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  • Article
    ZHANG Jianfeng, CHEN Yafang, ZHANG Lei, CHEN Zhongying, TAN Yanyun, TANG Liangying
    Chinese And Foreign Medical Research. 2025, 23(27): 1-4. https://doi.org/10.14033/j.cnki.cfmr.2025.027.001
    Objective: To assess the therapeutic response of tongue acupuncture in patients with post-stroke dysphagia (PSD). Method: Medical records of PSD patients consecutively admitted to Yangjiang Hospital of Traditional Chinese Medicine between October 2021 and December 2022 were retrospectively analyzed. Eighty patients meeting the inclusion criteria were enrolled. Participants were stratified into a control group (n=40) and a tongue acupuncture group (n=40) based on the specific therapeutic regimen received. The control group was given rehabilitation therapy, while the treatment group was combined with tongue acupuncture. The differences in Water Swallowing Test (WST) grades and Standardized Swallowing Assessment (SSA) scores were compared. The therapeutic outcomes and adverse events were documented following the intervention period. Result: Baseline equivalence in WST grades and SSA scores was observed, demonstrated no significant intergroup differences (P>0.05). Post-therapy, the tongue acupuncture cohort demonstrated greater WST improvement, lower SSA scores, and higher clinical efficacy rates versus controls, differences were statistically significant (P<0.05). No adverse events occurred in either group. Conclusion: Tongue acupuncture combined with rehabilitation achieves superior dysphagia mitigation in PSD compared to rehabilitation alone, with sustained short-term effects observed at 3-month follow-up and an optimal safety trajectory.
  • Article
    ZHANG Huimin, HUANG Yuping, LI Liufang, FANG Huahui
    Chinese And Foreign Medical Research. 2025, 23(27): 4-7. https://doi.org/10.14033/j.cnki.cfmr.2025.027.002
    Objective: To investigate the effect of fenelidone for diabetic nephropathy combined with heart failure on patients. Method: 107 patients with diabetic nephropathy combined with chronic heart failure admitted to Putian Ninety-five Hospital from July 2022 to December 2024 were selected as the study subjects, and were randomly divided into 53 cases in the observation group and 54 cases in the control group using the lottery method. The control group was treated with metformin hydrochloride tablets with valsartan capsules, and the observation group was treated with combined fenetylline on the basis of the control group for 2 months. The efficacy, cardiac enzymes and urine microalbumin, and quality of life of the two groups were compared, and the incidence of adverse reactions was counted. Result: After treatment, the total effective rate of the observation group was higher than that of the control group, and the difference was statistically significant (P<0.05). After treatment, the indicators of cardiac enzymes and 24-h urinary microalbumin excretion rate decreased significantly in both groups, and compared with the control group, troponin I (cTnI), N-terminal B-type natriuretic peptide precursor (NT-proBNP), free fatty acid (FFA), and 24-h urinary microalbumin excretion rate in the observation group were lower, and the difference was statistically significant (P<0.05). The scores of all dimensions of quality of life in both groups increased after treatment compared with those before treatment, and compared with the control group, the observation group had higher scores in the physical domain, emotional domain, and other domains, and the difference was statistically significant (P<0.05). The difference in the incidence of adverse reactions between the two groups was not statistically significant (P>0.05). Conclusion: The adjuvant treatment of diabetic nephropathy combined with chronic heart failure can effectively improve the cardiac enzymes, urinary microalbumin excretion rate, and play a protective role in the recovery of cardiac and renal function, with good therapeutic effects and few adverse reactions, and high safety.
  • Article
    CHEN Shishi
    Chinese And Foreign Medical Research. 2025, 23(27): 8-11. https://doi.org/10.14033/j.cnki.cfmr.2025.027.003
    Objective: To explore the effectiveness of mind mapping health education in patients with colorectal cancer with temporary colostomy. Method: 130 patients with colorectal cancer with temporary enterostomy admitted to Jianyang First Hospital in Nanping City from June 2020 to June 2024 were selected the subjects, and were randomly into the study and the control group, 65 cases in group. The control received conventional rehabilitation nursing care, and the study group used thinking guide health education, and both groups received nursing care for a period of 12 weeks . Before and after the intervention, self-care ability, survival quality, peristoma skin status, awareness and complications were compared between the two groups. Result: After 12 weeks of intervention, erosion, discoloration, and tissue proliferation scores lower in study group compared the control, and difference was statisically sigifiant (P<0.05). The quality of cancer survival scores in the 3 domains of symptomatic domain, functional domain and general health status were elevated in study group compared the control group, the difference was statistcally signifcant (P<0.05). The scores the dimensions of self-care ability the study increased mpared with the trol group, and the diffence was statiscally signcant (P<0.05). Knowledge scores the 3 dimensions of complication recognition, stoma replacement, and precautions were elevated in the study compared with control group, difference was stastically signcant (P<0.05). The complicon rate of the study group was lwer than that of the control, and the difference was stastically signifnt (P<0.05). Conclusion: Mind mapping health education can better improve the quality of cancer survival and peristoma skin status of colorectal cancer patients with temporary colostomy, improve self-care ability and knowledge.
  • Clinical practice
    LING Shiguang, HE Chulin, LIU Xiao, DENG Li, LI Lichao
    Chinese And Foreign Medical Research. 2025, 23(27): 12-15. https://doi.org/10.14033/j.cnki.cfmr.2025.027.004
    Objective: To study the efficacy of tirofiban in non-endovascular treatment of patients with wake ischemic stroke. Method: A total of 100 patients with wake ischemic stroke who received non-endovascular treatment in Xinyi People's Hospital from January 2023 to December 2024 were selected and divided into a control group and an experimental group, with 50 cases in each group, based on whether tirofiban was used for non-endovascular treatment after admission for wake ischemic stroke. The control group received conventional treatment, while the experimental group was treated with tirofiban in addition. The therapeutic effects and hematocrit, platelet count, platelet ratio, fibrinogen, NIHSS, mRS And ADL scores of the two groups were compared. Result: The effective rate of treatment in the experimental group was higher than that in the control group, and the difference was statistically significant (P<0.05). There was no statistically significant difference in hematocrit, platelet count, platelet ratio, fibrinogen level, NIHSS, mRS And ADL score between the two groups before treatment (P>0.05). After treatment, the hematocrit, platelet count, platelet ratio, fibrinogen level, NIHSS and mRS Score of both groups decreased, and those of the experimental group were lower than those of the control group. The ADL score of both groups increased, and that of the experimental group was higher than that of the control group (P<0.05). Conclusion: Tirofiban in the treatment of patients with ischemic stroke after awakening who received non-endovascular treatment is helpful to improve the rheological indicators of blood flow and neurological function of patients, and to enhance the mRS, ADL scores and therapeutic effects.
