Objective: To analyze the effect of labetalol-based comprehensive treatment on gestational hypertension (PIH) patients in high-altitude areas. Method: A total of 84 PIH patients admitted to Qinghai Women and Children's Hospital from July 2023 to November 2024 were enrolled in this study and randomly divided into two groups, with 42 cases each. The control group received conventional antihypertensive treatment, while the experimental group was treated with labetalol-based comprehensive treatment. Both groups were treated for 14 days. The hypertension levels, pregnancy outcomes, biochemical test indicators, and clinical efficacy rates of the two groups were analyzed and compared. Result: Before treatment, both groups had high blood pressure levels. At 1 to 3 months post-treatment, blood pressure levels in both groups showed a downward trend, with the experimental group exhibiting lower diastolic/systolic blood pressure parameters compared to the control group, and the difference was statistically significant (P<0.05). The experimental group had fewer cases and a lower proportion of adverse pregnancy outcomes, with a statistically significant difference (P<0.05). No statistically significant difference was observed in blood biochemical indicators between the two groups before treatment (P>0.05). After treatment, the experimental group showed superior blood biochemical test results, with three indicator levels lower than those of the control group, and the difference was statistically significant (P<0.05). In the labetalol-based experimental group, the condition of PIH patients was effectively controlled, and the total efficacy rate was higher than that of the control group, with a statistically significant difference (P<0.05). Conclusion: Labetalol-based comprehensive treatment plays a significant role in controlling PIH symptoms, effectively reducing blood pressure, protecting vital organ functions, and improving maternal pregnancy outcomes.

Objective: To investigate the effect of dopamine combined with phentolamine in the treatment of children with pneumonia complicated with heart failure. Method: A total of 86 children with pneumonia complicated with heart failure admitted to the First Hospital of Hanbin District of Ankang from June 2022 to September 2024 were selected as the study objects. And they were divided into two groups according to the random number table method, with 43 cases in each group. The control group was treated with phentolamine, while the observation group was treated with dopamine. The effective rate, clinical indicators, improvement of myocardial enzymes and adverse reactions were compared between the two groups. Result: The effective rate of the observation group was higher than control group, and the difference was significant (P<0.05). The heart rate recovery time, respiratory recovery time, heart failure correction time, hospitalization time in observation group were shorter than those in control group, and the differences were statistically significant (P<0.05). After treatment, the levels of CK-MB, LDH, CK in the observation group were lower than those in control group, and the differences were statistically significant (P<0.05). Compared with the control group, the incidence of adverse reactions in the observation group was lower, the difference was significant (P<0.05). Conclusion: For children with pneumonia complicated with heart failure, the combination of phentolamine and dopamine can effectively improve the clinical efficacy, shorten the recovery time of the disease, promote the improvement of heart failure symptoms, reduce the level of myocardial enzyme spectrum indicators, and reduce the risk of adverse reactions.

Objective: Based on the cross-lag method, the changing trends and mutual influences of fear of disease progression and sleep quality in postoperative patients with cerebral hemorrhage over time were explored. Method: A total of 360 patients with cerebral hemorrhage who underwent surgical treatment at Zhongshan People's Hospital from January 2023 to January 2024 were selected as the research subjects. The Fear of Progression Questionnaire-Short Form (FoP-Q-SF) and the Pittsburgh Sleep Quality Score Index (PSQI) were used to evaluate and detect the fear of disease progression and sleep quality of patients at 24 hours after anesthesia and awakening (T1), 14 days after surgery (T2), and 1 month after surgery (T3), respectively. The Spearman method was used to analyze the correlation between fear of disease progression and sleep quality at different time points. The Mplus software was applied to construct a cross-lag analysis model to analyze the causal temporal relationship and direction of action between postoperative fear disease progression and sleep quality in patients with cerebral hemorrhage. Result: After excluding those who dropped out halfway and those with invalid data, a total of 338 patients completed the study. The FoP-Q-SF scores of 338 patients with cerebral hemorrhage at T1, T2 and T3 were (33.52±3.67), (28.24±2.96) and (25.37±2.41) respectively, and the PSQI scores were (15.36±2.14), (12.38±1.53) and (9.62±1.47) respectively. The results of the correlation analysis showed that the PSQI measured in the three times was positively correlated with the FoP-Q-SF score (P<0.05). The results of cross-hysteresis analysis showed that the FoP-Q-SF score of T1 in patients with cerebral hemorrhage could positively predict the T2PSQI score, and the T2FoP-Q-SF score could positively predict the T3PSQI score. The path coefficients were 0.242 and 0.359 respectively (P<0.05). The PSQI score of T1 can positively predict the FoP-Q-SF score of T2, and the PSQI score of T2 can positively predict the FOP-Q-SF score of T3. The path coefficients are 0.511 and 0.311 respectively (P<0.05). Conclusion: There is a cross-lagged effect between the fear of disease progression and sleep quality in patients with cerebral hemorrhage, suggesting a causal relationship between the two over multiple time spans. The relationship between the two can be utilized to formulate targeted postoperative care measures for patients, improving the prognosis quality of patients with cerebral hemorrhage.

Objective: To explore the application of magnetic resonance imaging (MRI) in the differential diagnosis of benign and malignant adnexal masses. Method: A total of 110 patients admitted to Longyan People's Hospital due to adnexal masses from January 2021 to December 2024 were selected as the research subjects and underwent MRI examinations. Taking the pathological examination results as the "gold standard", the benign and malignant conditions of adnexal masses detected by the two examination methods were compared. Result: The pathological results showed that among 110 patients, 76 were benign and 34 were diagnosed as malignant. MRI examination showed 75 benign cases and 31 malignant cases. Taking pathological diagnosis as the gold standard, the sensitivity of MRI in differentiating the benign and malignant of adnexal masses was 94.12%, the specificity was 96.05%, the accuracy rate was 95.45%, and the Kappa value was 0.894. The consistency of the two in diagnosing the benign and malignant of adnexal masses was relatively high. MRI has a relatively high detection rate for malignant teratoma, malignant ovarian choroidal stromal tumor, ovarian cyst and benign choroidal stromal tumor, all being 100.00%. The comparison of DWI signal intensity values and ADC values of benign and malignant cystic masses showed no statistically significant difference. (P>0.05). The DWI signal intensity value of malignant solid masses was higher than that of benign masses, while the ADC value was lower than that of benign masses, and the difference was statistically significant (P<0.05). Conclusion: MRI has a relatively high accuracy in differentiating benign and malignant adnexal masses and can provide a reliable basis for clinical intervention.

Objective: To analyze the effects of intrauterine balloon tamponage (IUBT) combined with bilateral uterine artery ligation (BUAL) on blood loss and thromboelastogram (TEG) in patients with postpartum hemorrhage (PPH) after cesarean section. Method: Clinical data of 95 patients with PPH during cesarean section were collected from February 2023 to September 2024. They were divided into control group (48 cases) and observation group (47 cases) according to different treatment plans. The control group was hemostatic with BUAL regimen, and the observation group was hemostatic with combination BUAL regimen. The bleeding and blood transfusion, postoperative recovery indexes and adverse events were compared between the two groups. TEG indexes [reaction time (R time), coagulation time (K time), maximum thrombus elastic force (MA)] of the two groups were compared before and 12 h after surgery. Result: Compared with the control group, the total blood loss and blood transfusion in the observation group were lower, and the time of hemostasis, getting out of bed and staying in hospital were shorter (P<0.05). 12 h after operation, the R time and K time of both groups were shortened and the MA was increased, and the R time of observation group was shorter and the MA was higher than that of control group (P<0.05). The incidence of adverse events in the observation group was lower than that in the control group (P<0.05). Conclusion: IUBT combined with BUAL can improve hemostasis, reduce blood loss, improve coagulation function and promote postoperative recovery in PPH patients after cesarean section.

