Objective: To investigate the effect of using pressure tourniquets throughout and halfway of total knee arthroplasty. Method: 120 patients with knee osteoarthritis (KOA) in the hospital from March 2022 to March 2024 were selected and randomly divided into two groups using a random number table: Group A and Group B, with 60 patients in each group. In total knee replacement surgery, Group A was given a full tourniquet, while Group B was given a half tourniquet. The intraoperative blood loss, surgical time, postoperative pain [Visual Analog Scale (VAS)], degree of swelling, quadriceps muscle strength [Manual Muscle Strength Test (MMT) score], and knee joint function [Hospital for Special Surgery Knee Score (HSS)] between two groups were compared. Result: The intraoperative blood output of patients in group B was higher than that in group A, and the operation time in group B was longer than that in group A (P<0.05). 1 d and 3 d after operation, VAS scores in group B were lower than those in group A (P<0.05). 1 d and 3 d after operation, the degree of limb swelling in group B was lower than that in group A (P<0.05). 7 d and 14 d after operation, the MMT scores of patients in group B were higher than those in the control group (P<0.05). 7 d and 14 d after operation, the HSS score in group B was higher than that in group A (P<0.05). Conclusion: The use of a half tourniquet in total knee arthroplasty can alleviate early postoperative pain and limb swelling in patients, promote the recovery of quadriceps muscle strength, and improve knee joint function. However, using a half tourniquet during surgery can prolong the patient's surgery time and increase intraoperative bleeding.

Objective: To investigate the application value of laparoscopic gallstones surgery in the patients with gallstones. Method: 90 patients with gallstones surgery from January 2023 to March 2024 were divided into control group (n=45) and observation group (n=45) according to the method of random number table. The control group were treated with small incision surgery, and the observation group were treated with laparoscopic gallstones surgery. Then the operation time, blood loss, hospitalization time, complication rates, cholecystokinin(CCK) and its receptor, inflammatory mediators [cytokines interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), interleukin-8 (IL-8) and other inflammatory mediators prostaglandin E2 (PGE2) and platelet-activating factor (PAF)] before and after the surgery of two groups were compared. Result: The operation time of two groups were compared, and the difference was not statistically significant (P>0.05), and the hospitalization time of observation group was significantly shorter than that of control group, the blood loss was significantly less than that of control group, the total complication rate was significantly lower than that of control group, and the differences were statistically significant (P<0.05). The CCK and its receptor, cytokines and other inflammatory mediators of two groups before the surgery were compared, and the differences were not statistically significant (P>0.05). The CCK and its receptor of observation group 1 d and 3 d after the surgery were significantly higher than those of control group, the cytokines and other inflammatory mediators were significantly lower than those of control group, and the differences were statistically significant (P<0.05). Conclusion: Among patients undergoing gallstone surgery, laparoscopic surgery has better surgical indicators and lower complications. The expression changes of CCK, its receptors and inflammatory mediators during the perioperative period are different from those of small incision surgery. It is more suitable for patients undergoing gallstone surgery.

Objective: To study the therapeutic effect of gonadotropin-releasing hormone agonist (GnRH-a) combined with laparoscopic cyst removal for ovarian endometriosis. Method: 84 patients with ovarian endometriosis cysts admitted to the Obstetrics and Gynecology Department of Chenggu County Hospital from January 2023 to January 2024 were randomly divided into an observation group (n=43) and a control group (n=41). Both groups underwent laparoscopic cystectomy treatment, with the control group receiving a combination of gestrel and the observation group receiving a combination of GnRH-a. The efficacy, sex hormones [estradiol (E2), luteinizing hormone (LH), follicle stimulating hormone (FSH)], immune function indicators [T lymphocyte subsets (CD4+, CD8+, CD4+/CD8+)], adverse reactions, pregnancy and recurrence rates between two groups were compared. Result: The effective rate of the observation group was higher than that of the control group, and the difference was statistically significant (P<0.05). The levels of E2, LH, FSH, CD4+, CD4+/CD8+, incidence of adverse reactions, and recurrence rate in the observation group were lower than those in the control group, while the levels of CD8+ and pregnancy rate were higher than those in the control group, with statistically significant differences (P<0.05). Conclusion: Laparoscopic cystectomy combined with GnRH-a for the treatment of ovarian endometriosis cysts can enhance immune function, inhibit hormone release, and have a low postoperative recurrence rate and few adverse reactions. The medication is safe and reliable, and can also improve pregnancy rates.

Objective: To explore the application value of percutaneous vertebroplasty in the treatment of old unstable osteoporotic spinal fractures. Method: 83 cases of old unstable osteoporotic spinal fractures in the hospital from September 2021 to September 2023 were selected, and divided into PVP group and PKP group according to surgical methods, with 41 and 42 patients in each group, respectively. PKP group underwent percutaneous kyphoplasty, while the PVP group underwent percutaneous kyphoplasty. The spinal condition (Cobb angle and anterior vertebral height), mobility (Oswestry disability index, ODI), the incidence of adverse reactions (respiratory/reproductive system infections, deep vein thrombosis, constipation, adjacent vertebral compression fractures) were compared between the two groups. Result: The anterior vertebral height of both groups of patients significantly increased 3 and 6 months after surgery, but the improvement of various indicators in the PKP group was better than that in the PVP group (P<0.05). The clinical indicators and postoperative recovery of the PVP group were superior to those of the PKP group, with statistically significant difference (P<0.05). 3 and 6 months after surgery, the ODI index scores of both groups of patientsdecreased significantly, and there was no significant difference in the level (P>0.05). The incidence of adverse reactions in the PVP group was slightly lower than that in the PKP group, but there was no statistically significant difference (P>0.05). Conclusion: For patients with old and unstable osteoporotic spinal fractures, percutaneous vertebroplasty can effectively improve spinal condition, increase daily activity level, and have a short recovery period. The treatment cost is also quite affordable. However, compared to kyphoplasty, the risk of pathological fractures after surgery is slightly higher. Therefore, when selecting a surgical plan, individual differences and the actual condition of the patient should be taken into account.

Objective: To investigate the application effect of lauromacrogol sclerosing foam in the patients with intracavitary laser closure surgery for varicosis of great saphenous vein. Method: 110 patients with varicosis of great saphenous vein in Second Hospital of Nanping City from March 2021 to December 2023 were divided into 55 cases in control group and in 55 cases observation group by the random number table. The control group were treated with intracavitary laser closure surgery, the observation group were treated with intracavitary laser closure surgery combined with lauromacrogol sclerosing foam. Then the total effective rates for varicosis of great saphenous vein, complication rates, saphenous nerve injury rates at different time after the surgery, saphenous nerve conduction indexes (conduction velocity, latency and wave amplitude) and life quality [chronic venous insufficiency questionnaire (CIVIQ score)] before and after the surgery of two groups were compared. Result: The total effective rates for varicosis of great saphenous vein of two groups were compared, the difference was statistically significant(P>0.05), the complication rates and saphenous nerve injury rates at different time after the surgery of observation group were significantly lower than those of control group (P<0.05), the saphenous nerve conduction indexes and CIVIQ score of two groups before the surgery were compared, the differences were not statistically significant(P>0.05). The conduction velocity, wave amplitude and CIVIQ score of observation group were significantly higher than those of control group, the latency were significantly lower than those of control group (P<0.05). Conclusion: The application effect of lauromacrogol sclerosing foam in the patients with intracavitary laser closure surgery for varicosis of great saphenous vein is good, and it can effectively control the saphenous nerve injury and is helpful to the improvement of life quality of patients, so its application value is higher.