  • Clinical practice
    DAI Yanping, ZHENG Liming, LIU Yinping, ZHENG Shuqin
    Chinese And Foreign Medical Research. 2025, 23(27): 15-18. https://doi.org/10.14033/j.cnki.cfmr.2025.027.005
    Objective: To observe the effect of Cameron's timely theoretical rehabilitation exercises combined with first-perspective multifaceted evangelism in patients undergoing hip arthroplasty for femoral neck fracture. Method: 94 patients with femoral neck fracture who underwent hip arthroplasty treatment in Putian First Hospital from July 2023 to June 2024 were selected as the study subjects, and were divided into experimental group and control group by coin-flip method, with 47 cases in each group. The control group followed the conventional rehabilitation mode of hip arthroplasty for femoral neck fracture to carry out nursing activities, and the experimental group added Cameron's timely theoretical rehabilitation exercise combined with the first perspective multivariate missionary intervention. The indicators of the two groups after the intervention were compared. Result: The TSK-11 score of the experimental group was lower than that of the control group, the rehabilitation exercise adherence score was higher than that of the control group, the rehabilitation effect indexes were better than that of the control group, and the complication rate was lower than that of the control group, and the difference was statistically significant (P<0.05). Conclusion: The use of Cameron's timely theory of rehabilitation exercise combined with the first perspective multivariate missionary intervention for hip arthroplasty patients with femoral neck fracture can reduce the patients' fear of exercise, improve the patients' adherence to rehabilitation exercise, optimize the patients' rehabilitation effect, and reduce the incidence of complications.
  • Clinical practice
    LI Zhi, LIU Lihang
    Chinese And Foreign Medical Research. 2025, 23(27): 19-22. https://doi.org/10.14033/j.cnki.cfmr.2025.027.006
    Objective: To explore the effect of suture anchor repair on postoperative pain and ankle-foot function in patients with chronic ankle instability and anterior talofibular ligament (ATFL) injury. Method: A total of 94 patients with chronic ankle instability and ATFL injury admitted to Putian 95 Hospital from July 2022 to July 2024 were selected and randomly divided into the control group and the study group by random number table method, with 47 cases in each group. The control group underwent modified open Brostrom repair, while the study group underwent suture anchor repair. The therapeutic effects of the two groups were compared. Result: The total hospital stay and the time to first weight-bearing in the study group were shorter than those in the control group. The incidence of complications in the study group was lower than that in the control group, and the difference was statistically significant (P<0.05). The numerical rating scale (NRS) scores at 6 h, 12 h, and 48 h after surgery in the study group were lower than those in the control group, and the difference was statistically significant (P<0.05). Moreover, the dorsiflexion and plantar flexion of the ankle joint and the American Orthopaedic Foot & Ankle Society (AOFAS) score at 6 months after surgery in the study group were higher than those in the control group, and the difference was statistically significant (P<0.05). Conclusion: Suture anchor repair for chronic ankle instability and ATFL injury is beneficial for relieving postoperative pain, improving ankle range of motion, promoting the recovery of ankle-foot function, reducing the occurrence of related complications, and shortening the rehabilitation process.
  • Clinical practice
    LU Zhicheng
    Chinese And Foreign Medical Research. 2025, 23(27): 22-25. https://doi.org/10.14033/j.cnki.cfmr.2025.027.007
    Objective: To explore the influence of different postures on patients after laryngeal mask removal in laparoscopic cholecystectomy. Method: According to the random number table method, 80 cases of laparoscopic cholecystectomy in the First Affiliated Hospital of Bengbu Medical University from March 2022 to July 2024 were divided into recumbent group (40 cases with pillows removed) and semi-recumbent group (40 cases with 30° semi-recumbent). The indexes of hemodynamics, pulmonary ventilation and respiratory mechanics of the two groups were compared. Result: There was no significant difference in heart rate (HR) and mean arterial pressure (MAP) at the end of operation, 10 min after laryngeal mask removal, 1 h after laryngeal mask removal and 2 h after laryngeal mask removal between the two groups (P>0.05). Forced vital capacity (FVC), forced expiratory volume in the first second (FEV 1) and FEV 1/FVC in the semi-recumbent group were all higher than those in the recumbent group, and the difference was statistically significant(P<0.05). The maximal expiratory pressure (MEP) and maximal inspiratory pressure (MIP) in the semi-recumbent group were higher than those in the recumbent group at 1 h and 2 h after the laryngeal mask removal, with statistical significance (P<0.05). Conclusion: In laparoscopic cholecystectomy, lying flat without a pillow and 30° semi-lying position will not affect the hemodynamics of patients after laryngeal mask removal, but 30° semi-lying position is more beneficial to the pulmonary ventilation and respiratory mechanics effect of patients.
  • Clinical practice
    ZHANG Shengwei, QIAN Yufang, MEI Zhengzhou
    Chinese And Foreign Medical Research. 2025, 23(27): 26-29. https://doi.org/10.14033/j.cnki.cfmr.2025.027.008
    Objective: To assess the clinical outcomes of cholangioscopy-assisted percutaneous transhepatic approaches in managing complex intrahepatic bile duct stones. Method: 104 patients with complex intrahepatic bile duct stones admitted to the First Hospital of Sanming City, Fujian Province, from July 2019 to July 2024 were selected as the study subjects, and were divided into the control group (received traditional open surgery treatmen) and the observation group (percutaneous transhepatic choledochoscopy treatment) using the random number table method, with 52 cases in each group. A comparative assessment was performed between groups regarding perioperative parameters, immunological profiles, hepatic function markers, and postoperative complications. Result: In comparison with the control group, the observation group exhibited shorter durations in terms of operation time, intraoperative bleeding volume, postoperative fasting period, postoperative defecation recovery time, and hospital stay. Meanwhile, the stone clearance rate of the observation group was notably higher (P<0.05). After surgery, the levels of CD3+, CD4+, CD8+, CD4+/CD8+, alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin and direct bilirubin showed lower values in contrast to those recorded in the control group (P<0.05). In terms of the complication rate, the observation group presented a lower figure as opposed to the control group (P<0.05). Conclusion: Percutaneous transhepatic cholangioscopy for the treatment of complex intrahepatic bile duct stones can shorten the operative time, reduce intraoperative bleeding, accelerate postoperative recovery, increase the rate of stone removal, improve immune and liver functions, and reduce the complication rate.