Objective: To analyze the effect of combined treatment of sodium thiosulfate and hemoperfusion (HP) on skin itching score and calcium and phosphorus metabolism in patients with uremia complicated with refractory skin itching. Method: 86 patients with uremia complicated with refractory skin itching admitted to Fujian Tingzhou Hospital frrom January 2022 to August 2023 were taken as the subjects. All selected cases were assigned to two groups (43 cases each) with random numerical table. The control group received routine hemodialysis treatment, while the observation group received a combination of sodium thiosulfate and HP hemodialysis treatment. The clinical efficacy, renal function indicators (BUN, Scr, Cys-C), calcium and phosphorus metabolism indicators (Ca, P, iPTH), inflammation indicators (CRP, PCT, SAA), 14-item uremic skin itching scale (14-tem UP-Dial Scale), and complications in both groups were compared. Result: The observation group obtained higher effective rate than the control group (P<0.05). The observation group had lower BUN, Scr, Cys-C, Ca, P, iPTH, CRP, PCT, SAA levels and 14-tem UP-Dial Scale score compared with the control group (P<0.05). The comparison of the incidence of complications in both groups expressed no statistical difference (P>0.05). Conclusion: Sodium thiosulfate combined with HP can improve renal function, promote calcium and phosphorus metabolism, reduce inflammation in the blood, alleviate skin itching symptoms and have a low risk of complicationsin patients with uremia complicated by refractory skin itching.

Objective: This study aims to explore the application value of combined detection of lipoprotein a [Lp (a)], high-sensitivity C-reactive protein (hs-CRP), and homocysteine (Hcy) in the diagnosis of acute stroke. Method: 128 patients with acute stroke who were hospitalized in the Department of Neurology of the Eighth People's Hospital of Nanning from January 2022 to December 2024 were selected as the observation group, and another 116 healthy individuals undergoing physical examinations were selected as the control group. The levels of Lp(a), hs-CRP and Hcy in the serum of the two groups were detected. The collected data were statistically analyzed using SPSS 21.0 software, and the diagnostic validity of these biomarkers was evaluated. Result: The research results showed that the levels of Lp (a), hs-CRP and Hcy in the observation group were significantly higher than those in the healthy control group (P<0.05). In addition, the positive rate of the combined detection of these three indicators was significantly higher than that of the single indicator detection (P<0.05). Through analysis, it is indicated that the diagnostic efficacy of combined detection is superior to that of individual detection. The study also found that Lp (a) levels are associated with atherosclerotic status, hs-CRP can effectively reflect acute inflammatory responses, and Hcy is closely related to vascular endothelial dysfunction. Conclusion: To sum up, the combined detection of Lp (a), hs-CRP and Hcy has shown obvious clinical value in the early diagnosis and risk assessment of acute stroke, providing a scientific basis for the development of precision medicine.

Objective: To observe the clinical efficacy of the treatment of liver cancer with Xiaoji Huayu Pills combined with cyberknife and its influence on early recurrence and metastasis. Method: A total of 80 patients with primary liver cancer who had received cyberknife treatment from January 2021 to October 2023 were selected as the research subjects. And they were all admitted to Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine. They were randomly assigned to two group. The treatment group was also given oral Xiaoji Huayu Pills for a course of one year. The clinical effects and toxic side effects of the two groups were compared. Result: After half a year and one year of treatment, The treatment group showed a higher total effective rate for tumor reduction, with the difference being statistically significant (P<0.05). After one year of treatment, the treatment group's recurrence and metastasis rates was lower than the other with the difference being statistically significant (P<0.05). The serum vascular endothelial growth factor (VEGF) and alpha-fetoprotein (AFP) in both groups were down-regulated, and the expression of serum tumor protein 53 (P53) was up-regulated after treatment. Moreover, the treatment group's improvement was significantly greater, and this difference was statistically significant (P<0.05). A more significant improvement in both the traditional Chinese medicine symptom score and the quality of life score demonstrated in the treatment group, and the incidence of adverse reactions decreased by 20%. The difference was statistically significant (P<0.05). Conclusion: The combination of Xiaoji Huayu Pills and cyberknife in the treatment of liver cancer has a good clinical efficacy, effectively reduces the early recurrence and metastasis of tumors, and has good safety. It can be used for clinical promotion.

Objective: To explore the application value of electroacupuncture combined with Chinese herbal fumigation in patients with ankle fractures. Method: A total of 94 patients with ankle fractures admitted to the First Affiliated Hospital of Xiamen University from August 2019 to August 2024 were selected as the research subjects. Using the random numerical table, all selected patients were assigned to two groups (47 cases each). The patients of control group were provided with conventional treatment, while the observation group was treated with electroacupuncture combined with Chinese herbal fumigation on the basis of the control group. The degrees of pain and swelling, fracture healing, ankle joint function, incidence of complications and quality of life were compared between the two groups. Result: Compared with the control group, the observation group had lower degree of pain and swelling, shorter fracture healing time, higher score of ankle joint function, greater ankle joint range of motion, fewer complications, and higher score of quality of life after treatment (P<0.05). Conclusion: Electroacupuncture combined with Chinese herbal fumigation can alleviate postoperative pain and swelling in patients with ankle fractures, accelerate fracture healing, reduce complications, and promote the recovery of ankle joint function and the improvement of quality of life.

Objective: To explore the application value of modified Buzhong Yiqi Decoction combined with acupuncture in postpartum stress urinary incontinence of qi deficiency type. Method: 80 patients with postpartum stress urinary incontinence of qi deficiency type admitted to Xuzhou Central Hospital from April 2023 to April 2024 were taken as the objects. And they were assigned to two groups with random numerical table. The patients of control group were administrated electrical stimulation biofeedback therapy, and on this basis, the patients of observation group additionally took modified Buzhong Yiqi Decoction and acupuncture. The comparisons were made on clinical efficacy, pelvic floor surface electromyography values, TCM syndrome scores and pelvic floor muscle strength in both groups. Result: The observation group obtained higher overall effective rate than the control group (P<0.05). The observation group showed lower average values of the pre-resting stage and the post-resting stage compared to the control group, and the observation group had higher maximum values of the fast muscle (type Ⅱ fiber) stage, the average values of the slow muscle (type Ⅰ fiber) stage, and the average values of the endurance test stage than the control group after treatment (P<0.05). Compared with the control group, the observation group achieved lower scores of urinary incontinence, soreness and weakness of the waist and knees, lower abdominal distension and incomplete drainage after urination, and higher pelvic floor muscle strength (P<0.05). Conclusion: The modified Buzhong Yiqi Decoction combined with acupuncture has a definite effect in the treatment of postpartum stress urinary incontinence of qi deficiency type. It can improve the pelvic floor surface electromyography value and TCM syndrome score of patients, and enhance pelvic floor muscle strength.

