of the observation group was higher than that of the control group, and the difference was statistically significant (P<0.05). Before treatment, the plasma BNP, NT-proBNP levels of the two groups were compared, and the difference was not statistically significant (P>0.05). After treatment, the plasma BNP and NT-proBNP levels of the observation group were better than those of the control group, and the difference was statistically significant (P<0.05). Before treatment, the difference in cardiac function between the two groups was not statistically significant (P>0.05) . After treatment, the levels of LADd and LVEDd in the observation group were lower than those in the control group, and the levels of CO and SV were higher than those in the control group, and the difference was statistically significant (P<0.05). Before treatment, the difference in myocardial remodeling level between the two groups was not statistically significant (P>0.05). After treatment, the myocardial remodeling level of the observation group was better than that of the control group, and the difference was statistically significant (P<0.05). Conclusion: MIL-assisted treatment of CHF patients is effective, can effectively reduce the body BNP, NT-proBNP level, improve the effectiveness of treatment, but also improve the level of cardiac function of patients, improve the level of myocardial remodeling.

Objective: To study the effects of anesthesia, stress and inflammatory response, and quality of postoperative recovery of low-dose sevoflurane combined with oxycodone in laparoscopic inguinal hernia repair. Method: A study was conducted on 106 patients with inguinal hernia admitted to Wuxue First People's Hospital from February 2022 to February 2023. All patients underwent laparoscopic inguinal hernia repair at Wuxue First People's Hospital and were randomly divided into a control group and a study group using a random number table. The control group received conventional-dose sevoflurane combined with oxycodone for anesthesia, while the study group received low-dose sevoflurane combined with oxycodone. The differences in anesthesia effect, stress and inflammatory responses, hemodynamics, and complication rates between the two groups were compared. Result: The patients in the study group had better pain reflex disappearance time, eyelash reflex disappearance time, awakening time, cortisol (COR), norepinephrine (NA), glucose (GLU), tumor necrosis factor-α (TNF-a), interleukin-6 (IL-6), and hypersensitive C-Reactive Protein (hs-CRP) than the control group, and the difference between the groups was statistically significant. 6 (Interleukin-6, IL-6), and Hypersensitive C-Reactive Protein (hs-CRP) were better than those in the control group, and the difference was statistically significant (P<0.05). Compared with the pre-induction period, the heart rate (HR), systolic pressure (SP) and diastolic pressure (DP) of the patients 10 min after pneumoperitoneum were lower, and the study group was higher than the control group, with a statistically significant difference between the two groups (P<0.05). The probability of complications in the study group was lower than that in the control group, and the difference was statistically significant (P<0.05). Conclusion: Low-dose sevoflurane combined with oxycodone in laparoscopic inguinal hernia repair can rapidly induce and stably control the depth of anesthesia, reducing fluctuations in vital signs during surgery. At the same time, it exerts the potent analgesic and anti-inflammatory effects of oxycodone, effectively alleviating postoperative pain, lowering levels of inflammatory factors, and thereby promoting rapid recovery of patients and improving overall treatment outcomes.

Objective: To compare the therapeutic efficacy of holmium laser enucleation of the prostate (HoLEP) and bipolar plasma resection (TUPKP) in benign prostatic hyperplasia and the effect on sexual function. Method: 164 cases of BPH patients diagnosed and treated in the Second People's Hospital of Liaocheng City from March 2023 to September 2024 were selected as the study subjects, and were divided into the HoLEP group and the TUPKP group by using the random number table method, with 82 cases in each group. Post-treatment indicators were compared between the two groups. Result: The operation time of HoLEP group was longer than that of TUPKP group, and the difference was statistically significant (P<0.05). Intraoperative bleeding, bladder irrigation time, and urethral retention time of HoLEP group were lower than that of TUPKP group, and the difference was statistically significant (P<0.05). Postoperatively, the maximum urinary flow rate of HoLEP group was higher than that of TUPKP group, and the residual urine volume was lower than that of TUPKP group, and the difference was statistically significant (P<0.05). There was no statistically significant difference in the International Prostate Symptom Score (IPSS) and Quality of Life (QOL) scores between the two groups (P>0.05). The International Index of Erectile Function-5 (IIEF-5) score was lower in the TUPKP group than in the HoLEP group after treatment, and the difference was statistically significant (P<0.05). Serum total prostate-specific antigen (t-PSA) and free prostate-specific antigen (f-PSA) level were elevated in both groups after surgery, and the elevation was more obvious in the TUPKP group, and the difference was not statistically significant (P>0.05). The difference in the incidence of adverse reactions between the two groups was not statistically significant (P>0.05). Conclusion: Both HoLEP and TUPKP can achieve good efficacy and better safety in the treatment of BPH, HoLEP has less surgical bleeding, shorter bladder flushing time, shorter ureter retention time, lower patient stress level, and better postoperative sexual function.