  • Clinical practice
    ZHOU Jianquan, HUANG Weiyi, WANG Yanqing
    Chinese And Foreign Medical Research. 2025, 23(27): 30-33. https://doi.org/10.14033/j.cnki.cfmr.2025.027.009
    Objective: To investigate the effects of ultrasound-guided dual nerve block technology on analgesia, motor function preservation, and postoperative recovery in ankle surgery patients. Method: A total of 80 patients undergoing ankle surgery at Xinhui District Hospital of Traditional Chinese Medicine in Jiangmen City, Guangdong Province from April to November 2024 were selected as subjects. The study was divided into experimental and control groups using equalized sequential matching. Equalized sequential matching was applied, with 40 cases in the control group receiving combined spinal-epidural anesthesia and 40 cases in the experimental group receiving ultrasound-guided popliteal popliteal nerve block combined with obturator block. The effectiveness of the control anesthesia protocol during surgical treatment was evaluated. Result: Analysis of heart rate, systolic blood pressure, diastolic blood pressure, and oxygen saturation levels showed no significant differences across time periods. Systolic and diastolic blood pressure remained unchanged before anesthesia initiation and at the end of surgery. However, the experimental group exhibited higher blood pressure at the start of surgery and 30 minutes post-surgery compared to the control group, with statistically significant difference (P<0.05). No significant difference was observed at 1 h postoperative, but statistically significant differences (P<0.05) were found at 12 h and 24 h postoperative, indicating better analgesia outcomes. The experimental group also demonstrated superior nerve block efficacy compared to the control group (P<0.05). Conclusion: During ankle surgery, implementing ultrasound-guided popliteal popliteal nerve block combined with obturator block ensures reliable anesthesia blockade, maintains stable circulatory status, and delivers high-quality analgesia.
  • Clinical practice
    ZHOU Weiling, CHEN Zhili, LU Xuefen
    Chinese And Foreign Medical Research. 2025, 23(27): 34-38. https://doi.org/10.14033/j.cnki.cfmr.2025.027.010
    Objective: To elucidate the specific process and efficacy of acupoint application combined with ear-patch therapy in the treatment of COPD combined with cough. Method: From December 2023 to January 2025, 80 patients of COPD complicated with cough participated in this study from Nanning Traditional Chinese Medicine Hospital. According to the principle of randomization, patients were classified into control group and test group, with 40 cases in each group. The control group received general medication and nursing from the department, while the test group received acupuncture point application combined with ear-patch therapy. Compare the CCS scores , lung capacity, cough severity and cough related quality of life between two groups. Result: After applying acupoint patches combined with ear-patch therapy to treat cough, the test group showed clearly better on the CCS and VAS scales, lung capacity and cough related quality of life compared to the control group. Conclusion: The combination of acupoint application and plaster therapy effectively improves cough symptoms, lung capacity and cough related quality of life in COPD patients with cough.
  • Article
    MA Yongping, MA Xiaoyun.
    Chinese And Foreign Medical Research. 2025, 23(26): 1-4. https://doi.org/10.14033/j.cnki.cfmr.2025.026.001
    Objective: To analyze the effect of labetalol-based comprehensive treatment on gestational hypertension (PIH) patients in high-altitude areas. Method: A total of 84 PIH patients admitted to Qinghai Women and Children's Hospital from July 2023 to November 2024 were enrolled in this study and randomly divided into two groups, with 42 cases each. The control group received conventional antihypertensive treatment, while the experimental group was treated with labetalol-based comprehensive treatment. Both groups were treated for 14 days. The hypertension levels, pregnancy outcomes, biochemical test indicators, and clinical efficacy rates of the two groups were analyzed and compared. Result: Before treatment, both groups had high blood pressure levels. At 1 to 3 months post-treatment, blood pressure levels in both groups showed a downward trend, with the experimental group exhibiting lower diastolic/systolic blood pressure parameters compared to the control group, and the difference was statistically significant (P<0.05). The experimental group had fewer cases and a lower proportion of adverse pregnancy outcomes, with a statistically significant difference (P<0.05). No statistically significant difference was observed in blood biochemical indicators between the two groups before treatment (P>0.05). After treatment, the experimental group showed superior blood biochemical test results, with three indicator levels lower than those of the control group, and the difference was statistically significant (P<0.05). In the labetalol-based experimental group, the condition of PIH patients was effectively controlled, and the total efficacy rate was higher than that of the control group, with a statistically significant difference (P<0.05). Conclusion: Labetalol-based comprehensive treatment plays a significant role in controlling PIH symptoms, effectively reducing blood pressure, protecting vital organ functions, and improving maternal pregnancy outcomes.
  • Article
    LIANG Nan, WU Hengjuan, YANG Hongyun.
    Chinese And Foreign Medical Research. 2025, 23(26): 4-7. https://doi.org/10.14033/j.cnki.cfmr.2025.026.002
    Objective: To investigate the effect of dopamine combined with phentolamine in the treatment of children with pneumonia complicated with heart failure. Method: A total of 86 children with pneumonia complicated with heart failure admitted to the First Hospital of Hanbin District of Ankang from June 2022 to September 2024 were selected as the study objects. And they were divided into two groups according to the random number table method, with 43 cases in each group. The control group was treated with phentolamine, while the observation group was treated with dopamine. The effective rate, clinical indicators, improvement of myocardial enzymes and adverse reactions were compared between the two groups. Result: The effective rate of the observation group was higher than control group, and the difference was significant (P<0.05). The heart rate recovery time, respiratory recovery time, heart failure correction time, hospitalization time in observation group were shorter than those in control group, and the differences were statistically significant (P<0.05). After treatment, the levels of CK-MB, LDH, CK in the observation group were lower than those in control group, and the differences were statistically significant (P<0.05). Compared with the control group, the incidence of adverse reactions in the observation group was lower, the difference was significant (P<0.05). Conclusion: For children with pneumonia complicated with heart failure, the combination of phentolamine and dopamine can effectively improve the clinical efficacy, shorten the recovery time of the disease, promote the improvement of heart failure symptoms, reduce the level of myocardial enzyme spectrum indicators, and reduce the risk of adverse reactions.
  • Article
    XUAN Mulian, LIU Lanbin, CHEN Jianbing.