Objective: To explore the impact of Cognitive Behavioral Therapy for Insomnia (CBT-I) combined with vagal nerve stimulation on the sleep quality of patients with anxiety-related insomnia during the perioperative period. Method: The study included 92 patients with anxiety-related insomnia treated in the First People's Hospital of Huai'an from June to October 2024. Patients were randomly divided using a drawing method, with odd numbers assigned to the control group (n=46) and even numbers to the observation group (n=46). The control group received standard care, while the observation group underwent CBT-I combined with VNS. The clinical efficacy, psychological state before and after 1 weeks of treatment [Generalized Anxiety Disorder Scale (GAD-7) and Patient Health Questionnaire (PHQ-9)], sleep quality [Pittsburgh Sleep Quality Index (PSQI)], and insomnia severity [Insomnia Severity Index (ISI)] were compared between the two groups. Result: After treatment, the total efficacy rate in the observation group was higher than in the control group. Scores for GAD-7 and PHQ-9 were lower in the observation group. Scores across all dimensions of the PSQI were lower in the observation group. ISI scores were lower in the observation group, with statistically significant difference (P<0.05). Conclusion: CBT-I combined with VNS significantly improves sleep quality and psychological state in patients with anxiety-related insomnia during the perioperative period. The treatment efficacy is higher than that of CBT-I alone, showing significant improvements in anxiety, depression, and the severity of insomnia.

Objective: To compare the effects of transabdominal preperitoneal hernia repair (TAPP) and Lichtenstein tension-free hernia repair on gastrointestinal function in the treatment of incarcerated inguinal hernia in adults. Method: 120 adult patients with incarcerated inguinal hernia from Xiamen Fifth Hospital from September 2019 to September 2023 were selected as the research subjects. They were divided into different surgical groups, namely TAPP group (60 cases) and Lichtenstein group (60 cases). The surgical related indicators and gastrointestinal function recovery indicators pain level, recurrence rate, and incidence of complications at different postoperative time points between two groups were compared. Result: The perioperative improvement in the TAPP group (hospitalization, anal exhaust, defecation, surgical time, and intraoperative bleeding) was significantly better than that in the Lichtenstein group. 2 h and 8 h VAS scores in TAPP group were lower than those in Lichtenstein group, and the differences were statistically significant (P<0.05), but there was no statistically significant difference in recurrence rate and complication rate between the two groups (P>0.05). Conclusion: TAPP has outstanding advantages in the treatment of adult incarcerated inguinal hernia in terms of surgical trauma and recovery, while Lichtenstein tension-free hernia repair has certain advantages in the treatment of hernia contents and spermatic cord, but the clinical selection still needs to consider the specific situation of the patients.

Objective: To investigate the effect of transverse abdominal muscle plane block combined with general anesthesia during radical cervical cancer operation. Method: From June 2019 to December 2024, 82 consecutive patients scheduled for radical hysterectomy in Fuqing Maternal and Child Health Hospital were randomly assigned with random number method to a control group (n=41) receiving balanced intravenous-inhalational general anesthesia alone and a study group (n=41) receiving TAP block in addition to the same general anesthetic regimen. Postoperative analgesia, intraoperative hemodynamics at specified time points, perioperative oxidative stress markers, and adverse events were compared. Result: Numeric Rating Scale (NRS) pain scores at 6, 12, and 24 h postoperatively were significantly lower in the study group than in the control group (P<0.05). Ramsay sedation scores did not differ between groups (P>0.05). Baseline heart rate (HR) and mean arterial pressure (MAP) were comparable (P>0.05). Five minutes after induction, HR and MAP were higher in the study group than in the control group, while at extubation they were lower in the study group (P<0.05). Before operation, the levels of superoxide dismutase (SOD), malondialdehyde (MDA) and total antioxidant capacity (T-AOC) were similar between the two groups, but there was no statistically significant difference (P>0.05). SOD and T-AOC were significantly reduced after operation, but the reduction of the study group was smaller than that of the conventional group. MDA was significantly increased in both groups, but the increase in the study group was smaller than that in the conventional group, and the difference was statistically significant (P<0.05). The incidence of adverse reactions was similar between the study group and the conventional group, and the difference was not statistically significant (P>0.05). Conclusion: The application of transversal muscle plane block combined with general anesthesia during radical cervical cancer operation can effectively reduce postoperative pain and oxidative stress reaction, stabilize intraoperative hemodynamics, and have high safety.

Objective: To explore the application effect of AIDET communication mode in elderly patients undergoing painless gastroscopy. Method: Selecting 120 elderly patients who underwent painless gastrointestinal examinations in Jiangmen People's Hospital from June 2023 to May 2024, and they were divided into two groups, with 60 in each group using a random number table method. The control group received routine nursing care, while the observation group received AIDET communication mode. The emotional state, psychological burden perception, vital sign indicators, and examination cooperation between two groups were compared. Result: After nursing, the observation group had lower levels of Self Rating Anxiety Scale (SAS), Self Rating Depression Scale (SDS), Self Perceived Burden Scale (SPBS), respiratory rate, heart rate, systolic blood pressure, and diastolic blood pressure than the control group. The degree of cooperation was higher than that of the control group, and the difference was statistically significant (P<0.05). Conclusion: The AIDET communication mode can improve the emotional state of elderly patients undergoing painless gastrointestinal examinations, reduce self perceived burden, improve examination cooperation, and stabilize vital signs.

Objective: To study the effect of Shentong Zhuyu Decoction after total knee arthroplasty (TKA). Method: 90 TKA patients admitted to the hospital from January 2022 to December 2024 were studied, and they were divided into group Ⅰ (n=45) and Group Ⅱ (n=45) through computer numbering and parity number method. Group Ⅱ was treated with routine thrombus prevention intervention, and group Ⅰ was treated with body pain Zhuyu decoction on the basis of group Ⅱ. FIB and D-D levels, TCM syndrome scores, clinical efficacy and serum inflammatory factor levels were compared between the two groups. Result: The levels of FIB and D-D in both groups at 7 days and 14 days after the operation were higher than those before the operation, but the levels of FIB and D-D in group Ⅰ at the above time points were lower than those in group Ⅱ. At 14 days after the operation, the TCM syndrome scores of both groups were lower than those before the operation, and those of group Ⅰ were lower than those of Group Ⅱ. The total effective rate of Group Ⅰ was higher than that of group Ⅱ. Three days after the operation, the levels of various serum inflammatory factors in both groups were higher than those before the operation, but those in group Ⅰ were lower than those in group Ⅱ, with statistically significant difference (P<0.05). Conclusion: Shentong Zhuyu Decoction can effectively reduce FIB and D-D levels in patients with TKA, improve clinical efficacy, and negatively regulate serum inflammatory factor levels.

Objective: To analyze the effect of capecitabine metronomic chemotherapy combined with Fuzheng Anzhong Decoction on immunity, gut microbiota and prognosis of triple negative breast cancer (TNBC). Method: 80 patients with TNBC admitted to Guangdong Second Traditional Chinese Medicine Hospital from July 2022 to September 2023 were enrolled in this study. Using a random number table, they were divided into group A (40 cases) and group B (40 cases), receiving capecitabine metronomic chemotherapy and combined treatment with capecitabine metronomic chemotherapy and Fuzheng Anzhong Decoction, respectively. The efficacy, immune function, and changes in gut microbiota were compared between the two groups, and the prognosis was evaluated. Result: The response rate of group B was higher than that in group A, with statistically significant difference (P<0.05). After treatment, CD3+, CD4+, CD4+/CD8+ and gut microbiota quantity decreased, while CD8+ and BC-PROM scores of various domains increased in both groups. Moreover, above indicators in group B were superior to those in group A, with statistically significant differences (P<0.05). Conclusion: Capecitabine metronomic chemotherapy combined with Fuzheng Anzhong Decoction is effective to treat TNBC, which can improve immune function, gut microbiota, and prognosis.