Objective: To investigate the effect of ultrasound-guided rectus abdominis sheath block with different doses of dexmedetomidine combined with ropivacaine in postoperative analgesia after laparoscopic radical gastric cancer surgery. Method: 99 cases of patients who were admitted to the People's Hospital of Macheng City and proposed to undergo laparoscopic radical gastric cancer surgery from March 2022 to March 2024 were selected as the study subjects, and were divided into three groups of small, medium and large dose groups equally by simple randomization method, with 33 cases in each group. In all three groups, ultrasound-guided rectus abdominis sheath block was performed, and 0.2 μg/kg dexmedetomidine combined with ropivacaine was given to the small-dose group, 0.5 μg/kg dexmedetomidine combined with ropivacaine was given to the medium-dose group, and 1.0 μg/kg dexmedetomidine combined with ropivacaine was given to the large-dose group. The sedation, analgesia, hemodynamic indices and adverse effects were compared among the three groups. Result: The Prince-Henry score was lower in the medium-dose group at T1, T2, and T3 than at the same moments in the low-dose and high-dose groups, respectively, whereas the Ramsay score was higher than at the same moments in the low-dose and high-dose groups, with a statistically significant difference (P<0.05). The mean arterial pressure (MAP) as well as heart rate (HR) at the t2 and t3 moments in the medium-dose group were lower than those at the same moments in the low-dose group and the high-dose group, and the difference was statistically significant (P<0.05). The difference in the incidence of adverse reactions among the three groups was not statistically significant (P>0.05). Conclusion: The application of medium-dose (0.5 μg/kg) dexmedetomidine combined with ropivacaine for ultrasound-guided rectus abdominis sheath block in laparoscopic radical surgery for gastric cancer has a good sedative effect, which is conducive to the improvement of hemodynamic indexes of the patients and the reduction of postoperative pain.

Objective: To explore the clinical effect of early and delayed cholecystectomy for acute cholecystitis. Method: Take 80 acute cholecystitis patients undergoing laparoscopic cholecystectomy in our hospital from August 2022 to August 2024 as study object, group patients according to priority anti-inflammatory treatment after admission, 40 patients who did not undergo anti-inflammatory treatment and received surgery within 72h after admission as early group, 40 patients who underwent anti-inflammatory treatment after admission and underwent surgery after inflammation disappeared surgery as delay group, and compare the short-term prognosis of the two groups. Result: Operation time, blood loss and hospitalization in the early group were shorter than those in the delayed group, the differences were statistically significant (P<0.05). Early bowel sound recovery, first exhaust and defecation time were shorter than the delayed group, the differences were statistically significant (P<0.05). The pain scores at 24 h in the early group was lower than the delayed group, the differences were statistically significant (P<0.05). The postoperative complication rate in the early group was shorter than that in the delayed group, the differences were statistically significant (P<0.05). Conclusion: Laparoscopic cholecystectomy is an effective treatment for acute cholecystitis. Compared with delayed surgery after anti-inflammatory treatment, early surgery after admission is more conducive to early rehabilitation.

Objective: To investigate the effect of Weisu Granules based on four joint program in the treatment of gastric mucosal lesions in patients with Helicobacter pylori (HP) infection complicated with atrophic gastritis. Method: A total of 90 patients with HP infection complicated with atrophic gastritis admitted to Wuxue Hospital of Traditional Chinese Medicine from April 2022 to April 2023 were selected as the research objects. They were divided into the Western medicine group, the traditional Chinese medicine group and the integrated traditional Chinese and Western medicine group according to the random number table method, with 30 cases in each group. The Western medicine group was treated with the quadruple therapy, the traditional Chinese medicine group was treated with Weisu Granules, and the integrated traditional Chinese and Western medicine group was treated with the quadruple therapy combined with Weisu Granules. The levels of gastrin (GAS), motilin (MTL), and gastrin-17 (G-17), as well as the TCM syndrome scores were compared among the three groups. Levels of inflammatory factors [C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α)]. Result: After treatment, the GAS and MTL in the integrated traditional Chinese and Western medicine group were lower than those in the Western medicine group and the traditional Chinese medicine group, while the G-17 level was higher than that in the Western medicine group and the traditional Chinese medicine group, and the differences were statistically significant (P<0.05). The TCM syndrome scores (belching, acid reflux, abdominal distension and abdominal pain) in the integrated Chinese and Western medicine group were lower than those in the Western medicine group and the traditional Chinese medicine group, and the difference was statistically significant (P<0.05). The levels of CRP, IL-6 and TNF-α in the integrated traditional Chinese and Western medicine group were lower than those in the Western medicine group and the traditional Chinese medicine group, and the difference was statistically significant (P<0.05). Conclusion: Gaisu Granules have a significant effect in the treatment of patients with HP infection complicated with atrophic gastritis. It can improve the clinical gastric discomfort symptoms of patients, effectively regulate the levels of gastrointestinal hormones, promote the repair of gastric mucosa, and reduce the inflammatory response.

Objective: To explore the clinical diagnostic value of combined detection of serum human epididymal protein 4 (HE4), carbohydrate antigen 199 (CA199), human chorionic gonadotropin β subunit (β-HCG), and thyroid stimulating hormone (TSH) for endometrial cancer (EC). Method: A total of 112 patients with EC admitted to Shaanxi Provincial Transportation Hospital from February 2023 to September 2024 were selected as the research objects and included in the case group. They were finely divided according to different pathological types. During the same period, 60 patients with benign uterine lesions were selected as the control group. The levels of serum HE4, CA199, β-HCG and TSH in each group were detected by electrochemiluminescence immunoassay. The differences in serum marker levels among each group were compared. The receiver operating characteristic (ROC) curve was drawn to analyze the diagnostic efficacy of each marker and the combined detection. Result: The levels of serum HE4 and CA199 in the endometrial cancer group were higher than those in the benign lesion group, and the differences were statistically significant (P<0.05). While there was no statistically significant difference in the levels of β-HCG and TSH between the two groups (P>0.05). Among different pathological classifications, there were certain differences in the levels of each marker (P<0.05). The ROC curve showed that the diagnostic efficacy of HE4 alone was relatively high. The area under the curve (AUC) of the combined detection of the four markers reached 0.912, and the sensitivity and specificity were 86.6% and 88.3%, respectively. Conclusion: The combined detection of serum HE4, CA199, β-HCG and TSH can improve the diagnostic efficacy of endometrial cancer and provide a strong basis for clinical diagnosis and treatment.