    Chinese And Foreign Medical Research. 2025, 23(26): 8-13. https://doi.org/10.14033/j.cnki.cfmr.2025.026.003
    Objective: Based on the cross-lag method, the changing trends and mutual influences of fear of disease progression and sleep quality in postoperative patients with cerebral hemorrhage over time were explored. Method: A total of 360 patients with cerebral hemorrhage who underwent surgical treatment at Zhongshan People's Hospital from January 2023 to January 2024 were selected as the research subjects. The Fear of Progression Questionnaire-Short Form (FoP-Q-SF) and the Pittsburgh Sleep Quality Score Index (PSQI) were used to evaluate and detect the fear of disease progression and sleep quality of patients at 24 hours after anesthesia and awakening (T1), 14 days after surgery (T2), and 1 month after surgery (T3), respectively. The Spearman method was used to analyze the correlation between fear of disease progression and sleep quality at different time points. The Mplus software was applied to construct a cross-lag analysis model to analyze the causal temporal relationship and direction of action between postoperative fear disease progression and sleep quality in patients with cerebral hemorrhage. Result: After excluding those who dropped out halfway and those with invalid data, a total of 338 patients completed the study. The FoP-Q-SF scores of 338 patients with cerebral hemorrhage at T1, T2 and T3 were (33.52±3.67), (28.24±2.96) and (25.37±2.41) respectively, and the PSQI scores were (15.36±2.14), (12.38±1.53) and (9.62±1.47) respectively. The results of the correlation analysis showed that the PSQI measured in the three times was positively correlated with the FoP-Q-SF score (P<0.05). The results of cross-hysteresis analysis showed that the FoP-Q-SF score of T1 in patients with cerebral hemorrhage could positively predict the T2PSQI score, and the T2FoP-Q-SF score could positively predict the T3PSQI score. The path coefficients were 0.242 and 0.359 respectively (P<0.05). The PSQI score of T1 can positively predict the FoP-Q-SF score of T2, and the PSQI score of T2 can positively predict the FOP-Q-SF score of T3. The path coefficients are 0.511 and 0.311 respectively (P<0.05). Conclusion: There is a cross-lagged effect between the fear of disease progression and sleep quality in patients with cerebral hemorrhage, suggesting a causal relationship between the two over multiple time spans. The relationship between the two can be utilized to formulate targeted postoperative care measures for patients, improving the prognosis quality of patients with cerebral hemorrhage.
  • Article
    CHEN Qikai.
    Chinese And Foreign Medical Research. 2025, 23(26): 13-16. https://doi.org/10.14033/j.cnki.cfmr.2025.026.004
    Objective: To explore the application of magnetic resonance imaging (MRI) in the differential diagnosis of benign and malignant adnexal masses. Method: A total of 110 patients admitted to Longyan People's Hospital due to adnexal masses from January 2021 to December 2024 were selected as the research subjects and underwent MRI examinations. Taking the pathological examination results as the "gold standard", the benign and malignant conditions of adnexal masses detected by the two examination methods were compared. Result: The pathological results showed that among 110 patients, 76 were benign and 34 were diagnosed as malignant. MRI examination showed 75 benign cases and 31 malignant cases. Taking pathological diagnosis as the gold standard, the sensitivity of MRI in differentiating the benign and malignant of adnexal masses was 94.12%, the specificity was 96.05%, the accuracy rate was 95.45%, and the Kappa value was 0.894. The consistency of the two in diagnosing the benign and malignant of adnexal masses was relatively high. MRI has a relatively high detection rate for malignant teratoma, malignant ovarian choroidal stromal tumor, ovarian cyst and benign choroidal stromal tumor, all being 100.00%. The comparison of DWI signal intensity values and ADC values of benign and malignant cystic masses showed no statistically significant difference. (P>0.05). The DWI signal intensity value of malignant solid masses was higher than that of benign masses, while the ADC value was lower than that of benign masses, and the difference was statistically significant (P<0.05). Conclusion: MRI has a relatively high accuracy in differentiating benign and malignant adnexal masses and can provide a reliable basis for clinical intervention.
  • Article
    SHEN Sijin, SONG Lei.
    Chinese And Foreign Medical Research. 2025, 23(26): 17-20. https://doi.org/10.14033/j.cnki.cfmr.2025.026.005
    Objective: To analyze the effects of intrauterine balloon tamponage (IUBT) combined with bilateral uterine artery ligation (BUAL) on blood loss and thromboelastogram (TEG) in patients with postpartum hemorrhage (PPH) after cesarean section. Method: Clinical data of 95 patients with PPH during cesarean section were collected from February 2023 to September 2024. They were divided into control group (48 cases) and observation group (47 cases) according to different treatment plans. The control group was hemostatic with BUAL regimen, and the observation group was hemostatic with combination BUAL regimen. The bleeding and blood transfusion, postoperative recovery indexes and adverse events were compared between the two groups. TEG indexes [reaction time (R time), coagulation time (K time), maximum thrombus elastic force (MA)] of the two groups were compared before and 12 h after surgery. Result: Compared with the control group, the total blood loss and blood transfusion in the observation group were lower, and the time of hemostasis, getting out of bed and staying in hospital were shorter (P<0.05). 12 h after operation, the R time and K time of both groups were shortened and the MA was increased, and the R time of observation group was shorter and the MA was higher than that of control group (P<0.05). The incidence of adverse events in the observation group was lower than that in the control group (P<0.05). Conclusion: IUBT combined with BUAL can improve hemostasis, reduce blood loss, improve coagulation function and promote postoperative recovery in PPH patients after cesarean section.
  • Article
    ZHANG Shuilian, LIAO Yingfeng.
    Chinese And Foreign Medical Research. 2025, 23(26): 20-24. https://doi.org/10.14033/j.cnki.cfmr.2025.026.006
    Objective: To analyze the effect of combined treatment of sodium thiosulfate and hemoperfusion (HP) on skin itching score and calcium and phosphorus metabolism in patients with uremia complicated with refractory skin itching. Method: 86 patients with uremia complicated with refractory skin itching admitted to Fujian Tingzhou Hospital frrom January 2022 to August 2023 were taken as the subjects. All selected cases were assigned to two groups (43 cases each) with random numerical table. The control group received routine hemodialysis treatment, while the observation group received a combination of sodium thiosulfate and HP hemodialysis treatment. The clinical efficacy, renal function indicators (BUN, Scr, Cys-C), calcium and phosphorus metabolism indicators (Ca, P, iPTH), inflammation indicators (CRP, PCT, SAA), 14-item uremic skin itching scale (14-tem UP-Dial Scale), and complications in both groups were compared. Result: The observation group obtained higher effective rate than the control group (P<0.05). The observation group had lower BUN, Scr, Cys-C, Ca, P, iPTH, CRP, PCT, SAA levels and 14-tem UP-Dial Scale score compared with the control group (P<0.05). The comparison of the incidence of complications in both groups expressed no statistical difference (P>0.05). Conclusion: Sodium thiosulfate combined with HP can improve renal function, promote calcium and phosphorus metabolism, reduce inflammation in the blood, alleviate skin itching symptoms and have a low risk of complicationsin patients with uremia complicated by refractory skin itching.
  • Article
    WEI Zongkun, LIAO Bin, MO Si, HUANG Libing, XIANG Ping, QIN Xihuan.