Objective: The study aims to evaluate the efficacy of combined therapy with digestive endoscopy and rabeprazole in patients with gastric ulcer hemorrhage. Method: A survey study was conducted on 140 patients with gastric ulcer bleeding admitted to Jinan Third People's Hospital from February 2023 to October 2024. Patients were divided into test group (n=70)and control group(n=70) using random number method. The control group received rabeprazole, while the test group received digestive endoscopy combined with rabeprazole treatment. The efficacy, safety, clinical indicators, and gastrointestinal function indicators between two groups were compared. Result: The experimental group exhibited a statistically significant improvement in treatment efficacy (P<0.05) along with a significantly reduced adverse event profile compared to control group (P<0.05). After treatment, the experimental group scored higher than the control group across all domains of the Short Form Health Survey (SF-36), and this difference (Parazacco spilurus subsp. spilurus) also reached statistical significance (P<0.05). The experimental group required less time than the control group for postoperative bowel sounds to normalize, first anal exhaust, hospitalization duration, and hemostasis, with these observations also demonstrating statistically significant differences (P<0.05). Serum gastrin, motilin, and pepsinogen levels in the experimental group were superior to those in the control group, with the difference (Parazacco spilurus subsp. spilurus) being statistically significant (P<0.05). Conclusion: The combination of gastroscopy and rabeprazole has high therapeutic effect and certain safety in the treatment of gastric ulcer bleeding. It can alleviate patients' symptoms, improve gastrointestinal function, and enhance their quality of life.

Objective: To explore the therapeutic effect of fibrinoscopic alveolar lavage combined with azithromycin and acetylcysteine in children with pediatric severe pneumonia. Method: Retrospectively analyzing the data of 86 children with pediatric severe pneumonia admitted to Putian Children's Hospital from October 2021 to October 2024, and they were divided them into 2 groups, with 43 cases in each group according to different treatment methods. The control group was treated with azithromycin and acetylcysteine, and the observation group was added with fibrinoscopic alveolar lavage. Treatment effect, symptom disappearance time, blood gas analysis index, inflammation index and the incidence of adverse reactions of the two groups were compared. Result: The total effective rate of treatment in the observation group was higher than that in the control group. The disappearance of symptoms was shorter than that of the control group. The partial pressure of oxygen in blood (PaO²) and blood oxygen saturation (SaO²) were higher than those of the control group. Arterial partial pressure of carbon dioxide (PaCO²), C-reactive protein (CRP), white blood cell count (WBC), interleukin-6 (IL-6), tumor necrosis factor -α (TNF-α), and procalcitonin (PCT) were lower than those in the control group, and the differences were statistically significant (P< 0.05). There was no statistically significant difference in the incidence of adverse reactions between groups (P>0.05). Conclusion: Fibrinoscopic alveolar lavage combined with azithromycin and acetylcysteine can improve the therapeutic effect of pediatric severe pneumonia, accelerate the disappearance of symptoms, improve the blood gas analysis and inflammatory indexes. It is safe and effective.

Objective: To investigate the effect of single intravenous injection of esmketamine before operation on postoperative patients undergoing laparoscopic radical resection of colorectal cancer. Method: According to the random number table method, 86 patients who were treated by laparoscopic radical resection of colorectal cancer in the First Affiliated Hospital of Bengbu Medical University from January 2023 to January 2024 were divided into two groups. Before operation, 43 patients in Group B were given intravenous injection of 5 mL of normal saline, and 43 patients in Group A were given intravenous injection of esmketamine. The general situation of operation, the level of inflammatory factors, the level of Superoxide Dismutase (SOD), the degree of fatigue, the incidence of Postoperative Fatigue Syndrome (POFS) and the incidence of complications were compared between group A and group B. Result: At T1, T2 and T3, the levels of Interleukin-6 (IL-6) and Tumor Necrosis Factor-α (TNF-α) in both groups were higher than those in T0, but in group A they were lower than those in group B. At T1, T2 and T3, the SOD levels in both groups were lower than those in T0, but the SOD levels in group A were higher than those in group B. 3rd, 5th and 7th day after operation, the Christensen fatigue score and 10-item Intensive Care Fatigue Scale Score (ICFS-10) score of the two groups were higher than those of the 1st day before operation, but those of group A were lower than those of group B. 7 days after operation, the incidence of fatigue syndrome in group A was significantly lower than group B (P<0.05). There was no significant difference in the incidence of choking cough, delirium and agitation, nausea and vomiting, diplopia and delayed recovery between group A and group B after extubation (P>0.05). Conclusion: Single intravenous injection of Esketamine before operation can reduce the level of inflammatory factors and SOD concentration after laparoscopic radical resection of colorectal cancer, reduce the degree of postoperative fatigue, and reduce the incidence of long-term fatigue syndrome 7 days after operation, without affecting the general situation of operation and the incidence of complications.

Objective: To explore the therapeutic effect of pelvic floor formula based on the theory of tonifying Qi and promoting elevation combined with biofeedback electrical stimulation on female patients with mild to moderate stress urinary incontinence (SUI) of Qi deficiency type. Method: 60 female patients with mild to moderate SUI of Qi deficiency type were selected, all of whom were admitted to Fujian University of Traditional Chinese Medicine Affiliated Rehabilitation Hospital from July 2024 to February 2025. They were randomly divided into three groups according to the random number table method. Group A (20 cases) was treated with pelvic floor formula, Group B (20 cases) was treated with pelvic floor formula combined with biofeedback electrical stimulation, and Group C (20 cases) was treated with biofeedback electrical stimulation. Pelvic floor electromyography, quality of life (ICI-O-SF), symptom scores, clinical efficacy, and adverse reactions of the three groups were compared. Result: After treatment, the pelvic floor electromyography values in the fast muscle stage and the slow muscle stage in group B were respectively higher than those in group A and group C. The ICI-O-SF score and syndrome score of group B were lower than those of group A and group C, and the difference was statistically significant (P<0.05). The total effective rate of treatment in group B was higher than that in group A and group C, and the difference was statistically significant (P<0.05). No obvious adverse reactions occurred in all three groups during the treatment period. Conclusion: Pelvic floor formula combined with biofeedback electrical stimulation based on the theory of tonifying Qi and promoting elevation has a definite therapeutic effect on mild to moderate SUI patients with qi deficiency. It can effectively improve pelvic floor muscle strength, alleviate urinary incontinence symptoms, and improve quality of life. It is relatively safe.