Objective: The effects of traditional Chinese medicine enema and external application of mirnitus on patients with acute pancreatitis were compared. Method: 60 patients with acute pancreatitis admitted to the Second People's Hospital Affiliated to Fujian University of Traditional Chinese Medicine from January 2023 to September 2024 were selected as the research objects. They were divided into the control group and the observation group by the random number table method, with 30 cases in each group. Both groups received routine care. The control group was given enema with traditional Chinese medicine, while the observation group was treated with external application of mirnitus. The syndrome of TCM, symptom recovery time and intra-abdominal pressure before and after the intervention in the two groups were compared. Result: Before the intervention, there was no statistically significant difference in the TCM syndrome scores between the two groups (P>0.05). After the intervention, the syndrome TCM of the patients all decreased, and the decrease in the observation group was higher than that in the control group, with statistically significant differences (P<0.05). The pain relief time, the disappearance time of abdominal distension and the cessation time of nausea and vomiting in the observation group were all shorter than those in the control group, and the differences were statistically significant (P<0.05). Before the intervention, there was no statistically significant difference in intra-abdominal pressure between the two groups (P>0.05). After 3 and 7 days of intervention, the intra-abdominal pressure of the patients gradually decreased, and the observation group was lower than the control group, and the difference was statistically significant (P<0.05). Conclusion: Enema with traditional Chinese medicine and external application of mirnitus can shorten the symptom recovery time of patients with acute pancreatitis, improve the TCM syndrome score and reduce intra-abdominal pressure.

Objective: To explore the relationship between the platelet/lymphocyte ratio (PLR), neutrophil/lymphocyte ratio (NLR), monocyte/lymphocyte ratio (MLR) and the severity of the disease in children with mycoplasma pneumoniae pneumonia (MPP). Method: Fifty children with common MPP and fifty children with severe MPP who were treated at Quanzhou Women's and Children's Hospital from January 2023 to June 2024 were selected as the study objects and they were set as the common group and the severe group respectively. The general data, PLR, NLR, MLR, C-reactive protein (CRP), D-dimer (D-D), lactate dehydrogenase (LDH) and other indicators of the two groups were compared. Multivariate logistic regression analysis and receiver operating characteristic (ROC) curve analysis were used to analyze the correlations between PLR, NLR, MLR and the severity of the disease in children with MPP, as well as their predictive value. Result: There was no statistically significant difference in gender, the proportion of fever peak ≥39℃, fever duration, D-D, and LDH levels between the two groups (P>0.05). The age, proportion of fever, blood oxygen saturation and MLR in the severe group were all lower than those in the common group, while the proportions of shortness of breath and multi-lobe invasion, PLR, NLR and CRP were all higher than those in the common group, and the differences were statistically significant (P<0.05). Multivariate logistic regression analysis indicated that PLR, NLR, and MLR were independent influencing factors for the severity of the disease in children with MPP, and the difference was statistically significant (P<0.05). ROC curve analysis showed that the areas under the curves of PLR, NLR, and MLR for predicting the severity of MPP in children were 0.720, 0.869, and 0.713, respectively (P<0.05). Conclusion: PLR, NLR, and MLR are independent influencing factors for the severity of the disease in children with MPP, and they also have high predictive value for the severity of the disease.

Objective: To explore the effect of vitamin D3 combined with low-intensity resistance exercise in the treatment of sarcopenia in the elderly. Method: A total of 94 elderly patients with sarcopenia admitted to the First Affiliated Hospital of Xiamen University from January to September 2023 were selected as the research subjects. According to the random number table method, they were divided into Group A and Group B, with 47 cases in each group. Group A received low-intensity resistance exercise therapy, while Group B received vitamin D3 combined with low-intensity resistance exercise therapy. The therapeutic effects, Appendicular Skeletal Muscle Mass Index (ASMI) of the extremities before and after treatment, muscle strength-related indicators (grip strength, knee extensor muscle strength, 6-meter walking speed), pulmonary function indicators, and the levels of serum inflammatory factors were compared between the two groups. Result: The effective rate of treatment in group B was higher than that in group A, and the difference was statistically significant (P<0.05). Before treatment, the levels of ASMI, grip strength, knee extensor muscle strength and 6-meter walking speed in the two groups were similar, and the difference was not statistically significant (P>0.05). After the treatment, the ASMI level and grip strength level in group B were higher than those in group A, and the difference was statistically significant (P<0.05). After the treatment, the muscle strength of the knee extensor muscles and the 6-meter walking speed level in group B were similar to those in group A, and the difference was not statistically significant (P>0.05). Before treatment, the levels of forced vital capacity (FVC) and forced expiratory volume in the first second (FEV1) in group B were similar to those in group A, and the difference was not statistically significant (P>0.05). After the treatment, the levels of FVC and FEV1 in group B were higher than those in group A, and the difference was statistically significant (P<0.05). Before treatment, the levels of C-reactive protein (CRP) and interleukin-1 β (IL-1β) in group B were similar to those in group A, and the difference was not statistically significant (P>0.05). After the treatment, the levels of CRP and IL-1β in group B were lower than those in group A, and the difference was statistically significant (P<0.05). Conclusion: The implementation of vitamin D3 combined with low-intensity resistance exercise therapy for elderly patients with sarcopenia can enhance the therapeutic effect, improve the muscle strength level and lung function of patients, and reduce the levels of serum inflammatory factors of patients.