Objective: To analyze the therapeutic effect of using intraventricular drilling drainage combined with craniotomy hematoma removal surgery in the treatment of patients with hypertensive intracerebral hemorrhage and cerebral herniation. Method: 64 patients with hypertensive intracerebral hemorrhage and cerebral herniation admitted to Qiannan Traditional Chinese Medicine Hospital from June 2021 to August 2023 were selected as the observation subjects for this study. They were randomly divided into two groups using a number table method. The observation group (32 cases) received intraventricular drilling drainage combined with craniotomy hematoma removal surgery, while the control group (32 cases) received conventional decompression treatment. The clinical efficacy of two groups of patients after treatment was compared. The inflammatory response neurotransmitter indicators before and after treatment, i.e. procalcitonin (PCT), C-reactive protein (CRP), and interleukin-6 (IL-6), and the motor function assessment (FMA) score, the National Institutes of Health Stroke Scale (NIHSS) score, and the Barthel Index score for various scales of daily livingability were analyzed. Result: After treatment, it can be seen that the clinical efficacy of the observation group patients was higher than that of the control group patients. There was no statistically significant difference in inflammatory response neurotransmitter indicators, FMA scores, NIHSS scores, and Barthel index scores between two groups of patients before treatment intervention (P>0.05). After treatment, the inflammatory response neurotransmitter indicators, FMA score, NIHSS score, and Barthel index score of the observation group were better than those of the control group, with statistically significant difference (P<0.05). Conclusion: In the treatment of hypertensive intracerebral hemorrhage combined with cerebral herniation, the combination of intraventricular drilling drainage and craniotomy hematoma removal surgery can improve clinical efficacy, improve inflammatory response neurotransmitters. Compared to conventional treatment measures, it is more effective in reducing neurological damage. It can improve FMA score, and it contributes to the improvement of quality of life.

Objective: To investigate the effects of different laparoscopic surgical approaches on perioperative indicators, stress response, and postoperative complications in patients with acute cholecystitis. Method: A total of 315 patients with acute cholecystitis treated with laparoscopic surgery in the Third People's Hospital of Jingzhou City from January 2022 to September 2024 were selected as the study subjects. The patients were divided into a lateral group (n=165) and an anterograde/retrograde group (n=150) according to the laparoscopic surgical approach. The lateral group underwent lateral laparoscopic cholecystectomy, while the anterograde/retrograde group underwent either anterograde or retrograde laparoscopic cholecystectomy. The perioperative indicators (surgical time, drainage tube placement time, length of hospital stay, intraoperative bleeding volume and postoperative drainage volume), stress response [norepinephrine (NE), adrenocorticotropic hormone (ACTH), cortisol (Cor)], and postoperative outcomes were compared between the two groups. Result: The surgical time, length of hospital stay, and drainage tube placement time of the lateral group were shorter than those of the anterograde/retrograde group (P<0.05). Before surgery, there was no statistically significant difference in stress response between the two groups (P>0.05). 24 h and 72 h after surgery, the stress response in the lateral group was lower than that in the anterograde/retrograde group, and the difference was statistically significant (P<0.05). The total incidence rate of the lateral group was significantly lower than the anterograde/retrograde group, and the difference was statistically significant (P<0.05). Conclusion: The use of lateral laparoscopic surgical approach in patients with acute cholecystitis can reduce stress response, decrease bleeding volume, improve postoperative complications, and shorten hospitalization time.

Objective: To investigate the therapeutic effect of tanshinone IIA sodium sulfonate combined with amiodarone hydrochloride on ventricular arrhythmia (VA). Method: 98 VA patients treated in Qianjiang Central Hospital from January 2023 to January 2024 were selected and divided into combination group and routine group, with 49 cases in each group according to random number table method. The conventional group was treated with amiodarone hydrochloride injection, and the combined group was treated with tanshinone ⅡA sodium sulfonate injection. The clinical efficacy and adverse drug reactions were compared between the two groups. HRV [global standard deviation during sinus R-R (SDNN), mean standard deviation during RR (SDANN), root mean square of the difference between adjacent normal RR periods (RMSSD)], B-type natriuretic peptide (BNP), cardiac function indicators [left ventricular ejection fraction (LVEF), heart index (CI)] and 6 min walking distance (6MWD), cardiac function grade, inflammatory markers [tumor necrosis factor-α (TFN-α), interleukin-6 (IL-6), C-reactive protein (CRP)] were compared between the two groups before and after treatment. Result: The clinical effect of the combined group was significantly better than that of the conventional group, and the difference was statistically significant (P<0.05). After treatment, SDNN, SDANN, RMSSD, LVEF, CI and 6MWD were increased in 2 groups, the combined group was higher than the conventional group, and the difference was statistically significant (P<0.05). After treatment, BNP, TFN-α, IL-6 and CRP in 2 groups were decreased, the combined group was lower than the conventional group, and the difference was statistically significant (P<0.05). After treatment, the cardiac function grade of the combined group was significantly better than that of the conventional group, and the proportion of grade Ⅱ in the combined group was higher than that of the conventional group, the proportion of grade Ⅲ was lower than that of the conventional group, and the difference was statistically significant (P<0.05). There was no significant difference in the incidence of adverse drug reactions between the two groups (P>0.05). Conclusion: Tanshinone ⅡA sodium sulfonate injection combined with amiodarone hydrochloride injection can improve heart function and heart rate variability in VA patients, promote myocardial function recovery, and reduce inflammation. The side effects are mild.

Objective: To explore the clinical efficacy of Remote Ischemic Post adaptation (RIPostC) in the treatment of acute posterior circulation cerebral infarction (APCI). Method: 100 APCI patients admitted to Xinhua Hospital of Ili Kazakh Autonomous Prefecture from May 2023 to April 2024 were randomly divided into experimental group (n=50) and control group (n=50). The control group received conventional treatment, while the experimental group received conventional treatment plus RIPostC treatment for 2 weeks. The modified Ranlin Scale (mRS) scores, Barthel Index (BI) scores, Extended National Institutes of Health Stroke Scale (e-NIHSS) scores, and incidence of adverse reactions during treatment in two groups before and after 2, 4, and 12 weeks of treatment were observed. Result: The total effective rate of the experimental group was higher than that of the control group, and the difference was statistically significant (P<0.05). There were statistically significant differences in the time factors, inter group factors, and time and inter group interactions of e-NIHSS, BI, and mRS scores between the two groups (P<0.05). After treatment, the BI scores of the experimental group were higher than those of the control group at all time points, while the e-NIHSS and mRS scores were lower than those of the control group, and the differences were statistically significant (P<0.05). There was no statistically significant difference in the total incidence of adverse reactions between the two groups (P>0.05). Conclusion: RIPostC treatment for APCI patients can significantly improve clinical outcomes, neurological function, and daily living abilities. It has good safety.

Objective: To investigate the clinical efficacy of high-frequency oscillatory sputum drainage machine combined with nebulization inhalation in the treatment of hospital-acquired pneumonia (HAP) in elderly hospitalized patients. Method: 100 elderly HAP patients admitted to Jinnan Branch of Jinjiang Hospital from January 2022 to January 2024 were randomly divided into control group (n=50) and experimental group (n=50). Both groups received nebulization treatment, and in addition, the control group received conventional sputum drainage treatment, while the experimental group received high-frequency oscillatory sputum drainage machine treatment. The oxygenation index (OI), C-reactive protein (CRP), blood routine [white blood cell count (WBC), neutrophil percentage (NEUT%)], lung function indicators [forced vital capacity (FVC), forced expiratory volume (FEV1)], symptom disappearance time, and acute and chronic health score (APACHE Ⅱ score) were compared between the two groups. Result: The cough cessation time, lung rales disappearance time, and fever duration were shorter, and the daily sputum volume was higher in the experimental group than in the control group, with statistically significant differences (P<0.05). After treatment, CRP, WBC, and NEUT% in the experimental group were lower than those in the control group, with statistically significant differences (P<0.05). The FVC, FEV1, and OI in the experimental group were better than those in the control group, with statistically significant differences (P<0.05). The APACHE Ⅱ score in the experimental group was lower than that in the control group, with statistically significant difference (P<0.05). Conclusion: The combination of high-frequency oscillatory sputum drainage machine and nebulization inhalation treatment for elderly HAP can achieve significant efficacy, reduce the incidence of complications, and improve the cure rate.