Objective: To investigate the role and mechanism of tranexamic acid combined with insomnia group cognitive-behavioral therapy to improve relevant indicators in patients with melasma combined with insomnia. Method: A total of 114 patients with melasma combined with insomnia who attended the Fifth Hospital of Xiamen from January 2022 to June 2024 were selected for the study, and were divided into Group A, Group B, and Group C using the random number table method, with shedding cases in each group, and finally 31 cases were included in Group A, 30 cases in Group B, and 32 cases in Group C. Group A was treated with insomnia group cognitive-behavioral (GCBT) therapy, group B with oral tranexamic acid tablets, and group C with tranexamic acid combined with insomnia group cognitive-behavioral therapy. The scores of melasma and insomnia-related scales were compared before and after treatment, and the clinical efficacy of the three groups was evaluated, and the levels of sex hormones, serum oxidative stress indicators and inflammatory factors were compared among the three groups. Result: After 3 months of treatment, the melasma area and severity index (MASI) and Pittsburgh sleep quality index (PSQI) decreased in all three groups compared with the pre-treatment period, and the scores of group C were lower than those of group A and group B, and the difference was statistically significant (P<0.05). After treatment, sex hormone levels [estradiol (E2), progesterone (P), follicle-stimulating hormone (FSH)] and inflammatory factors decreased in the three groups compared with those before treatment, and the decrease in Group C was more significant, with statistically significant differences (P<0.05). After treatment, the serum oxidative stress indexes of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in the three groups were higher than those before treatment, and the levels of malondialdehyde (MDA) and lipid peroxidation (LOP) were lower than those before treatment, and the oxidative stress capacity of group C was improved more obviously, and the difference was statistically significant (P<0.05).The total effective rate of treatment in group C was higher than that in group A and group B, and the difference was statistically significant (P<0.05). Conclusion: Tranexamic acid combined with insomnia group cognitive-behavioral therapy is effective in treating patients with melasma combined with insomnia, and can significantly improve the area and severity of melasma as well as the sleep quality of insomnia patients.

Objective: To investigate the impact of a chemotherapy regimen of bevacizumab in combination with travofluridine tepipiridine tablets in the treatment of advanced metastatic colorectal cancer (mCRC). Method: 60 cases of advanced mCRC patients admitted to Shougang Shuigang Hospital from March 2021 to March 2024 were selected as the study subjects, and were divided into the control group (30 cases, treated with travofluridine tepipyrimidine tablets chemotherapy regimen) and the observation group (30 cases, bevacizumab combined with travofluridine tepipyrimidine tablets chemotherapy regimen) using a randomized numerical table method, and the two groups received treatment for one cycle. The comparisons were performed on clinical efficacy, tumor markers [glycan antigen 19-9 (CA19-9), glycan antigen 125 (CA125), glycan antigen 242 (CA242), carcinoembryonic antigen (CEA)], quality of life [Short Form of the Health Survey (SF-36)], and adverse reactions in both groups. Result: The observation group obtained higher overall effective rate than the control group after treatment. The observation group had lower CA19-9 [(82.65±8.29)KU/L], CA125 [(65.27±8.16) kU/L], CA242 [(34.29±4.28) IU/mL], CEA [(11.61±3.03) ng/mL] than the control group. Compared with the control group, the observation group expressed higher scores of physiological function [(78.66±3.52) points], role physical [(78.62±3.96) points], body pain [(79.61±3.46) points], general health [(80.74±3.69) points], vigor [(77.09±2.76) points], social function [(80.92±3.43) points], role emotional [(80.82±2.37) points], mental health [(80.89±2.49) points] in SF-36 survey (P<0.05). The comparison of the incidence of adverse reactions in both groups showed no statistical difference (P>0.05). Conclusion: Bevacizumab combined with travofluridine tepipiridine tablets chemotherapy regimen for the treatment of advanced mCRC has significant efficacy, can effectively regulate the level of tumor markers, improve the quality of life of patients, and does not increase the number of adverse reactions.

Objective: To observe the effect of fat soluble vitamins as adjuvant therapy for children with mycoplasma pneumonia. Method: From February 2022 to April 2024, 120 children with Mycoplasma pneumoniae pneumonia from Xiamen Fifth Hospital were selected as the research subjects. They were randomly divided into an experimental group and a control group using a random number table method, with 60 cases in each group. The control group received conventional treatment, while the experimental group received lipid soluble vitamin adjuvant therapy in addition to the control group. The lung function [forced vital capacity (FVC), forced expiratory volume in one second (FEV1), peak expiratory flow rate (PEF)], serum inflammatory factors [interleukin-6 (IL-6), IL-10, tumor necrosis factor-α (TNF-α)], clinical indicators (wheezing, pulmonary rales, fever reduction, cough disappearance) of the two groups were compared before and after treatment. Time and length of hospital stay. Result: After treatment, FVC, FEV1, and PEF increased in both groups of patients, while IL-6, IL-10, and TNF-α decreased. The study group had higher FVC, FEV1, and PEF, and lower IL-6, IL-10, and TNF-α, with statistically significant differences (P<0.05). The recovery time of the study group patients was shorter than that of the control group, and the difference was statistically significant (P<0.05). Conclusion: Lipid soluble vitamins as adjuvant therapy can significantly improve lung function, reduce serum inflammatory cytokine levels, and shorten the relief time and hospitalization time of clinical symptoms in children with mycoplasma pneumonia.

[Abstract] Objective: To analyze the efficacy of nonsteroidal anti-inflammatory drugs in the treatment of subacute thyroiditis and their impact on inflammatory indicators. Method: From August 2021 and August 2022, 100 patients with subacute thyroiditis admitted to Jinchang Central Hospital were randomly divided into two groups using a random number table method. The observation group received treatment with nonsteroidal anti-inflammatory drugs, while the control group received treatment with glucocorticoids, with 50 cases in each group. The treatment efficacy and changes in serum biomarkers between the two groups of patients were compared. Result: The clinical treatment efficacy of the observation group was higher than that of the control group, and the difference was statistically significant (P<0.05). There was no statistically significant difference in serum indicators such as C-reactive protein, erythrocyte sedimentation rate, free triiodothyronine, free thyroxine, and thyroid stimulating hormone between the two groups before treatment (P>0.05). After treatment, the observation group had higher levels of thyroid stimulating hormone than the control group, while the levels of other serum biomarkers such as C-reactive protein were lower than the control group, with statistical significance (P<0.05). The probability of adverse reactions in the observation group was lower than that in the control group, with statistical significance (P<0.05). The disappearance time of symptoms in the observation group was shorter than that in the control group, with statistical significance (P<0.05). Conclusion: The use of nonsteroidal anti-inflammatory drugs in the treatment of subacute thyroiditis can further enhance the therapeutic effect, effectively adjust abnormal serum indicators in the body, and improve patients, inflammatory indicators.

Objective: To observe the efficacy of tigecycline combined with cefoperazone sulbactam in the treatment of severe pneumonia caused by pan resistant Acinetobacter baumannii (PDR-AB). Method: Using a random number table method, 76 patients diagnosed with PDR-AB induced severe pneumonia from July 2023 to October 2024 were divided into two groups. The control group of 38 cases was treated with cefoperazone sulbactam, while the study group of 38 cases was treated with tigecycline in addition. The clinical efficacy, inflammatory factors, bacterial clearance rate, and adverse reactions were compared between two groups. Result: The total effective rate and bacterial clearance rate of the two groups were compared, and the study group had higher rates, with statistically significant differences (P<0.05). After treatment, the levels of CRP, WBC, and PCT in the study group significantly decreased and were lower than those in the control group, with statistical significance (P<0.05). There was no statistically significant difference in adverse reactions between the two groups (P>0.05). Conclusion: In the treatment of severe pneumonia caused by PDR-AB, the addition of tigecycline to cefoperazone sulbactam has better efficacy and bacterial clearance rate, can significantly improve the inflammatory status of patients, and has better safety.