Objective: To study the changes and significance of retinol-binding protein (RBP), α 1-microglobulin (α1-MG), and transferrin (TRF) levels in the serum and urine of elderly patients with diabetic nephropathy. Method: 81 elderly patients with diabetic nephropathy admitted to Qianxinan Prefecture Hospital of Traditional Chinese Medicine from July 2021 to December 2022 were selected as the experimental group, and another 65 elderly patients with simple diabetes were selected as the control group. The levels of serum and urine RBP, α1-MG, and transferrin in both groups were detected on the day of visit. The levels of RBP, α1-MG and transferrin in serum and urine of the two groups of patients were compared. Then, the differences of the above indicators among patients with different stages of renal injury in the experimental group were compared, and the correlation between the research indicators and renal function was analyzed. Result: The levels of serum RBP and α1-MG, as well as the levels of urine RBP, α1-MG and TRF in the experimental group were all higher than those in the control group, while the level of serum TRF was lower than that in the control group. The differences were statistically significant (P<0.05). The levels of serum RBP and α1-MG, as well as the levels of urine RBP, α1-MG and TRF in patients with stage Ⅲ and stage Ⅳ renal injury were all higher than those in patients with stage Ⅱ, while the level of serum TRF was lower than that in patients with stage Ⅱ, and the differences were statistically significant (P<0.05). The levels of serum RBP and α1-MG, as well as the levels of urine RBP, α1-MG and TRF, were all positively correlated with the severity of diabetic nephropathy. The level of serum TRF was negatively correlated with the severity of diabetic nephropathy, and the differences were statistically significant (P<0.05). Conclusion: The levels of serum RBP and α1-MG in patients with diabetic nephropathy abnormally increase compared with the levels of urine RBP, α1-MG and TRF, and the level of serum TRF abnormally decreases. Moreover, all the above changes are closely related to the severity of diabetic nephropathy. Monitoring the levels of RBP, α1-MG and TRF in serum and urine is helpful for the early clinical diagnosis of diabetic nephropathy and the monitoring of disease progression.

Objective: To investigate the clinical application effect of remimazolam besylate combined with sufentanil intravenous general anesthesia in hysteroscopic polyp removal surgery. Method: 200 patients who underwent hysteroscopic polyp removal in Zhaoqing Central People's Hospital from March 2021 to August 2024 were selected as the research subjects. They were divided into the control group and the experimental group according to the double-blind method, with 100 cases in each group. The control group received anesthesia induction and surgery with conventional propofol at 2 mk/kg and sufentanil at 5 ug, while the experimental group received anesthesia induction and surgery with remimazolam besylate at 7 mg and sufentanil at 5 ug. The modified sedation score (1 min after administration, 15 min after the start of the operation, and 5 min after disadministration), intraoperative adverse events (including abnormal blood pressure, bradycardia, abnormal breathing, etc.), degree of injection pain [evaluated by visual analogue scale (.VAS)], and time from injection to sleep were recorded and compared between the two groups of patients. The time from the last administration to recovery, the occurrence of postoperative adverse reactions, etc. Result: There was no statistically significant difference in the modified sedation scores between the two groups at 15 minutes after the start of the operation (P>0.05). The modified sedation score of the experimental group 1 minute after administration was lower than that of the control group, and the modified sedation score 5 minutes after drug withdrawal was higher than that of the control group. The difference was statistically significant (P<0.05). There was no statistically significant difference in the abnormal blood pressure rate between the two groups of patients (P>0.05). The rates of bradycardia and abnormal breathing in the experimental group were both lower than those in the control group, and the difference was statistically significant (P<0.05). The VAS score for pain injection, the time from drug injection to sleep, and the time from the last drug administration to awakening in the experimental group were lower than those in the control group, and the differences were statistically significant (P<0.05). There was no statistically significant difference in the occurrence of postoperative adverse reactions between the two groups (P>0.05). Conclusion: Remimazolam besylate combined with sufentanil intravenous general anesthesia has a good clinical effect on hysteroscopic polyp removal surgery. It has the advantages of rapid anesthesia induction and faster postoperative recovery, and can reduce intraoperative bradycardia, abnormal breathing and other conditions in patients, improve tolerance, and has good safety.