Objective: To investigate the expression of peripheral blood microRNA-221 (miR-221) and microRNA-222 (miR-222) in American College of Radiology thyroid reporting and data system (ACR Ti-RADS) 3 to 5 grade thyroid nodules, and analyze their value in evaluating benign and malignant thyroid nodules. Method: 91 patients with thyroid nodules who underwent B-ultrasound examination and had ACR Ti RADS levels of 3 to 5 in the Fifth Affiliated Hospital (Zhuhai) of Zunyi Medical University were selected as the study objects, and divided into benign group (n=53) and malignant group (n=38) based on pathological examination results. The differential expression of miR-221 and miR-222 in peripheral blood were compared between two groups. The correlation between the expression of miR-221 and miR-222 in peripheral blood and ultrasound grading was analyzed using partial correlation. Receiver operating characteristic (ROC) curve was established to analyze the efficacy of miR-221 and miR-222 in the diagnosis of thyroid cancer. Result: There were significant differences in age, ACR Ti-RADS grade and lymph node metastasis between the two groups (P<0.05). The positive expression rates of miR-221 and miR-222 in the malignant group were higher than those in the benign group, and the difference was statistically significant (P<0.05). Partial correlation analysis showed that the expression of miR-221 and miR-222 in peripheral blood was positively correlated with the grading of ACR Ti-RADS, and the difference was statistically significant (r=0.344, 0.453, P<0.05). ROC analysis showed that the AUC of peripheral blood miR-221 and miR-222 expression for benign and malignant thyroid nodules were 0.605 and 0.784, respectively. Delong method compared the AUC differences and found that the AUC of miR-222 expression curve was significantly higher than that of miR-221 expression curve, with statistical significance (Z=3.381, P=0.001). When cut-off value was taken, the sensitivity and specificity of miR-222 expression were 0.605 and 0.962, respectively. Conclusion: Peripheral blood miR-221 and miR-222 are positively correlated with ACR Ti-RADS grading of thyroid nodules. miR-222 has good predictive value for benign and malignant diagnosis of thyroid nodules, and may be a new biomarker for the diagnosis of thyroid cancer.

Objective: To analyze the induction factors of failure of arteriovenous fistula (AVF) in patients with chronic renal failure treated by hemodialysis. Method: 62 patients with chronic kidney disease (CKD) admitted to Nanping First Hospital Affiliated to Fujian Medical University from June 2020 to May 2024 were selected for retrospective analysis, and their clinical data were collected. 16 patients with failure of AVF and 46 patients whose AVF was not dysfunctional with possible influencing factors were included. Logistic regression analysis was used to screen the factors related to failure of AVF for hemodialysis patients. Result: The blood phosphorus, calcium phosphorus product, platelet (PLT), C-reactive protein (CRP), albumin (ALB) levels and primary disease diabetes, hypotension and thrombosis in the disabled group were higher than those in the non-disabled group, and the proportion of patients with long hemostatic compression time after dialysis was higher than that in the non-disabled group. Logistic regression analysis showed that patients with diabetes, prolonged compression after dialysis, hypotension, thrombosis, and ALB High blood level, high blood phosphorus level, high product of calcium and phosphorus, high CRP level and high PLT level were all risk factors for AVF loss in hemodialysis patients (Or=4.494, 1.723, 1.682, 1.624, 1.079, 3.239, 1.789, 3.097, 3.095, P<0.05). Conclusion: Diabetes mellitus, low blood pressure, thrombosis, high ALB level, high blood phosphorus level, high calcium-phosphorus product, high CRP level and high PLT level are risk factors for failure of arteriovenous fistula, which can be reduced by the implementation of early effective intervention.

Objective: To investigate the effects of Tanggui Xugu Tang combined with manual reduction and splint external fixation on serum pain mediators and fracture healing in patients with distal radius fracture. Method: A total of 80 patients with distal radius fracture who received treatment in Longyan Hospital of Traditional Chinese Medicine from January 2021 to June 2023 were selected as the study objects and divided into two groups according to random number table method, with 40 cases in each group. The control group was treated with manual reduction and splint, while the observation group was treated with Danggui Xugu Tang for 8 weeks. The clinical efficacy, fracture healing, serum pain mediators, bone metabolism indexes, wrist joint function and joint motion were compared between the two groups. Result: The total effective rate of the observation group was higher than that of the control group, and the time of pain, swelling relief and fracture healing was shorter than that of the control group, and the difference was statistically significant (P<0.05). The level of pain mediators in the observation group was lower than that in the control group after treatment, and the difference was statistically significant (P<0.05). After treatment, the levels of carboxyl-terminal peptide β (β-CTX) and amino terminal peptide of total type I procollagen (PⅠNP) in observation group were lower than those in control group, the score of Gartland-Werley wrist joint scoring system was lower than that in control group, and the joint motion was higher than that in control group, with statistical significance (P<0.05). Conclusion: The combination of Danggui Xugu Tang on the basis of manual reduction and splint external fixation can shorten the fracture healing time of patients with distal radius fracture, relieve postoperative pain and promote the recovery of joint function.

Objective: To analyze and explore the efficacy and safety of simvastatin in patients with myocardial infarction undergoing percutaneous coronary intervention (PCI). Method: 122 patients with myocardial infarction admitted to Hebei Chest Hospital from September 2022 to February 2024 were selected as the study objects. According to the random envelope drawing method, 122 patients were divided into simvastatin group and atorvastatin group, with 61 cases in each group. Atorvastatin group was given atorvastatin treatment, simvastatin group was given simvastatin treatment, both groups were observed for 14 days, and clinical efficacy and follow-up safety were recorded. Result: After 14 days of treatment, the total effective rate of simvastatin group was higher than that of atorvastatin group, and the difference was statistically significant (P<0.05). The expression levels of serum C-reactive protein (CRP) and interleukin-6 (IL-6) in both groups after 14 days of treatment were lower than those before treatment,and they were lower in Simvastation group simvastatin group were lower than those in atorvastatin group, with statistical significance (P<0.05). The left ventricular end-systolic diameter and left ventricular end-diastolic diameter of the two groups after 14 days of treatment were lower than those before treatment, and they were lower in Simvastation group, with statistical significance (P<0.05). After 6 months of follow-up, the incidence of major adverse cardiovascular events such as reinfarction, angina pectoris, heart failure and cardiac death in simvastatin group was lower than that in atorvastatin group, with statistical significance (P<0.05). Conclusion: Simvastatin used in patients with myocardial infarction can improve the therapeutic effect, inhibit the expression of inflammatory factors, and improve the left ventricular end-systolic diameter and left ventricular end-diastolic diameter of patients, thereby reducing the incidence of major cardiovascular adverse events during follow-up.

Objective: To explore analysis of depression levels in stroke patients and their correlation with the occurrence cognitive dysfunction. Method: 225 stroke patients admitted to Shougang Hospital of Peking University from August 2023 to August 2024 were selected as the research subjects.The depression level of patients was evaluated using the Health Questionnaire -9 Items (PHQ-9) scale. According to the scoring results, they were divided into four grades: severe depression, moderate depression, mild depression, and no depression. Cognitive function was evaluated using the Montreal Cognitive Assessment Scale (MoCA). Pearson correlation analysis was used to explore the correlation between depression levels and cognitive dysfunction. Result: The MoCA scores of stroke patients with severe depression, moderate depression and mild depression were lower than those of patients without depression, and the difference was statistically significant (P<0.001). The incidence of cognitive dysfunction in patients with severe depression, moderate depression and mild depression after stroke was higher than that in patients without depression, and the difference was statistically significant (P<0.001). Pearson correlation analysis showed that the depression level of patients after stroke was negatively correlated with the cognitive function score (r=-0.625, P<0.001). Conclusion: The depression level of patients after stroke is relatively high, and the depression level is significantly negatively correlated with the cognitive function score. That is, the more severe the depressive symptoms are, the more obvious the cognitive function impairment of the patients is.