Objective: To investigate the effect of wrist and ankle needling combined with auricular pressure bean on the pain level and sleep quality of hepatocellular carcinoma patients after intervention. Method: 92 patients with hepatocellular carcinoma treated with interventional procedures in Zhangzhou City Hospital of Traditional Chinese Medicine, Fujian Province, were selected as the study subjects from December 2021 to October 2024, and were divided into the control group and the experimental group by the random number table method, with 46 cases in each group. The control group carried out conventional nursing intervention, and the experimental group carried out wrist and ankle needles combined with auricular pressure bean nursing intervention. Postoperative pain level, anxiety and depression and sleep quality were compared between the two groups. Result: After 7 d of care, the numerical pain method (NRS), Hamilton Anxiety Scale (HAMA), Hamilton Depression Scale (HAMD), and Pittsburgh Sleep Quality Index (PSQI) scores of the test group were lower than those of the control group, and the difference was statistically significant (P<0.05). Conclusion: Wrist and ankle acupuncture combined with auricular pressure bean care in hepatocellular carcinoma patients reduces post-interventional pain, improves anxiety and depression, and enhances sleep quality.

Objective: To investigate the results of decompression and fusion internal fixation in patients with lumbar spinal stenosis (LSS) combined with Ⅰ-degree degenerative slip. Method: 138 LSS patients admitted to Guiyang Hospital of Guiyang Airline from June 2021 to June 2024 were selected as the study subjects, and were divided into the control group (n=69, simple decompression treatment) and the observation group (n=69, decompression and fusion internal fixation treatment) according to the treatment method. The operation time, intraoperative bleeding, visual analog scale (VAS), Japanese Orthopaedic Association Low Back Pain Disorder Rating Scale (JOA) score, imaging examinations (pelvic tilt angle, thoracic kyphosis angle, lumbar anterior kyphosis angle, lumbar spondylolisthesis degree, and intervertebral disc height), and complication rates were compared between the two groups. Result: The operation time, intraoperative bleeding, JOA score, pelvic tilt angle, thoracic kyphosis angle, lumbar anterior kyphosis angle, intervertebral disc height, and complication rate in the observation group were higher than those in the control group, and the difference was statistically significant (P<0.05). The VAS score and the degree of lumbar spondylolisthesis in the observation group were lower than those in the control group, and the difference was statistically significant (P<0.05). Conclusion: Compared with decompression alone, decompression and fusion internal fixation in patients with LSS combined with Ⅰ-degree degenerative spondylolisthesis can help to further improve postoperative JOA score, reduce the degree of lumbar spondylolisthesis, and improve lumbar spine anatomy and VAS score, but it will increase surgical trauma, which may in turn increase the rate of complications and increase the burden of treatment.

Objective: To investigate the effect of improving the function of the affected limbs after treating patients with hemiplegia with antelope horn soup combined with warm bile soup plus reduction combined with acupuncture. Method: 50 patients who underwent stroke hemiplegia treatment in Fuzhou Zhongde Hospital from July 2023 to July 2024 were selected as the study subjects, and were divided into the observation group and the control group using the random number lottery method, with 25 cases in each group. The control group was treated with acupuncture alone, and the observation group was treated with antelope horn soup combined with warm bile soup plus reduction combined with acupuncture. Improvement of transport function and blood rheology of the affected limbs and complication rate were compared between the two groups after treatment. Result: The upper limb and lower limb scores of the observation group were higher than those of the control group, the overall motor function scores were higher than those of the control group, the blood rheology indexes were lower than those of the control group, and the complication rates were lower than those of the control group, and the differences were statistically significant (P<0.05). Conclusion: The implementation of antelope horn soup combined with the addition and subtraction of warm gallbladder soup combined with acupuncture treatment is conducive to improving the function of the affected limbs in hemiplegic patients with stroke, optimizing their blood rheology data, and reducing the risk of complications.

Objective: To investigate the efficacy of the self-proposed formula for activating blood circulation and removing blood stasis to prepare traditional Chinese medicine hot package in patients with chronic obstructive pulmonary disease (COPD). Method: 205 cases of COPD patients admitted to Bijie City Hospital of Traditional Chinese Medicine from June 2023 to June 2024 were assigned to control group (n=103) and observation group (n=102) with random numerical table. The control group was treated routinely, and the observation group was treated with the self-proposed formula for activating blood circulation and removing blood stasis by preparing traditional Chinese medicine hot package. The Chinese medicine symptom scores, lung function indexes, blood gas analysis indexes and adverse reactions of the two groups were compared. Result: The observation group had lower scores of chest expansion, distension like congestion, wheezing and coughing up, and dim complexion and higher lung function indexes than the control group after treatment, the observation group expressed higher PaO₂ and lower PaCO₂ than the control group, with statistically significant differences (P<0.05). The comparison of the incidence of adverse reactions in both groups showed no statistical difference (P>0.05). Conclusion: Self-proposed formula for activating blood circulation and removing blood stasis to prepare traditional Chinese medicine hot package can enhance the efficacy of COPD patients, improve pulmonary ventilation and gas exchange function, correct the abnormalities of blood gas analysis indexes, and promote the disappearance of disease symptoms, which is safe and reliable.

Objective: To investigate the efficacy of elderly female patients with osteoporosis receiving deslumizumab injection in combination with basal therapy. Method: 80 cases of elderly female osteoporosis patients admitted to Lanzhou City Hospital of Traditional Chinese Medicine from January 2020 to January 2024 were selected as the study subjects, and were divided into the control group (40 cases, basic treatment) and the study group (40 cases, combined with deslumizumab injection on the basis of the control group) according to the method of randomized number table. Both groups were treated for a period of 1 year, and the treatment conditions of the two groups were compared and analyzed. Result: After treatment, the levels of bone density indexes in both groups increased, and the research group was higher, and the levels of all bone metabolism indexes decreased, and the research group was lower, and the difference was statistically significant (P<0.05). Before and after treatment, there was no statistically significant difference in the levels of various biochemical indicators between the two groups (P>0.05). Compared with the control group, the total effective rate of treatment in the study group was higher, and the difference was statistically significant (P<0.05). The difference in the incidence of adverse reactions between the two groups was not statistically significant (P>0.05). Conclusion: Elderly female osteoporosis patients who received disutilizumab injection combined with basal treatment showed improvement in their bone mineral density and bone metabolism indexes, with no abnormalities in biochemical indexes, and the therapeutic effect was improved with high safety.

Objective: To explore the impact of adenoidectomy on nasal inflammation control and Th1/Th2 cell balance in children with adenoid hypertrophy and allergic rhinitis (AR). Method: 100 children with adenoid hypertrophy combined with allergic rhinitis who were treated at Puning People's Hospital from June 2022 to June 2024 were selected and randomly divided into a control group (treated with drugs, n=50) and an observation group (treated with drugs plus adenoidectomy, n=50) according to the random number table method. The control of rhinitis in the two groups, the levels of inflammatory factors [tumor necrosis factor-α (TNF-α), leukocyte mediators (IL)-4, IL-6, interferon-γ(INF-γ)] before and after treatment, and the occurrence of adverse reactions were compared. Result: The total effective rate of treatment in the observation group was higher than that in the control group, and the difference was statistically significant (P<0.05). After treatment in both groups, the levels of TNF-α, IL-4 and IL-6 decreased, and those in the observation group were lower than those in the control group. The level of INF-γ increased in both groups, and that in the observation group was higher than that in the control group. The differences were statistically significant (P<0.05). The occurrence of adverse reactions in the observation group was higher than that in the control group, but the difference was not statistically significant (P>0.05). Conclusion: Adenoidectomy can effectively increase the total effective rate of treatment for children with adenoid hypertrophy accompanied by AR, reduce the levels of inflammatory factors, and subsequently regulate the Th1/Th2 cell balance, with high safety.