Objective: To explore the effects of Yifei Bi'an decoction combined with Montelukast sodium on symptom improvement, serum monocyte chemoattractant protein-1 (MCP-1) level, and nasal physiological function in patients with allergic rhinitis (AR). Method: A total of 150 AR patients admitted Qingyang Hospital of Traditional Chinese Medicine from January 2021 to January 2023 were selected as the study objects and divided into the Western medicine group (n=75, treated with Monteluast sodium) and the combined group (n=75, treated with Yifei Bi 'an decoction combined with Monteluast sodium) according to the random number table method. The clinical data of the two groups were collected and the improvement of symptoms, serum MCP-1 levels, changes in nasal physiological functions and the incidence of adverse reactions before and after treatment were compared between the two groups. Result: Compared with the Western medicine group, the total effective rate of the combined group increased significantly, and the difference was statistically significant (P<0.05). Before treatment, there was no statistically significant difference in the symptom score, MCP-1, nasal resistance (NR), nasal mucociliary transport time (MTT), Mucociliary Clearance Rate (MCR), interleukin-6 (IL-6), and tumor necrosis factor -α (TNF-α) levels between the two groups of AR patients (P>0.05). After treatment, the symptom scores, MCP-1, NR, MTT, MCR, IL-6 and TNF-α of AR patients in both groups decreased, and the difference was statistically significant (P<0.05). Moreover, the reduction of the above indicators in the combined group was more obvious, and the difference was statistically significant (P<0.05). Compared with the Western medicine group, the total incidence of adverse reactions in the combined group was lower, and the difference was statistically significant (P<0.05). Conclusion: Yifei Bi 'an decoction combined with Montelukast sodium has a definite effect in the treatment of AR patients. It can improve the clinical symptoms and nasal physiological functions of patients, and reduce the serum MCP-1 level, with high safety.

Objective: To explore the clinical efficacy of modified cough suppressant in the treatment of chronic cough and its influence on lung function. Method: 80 patients with chronic cough admitted to Xianning Hospital of Traditional Chinese Medicine from December 2022 to November 2024 were selected as the research subjects and divided into the Western medicine group and the traditional Chinese medicine group according to the random number table method, with 40 cases in each group. The Western medicine group was given the conventional Western medicine therapy (Compound choline Tablets), while the traditional Chinese medicine group was treated with modified cough suppressants on the basis of the treatment of the Western medicine group. The TCM symptom scores, Mandarin Chinese version of the Leicester Cough Questionnaire (LCQMC) scores, inflammatory factor indicators [interleukin-4 (IL-4), tumor necrosis factor -α (TNF-α), interferon -γ (IFN-γ)], pulmonary function indicators [forced vital capacity (FVC), peak expiratory flow rate (PEF), forced expiratory in the first second] before and after treatment were compared between the two groups. Changes in the proportion of volume to total expiratory volume (FEV1/FVC) and adverse reactions. Result: The total effective rate of the traditional Chinese medicine group was higher than that of the Western medicine group, and the difference was statistically significant (P<0.05). After treatment, the symptom scores of cough, sputum volume, fatigue, chest tightness and shortness of breath, the levels of IL-4 and TNF-α in both groups decreased, and the traditional Chinese medicine group was lower than the Western medicine group, and the difference was statistically significant (P<0.05). After treatment, the LCQ-MC scores, IFN-γ, FVC, PEF, and FEV1/FVC levels in both groups increased, and the levels in the traditional Chinese medicine group were higher than those in the Western medicine group, with statistically significant differences (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups, and the difference was not statistically significant (P>0.05). Conclusion: The modified Zhike Powder has a definite therapeutic effect on chronic cough. It is conducive to the quick resolution of cough symptoms, reduces the inflammatory response of the body, improves lung function, and the adverse reactions are mild.

Objective: To explore the clinical application effect of berberine combined with vonoprazine fumarate in the treatment of Refractory Gastroesophageal Reflux Disease (rGERD). Method: A total of 120 patients with rGERD who visited Yidu People's Hospital from January 2021 to December 2023 were selected as the research subjects and divided into the control group and the observation group by the random number table method, with 60 cases in each group. The control group received treatment with voronoprazen fumarate, while the observation group was treated with berberine combined with voronoprazen fumarate. The gastric function indicators, laryngopharyngeal reflux symptom scores, inflammatory factor levels, complication rates and disease recurrence rates were compared between the two groups. Result: Before treatment, there was no statistically significant difference in the levels of gastric function indicators, laryngopharyngeal reflux symptom scores and inflammatory factor levels between the two groups (P>0.05). After the treatment, the improvement of gastric function index levels in the observation group was better than that in the control group, and the difference was statistically significant (P<0.05). The reduction amplitude of laryngopharyngeal reflux symptom score and inflammatory factor levels in the observation group was greater than that in the control group, and the difference was statistically significant (P<0.05). The incidence of complications and the recurrence rate of diseases in the observation group were both lower than those in the control group, and the difference was statistically significant (P<0.05). Conclusion: Berberine combined with vonolasone fumarate has shown significant clinical efficacy in the treatment of rGERD. It can more effectively improve the gastric function of patients, alleviate the symptoms of laryngopharyngeal reflux, reduce the levels of inflammatory factors, and reduce complications and disease recurrence. Therefore, this combined treatment plan can be an effective option for the treatment of RRE.