    Chinese And Foreign Medical Research. 2025, 23(26): 25-27. https://doi.org/10.14033/j.cnki.cfmr.2025.026.007
    Objective: This study aims to explore the application value of combined detection of lipoprotein a [Lp (a)], high-sensitivity C-reactive protein (hs-CRP), and homocysteine (Hcy) in the diagnosis of acute stroke. Method: 128 patients with acute stroke who were hospitalized in the Department of Neurology of the Eighth People's Hospital of Nanning from January 2022 to December 2024 were selected as the observation group, and another 116 healthy individuals undergoing physical examinations were selected as the control group. The levels of Lp(a), hs-CRP and Hcy in the serum of the two groups were detected. The collected data were statistically analyzed using SPSS 21.0 software, and the diagnostic validity of these biomarkers was evaluated. Result: The research results showed that the levels of Lp (a), hs-CRP and Hcy in the observation group were significantly higher than those in the healthy control group (P<0.05). In addition, the positive rate of the combined detection of these three indicators was significantly higher than that of the single indicator detection (P<0.05). Through analysis, it is indicated that the diagnostic efficacy of combined detection is superior to that of individual detection. The study also found that Lp (a) levels are associated with atherosclerotic status, hs-CRP can effectively reflect acute inflammatory responses, and Hcy is closely related to vascular endothelial dysfunction. Conclusion: To sum up, the combined detection of Lp (a), hs-CRP and Hcy has shown obvious clinical value in the early diagnosis and risk assessment of acute stroke, providing a scientific basis for the development of precision medicine.
  • Clinical practice
    MO Yuanjun, LU Xuquan, ZHOU Hui, TAN Zhiwei, ZHANG Xiaofei, LU Yunxin.
    Chinese And Foreign Medical Research. 2025, 23(26): 28-32. https://doi.org/10.14033/j.cnki.cfmr.2025.026.008
    Objective: To observe the clinical efficacy of the treatment of liver cancer with Xiaoji Huayu Pills combined with cyberknife and its influence on early recurrence and metastasis. Method: A total of 80 patients with primary liver cancer who had received cyberknife treatment from January 2021 to October 2023 were selected as the research subjects. And they were all admitted to Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine. They were randomly assigned to two group. The treatment group was also given oral Xiaoji Huayu Pills for a course of one year. The clinical effects and toxic side effects of the two groups were compared. Result: After half a year and one year of treatment, The treatment group showed a higher total effective rate for tumor reduction, with the difference being statistically significant (P<0.05). After one year of treatment, the treatment group's recurrence and metastasis rates was lower than the other with the difference being statistically significant (P<0.05). The serum vascular endothelial growth factor (VEGF) and alpha-fetoprotein (AFP) in both groups were down-regulated, and the expression of serum tumor protein 53 (P53) was up-regulated after treatment. Moreover, the treatment group's improvement was significantly greater, and this difference was statistically significant (P<0.05). A more significant improvement in both the traditional Chinese medicine symptom score and the quality of life score demonstrated in the treatment group, and the incidence of adverse reactions decreased by 20%. The difference was statistically significant (P<0.05). Conclusion: The combination of Xiaoji Huayu Pills and cyberknife in the treatment of liver cancer has a good clinical efficacy, effectively reduces the early recurrence and metastasis of tumors, and has good safety. It can be used for clinical promotion.
  • Clinical practice
    DAI Shaochuan.
    Chinese And Foreign Medical Research. 2025, 23(26): 32-35. https://doi.org/10.14033/j.cnki.cfmr.2025.026.009
    Objective: To explore the application value of electroacupuncture combined with Chinese herbal fumigation in patients with ankle fractures. Method: A total of 94 patients with ankle fractures admitted to the First Affiliated Hospital of Xiamen University from August 2019 to August 2024 were selected as the research subjects. Using the random numerical table, all selected patients were assigned to two groups (47 cases each). The patients of control group were provided with conventional treatment, while the observation group was treated with electroacupuncture combined with Chinese herbal fumigation on the basis of the control group. The degrees of pain and swelling, fracture healing, ankle joint function, incidence of complications and quality of life were compared between the two groups. Result: Compared with the control group, the observation group had lower degree of pain and swelling, shorter fracture healing time, higher score of ankle joint function, greater ankle joint range of motion, fewer complications, and higher score of quality of life after treatment (P<0.05). Conclusion: Electroacupuncture combined with Chinese herbal fumigation can alleviate postoperative pain and swelling in patients with ankle fractures, accelerate fracture healing, reduce complications, and promote the recovery of ankle joint function and the improvement of quality of life.
  • Clinical practice
    YAN Zhoudan.
    Chinese And Foreign Medical Research. 2025, 23(26): 36-39. https://doi.org/10.14033/j.cnki.cfmr.2025.026.010
    Objective: To explore the application value of modified Buzhong Yiqi Decoction combined with acupuncture in postpartum stress urinary incontinence of qi deficiency type. Method: 80 patients with postpartum stress urinary incontinence of qi deficiency type admitted to Xuzhou Central Hospital from April 2023 to April 2024 were taken as the objects. And they were assigned to two groups with random numerical table. The patients of control group were administrated electrical stimulation biofeedback therapy, and on this basis, the patients of observation group additionally took modified Buzhong Yiqi Decoction and acupuncture. The comparisons were made on clinical efficacy, pelvic floor surface electromyography values, TCM syndrome scores and pelvic floor muscle strength in both groups. Result: The observation group obtained higher overall effective rate than the control group (P<0.05). The observation group showed lower average values of the pre-resting stage and the post-resting stage compared to the control group, and the observation group had higher maximum values of the fast muscle (type Ⅱ fiber) stage, the average values of the slow muscle (type Ⅰ fiber) stage, and the average values of the endurance test stage than the control group after treatment (P<0.05). Compared with the control group, the observation group achieved lower scores of urinary incontinence, soreness and weakness of the waist and knees, lower abdominal distension and incomplete drainage after urination, and higher pelvic floor muscle strength (P<0.05). Conclusion: The modified Buzhong Yiqi Decoction combined with acupuncture has a definite effect in the treatment of postpartum stress urinary incontinence of qi deficiency type. It can improve the pelvic floor surface electromyography value and TCM syndrome score of patients, and enhance pelvic floor muscle strength.
  • Article
    XIA Hui, WANG Huan, ZHANG Yang.
    Chinese And Foreign Medical Research. 2025, 23(25): 1-5. https://doi.org/10.14033/j.cnki.cfmr.2025.25.001
    Objective: To explore the impact of Cognitive Behavioral Therapy for Insomnia (CBT-I) combined with vagal nerve stimulation on the sleep quality of patients with anxiety-related insomnia during the perioperative period. Method: The study included 92 patients with anxiety-related insomnia treated in the First People's Hospital of Huai'an from June to October 2024. Patients were randomly divided using a drawing method, with odd numbers assigned to the control group (n=46) and even numbers to the observation group (n=46). The control group received standard care, while the observation group underwent CBT-I combined with VNS. The clinical efficacy, psychological state before and after 1 weeks of treatment [Generalized Anxiety Disorder Scale (GAD-7) and Patient Health Questionnaire (PHQ-9)], sleep quality [Pittsburgh Sleep Quality Index (PSQI)], and insomnia severity [Insomnia Severity Index (ISI)] were compared between the two groups. Result: After treatment, the total efficacy rate in the observation group was higher than in the control group. Scores for GAD-7 and PHQ-9 were lower in the observation group. Scores across all dimensions of the PSQI were lower in the observation group. ISI scores were lower in the observation group, with statistically significant difference (P<0.05). Conclusion: CBT-I combined with VNS significantly improves sleep quality and psychological state in patients with anxiety-related insomnia during the perioperative period. The treatment efficacy is higher than that of CBT-I alone, showing significant improvements in anxiety, depression, and the severity of insomnia.