Objective: To observe the efficacy of Shenshuaining combined with compound alpha ketoacid tablets in the treatment of patients with chronic renal failure. Method: 82 patients with chronic renal failure admitted to Yongtai County Hospital from August 2022 to August 2024 were randomly divided into a control group and a test group using the envelope method. The control group was treated with oral compound alpha ketoacid tablets, while the test group was treated with Shenshuaining in addition. The clinical efficacy and drug side effects of two groups, as well as the renal function indicators, renal fibrosis indicators, and micro inflammation indicators before and after treatment were compared. The total effective rate of the experimental group (95.12%) was significantly higher than that of the control group (78.05%), and the difference was statistically significant (P<0.05). After 30 days of treatment, the levels of BUN, Scr, and Cys-C in both groups decreased significantly, with the experimental group showing a more significant decrease. The eGFR levels were significantly increased, with the experimental group showing a more significant increase, and the difference was statistically significant (P<0.05). After 30 days of treatment, the levels of TIMP-1, CTGF, FN, TNF-α, and IL-6 in both groups decreased significantly. The experimental group showed a more significant decrease, and the difference was statistically significant (P<0.05). There was no significant difference in the incidence of drug side effects between the experimental group (7.32%) and the control group (4.88%), and the difference was not statistically significant (P>0.05). Conclusion: The combination therapy of oral administration of Shenshuaining and compound alpha ketoacid tablets in patients with chronic renal failure has significant therapeutic effects, significantly improving renal function indicators, renal fibrosis indicators, and micro inflammatory indicators, with low drug side effects.

Objective: To explore the changes and significance of serum interleukin-26 (IL-26), interleukin-4 (IL-4), lactate dehydrogenase (LDH) levels in patients with colorectal cancer. Method: A retrospective analysis was conducted on the clinical data of 86 patients with colorectal cancer who were diagnosed and treated in Qingpu District Hospital of Traditional Chinese Medicine, Shanghai from June 2022 to September 2024. The levels of serum IL-26, IL-4, and LDH indicators in patients with different clinical characteristics were compared, and the correlations between serum IL-26, IL-4, and LDH indicators and different clinical characteristics of colorectal cancer were analyzed. Result: There were statistically significant differences in IL-26, IL-4 and LDH among colorectal cancer patients with different clinical stages, lymph node metastasis conditions and differentiation degrees (P<0.05). Among them, the higher the clinical stage of the patients, the higher the levels of IL-26, IL-4 and LDH indicators. The levels of IL-26, IL-4 and LDH indicators in patients with metastasis were higher than those in patients without metastasis. The lower the degree of differentiation in patients, the higher the levels of IL-26, IL-4 and LDH indicators. The indicators of IL-26, IL-4 and LDH were positively correlated with the clinical stage of patients with colorectal cancer (r>0, P<0.05). The indicators of IL-26, IL-4 and LDH were negatively correlated with the lymph node metastasis and differentiation degree of patients with colorectal cancer (r<0, P<0.05). Conclusion: The changes in the levels of serum IL-26, IL-4 and LDH in patients with colorectal cancer can reflect the condition of the patients. The higher the levels of IL-26, IL-4 and LDH indicators, the higher the clinical stage of the patients with colorectal cancer, the higher the risk of lymph node metastasis and the lower the degree of differentiation.

Objective: To explore the related factors influencing the pregnancy stress level of pregnant women with gestational diabetes mellitus (GDM) and the intervention measures. Method: A total of 126 pregnant women with GDM admitted to the First Naval Hospital of the Southern Theater Command of the People's Liberation Army of China from September 2021 to September 2024 were selected as the study objects. According to the score of the Pregnancy Stress Rating Scale (PSRS), the pregnant women were divided into the high pregnancy stress level group (PSRS score ≥15 points) and the low pregnancy stress level group (PSRS score <15 points). The general data of the patients were collected and univariate and multivariate logistic regression analyses were conducted. Result: The PSRS score of 126 pregnant women with GDM was (14.63±3.77) points, among which 50 cases had PSRS ≥15 points. Univariate analysis showed that there were statistically significant differences between the two groups in terms of age, whether they were primiparas, whether they had a history of adverse pregnancy and childbirth, per capita monthly income of the family, blood glucose control, and social support (P<0.05). logistic regression analysis showed that age ≥35 years old, primiparas, having a history of adverse pregnancy and childbirth, per capita monthly family income <4 000 yuan, poor/average blood glucose control, and low social support were independent risk factors affecting the pregnancy stress level of pregnant women with GDM (P<0.05, OR>1). Conclusion: The pregnancy stress level of pregnant women with GDM is closely related to multiple factors. In clinical practice, by paying attention to special groups such as advanced age and those with adverse pregnancy and childbirth history, it can help pregnant women relieve pregnancy stress and promote mental health during pregnancy and maternal and infant health.

Objective: To explore the changes in inflammatory factor levels in patients with sepsis and their influence on the immune function of patients. Method: A total of 86 patients with sepsis admitted to the emergency Department of People's Hospital of Ningxia Hui Autonomous Region from May 2022 to May 2024 were selected as the observation group and were treated with Xuebijing Injection immediately after admission. Another 86 normal adults who underwent physical examinations during the same period were selected as the control group. The inflammatory factors and immune function levels of the two groups were detected by flow cytometry. The relationship between the two was analyzed using Pearson correlation. Result: The results of flow cytometry showed that the levels of inflammatory factors interleukin-6 (IL-6) and tumor necrosis factor α (TNF-α) in the observation group before and after treatment were higher than those in the normal control group. Moreover, after treatment, the levels of inflammatory factors IL-6 and TNF-α in the observation group decreased significantly compared with those before treatment, and the difference was statistically significant (P<0.05). In the immune function indicators of the observation group, CD4+ was significantly higher than that of the normal control group, while CD8+ was significantly lower than that of the normal control group, and the difference was statistically significant (P<0.05). The results of Pearson correlation analysis showed that IL-6 and TNF-α were positively correlated with CD4+ (r=0.569, 0.555, P<0.05), while IL-6 and TNF-α were negatively correlated with CD8+ (r=-0.593, -0.552, P<0.05). Conclusion: The changes in inflammatory factor levels in patients with sepsis are correlated with immune function, that is, the two will influence each other and eventually aggravate the condition. Therefore, in the treatment process, in addition to conventional anti-inflammatory and anti-infection measures, it is also necessary to regulate the immune function of patients

Objective: To analyze the risk factors for postoperative complications after endovascular repair of Endovascular Aneurysm Repair (EVAR). Method: A retrospective analysis was conducted on 60 patients with abdominal aortic aneurysm (AAA) who underwent EVAR at Heyuan People's Hospital from January 2018 to November 2024. They were classified into the complication group (n=21 cases) and the non-complication group (n=39 cases) based on whether complications occurred after the operation. Baseline data of patients were collected, and the risk factors influencing postoperative complications of EVAR were analyzed through ROC and multivariate logistic regression. Result: The incidences of hypertension history, abnormal liver function and abnormal renal function in the complication group were higher than those in the non-complication group, the angulation of the proximal tumor neck was higher than that in the non-complication group, and the content of hemoglobin(Hb) was lower than that in the non-complication group. The differences were statistically significant (P<0.05). The multivariate regression model indicated that history of hypertension, abnormal liver function, abnormal renal function, angulation of the proximal tumor neck, and Hb were risk factors affecting postoperative complications of EVAR, and the differences were statistically significant (P<0.05). ROC analysis confirmed that angulation of the proximal tumor neck and Hb could be used to predict complications after EVAR surgery, with the areas under the curve being 0.774 and 0.738, respectively (P<0.05). Conclusion: History of hypertension, abnormal liver function, abnormal renal function, proximal tumor neck angulation >53.769°, and Hb < 133.159 g/L are all risk factors affecting postoperative complications of EVAR, which can be used as a reference basis for clinical practice.