Objective: To investigate the effect of using pressure tourniquets throughout and halfway of total knee arthroplasty. Method: 120 patients with knee osteoarthritis (KOA) in the hospital from March 2022 to March 2024 were selected and randomly divided into two groups using a random number table: Group A and Group B, with 60 patients in each group. In total knee replacement surgery, Group A was given a full tourniquet, while Group B was given a half tourniquet. The intraoperative blood loss, surgical time, postoperative pain [Visual Analog Scale (VAS)], degree of swelling, quadriceps muscle strength [Manual Muscle Strength Test (MMT) score], and knee joint function [Hospital for Special Surgery Knee Score (HSS)] between two groups were compared. Result: The intraoperative blood output of patients in group B was higher than that in group A, and the operation time in group B was longer than that in group A (P<0.05). 1 d and 3 d after operation, VAS scores in group B were lower than those in group A (P<0.05). 1 d and 3 d after operation, the degree of limb swelling in group B was lower than that in group A (P<0.05). 7 d and 14 d after operation, the MMT scores of patients in group B were higher than those in the control group (P<0.05). 7 d and 14 d after operation, the HSS score in group B was higher than that in group A (P<0.05). Conclusion: The use of a half tourniquet in total knee arthroplasty can alleviate early postoperative pain and limb swelling in patients, promote the recovery of quadriceps muscle strength, and improve knee joint function. However, using a half tourniquet during surgery can prolong the patient's surgery time and increase intraoperative bleeding.

Objective: To investigate the application value of laparoscopic gallstones surgery in the patients with gallstones. Method: 90 patients with gallstones surgery from January 2023 to March 2024 were divided into control group (n=45) and observation group (n=45) according to the method of random number table. The control group were treated with small incision surgery, and the observation group were treated with laparoscopic gallstones surgery. Then the operation time, blood loss, hospitalization time, complication rates, cholecystokinin(CCK) and its receptor, inflammatory mediators [cytokines interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), interleukin-8 (IL-8) and other inflammatory mediators prostaglandin E2 (PGE2) and platelet-activating factor (PAF)] before and after the surgery of two groups were compared. Result: The operation time of two groups were compared, and the difference was not statistically significant (P>0.05), and the hospitalization time of observation group was significantly shorter than that of control group, the blood loss was significantly less than that of control group, the total complication rate was significantly lower than that of control group, and the differences were statistically significant (P<0.05). The CCK and its receptor, cytokines and other inflammatory mediators of two groups before the surgery were compared, and the differences were not statistically significant (P>0.05). The CCK and its receptor of observation group 1 d and 3 d after the surgery were significantly higher than those of control group, the cytokines and other inflammatory mediators were significantly lower than those of control group, and the differences were statistically significant (P<0.05). Conclusion: Among patients undergoing gallstone surgery, laparoscopic surgery has better surgical indicators and lower complications. The expression changes of CCK, its receptors and inflammatory mediators during the perioperative period are different from those of small incision surgery. It is more suitable for patients undergoing gallstone surgery.

Objective: To study the therapeutic effect of gonadotropin-releasing hormone agonist (GnRH-a) combined with laparoscopic cyst removal for ovarian endometriosis. Method: 84 patients with ovarian endometriosis cysts admitted to the Obstetrics and Gynecology Department of Chenggu County Hospital from January 2023 to January 2024 were randomly divided into an observation group (n=43) and a control group (n=41). Both groups underwent laparoscopic cystectomy treatment, with the control group receiving a combination of gestrel and the observation group receiving a combination of GnRH-a. The efficacy, sex hormones [estradiol (E2), luteinizing hormone (LH), follicle stimulating hormone (FSH)], immune function indicators [T lymphocyte subsets (CD4+, CD8+, CD4+/CD8+)], adverse reactions, pregnancy and recurrence rates between two groups were compared. Result: The effective rate of the observation group was higher than that of the control group, and the difference was statistically significant (P<0.05). The levels of E2, LH, FSH, CD4+, CD4+/CD8+, incidence of adverse reactions, and recurrence rate in the observation group were lower than those in the control group, while the levels of CD8+ and pregnancy rate were higher than those in the control group, with statistically significant differences (P<0.05). Conclusion: Laparoscopic cystectomy combined with GnRH-a for the treatment of ovarian endometriosis cysts can enhance immune function, inhibit hormone release, and have a low postoperative recurrence rate and few adverse reactions. The medication is safe and reliable, and can also improve pregnancy rates.

Objective: To explore the application value of percutaneous vertebroplasty in the treatment of old unstable osteoporotic spinal fractures. Method: 83 cases of old unstable osteoporotic spinal fractures in the hospital from September 2021 to September 2023 were selected, and divided into PVP group and PKP group according to surgical methods, with 41 and 42 patients in each group, respectively. PKP group underwent percutaneous kyphoplasty, while the PVP group underwent percutaneous kyphoplasty. The spinal condition (Cobb angle and anterior vertebral height), mobility (Oswestry disability index, ODI), the incidence of adverse reactions (respiratory/reproductive system infections, deep vein thrombosis, constipation, adjacent vertebral compression fractures) were compared between the two groups. Result: The anterior vertebral height of both groups of patients significantly increased 3 and 6 months after surgery, but the improvement of various indicators in the PKP group was better than that in the PVP group (P<0.05). The clinical indicators and postoperative recovery of the PVP group were superior to those of the PKP group, with statistically significant difference (P<0.05). 3 and 6 months after surgery, the ODI index scores of both groups of patientsdecreased significantly, and there was no significant difference in the level (P>0.05). The incidence of adverse reactions in the PVP group was slightly lower than that in the PKP group, but there was no statistically significant difference (P>0.05). Conclusion: For patients with old and unstable osteoporotic spinal fractures, percutaneous vertebroplasty can effectively improve spinal condition, increase daily activity level, and have a short recovery period. The treatment cost is also quite affordable. However, compared to kyphoplasty, the risk of pathological fractures after surgery is slightly higher. Therefore, when selecting a surgical plan, individual differences and the actual condition of the patient should be taken into account.