  • Article
    HONG Yongqiang, BAI Zhibo.
    Chinese And Foreign Medical Research. 2025, 23(25): 5-8. https://doi.org/10.14033/j.cnki.cfmr.2025.25.002
    Objective: To compare the effects of transabdominal preperitoneal hernia repair (TAPP) and Lichtenstein tension-free hernia repair on gastrointestinal function in the treatment of incarcerated inguinal hernia in adults. Method: 120 adult patients with incarcerated inguinal hernia from Xiamen Fifth Hospital from September 2019 to September 2023 were selected as the research subjects. They were divided into different surgical groups, namely TAPP group (60 cases) and Lichtenstein group (60 cases). The surgical related indicators and gastrointestinal function recovery indicators pain level, recurrence rate, and incidence of complications at different postoperative time points between two groups were compared. Result: The perioperative improvement in the TAPP group (hospitalization, anal exhaust, defecation, surgical time, and intraoperative bleeding) was significantly better than that in the Lichtenstein group. 2 h and 8 h VAS scores in TAPP group were lower than those in Lichtenstein group, and the differences were statistically significant (P<0.05), but there was no statistically significant difference in recurrence rate and complication rate between the two groups (P>0.05). Conclusion: TAPP has outstanding advantages in the treatment of adult incarcerated inguinal hernia in terms of surgical trauma and recovery, while Lichtenstein tension-free hernia repair has certain advantages in the treatment of hernia contents and spermatic cord, but the clinical selection still needs to consider the specific situation of the patients.
  • Article
    WU Qianhai
    Chinese And Foreign Medical Research. 2025, 23(25): 9-12. https://doi.org/10.14033/j.cnki.cfmr.2025.25.003
    Objective: To investigate the effect of transverse abdominal muscle plane block combined with general anesthesia during radical cervical cancer operation. Method: From June 2019 to December 2024, 82 consecutive patients scheduled for radical hysterectomy in Fuqing Maternal and Child Health Hospital were randomly assigned with random number method to a control group (n=41) receiving balanced intravenous-inhalational general anesthesia alone and a study group (n=41) receiving TAP block in addition to the same general anesthetic regimen. Postoperative analgesia, intraoperative hemodynamics at specified time points, perioperative oxidative stress markers, and adverse events were compared. Result: Numeric Rating Scale (NRS) pain scores at 6, 12, and 24 h postoperatively were significantly lower in the study group than in the control group (P<0.05). Ramsay sedation scores did not differ between groups (P>0.05). Baseline heart rate (HR) and mean arterial pressure (MAP) were comparable (P>0.05). Five minutes after induction, HR and MAP were higher in the study group than in the control group, while at extubation they were lower in the study group (P<0.05). Before operation, the levels of superoxide dismutase (SOD), malondialdehyde (MDA) and total antioxidant capacity (T-AOC) were similar between the two groups, but there was no statistically significant difference (P>0.05). SOD and T-AOC were significantly reduced after operation, but the reduction of the study group was smaller than that of the conventional group. MDA was significantly increased in both groups, but the increase in the study group was smaller than that in the conventional group, and the difference was statistically significant (P<0.05). The incidence of adverse reactions was similar between the study group and the conventional group, and the difference was not statistically significant (P>0.05). Conclusion: The application of transversal muscle plane block combined with general anesthesia during radical cervical cancer operation can effectively reduce postoperative pain and oxidative stress reaction, stabilize intraoperative hemodynamics, and have high safety.
  • Article
    HUANG Minli, XIE Hong, CHEN Xiaoyuan, SU Xuetang, YAN Jia'en.
    Chinese And Foreign Medical Research. 2025, 23(25): 13-16. https://doi.org/10.14033/j.cnki.cfmr.2025.25.004
    Objective: To explore the application effect of AIDET communication mode in elderly patients undergoing painless gastroscopy. Method: Selecting 120 elderly patients who underwent painless gastrointestinal examinations in Jiangmen People's Hospital from June 2023 to May 2024, and they were divided into two groups, with 60 in each group using a random number table method. The control group received routine nursing care, while the observation group received AIDET communication mode. The emotional state, psychological burden perception, vital sign indicators, and examination cooperation between two groups were compared. Result: After nursing, the observation group had lower levels of Self Rating Anxiety Scale (SAS), Self Rating Depression Scale (SDS), Self Perceived Burden Scale (SPBS), respiratory rate, heart rate, systolic blood pressure, and diastolic blood pressure than the control group. The degree of cooperation was higher than that of the control group, and the difference was statistically significant (P<0.05). Conclusion: The AIDET communication mode can improve the emotional state of elderly patients undergoing painless gastrointestinal examinations, reduce self perceived burden, improve examination cooperation, and stabilize vital signs.
  • Article
    SUN Li, WANG Yaohui, HE Fang, YU Xiaojie.
    Chinese And Foreign Medical Research. 2025, 23(25): 16-19. https://doi.org/10.14033/j.cnki.cfmr.2025.25.005
    Objective: To study the effect of Shentong Zhuyu Decoction after total knee arthroplasty (TKA). Method: 90 TKA patients admitted to the hospital from January 2022 to December 2024 were studied, and they were divided into group Ⅰ (n=45) and Group Ⅱ (n=45) through computer numbering and parity number method. Group Ⅱ was treated with routine thrombus prevention intervention, and group Ⅰ was treated with body pain Zhuyu decoction on the basis of group Ⅱ. FIB and D-D levels, TCM syndrome scores, clinical efficacy and serum inflammatory factor levels were compared between the two groups. Result: The levels of FIB and D-D in both groups at 7 days and 14 days after the operation were higher than those before the operation, but the levels of FIB and D-D in group Ⅰ at the above time points were lower than those in group Ⅱ. At 14 days after the operation, the TCM syndrome scores of both groups were lower than those before the operation, and those of group Ⅰ were lower than those of Group Ⅱ. The total effective rate of Group Ⅰ was higher than that of group Ⅱ. Three days after the operation, the levels of various serum inflammatory factors in both groups were higher than those before the operation, but those in group Ⅰ were lower than those in group Ⅱ, with statistically significant difference (P<0.05). Conclusion: Shentong Zhuyu Decoction can effectively reduce FIB and D-D levels in patients with TKA, improve clinical efficacy, and negatively regulate serum inflammatory factor levels.