Objective: To explore the combined predictive value of serum pepsinogenⅠ(PGⅠ), serum pepsinogenⅡ(PGⅡ), gastrin-17 (G-17) expression and changes in gastric tissue C-X-C motif chemokine ligand 5 (CXCL5) for gastric precancerous lesions. Method: The clinical data of 300 patients undergoing gastroscopy for gastric diseases admitted to Yangjiang People's Hospital from August 2023 to November 2024 were retrospectively analyzed. According to the results of gastroscopy and pathological examination, they were divided into gastric cancer group (n=120) and gastric precancerous lesion group (n=180), and 100 healthy subjects in the same period were selected as control group (n=100). The levels of serum PGⅠ, PGⅡ, G-17 and gastric CXCL5 were compared among the three groups, and the correlation between PGⅠ, PGⅡ, G-17 and gastric CXCL5 and gastric precancerous lesions was investigated by Pearson and Spearman correlation analysis. Logistic regression was used to analyze the influencing factors of gastric cancer prelesions. The predictive value of serum PGⅠ, PGⅡ, G-17 levels and gastric CXCL5 combined with receiver operating characteristic curve (ROC) was used to detect the precancerous lesions of gastric cancer. Result: The ratio of PGⅠand PGⅡ/PGⅡin control group was higher than that in precancerous gastric cancer group and gastric cancer group, and the level of PGⅡand G-17 and the positive expression rate of CXCL5 in gastric tissue in gastric cancer group were higher than those in precancerous gastric cancer group and control group, with statistical significance (P<0.05). PG-Ⅰwas negatively correlated with precancerous lesions, while PG-Ⅱ, G-17 and CXCL5 were positively correlated with precancerous lesions. PGⅠ, PGⅡ, G-17 and CXCL5 were independent factors of gastric precancerous lesions. The area under ROC curve (AUC) was 0.996, the sensitivity was 0.967, and the specificity was 0.983. Serum PGⅠ, PGⅡ, G-17 and gastric CXCL5 had high predictive value for the prediction model of gastric precancerous lesions. Conclusion: The combined detection of serum PGⅠ, PGⅡ, G-17 and gastric CXCL5 is helpful for the early diagnosis of gastric precancerous lesions.

Objective: To investigate the incidence and risk factors of vascular reocclusion in patients with acute cerebral infarction (ACI) after intravenous thrombolysis with alteplase. Method: The clinical data of 80 patients with ACI admitted to Xinyi People's Hospital from May 2020 to May 2024 was retrospectively analyzed and studied. According to the situation of vascular re-occlusion after thrombolysis, they were divided into vascular re-occlusion group and non vascular re-occlusion group. All patients' basic data such as age, sex, body mass index, onset to thrombolysis time, hypertension, diabetes, smoking history, alcohol drinking history, National Institutes of Health Stroke Scale (NIHSS) score before thrombolysis, and history of atrial fibrillation were collected. Logistic regression analysis was carried out to analyse the risk factors of vascular re-occlusion after thrombolysis. Result: Vascular re-occlusion occurred in 21 of the 80 ACI patients, with an incidence of 26.25% (21/80). Single result factor showed that age, onset time to thrombolysis, diabetes combined, NIHSS score before thrombolysis were related to vascular re-occlusion after intravenous thrombolysis, and the difference was statistically significant (P<0.05). Gender, body mass index, combined hypertension, smoking history, drinking history, and history of atrial fibrillation were not correlated with vascular re-occlusion after intravenous thrombolysis, and there was no statistical significance (P>0.05). Multivariate result showed that age≥65 years old, time from onset to thrombolysis≥3 h, combined diabetes mellitus, and pre-thrombolysis NIHSS score≥13 were risk factors for vascular re-occlusion after intravenous thrombolytic therapy in ACI patients (OR>1, P<0.05). Conclusion: Vascular re-occlusion in ACI patients after intravenous thrombolysis is influenced by factors such as age and the time from onset to thrombolysis, and requires high attention. Early targeted prevention and treatment should be carried out to ensure the effectiveness of thrombolysis.

Objective: To explore the influence of albumin-bound paclitaxel on the recurrence and metastasis indicators and ultrasound parameters of patients with refractory breast cancer. Method: A total of 80　patients with refractory breast cancer admitted to Chinese People,s Liberation. Joint Logistic Support Force No.910 Hospital from February 2022 to December 2023 were selected and divided into thewere selected, and they were divided into control group (n=40) and observation group (n=40) according to the random number table method. The control group was treated with Pemetrexed, while the observation group were treated with albumin-bound paclitaxel. The disease control rate, incidence of toxic and side effects, recurrence and metastasis indicators before and after treatment [serum vascular endothelial growth factor (VEGF), matrix metalloproteinase-9 (MMP-9), and angiopoietin-like protein-2 (Angptl-2)] and ultrasound parameters [blood flow parameters such as peak systolic velocity (PSV), end-diastolic velocity (EDV), resistance Index (RI), minimum elastic modulus (Emin) and maximum elastic modulus (Emax)] were compared between the two groups. Result: The disease control rate in the observation group was significantly higher than that in the control group, and the incidence of toxic and side effects was lower than that in the control group. The difference was statistically significant (P<0.05). Before treatment, there was no statistically significant difference in the recurrence and metastasis indicators and ultrasound parameters between the two groups (P>0.05). After treatment, the recurrence and metastasis indicators and ultrasound parameters in the observation group were lower than those in the control group, and the recurrence and metastasis indicators and ultrasound parameters in both groups after treatment were lower than those before treatment, with statistically significant differences (P<0.05). Conclusion: Albumin-bound paclitaxel has a good efficacy in patients with refractory breast cancer, high application safety, and can significantly improve the recurrence and metastasis indicators and ultrasound parameters of patients.

Objective: To explore the clinical effect of aerosol inhalation of salbutamol and budesonide micro pump for infantile asthma. Method: A total of 80 children with asthma in infants and young children treated in Longyan People's Hospital from January 2021 to January 2024 were selected as research objects and divided into control group and observation group by random number table method, with 40 cases in each group. The control group was treated with budesonide, and the observation group was treated with salbutamol. The clinical efficacy, resolution time, length of hospital stay, lung function, inflammatory factors and adverse reactions were compared between the two groups. Result: The total effective rate of observation group was higher than that of control group. The time of dyspnea, cough, wheezing and wheezing in the observation group were shorter than those in the control group. After treatment, the peak expiratory flow rate (PEF), forced expiratory volume in the first second (FEV1), forced vital capacity (FVC) and expiratory flow rate when forced to exhale 50% of vital capacity (FVE50%) in the observation group were higher than those in the control group. The levels of interleukin-1β (IL-1β) and interleukin-12 (IL-12) in observation group were lower than those in control group, and the differences were statistically significant (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: In the clinical treatment of infant asthma, salbutamol and budesonide are effective, can improve the symptoms and lung function of children, reduce the level of inflammatory factors in the body, and are relatively safe.

Objective: To explore the correlation between blood glucose, lipid levels, and liver function in patients with liver cirrhosis, aiming to provide new ideas and methods for the diagnosis and treatment of liver cirrhosis. Method: 975 patients with cirrhosis treated in the Second People's Hospital of Baoji City from March 2021 to January 2024 and 500 normal individuals who underwent physical examinations during the same time were selected as the study objects. 469 patients with Child-Pugh grade A and B were included in the good group, 506 patients with Child-Pugh grade C were included in the worsening group. and 500 patients with normal physical examination were included in the control group. The levels of blood glucose, blood lipids and liver function indexes were compared among the three groups. Pearson correlation analysis was used to investigate the correlation between blood glucose, blood lipids and liver function.Multivariate regression was used to analyze the relationship between blood glucose, blood lipid and abnormal liver function. Result: There were statistically significant differences in fasting insulin (FINS), 2-hour postprandial glucose (PPG), post-prandial insulin (PINS), high-density lipoprotein cholesterol (HDL-C) and total cholesterol (TC) levels among three groups (P<0.05). There was no significant difference in fasting blood glucose (FBG), low density lipoprotein cholesterol (LDL-C) and triglyceride (TG) levels among the three groups (P>0.05). There were significant differences in liver function indexes among the three groups (P<0.05). The levels of FINS, PPG, PINS, HDL-C and TC in patients with cirrhosis were closely correlated with liver function indexes glutamic-pyruginous aminotransferase (ALT), albumin (ALB), total bilirubin (TBIL) and prothrombin time (PT). Conclusion: Blood glucose and lipid levels are closely related to liver function in patients with cirrhosis. High levels of FINS, PPG, PINS and TC and low levels of HDL-C may indicate the deterioration of liver function in patients with cirrhosis.