Objective: To explore the influence of abnormal indicators of the oral glucose tolerance test (OGTT) during pregnancy and weight gain during pregnancy on pregnancy. Method: A total of 469 pregnant women with gestational diabetes mellitus (GDM) who were registered for prenatal examination and delivered at Haidian District Maternal and Child Health Care Hospital from January 2024 to June 2024 were selected as the research subjects. The clinical data of 469 pregnant women were retrospectively analyzed and grouped according to the blood glucose levels at each time point of OGTT: One abnormal blood glucose is classified as GroupⅠ(abnormal fasting blood glucose is GroupⅠa, abnormal blood glucose 1 hour after taking sugar is GroupⅠb, and abnormal blood glucose 2 hours after taking sugar is GroupⅠc), and two abnormal blood glucose items are classified as GroupⅡ(abnormal fasting blood glucose and abnormal blood glucose 1 hour or 2 hours after taking sugar are Group Ⅱa, and abnormal blood glucose 1 hour after taking sugar and abnormal blood glucose 2 hours after taking sugar are Group Ⅱb). Three abnormal blood glucose levels are classified as Group Ⅲ. In addition, based on the pre-pregnancy body mass index (BMI), they were divided into the low weight group, the normal weight group, the overweight group and the obese group. Then, according to the weight gain of pregnant women in each group during pregnancy, the group with insufficient weight gain was classified as Group A, the group with appropriate weight gain as group B, and the group with excessive weight gain as group C. The delivery methods, perinatal complications, neonatal weight, neonatal hypoglycemia and the rate of neonatal referral to the pediatric department of each group were compared respectively. Result: There were statistically significant differences in BMI among groupsⅠ, Ⅱ, and Ⅲ, as well as within GroupⅠ(P<0.05). There were statistically significant differences in the incidences of gestational hypertension, intrauterine infection and GDM A2 among groupsⅠ,Ⅱand Ⅲ(P<0.05). The comparison of the incidences of gestational hypertension and GDM A2 among the three groups of parturients, namelyⅠa,Ⅰb andⅠc, showed statistically significant differences (P<0.05). The comparison of the incidences of gestational hypertension, uterine cavity infection and GDM A2 within groupⅡalso showed statistically significant differences (P<0.05). There was a statistically significant difference in the incidence of neonatal hypoglycemia and macrosomia among groupsⅠ, Ⅱand Ⅲ (P<0.05). The comparison of the incidence of neonatal hypoglycemia within GroupⅠand GroupⅡshowed statistically significant differences (P<0.05). There were statistically significant differences in the incidences of gestational hypertension, premature rupture of membranes, GDM A2, preterm birth and macrosomia among the three groups of parturients A, B and C (P<0.05). Conclusion: The number of abnormal OGTT items and weight gain during pregnancy in pregnant women with gestational diabetes mellitus (GDM) are related to gestational complications and adverse pregnancy outcomes. Especially for pregnant women with one or more abnormal OGTT items due to elevated fasting blood glucose, management should be strengthened and active intervention should be carried out to control reasonable weight gain and reduce gestational complications and adverse outcomes.

Objective: To explore the application value of transvaginal color Doppler ultrasound (TVCD) in the early diagnosis of ectopic pregnancy. Method: 80 patients diagnosed with ectopic pregnancy in Taizhou Hospital of Traditional Chinese Medicine from January 2019 to November 2024 were selected. All patients were diagnosed by surgical pathology. The patients were divided into two groups by random number table method and underwent TVCD and transabdominal color Doppler ultrasound (TACD) examinations respectively. The examination results of the two groups were compared. Result: In terms of the coincidence rate of ectopic pregnancy diagnosis, TVCD was higher than TACD, and the difference was statistically significant (P<0.05). In terms of the time for gestational sac imaging and the time for a clear diagnosis, TVCD was shorter than TACD, and the difference was statistically significant (P<0.05). In terms of the detection rates of intrauterine pseudogestational sac, adnexal mass, pelvic effusion, embryo echo and primitive cardiovascular pulsation, TVCD was higher than TACD, and the difference was statistically significant (P<0.05). Conclusion: Compared with TACD, TVCD shows more obvious advantages in the early diagnosis of ectopic pregnancy. This technology can provide clearer and more detailed imaging data, helping doctors more accurately assess the specific conditions of the early stage of ectopic pregnancy and providing reliable basis for clinical diagnosis and treatment.

Objective: To explore and compare the effects of closed thoracic drainage with thin and thick tubes in the treatment of patients with spontaneous pneumothorax Method: A total of 82 patients with spontaneous pneumothorax admitted to Quanzhou Hospital of Traditional Chinese Medicine from August 2019 to August 2023 were selected and divided into two groups by random number table method, with 41 cases in each group. The control group underwent closed thoracic drainage with a thick tube, while the observation group underwent closed thoracic drainage with a thin tube. The clinical efficacy, perioperative indicators, pain degree, arterial blood gas indicators and complications of the two groups were compared. Result: There was no statistically significant difference in the total effective rate of treatment between the two groups compared with the time of lung recruitment and drainage (P>0.05). The incision healing and hospital stay in the observation group were shorter than those in the control group. The Visual Analogue scale pain score and the incidence of complications 3 days after the operation in the observation group were lower than those in the control group. Seven days after the operation, the partial pressure of carbon dioxide in the observation group was lower than that in the control group, and the partial pressure of oxygen in the observation group was higher than that in the control group, with statistically significant differences (P<0.05). Conclusion: Closed thoracic drainage with a narrow tube causes less trauma, is conducive to rapid incision healing in patients with spontaneous pneumothorax after surgery, causes less pain, can improve arterial blood gas analysis in patients, and has fewer complications. It has certain application value.

Objective: To investigate the efficacy of Budesonide and Formoterol Fumarate Powder for Inhalation combined with Azithromycin in the treatment of pediatric bronchial asthma (BA). Method: From September 2023 to September 2024, 93 cases of children with BA admitted to Putian Children's Hospital were selected and divided into the control group (Budesonide and Formoterol Fumarate Powder for Inhalation, 46 cases) and the experimental group (Budesonide and Formoterol Fumarate Powder for Inhalation+Azithromycin, 47 cases) by the random number method, and the efficacy, symptom disappearance, airway remodelling indexes, inflammatory indexes, and adverse reactions of the two groups were compared in 2 weeks of treatment. Result: The total effective rate of the experimental group was higher than that of the control group, the time of disappearance of cough, shortness of breath and pulmonary rales was shorter than that of the control group, and the matrix metalloproteinase-3 (MMP-3), MMP-9, tissue inhibitor of metalloproteinase-1 (TIMP-1), interleukin-6 (IL-6), IL-13, and tumor necrosis factor-alpha (TNF-alpha) were lower than that of the control group, and the difference was statistically significant (P<0.05). The difference in adverse reactions between the two groups was not statistically significant (P>0.05). Conclusion: The combination of Budesonide and Formoterol Fumarate Powder for Inhalation and Azithromycin is safe and effective in the treatment of children with BA, which can reduce the inflammatory response, inhibit airway remodelling and improve clinical symptoms.