  • Article
    FU Yafei, WU Bin, BAO Xiaoying, ZHONG Ying.
    Chinese And Foreign Medical Research. 2025, 23(25): 20-23. https://doi.org/10.14033/j.cnki.cfmr.2025.25.006
    Objective: To analyze the effect of capecitabine metronomic chemotherapy combined with Fuzheng Anzhong Decoction on immunity, gut microbiota and prognosis of triple negative breast cancer (TNBC). Method: 80 patients with TNBC admitted to Guangdong Second Traditional Chinese Medicine Hospital from July 2022 to September 2023 were enrolled in this study. Using a random number table, they were divided into group A (40 cases) and group B (40 cases), receiving capecitabine metronomic chemotherapy and combined treatment with capecitabine metronomic chemotherapy and Fuzheng Anzhong Decoction, respectively. The efficacy, immune function, and changes in gut microbiota were compared between the two groups, and the prognosis was evaluated. Result: The response rate of group B was higher than that in group A, with statistically significant difference (P<0.05). After treatment, CD3+, CD4+, CD4+/CD8+ and gut microbiota quantity decreased, while CD8+ and BC-PROM scores of various domains increased in both groups. Moreover, above indicators in group B were superior to those in group A, with statistically significant differences (P<0.05). Conclusion: Capecitabine metronomic chemotherapy combined with Fuzheng Anzhong Decoction is effective to treat TNBC, which can improve immune function, gut microbiota, and prognosis.
  • Article
    GAO Jiaju, YANG Na, WANG Guanhua, ZHOU Meiyan.
    Chinese And Foreign Medical Research. 2025, 23(25): 23-26. https://doi.org/10.14033/j.cnki.cfmr.2025.25.007
    Objective: The study aims to evaluate the efficacy of combined therapy with digestive endoscopy and rabeprazole in patients with gastric ulcer hemorrhage. Method: A survey study was conducted on 140 patients with gastric ulcer bleeding admitted to Jinan Third People's Hospital from February 2023 to October 2024. Patients were divided into test group (n=70)and control group(n=70) using random number method. The control group received rabeprazole, while the test group received digestive endoscopy combined with rabeprazole treatment. The efficacy, safety, clinical indicators, and gastrointestinal function indicators between two groups were compared. Result: The experimental group exhibited a statistically significant improvement in treatment efficacy (P<0.05) along with a significantly reduced adverse event profile compared to control group (P<0.05). After treatment, the experimental group scored higher than the control group across all domains of the Short Form Health Survey (SF-36), and this difference (Parazacco spilurus subsp. spilurus) also reached statistical significance (P<0.05). The experimental group required less time than the control group for postoperative bowel sounds to normalize, first anal exhaust, hospitalization duration, and hemostasis, with these observations also demonstrating statistically significant differences (P<0.05). Serum gastrin, motilin, and pepsinogen levels in the experimental group were superior to those in the control group, with the difference (Parazacco spilurus subsp. spilurus) being statistically significant (P<0.05). Conclusion: The combination of gastroscopy and rabeprazole has high therapeutic effect and certain safety in the treatment of gastric ulcer bleeding. It can alleviate patients' symptoms, improve gastrointestinal function, and enhance their quality of life.
  • Article
    HUANG Xiaomei, XU Haimei.
    Chinese And Foreign Medical Research. 2025, 23(25): 27-30. https://doi.org/10.14033/j.cnki.cfmr.2025.25.008
    Objective: To explore the therapeutic effect of fibrinoscopic alveolar lavage combined with azithromycin and acetylcysteine in children with pediatric severe pneumonia. Method: Retrospectively analyzing the data of 86 children with pediatric severe pneumonia admitted to Putian Children's Hospital from October 2021 to October 2024, and they were divided them into 2 groups, with 43 cases in each group according to different treatment methods. The control group was treated with azithromycin and acetylcysteine, and the observation group was added with fibrinoscopic alveolar lavage. Treatment effect, symptom disappearance time, blood gas analysis index, inflammation index and the incidence of adverse reactions of the two groups were compared. Result: The total effective rate of treatment in the observation group was higher than that in the control group. The disappearance of symptoms was shorter than that of the control group. The partial pressure of oxygen in blood (PaO2) and blood oxygen saturation (SaO2) were higher than those of the control group. Arterial partial pressure of carbon dioxide (PaCO2), C-reactive protein (CRP), white blood cell count (WBC), interleukin-6 (IL-6), tumor necrosis factor -α (TNF-α), and procalcitonin (PCT) were lower than those in the control group, and the differences were statistically significant (P< 0.05). There was no statistically significant difference in the incidence of adverse reactions between groups (P>0.05). Conclusion: Fibrinoscopic alveolar lavage combined with azithromycin and acetylcysteine can improve the therapeutic effect of pediatric severe pneumonia, accelerate the disappearance of symptoms, improve the blood gas analysis and inflammatory indexes. It is safe and effective.
  • Article
    ZHAI Mingjian.
    Chinese And Foreign Medical Research. 2025, 23(25): 30-33. https://doi.org/10.14033/j.cnki.cfmr.2025.25.009
    Objective: To investigate the effect of single intravenous injection of esmketamine before operation on postoperative patients undergoing laparoscopic radical resection of colorectal cancer. Method: According to the random number table method, 86 patients who were treated by laparoscopic radical resection of colorectal cancer in the First Affiliated Hospital of Bengbu Medical University from January 2023 to January 2024 were divided into two groups. Before operation, 43 patients in Group B were given intravenous injection of 5 mL of normal saline, and 43 patients in Group A were given intravenous injection of esmketamine. The general situation of operation, the level of inflammatory factors, the level of Superoxide Dismutase (SOD), the degree of fatigue, the incidence of Postoperative Fatigue Syndrome (POFS) and the incidence of complications were compared between group A and group B. Result: At T1, T2 and T3, the levels of Interleukin-6 (IL-6) and Tumor Necrosis Factor-α (TNF-α) in both groups were higher than those in T0, but in group A they were lower than those in group B. At T1, T2 and T3, the SOD levels in both groups were lower than those in T0, but the SOD levels in group A were higher than those in group B. 3rd, 5th and 7th day after operation, the Christensen fatigue score and 10-item Intensive Care Fatigue Scale Score (ICFS-10) score of the two groups were higher than those of the 1st day before operation, but those of group A were lower than those of group B. 7 days after operation, the incidence of fatigue syndrome in group A was significantly lower than group B (P<0.05). There was no significant difference in the incidence of choking cough, delirium and agitation, nausea and vomiting, diplopia and delayed recovery between group A and group B after extubation (P>0.05). Conclusion: Single intravenous injection of Esketamine before operation can reduce the level of inflammatory factors and SOD concentration after laparoscopic radical resection of colorectal cancer, reduce the degree of postoperative fatigue, and reduce the incidence of long-term fatigue syndrome 7 days after operation, without affecting the general situation of operation and the incidence of complications.