Objective: To explore the value of percutaneous curved vertebroplasty (PCVP) in the treatment of osteoporotic vertebral compression fractures (OVCF). Method: A total of 120 patients with OVCF who admitted to the Department of Spine and Joint Orthopedics of Jiangmen People's Hospital from April 2023 to October 2024 were selected, and they were divided into group A, group B and group C by random number table method, with 40 cases in each group. Group A was treated with traditional unilateral percutaneous vertebroplasty (PVP), group B was treated with traditional bilateral PVP, and group C was treated with PCVP. The operation related indexes, vertebral body shape, lumbar function and complications among three groups were counted and compared. Result: The operation time of group C was shorter than those of group A and group B, the bleeding volume was less than those of group A and group B, the distribution of bone cement was better than those of group A and group B, and the incidence of complications was lower than those of group A and group B, the differences were statistically significant (P<0.05); there was no significant difference in the number of intraoperative fluoroscopy among three groups (P>0.05). At 6 months after operation, the Cobb angle, vertebral compression rate, Oswestry disability index (ODI) scores and visual analogue scale (VAS) scores of three groups were lower than those before operation, and those of group C were lower than those of group A and group B, the differences were statistically significant (P<0.05). Conclusion: PCVP in the treatment of OVCF patients can ensure effective dispersion of bone cement, shorten operation time, reduce bleeding volume, and effectively improve vertebral body shape, regulate lumbar function and reduce the risk of complications.

Objective: To observe the clinical effect of Eucalyptol, Limonene and Pinene Enteric Capsules adjuvant Tiotropium Bromide in the treatment of elderly patients with bronchial asthma. Method: A total of 72 elderly patients with bronchial asthma admitted to Yellow River Sanmenxia Hospital from January 2022 to July 2024 were selected and they were divided into two groups according to the random number table method. The control group (n=36) was treated with Tiotropium Bromide, and the combined group (n=36) was additionally treated with Eucalyptol, Limonene and Pinene Enteric Capsules on the basis of the control group, treatment for 14 d. The lung function, levels of eosinophilic granulocyte (EOS), eosinophilic cationic protein (ECP) in induced sputum and serum inflammatory factors before and after treatment, and the occurrence of adverse reactions during treatment between the two groups. Result: After treatment, forced expiratory volume in one second (FEV1), forced vital capacity (FVC), FEV1/FVC and peak expiratory flow rate (PEF) of the two groups were higher than before treatment, and the indexes in the combined group were higher than those in the control group, the differences were statistically significant (P<0.05). After treatment, the levels of EOS and ECP in induced sputum of the two groups were lower than those before treatment, and the levels in the combined group were lower than those in the control group, the differences were statistically significant (P<0.05). After treatment, the levels of tumor necrosis factor-α (TNF-α), interleukin-8 (IL-8), interleukin-10 (IL-10) and interleukin-18 (IL-18) in the two groups were lower than those before treatment, and the levels in the combined group were lower than those in the control group, the differences were statistically significant (P<0.05). During treatment, the incidence of nausea and vomiting, rash and other adverse reactions in the combined group was 8.33%, which was not statistically significant compared with 16.67% in the control group (χ2=1.143, P=0.285). Conclusion: Eucalyptol, Limonene and Pinene Enteric Capsules adjuvant Tiotropium Bromide is safe and effective in the treatment elderly patients with bronchial asthma, which can improve lung function, reduce sputum EOS, and regulate the level of inflammatory factors.

Objective: To explore the clinical effect of early blood perfusion in the treatment of patients with pulmonary contusion complicated with acute lung injury (ALI). Method: A total of 96 patients with pulmonary contusion complicated with ALI who admitted to Maoming People's Hospital from November 2022 to October 2024 were prospectively selected as the research objects, they were divided into the control group and the treatment group according to the random number table method, with 48 cases in each group. The control group was given conventional treatment, while the treatment group was given 3 d blood perfusion on the basis of conventional treatment. The ventilator use time, ICU hospitalization time, occurrence of acute respiratory distress syndrome (ARDS), inflammatory indexes [interleukin (IL)-1β, IL-6, IL-8,

Objective: To explore the efficacy and safety of Tirofiban combined with coronary intervention in the treatment of acute myocardial infarction. Method: A total of 78 patients with acute myocardial infarction who admitted to the Department of Cardiology of the Second Hospital of Zhangzhou City from January 2022 to January 2024 were selected, and they were divided into the control group (n=39, routine coronary intervention) and the observation group (n=39, Tirofiban combined with coronary intervention) according to the random number table method. The cardiac function indexes [heart rate, left ventricular end-diastolic volume (LVEDV), left ventricular end-systolic volume (LVESV), left ventricular ejection fraction (LVEF)], inflammatory factors [high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α)], blood lipid indexes [triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C)] were compared between two groups before and after treatment. Result: Before treatment, there were no significant differences in the cardiac function indexes, inflammatory factors and blood lipid indexes between two groups (P>0.05); after treatment, the heart rate, LVEDV, LVESV, the levels of hs-CRP, IL-6, TNF-α, TG, TC and LDL-C in the observation group were lower than those in the control group, and the LVEF and level of HDL-C were higher than those in the control group, the differences were statistically significant (P<0.05). The incidence of adverse reactions in the observation group was lower than that in the control group, the difference was statistically significant (P<0.05). Conclusion: Tirofiban combined with coronary intervention in patients with acute myocardial infarction can improve cardiac function, improve blood lipid index, relieve inflammatory factors and reduce adverse reactions.

Objective: To explore the effects of Ribociclib combined with Fulvestrant in the treatment of patients with estrogen receptor/progesterone receptor (ER/PR) positive advanced breast cancer. Method: A total of 80 ER/PR positive advanced breast cancer patients treated in Tianjin Medical University Cancer Institute and Hospital from February 2022 to February 2024 were selected and randomly divided into control group (n=40) and observation group (n=40) using the random number table method. The control group received Fulvestrant monotherapy, while the observation group received a combination of Ribociclib and Fulvestrant. The short-term efficacy, serum tumor markers levels [cancer antigen 153 (CA153) and carcinoembryonic antigen (CEA)], immune function (CD3+, CD4+, CD8+, and CD4+/CD8+), and incidence of adverse reactions during treatment were compared between the two groups. Result: Compared with the control group, the short-term clinical benefit rate of the observation group was higher, the levels of CA153 and CEA were lower, and the immune function level was better, the differences were statistically significant (P<0.05). There was no statistically significant difference in the occurrence of adverse reactions between the two groups (P>0.05). Conclusion: Ribociclib combined with Fulvestrant significantly improves the short-term efficacy in patients with ER/PR positive advanced breast cancer, reduces serum tumor marker levels, and enhances immune function without significantly increasing adverse reactions.