Objective: To investigate the application effect of lauromacrogol sclerosing foam in the patients with intracavitary laser closure surgery for varicosis of great saphenous vein. Method: 110 patients with varicosis of great saphenous vein in Second Hospital of Nanping City from March 2021 to December 2023 were divided into 55 cases in control group and in 55 cases observation group by the random number table. The control group were treated with intracavitary laser closure surgery, the observation group were treated with intracavitary laser closure surgery combined with lauromacrogol sclerosing foam. Then the total effective rates for varicosis of great saphenous vein, complication rates, saphenous nerve injury rates at different time after the surgery, saphenous nerve conduction indexes (conduction velocity, latency and wave amplitude) and life quality [chronic venous insufficiency questionnaire (CIVIQ score)] before and after the surgery of two groups were compared. Result: The total effective rates for varicosis of great saphenous vein of two groups were compared, the difference was statistically significant(P>0.05), the complication rates and saphenous nerve injury rates at different time after the surgery of observation group were significantly lower than those of control group (P<0.05), the saphenous nerve conduction indexes and CIVIQ score of two groups before the surgery were compared, the differences were not statistically significant(P>0.05). The conduction velocity, wave amplitude and CIVIQ score of observation group were significantly higher than those of control group, the latency were significantly lower than those of control group (P<0.05). Conclusion: The application effect of lauromacrogol sclerosing foam in the patients with intracavitary laser closure surgery for varicosis of great saphenous vein is good, and it can effectively control the saphenous nerve injury and is helpful to the improvement of life quality of patients, so its application value is higher.

Objective: To analyze the therapeutic effect of using intraventricular drilling drainage combined with craniotomy hematoma removal surgery in the treatment of patients with hypertensive intracerebral hemorrhage and cerebral herniation. Method: 64 patients with hypertensive intracerebral hemorrhage and cerebral herniation admitted to Qiannan Traditional Chinese Medicine Hospital from June 2021 to August 2023 were selected as the observation subjects for this study. They were randomly divided into two groups using a number table method. The observation group (32 cases) received intraventricular drilling drainage combined with craniotomy hematoma removal surgery, while the control group (32 cases) received conventional decompression treatment. The clinical efficacy of two groups of patients after treatment was compared. The inflammatory response neurotransmitter indicators before and after treatment, i.e. procalcitonin (PCT), C-reactive protein (CRP), and interleukin-6 (IL-6), and the motor function assessment (FMA) score, the National Institutes of Health Stroke Scale (NIHSS) score, and the Barthel Index score for various scales of daily livingability were analyzed. Result: After treatment, it can be seen that the clinical efficacy of the observation group patients was higher than that of the control group patients. There was no statistically significant difference in inflammatory response neurotransmitter indicators, FMA scores, NIHSS scores, and Barthel index scores between two groups of patients before treatment intervention (P>0.05). After treatment, the inflammatory response neurotransmitter indicators, FMA score, NIHSS score, and Barthel index score of the observation group were better than those of the control group, with statistically significant difference (P<0.05). Conclusion: In the treatment of hypertensive intracerebral hemorrhage combined with cerebral herniation, the combination of intraventricular drilling drainage and craniotomy hematoma removal surgery can improve clinical efficacy, improve inflammatory response neurotransmitters. Compared to conventional treatment measures, it is more effective in reducing neurological damage. It can improve FMA score, and it contributes to the improvement of quality of life.

Objective: To investigate the effects of different laparoscopic surgical approaches on perioperative indicators, stress response, and postoperative complications in patients with acute cholecystitis. Method: A total of 315 patients with acute cholecystitis treated with laparoscopic surgery in the Third People's Hospital of Jingzhou City from January 2022 to September 2024 were selected as the study subjects. The patients were divided into a lateral group (n=165) and an anterograde/retrograde group (n=150) according to the laparoscopic surgical approach. The lateral group underwent lateral laparoscopic cholecystectomy, while the anterograde/retrograde group underwent either anterograde or retrograde laparoscopic cholecystectomy. The perioperative indicators (surgical time, drainage tube placement time, length of hospital stay, intraoperative bleeding volume and postoperative drainage volume), stress response [norepinephrine (NE), adrenocorticotropic hormone (ACTH), cortisol (Cor)], and postoperative outcomes were compared between the two groups. Result: The surgical time, length of hospital stay, and drainage tube placement time of the lateral group were shorter than those of the anterograde/retrograde group (P<0.05). Before surgery, there was no statistically significant difference in stress response between the two groups (P>0.05). 24 h and 72 h after surgery, the stress response in the lateral group was lower than that in the anterograde/retrograde group, and the difference was statistically significant (P<0.05). The total incidence rate of the lateral group was significantly lower than the anterograde/retrograde group, and the difference was statistically significant (P<0.05). Conclusion: The use of lateral laparoscopic surgical approach in patients with acute cholecystitis can reduce stress response, decrease bleeding volume, improve postoperative complications, and shorten hospitalization time.