Objective: To observe the clinical effect of the method of soothing liver and detoxification in the treatment of hyperthyroidism due to liver-spleen imbalance. Method: A total of 112 patients with hyperthyroidism due to liver-spleen imbalance who treated in the Dezhou Lingcheng District Traditional Chinese Medicine Hospital from February 2021 to June 2023 were selected, and they were randomly divided into the control group (56 cases) and the study group (56 cases) using the random number table. The control group was given conventional treatment, while the study group was given conventional treatment combined with the method of soothing liver and detoxification, both groups were treated continuously for 3 months. The clinical efficacy, clinical symptom scores and serum indicators before and after treatment, and adverse reactions in two groups were compared. Result: The total effective rate in the study group was significantly higher than that in the control group (91.07% vs 75.00%), the difference was statistically significant (χ2=5.134, P<0.05); after 3 months of treatment, the scores of poor appetite, fatigue, and throat discomfort in two groups were lower than those before treatment, the study group showed lower scores than those in the control group, the differences were statistically significant (P<0.05); after 3 months of treatment, the levels of thyroglobulin antibodies (TGAb), thyroid-stimulating hormone (TSH) and thyroid peroxidase antibodies (TPOAb) in both groups were lower compared with before treatment, while the levels of free triiodothyronine (FT3) and free thyroxine (FT4) were higher compared with before treatment, the study group showed a greater improvement than those in the control group, the differences were statistically significant (P<0.05); the incidence of adverse reactions in the study group was lower than that in the control group (3.57% vs 16.07%), the difference was statistically singnificant (χ2=4.940, P<0.05). Conclusion: The method of soothing liver and detoxification is effective in the treatment of hyperthyroidism due to liver-spleen imbalance, it can alleviate clinical symptoms, regulate serum indicators, and does not increase adverse reactions.

Objective: To explore the therapeutic effect of Hufu Tongbian Guasha in patients with peripheral facial paralysis (PFP) of wind-cold attacking collaterals syndrome. Method: from January 2023 to January 2024, A total of 275 patients with PFP of wind-cold attacking collaterals syndrome who admitted to the First Ward of Acupuncture and Moxibustion Department of Xiamen Traditional Chinese Medicine Hospital were selected, and they were divided into the control group (n=137) and observation group (n=138) according to the random number table method. The control group was given routine treatment, and the observation group was treated with Hufu Tongbian Guasha on the basis of the control group. The clinical efficacy, facial nerve function, traditional Chinese medicine symptom score and quality of life were compared between two groups. Result: The total effective rate of the observation group was 96.38%, which was higher than the 89.78% of the control group, the difference was statistically significant (P<0.05); after treatment, the scores of modified Portmann simple scoring method (RPA), Toronto facial nerve grading system scale (TFGS) and World Health Organization quality of life scale (WHOQOL-100) in the observation group were higher than those in the control group, and the traditional Chinese medicine symptom scores were lower than those in the control group, the differences were statistically significant (P<0.05). Conclusion: Hufu Tongbian Guasha can enhance the therapeutic effect of PFP of wind-cold attacking collaterals syndrome, improve facial nerve function, reduce traditional Chinese medicine syndrome scores, and improve quality of life.

Objective: To investigate the effect of Guizhi Fuling Pills on oxidative stress and inflammatory factors in patients with acute ischemic stroke after intravascular therapy. Method: From June 2021 to June 2024, 136 patients with ischemic stroke undergoing endovascular therapy in Jiangmen Wuyi Hospital of Traditional Chinese Medicine were randomly divided into control group (n=68) and observation group (n=68). The control group was given routine treatment after operation, and the observation group was treated with Guizhi Fuling Pills on this basis. Both groups were treated for 14 d. The oxidative stress indexes [superoxide dismutase (SOD), malondialdehyde (MDA) and nitric oxide (NO)], inflammatory factors [tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and interleukin-10 (IL-10)], neurological function before and after treatment and the adverse reactions during treatment were compared between the two groups. Result: After treatment, SOD and NO levels were increased and MDA levels were decreased in both groups, and SOD and NO levels were higher and MDA levels were lower in observation group than those in the control group, the differences were statistically significant (P<0.05). After treatment, the levels of TNF-α, IL-6 and IL-10 were decreased in both groups, and the levels were lower in the observation group than those in the control group, the differences were statistically significant (P<0.05). NIHSS scores of the two groups 7 d and 14 d of treatment were lower than before treatment, NIHSS scores of the two group at 14 d of treatment were lower than those of 7 d of treatment, the differences were statistically significant (P<0.05). At 7 d and 14 d of treatment, there were no significant differences in NIHSS scores between the two groups (P>0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: Guizhi Fuling Pills can alleviate the oxidative stress and inflammatory response after intravascular therapy in patients with acute ischemic stroke, improve the nerve function, and and do not increase the incidence of adverse reactions.

Objective: To analyze the effect of Ropivacaine combined with Dexmedetomidine for transversus abdominis plane block on patients undergoing laparoscopic cholecystectomy. Method: A total of 118 patients who underwent laparoscopic cholecystectomy in Yangjiang People's Hospital from March 2022 to March 2024 were selected, they were divided into control group and study group according to the anesthesia method, with 59 cases in each group. The control group was injected with Dexmedetomidine, and the study group was injected with Ropivacaine combined with Dexmedetomidine. The anesthetic effect, intestinal motor function, hemorheology, oxidative stress, inflammatory factors, autonomic nerve function and postoperative adverse reactions were compared between two groups. Result: The time of spontaneous breathing recovery, complete recovery, extubation, first bowel sound recovery, first exhaust, first defecation and first eating solid food in the study group were shorter than those in the control group, and the differences were statistically significant (P<0.05); the plasma viscosity, whole blood low-cut viscosity, whole blood high-cut viscosity, malondialdehyde (MDA), interleukin-6 (IL-6), high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-α (TNF-α) and low-frequency power (LF) in the study group at 2 h and 24 h after operation in the study group were lower than those in the control group, while total antioxidant capacity (T-AOC), superoxide dismutase (SOD), total power (TP) and high-frequency power (HF) were higher than those in the control group, and the differences were statistically significant (P<0.05); there was no significant difference in the incidence of postoperative adverse reactions between two groups (P>0.05). Conclusion: The use of Ropivacaine combined with Dexmedetomidine for transversus abdominis plane block in laparoscopic cholecystectomy can improve hemorheology and autonomic nerve function in vivo, reduce postoperative stress response, inhibit the expression of inflammatory cytokines, and promote the recovery of intestinal motor function, it has good anesthetic effect and high clinical safety.

Objective: To compare the clinical efficacy of one-time incision and radical surgery and simple incision and drainage surgery in the treatment of perianal abscess. Method: The relevant data of 100 patients with perianal abscess admitted to Anshun People's Hospital from March 2019 to March 2023 were retrospectively analyzed. They were divided into two groups according to different surgical methods. In the radical group, 54 cases were treated with one-time incision and radical surgery. In the drainage group, 46 cases were treated with simple incision and drainage surgery. The treatment effect, anal function, pain and recurrence of perianal abscess were compared between the two groups. Result: The postoperative recovery time of the radical group was shorter than that of the drainage group, and the difference was statistically significant (P<0.05). Postoperative anal morphology scores were increased in both groups, but the radical group was lower than that in the drainage group, the anal incontinence scores were decreased, and the radical group was lower than that in the drainage group, the numerical rating system (NRS) scores of the radical group were lower than those in the drainage group at 2 d, 3 d and 5 d after surgery, and the complication rate of the radical group was lower than that of the drainage group, the differences were statistically significant (P<0.05). There was no significant difference in recurrence rate at 6 months after operation between the two groups (P>0.05). Conclusion: Compared with simple incision and drainage surgery, one-time incision and radical surgery can promote the recovery of patients with perianal abscess, improve anal function, reduce postoperative pain and reduce postoperative complications.

Objective: To investigate the effect of different doses of Dexmedetomidine (DEX) combined with Sufentanil (SUF) and Dezocine (DEZ) for patient-controlled intravenous analgesia (PCIA) on postoperative pain, nausea and vomiting (PONV), and sleep quality in gynecological surgery patients. Method: A total of 99 patients who underwent gynecological surgery in Quanzhou First Hospital Affiliated to Fujian Medical University from June 2021 to May 2024 were selected, and they were divided into group C, group L and group H by random number table method, with 33 cases in each group. Postoperative PCIA was performed for 48 h of continuous analgesia. Group C given 1.5 μg/kg SUF+0.3 mg/kg DEZ, group L was given 1.5 μg/kg DEX+1.5 μg/kg SUF+0.3 mg/kg DEZ, group H was given 3.0 μg/kg DEX+1.5 μg/kg SUF+0.3 mg/kg DEZ. The recovery quality, pain degree at each time point after operation [visual analogue scale (VAS)], sleep quality before and after operation [Athens insomnia scale (AIS)] and the incidence of adverse reactions within 7 d after operation were compared among three groups. Result: The time of spontaneous breathing recovery, awakening and extubation in group C were longer than those in group L and group H, and the times of PCIA pressing and remedial analgesia were more than those in group L and group H, the differences were statistically significant (P<0.05); however, there were no significant differences in the recovery quality between group L and group H (P>0.05). At 6 h, 12 h and 24 h after operation, the VAS scores of three groups were lower than those at 1 h after operation, and the differences were statistically significant (P<0.05); there were no significant differences in VAS scores between the three groups at 1 h and 24 h after operation (P>0.05). the VAS scores of group L and group H at 6 h and 12 h after operation were lower than those of group C, and the differences were statistically significant (P<0.05), there was no significant difference between group L and group H (P>0.05). At 1 d before operation, there was no significant difference in AIS scores among three groups (P>0.05); at 1 d and 7 d after operation, the AIS scores of three groups were higher than those at 1 d before operation, and the AIS scores of group L and group H were lower than those of group C, the differences were statistically significant (P<0.05), there was no significant difference between group L and group H (P>0.05). There was no significant difference in the incidence of adverse reactions within 7 d after operation among three groups (P>0.05). Conclusion: Different doses of DEX combined with SUF and DEZ for PCIA can enhance the sedative and analgesic effects of patients undergoing gynecological surgery, have no effect on PONV, and improve sleep quality; compared with low-dose, high-dose DEX combined with PCIA did not significantly enhance the sedative effect.

Objective: To analyze the clinical effect of Shenqi Guizhi Siwei Decoction combined with western medicine in the treatment of patients with chronic heart failure of Qi deficiency and blood stasis type. Method: A total of 80 patients with chronic heart failure of Qi deficiency and blood stasis type who received by Qinzhou Hospital of Traditional Chinese Medicine from January 2022 to January 2024 were selected as the study objects, they were randomly divided into two groups, 40 cases in each group. The control group was treated with conventional western medicine, and the observation group was treated with Shenqi Guizhi Siwei Decoction combined with western medicine. The therapeutic effects of two groups were analyzed. Result: The total effective rate of the observation group was higher than that of the control group, the difference was statistically significant (P<0.05); after treatment, the scores of shortness of breath and fatigue, cough and asthma, palpitation and chest tightness, lower limb edema, left ventricular end systolic diameter (LVESD), left ventricular end diastolic diameter (LVEDD), blood urea nitrogen (BUN), N-terminal pro-B-type natriuretic peptide (NT-proBNP) and C-reactive protein (CRP) in two groups were lower than those before treatment, the left ventricular injection fraction (LVEF) of two groups were higher than those before treatment, and those in the observation group were better than those in the control group, the differences were statistically significant (P<0.05). Conclusion: Shenqi Guizhi Siwei Decoction combined with western medicine can improve clinical symptoms, restore heart function and reduce inflammation in patients with chronic heart failure of Qi deficiency and blood stasis type.

Objective: To compare and analyze the clinical effects of percutaneous pedicle nail fixation and posterior median intermuscular space approach pedicle fixation in the treatment of thoracolumbar fractures, and to provide a favorable reference for future clinical treatment options. Method: A total of 76 patients with thoracolumbar fractures who admitted to Beijing Royal Hospital of Integrated Traditional Chinese and Western Medicine from March 2021 to January 2024 were selected, and they were divided into percutaneous group 40 cases and posterior median intermuscular approach group 36 cases according to the fixation method. The percutaneous group was treated with percutaneous pedicle nail fixation, and the posterior median intermuscular approach group was treated with posterior median intermuscular space approach pedicle fixation. The clinical effects of two groups were compared. Result: The operation time of the percutaneous group was longer than that of the posterior median intermuscular approach group, the hospitalization time was shorter than that of the posterior median intermuscular approach group, and the intraoperative blood loss was less than that of the posterior median intermuscular approach group, the differences were statistically significant (P<0.05). At 1 month after operation, the scores of visual analogue scale (VAS) and Oswestry dysfunction index (ODI) in two groups were lower than those before operation, and those in the percutaneous group were lower than those in the posterior median intermuscular approach group, the differences were statistically significant (P<0.05). At 1 month after operation, the Cobb angle of two groups were smaller than those before operation, and the differences were statistically significant (P<0.05). The incidence of postoperative complications in the percutaneous group was 2.50%, compared with 5.56% in the posterior median intermuscular approach group, the difference was not statistically significant (P>0.05). Conclusion: The clinical effect of percutaneous pedicle nail fixation in the treatment of thoracolumbar fractures is significant, the intraoperative blood loss is less, the hospitalization time is shortened, and the postoperative recovery is faster. Compared with the posterior median intermuscular space approach pedicle fixation for the treatment of thoracolumbar fractures, the safety of both are better, but the operation time is longer, the pain degree is lighter at 1 month after operation, and the living ability and action ability are stronger.

Objective: To analyse the clinical effectiveness of short-term insulin intensification combined with Liraglutide in the treatment of patients with type 2 diabetes mellitus (T2DM). Method: A total of 80 newly diagnosed T2DM patients admitted to Anshun People's Hospital from January 2022 to June 2024 were selected and divided into groups according to random number table method, with 40 patients in each group. The hypoglycemic regimen of control group was Liraglutide; the observation group was treated with Liraglutide combined with insulin short-term intensive treatment, and the blood glucose control effect and islet function were compared between the two groups. Result: The blood glucose relief rate of the observation group was 97.50%, which was higher than 80.00% of the control group, the time for blood glucose to reach the standard was shorter than that of the control group, and the differences were statistically significant (P<0.05). At 3 months after treatment, the blood glucose levels in the observation group were lower than those in the control group, insulin resistance (HOMA-IR) was lower than that in the control group, and insulin secretion index (HOMA-β) was higher than that in the control group, the differences were statistically significant (P<0.05). There was no statistically significant difference in the recurrence of hypoglycemia and hyperglycemia between the two treatment groups (P>0.05). Conclusion: The use of short-term intensive insulin combined with Liraglutide treatment for T2DM patients can improve the effect of glycaemic control, reduce the magnitude of glycaemic fluctuations and improve the patients' pancreatic islet function.

Objective: To investigate the effect of selective cranioplasty (CP) after ventriculoperitoneal shunt (VPS) in patients with traumatic brain injury complicated with hydrocephalus and its effect on serum levels of myelin basic protein (MBP), calcium binding protein S-100β (S-100β) and neuron-specific enolase (NSE). Method: A total of 98 patients with traumatic brain injury complicated with hydrocephalus who treated in General Hospital of Ningxia Medical University from March 2021 to April 2024 were selected, they were divided into the observation group (elective CP after VPS treatment, 49 cases) and the control group (VPS and CP treatment at the same time, 49 cases) according to the computer grouping method. The postoperative outcomes, serological indicators and complications were compared between two groups. Result: There were no significant differences in the postoperative ICU stay time and hospitalization days between two groups (P>0.05); before operation, there were no significant differences in Fugl-Meyer motor function assessment scale (FMAS) scores and Barthel index rating scale (BI) scores between two groups (P>0.05); at 3 months after operation, the FMAS scores and BI scores of two groups increased, and those in the observation group were higher than those in the control group, the differences were statistically significant (P<0.05). At 7 d after operation, the levels of NSE, S-100β and MBP in two groups decreased, and those in the observation group were lower than those in the control group, the differences were statistically significant (P<0.05). There was no significant difference in the incidence of complications between two groups (P>0.05). Conclusion: The selective CP after VPS in patients with traumatic brain injury complicated with hydrocephalus can promote postoperative outcome, reduce the levels of NSE, S-100β and MBP, and has good safety.