Objective: To investigate the therapeutic effect of tanshinone IIA sodium sulfonate combined with amiodarone hydrochloride on ventricular arrhythmia (VA). Method: 98 VA patients treated in Qianjiang Central Hospital from January 2023 to January 2024 were selected and divided into combination group and routine group, with 49 cases in each group according to random number table method. The conventional group was treated with amiodarone hydrochloride injection, and the combined group was treated with tanshinone ⅡA sodium sulfonate injection. The clinical efficacy and adverse drug reactions were compared between the two groups. HRV [global standard deviation during sinus R-R (SDNN), mean standard deviation during RR (SDANN), root mean square of the difference between adjacent normal RR periods (RMSSD)], B-type natriuretic peptide (BNP), cardiac function indicators [left ventricular ejection fraction (LVEF), heart index (CI)] and 6 min walking distance (6MWD), cardiac function grade, inflammatory markers [tumor necrosis factor-α (TFN-α), interleukin-6 (IL-6), C-reactive protein (CRP)] were compared between the two groups before and after treatment. Result: The clinical effect of the combined group was significantly better than that of the conventional group, and the difference was statistically significant (P<0.05). After treatment, SDNN, SDANN, RMSSD, LVEF, CI and 6MWD were increased in 2 groups, the combined group was higher than the conventional group, and the difference was statistically significant (P<0.05). After treatment, BNP, TFN-α, IL-6 and CRP in 2 groups were decreased, the combined group was lower than the conventional group, and the difference was statistically significant (P<0.05). After treatment, the cardiac function grade of the combined group was significantly better than that of the conventional group, and the proportion of grade Ⅱ in the combined group was higher than that of the conventional group, the proportion of grade Ⅲ was lower than that of the conventional group, and the difference was statistically significant (P<0.05). There was no significant difference in the incidence of adverse drug reactions between the two groups (P>0.05). Conclusion: Tanshinone ⅡA sodium sulfonate injection combined with amiodarone hydrochloride injection can improve heart function and heart rate variability in VA patients, promote myocardial function recovery, and reduce inflammation. The side effects are mild.

Objective: To explore the clinical efficacy of Remote Ischemic Post adaptation (RIPostC) in the treatment of acute posterior circulation cerebral infarction (APCI). Method: 100 APCI patients admitted to Xinhua Hospital of Ili Kazakh Autonomous Prefecture from May 2023 to April 2024 were randomly divided into experimental group (n=50) and control group (n=50). The control group received conventional treatment, while the experimental group received conventional treatment plus RIPostC treatment for 2 weeks. The modified Ranlin Scale (mRS) scores, Barthel Index (BI) scores, Extended National Institutes of Health Stroke Scale (e-NIHSS) scores, and incidence of adverse reactions during treatment in two groups before and after 2, 4, and 12 weeks of treatment were observed. Result: The total effective rate of the experimental group was higher than that of the control group, and the difference was statistically significant (P<0.05). There were statistically significant differences in the time factors, inter group factors, and time and inter group interactions of e-NIHSS, BI, and mRS scores between the two groups (P<0.05). After treatment, the BI scores of the experimental group were higher than those of the control group at all time points, while the e-NIHSS and mRS scores were lower than those of the control group, and the differences were statistically significant (P<0.05). There was no statistically significant difference in the total incidence of adverse reactions between the two groups (P>0.05). Conclusion: RIPostC treatment for APCI patients can significantly improve clinical outcomes, neurological function, and daily living abilities. It has good safety.

Objective: To investigate the clinical efficacy of high-frequency oscillatory sputum drainage machine combined with nebulization inhalation in the treatment of hospital-acquired pneumonia (HAP) in elderly hospitalized patients. Method: 100 elderly HAP patients admitted to Jinnan Branch of Jinjiang Hospital from January 2022 to January 2024 were randomly divided into control group (n=50) and experimental group (n=50). Both groups received nebulization treatment, and in addition, the control group received conventional sputum drainage treatment, while the experimental group received high-frequency oscillatory sputum drainage machine treatment. The oxygenation index (OI), C-reactive protein (CRP), blood routine [white blood cell count (WBC), neutrophil percentage (NEUT%)], lung function indicators [forced vital capacity (FVC), forced expiratory volume (FEV1)], symptom disappearance time, and acute and chronic health score (APACHE Ⅱ score) were compared between the two groups. Result: The cough cessation time, lung rales disappearance time, and fever duration were shorter, and the daily sputum volume was higher in the experimental group than in the control group, with statistically significant differences (P<0.05). After treatment, CRP, WBC, and NEUT% in the experimental group were lower than those in the control group, with statistically significant differences (P<0.05). The FVC, FEV1, and OI in the experimental group were better than those in the control group, with statistically significant differences (P<0.05). The APACHE Ⅱ score in the experimental group was lower than that in the control group, with statistically significant difference (P<0.05). Conclusion: The combination of high-frequency oscillatory sputum drainage machine and nebulization inhalation treatment for elderly HAP can achieve significant efficacy, reduce the incidence of complications, and improve the cure rate.