Objective: To explore the effect of flexible ureteroscope holmium laser lithotripsy in renal calculus. Method: A total of 100 patients with renal calculus admitted to the Department of Urology of 922 Hospital of the Joint Service Logistics Support Force of the Chinese People's Liberation Army from November 2022 to July 2024 were selected for the study, they were randomly divided into two groups according to the random sampling method 1∶1, 50 cases in each group. The percutaneous group was treated with percutaneous holmium laser lithotripsy, and the flexible ureteroscopy group was treated with flexible ureteroscope holmium laser lithotripsy. The one-time stone clearance, operation-related indicators, oxidative stress indicators, renal function indicators and complications were compared between two groups. Result: The one-time stone clearance rate of the flexible ureteroscopy group was higher than that of the percutaneous group, the operation time, catheter indwelling time and hospitalization time were shorter than those of the percutaneous group, and the intraoperative blood loss was less than that of the percutaneous group, the differences were statistically significant (P<0.05); the level of superoxide dismutase (SOD) in the flexible ureteroscopy group after operation was higher than that in the percutaneous group, and the levels of norepinephrine (NE), nitric oxide (NO), serum creatinine (Cr), urea nitrogen (BUN), β2-microglobulin (β2-MG) and kidney injury molecule-1 (KIM-1) were lower than those in the percutaneous group, the differences were statistically significant (P<0.05); there was no significant difference in the incidence of complications between two groups (P>0.05). Conclusion: Flexible ureteroscope holmium laser lithotripsy has a good effect in the treatment of renal calculus, which can not only effectively improve the one-time stone clearance rate, but also reduce the oxidative stress function, and has a positive effect on protecting their renal function.

Objective: To investigate the influencing factors of low anterior resection syndrome (LARS) in patients with rectal cancer after laparoscopic radical resection of rectal cancer. Method: The clinical data of 104 patients with rectal cancer who underwent laparoscopic radical resection of rectal cancer in Kunming Traditional Chinese Medicine Hospital from June 2019 to August 2024 were collected, the incidence of LARS at 3 months after operation was counted, and the influencing factors of LARS were analyzed by univariate and multivariate logistic regression. Result: Among 104 patients with rectal cancer who underwent laparoscopic radical resection of rectal cancer were followed up for 3 months, the incidence of LARS was 59.62% (62/104). Univariate analysis showed that the proportion of body mass index ≥24 kg/m2, history of hypertension, preoperative radiotherapy, anastomotic distance <5 cm and postoperative anastomotic leakage in the LARS group were higher than those in the non-LARS group, and the differences were statistically significant (P<0.05); there were no significant differences in gender, age, history of diabetes, tumor location, tumor diameter, histopathology, operation time, length of resected intestine, anastomosis method and first postoperative exhaust time between two groups (P>0.05). Multivariate logistic regression analysis showed that preoperative radiotherapy (OR=5.181, P<0.05), anastomotic distance <5 cm (OR=4.600, P<0.05), and postoperative anastomotic leakage (OR=4.963, P<0.05) were risk factors for LARS after laparoscopic radical resection of rectal cancer in patients with colorectal cancer. Conclusion: The incidence of LARS is relatively high in patients with rectal cancer after laparoscopic radical resection of rectal cancer, among which preoperative radiotherapy, anastomotic distance <5 cm and postoperative anastomotic leakage are the main influencing factors, targeted management strategies should be developed to reduce the risk of LARS.

Objective: To analyze the effect of neuroendoscopic minimally invasive surgery combined with intensified antihypertensive therapy in the treatment of patients with hypertensive cerebral hemorrhage. Method: A total of 86 patients with hypertensive cerebral hemorrhage admitted to the nzeurosurgery Department of Liupanshui Municipal People's Hospital from March 2023 to June 2024 were included, they were treated with neuroendoscopic minimally invasive surgery. They were divided into control group and observation group according to the way of lowering blood pressure. The control group (n=43) received the standard antihypertensive regimen, and the observation group (n=43) received the intensive antihypertensive regimen. The volume of edema and the National Institute of Health stroke scale (NIHSS), middle cerebral arterial hemodynamics, state of consciousness, self-care ability and quality of life before and after treatment were compared between the two groups. Result: At 24 h after treatment, cerebral edema volume, NIHSS score and resistance index decreased in the two groups, and the observation group was lower, the arteriae cerebri media mean blood flow velocity, mean blood flow, Glasgow coma scale (GCS) and Glasgow outcome scale (GOS) at 1 month after treatment and the quality of life score at 3 months after treatment increased, and the observation group was higher, the differences were statistically significant (P<0.05). Conclusion: Neuroendoscopic minimally invasive surgery combined with intensified antihypertensive therapy treatment of hypertensive cerebral hemorrhage can reduce the volume of cerebral edema, improve cerebral hemodynamics and neurological function, and improve the quality of life of patients.

Objective: To explore the application effect of whole-process management based on rapid rehabilitation combined with damage control surgical techniques in the emergency treatment of patients with multiple injuries. Method: From January 2019 to December 2020, 41 patients with multiple injuries who adopted the traditional specialist treatment mode in Honghe Hospital Affiliated to Kunming Medical University were selected as the control group, from January 2021 to December 2022, 41 patients with multiple injuries who adopted the whole-process management based on rapid rehabilitation combined with damage control surgical techniques in our hospital were selected as the observation group. The postoperative treatment, postoperative clinical indicators, stress response and complication rate were compared between two groups. Result: The operation time, on-site treatment time, rescue reaction time, early warning time, base excess (BE) recovery time, coagulation index recovery time, lactic acid recovery time, body temperature recovery time, ICU stay time and hospitalization time of the observation group were shorter than those of the control group, the amount of bleeding was less than that of the control group, the blood oxygen saturation was higher than that of the control group, and the incidence of complications was lower than that of the control group, the differences were statistically significant (P<0.05); the acute physiology score (APS) and acute physiology and chronic health evaluation Ⅱ (APACHE Ⅱ) score in the observation group at 24 h after operation were lower than those in the control group, and the differences were statistically significant (P<0.05). Conclusion: In the emergency treatment, the whole-process management based on rapid rehabilitation combined with damage control surgical techniques can promote the recovery of clinical indicators, reduce postoperative complications and improve the prognosis.

Objective: To explore the effects of Budesonide and Formoterol Fumarate Combined with Thiotropium Bromide aerosol inhalation in treatment of chronic obstructive pulmonary disease (COPD). Method: A total of 200 patients diagnosed with COPD admitted to Minhou County General Hospital from February 2022 to February 2024 were included. According to random number table method, the patients were divided into two groups, 100 cases in each group. The control group was treated with conventional symptomatic treatment, and combined with Budesonide and Formoterol Fumarate aerosol inhalation, and the observation group was treated with Budesonide and Formoterol Fumarate combined with Thiotropium Bromide aerosol inhalation. Symptom control time, arterial blood gas index, respiratory mechanics index, lung function and serum inflammatory factors were compared between the two groups. Result: The control time of symptoms such as cough, sputum and wheezing in observation group were shorter than those in control group, and the differences were statistically significant (P<0.05). After treatment, the partial pressure of arterial blood oxygen (PaO₂) of the two groups were increased, and the observation group was higher than the control group; the partial pressure of arterial blood carbon dioxide (PaCO₂) of the two groups were decreased, and the observation group was lower than the control group, the differences were statistically significant (P<0.05). After treatment, total airway viscosity resistance at 5 Hz (R5) and central airway viscosity resistance at 20 Hz (R20) were decreased in two groups, and the indexes in observation group were lower than those in control group, the differences were statistically significant (P<0.05). After treatment, forced vital capacity, peak expiratory flow rate and forced expiratory volume in one second of the two groups were increased, and the indexes in observation group were higher than those in control group, the differences were statistically significant (P<0.05). After treatment, tumor necrosis factor-α (TNF-α), interleukin (IL-6)-6 and IL-8 were decreased in two groups, and the indexes in observation group were lower than those in control group, the differences were statistically significant (P<0.05). Conclusion: The treatment of Budesonide and Formoterol Fumarate combined with Tiotropium Bromide aerosol inhalation in the treatment of patients with COPD can control the impact of symptoms in a shorter period of time, improve arterial blood gas and respiratory mechanics indicators, adjust lung function status and serum inflammatory factors, and meet clinical medication expectations.