  • Clinical practice
    WANG Yanfang, YE Huayang, LIN Yanshan, ZHANG Jun, YE Yiru.
    Chinese And Foreign Medical Research. 2025, 23(25): 34-37. https://doi.org/10.14033/j.cnki.cfmr.2025.25.010
    Objective: To explore the therapeutic effect of pelvic floor formula based on the theory of tonifying Qi and promoting elevation combined with biofeedback electrical stimulation on female patients with mild to moderate stress urinary incontinence (SUI) of Qi deficiency type. Method: 60 female patients with mild to moderate SUI of Qi deficiency type were selected, all of whom were admitted to Fujian University of Traditional Chinese Medicine Affiliated Rehabilitation Hospital from July 2024 to February 2025. They were randomly divided into three groups according to the random number table method. Group A (20 cases) was treated with pelvic floor formula, Group B (20 cases) was treated with pelvic floor formula combined with biofeedback electrical stimulation, and Group C (20 cases) was treated with biofeedback electrical stimulation. Pelvic floor electromyography, quality of life (ICI-O-SF), symptom scores, clinical efficacy, and adverse reactions of the three groups were compared. Result: After treatment, the pelvic floor electromyography values in the fast muscle stage and the slow muscle stage in group B were respectively higher than those in group A and group C. The ICI-O-SF score and syndrome score of group B were lower than those of group A and group C, and the difference was statistically significant (P<0.05). The total effective rate of treatment in group B was higher than that in group A and group C, and the difference was statistically significant (P<0.05). No obvious adverse reactions occurred in all three groups during the treatment period. Conclusion: Pelvic floor formula combined with biofeedback electrical stimulation based on the theory of tonifying Qi and promoting elevation has a definite therapeutic effect on mild to moderate SUI patients with qi deficiency. It can effectively improve pelvic floor muscle strength, alleviate urinary incontinence symptoms, and improve quality of life. It is relatively safe.
  • Article
    LIU Changhua, ZHANG Meina, AN Caixia, LI Shiru, YAO Dong
    Chinese And Foreign Medical Research. 2025, 23(24): 1-5. https://doi.org/10.14033/j.cnki.cfmr.2025.24.001
    Objective: To investigate the role and mechanism of tranexamic acid combined with insomnia group cognitive-behavioral therapy to improve relevant indicators in patients with melasma combined with insomnia. Method: A total of 114 patients with melasma combined with insomnia who attended the Fifth Hospital of Xiamen from January 2022 to June 2024 were selected for the study, and were divided into Group A, Group B, and Group C using the random number table method, with shedding cases in each group, and finally 31 cases were included in Group A, 30 cases in Group B, and 32 cases in Group C. Group A was treated with insomnia group cognitive-behavioral (GCBT) therapy, group B with oral tranexamic acid tablets, and group C with tranexamic acid combined with insomnia group cognitive-behavioral therapy. The scores of melasma and insomnia-related scales were compared before and after treatment, and the clinical efficacy of the three groups was evaluated, and the levels of sex hormones, serum oxidative stress indicators and inflammatory factors were compared among the three groups. Result: After 3 months of treatment, the melasma area and severity index (MASI) and Pittsburgh sleep quality index (PSQI) decreased in all three groups compared with the pre-treatment period, and the scores of group C were lower than those of group A and group B, and the difference was statistically significant (P<0.05). After treatment, sex hormone levels [estradiol (E2), progesterone (P), follicle-stimulating hormone (FSH)] and inflammatory factors decreased in the three groups compared with those before treatment, and the decrease in Group C was more significant, with statistically significant differences (P<0.05). After treatment, the serum oxidative stress indexes of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in the three groups were higher than those before treatment, and the levels of malondialdehyde (MDA) and lipid peroxidation (LOP) were lower than those before treatment, and the oxidative stress capacity of group C was improved more obviously, and the difference was statistically significant (P<0.05).The total effective rate of treatment in group C was higher than that in group A and group B, and the difference was statistically significant (P<0.05). Conclusion: Tranexamic acid combined with insomnia group cognitive-behavioral therapy is effective in treating patients with melasma combined with insomnia, and can significantly improve the area and severity of melasma as well as the sleep quality of insomnia patients.
  • Article
    YE Yudong
    Chinese And Foreign Medical Research. 2025, 23(24): 5-8. https://doi.org/10.14033/j.cnki.cfmr.2025.24.002
    Objective: To investigate the impact of a chemotherapy regimen of bevacizumab in combination with travofluridine tepipiridine tablets in the treatment of advanced metastatic colorectal cancer (mCRC). Method: 60 cases of advanced mCRC patients admitted to Shougang Shuigang Hospital from March 2021 to March 2024 were selected as the study subjects, and were divided into the control group (30 cases, treated with travofluridine tepipyrimidine tablets chemotherapy regimen) and the observation group (30 cases, bevacizumab combined with travofluridine tepipyrimidine tablets chemotherapy regimen) using a randomized numerical table method, and the two groups received treatment for one cycle. The comparisons were performed on clinical efficacy, tumor markers [glycan antigen 19-9 (CA19-9), glycan antigen 125 (CA125), glycan antigen 242 (CA242), carcinoembryonic antigen (CEA)], quality of life [Short Form of the Health Survey (SF-36)], and adverse reactions in both groups. Result: The observation group obtained higher overall effective rate than the control group after treatment. The observation group had lower CA19-9 [(82.65±8.29)KU/L], CA125 [(65.27±8.16) kU/L], CA242 [(34.29±4.28) IU/mL], CEA [(11.61±3.03) ng/mL] than the control group. Compared with the control group, the observation group expressed higher scores of physiological function [(78.66±3.52) points], role physical [(78.62±3.96) points], body pain [(79.61±3.46) points], general health [(80.74±3.69) points], vigor [(77.09±2.76) points], social function [(80.92±3.43) points], role emotional [(80.82±2.37) points], mental health [(80.89±2.49) points] in SF-36 survey (P<0.05). The comparison of the incidence of adverse reactions in both groups showed no statistical difference (P>0.05). Conclusion: Bevacizumab combined with travofluridine tepipiridine tablets chemotherapy regimen for the treatment of advanced mCRC has significant efficacy, can effectively regulate the level of tumor markers, improve the quality of life of patients, and does not increase the number of adverse reactions.
  • Article
    CAI Shengbo, QIU Wenliu, HONG Shan, DING Linghui.
    Chinese And Foreign Medical Research. 2025, 23(24): 9-12. https://doi.org/10.14033/j.cnki.cfmr.2025.24.003
    Objective: To observe the effect of fat soluble vitamins as adjuvant therapy for children with mycoplasma pneumonia. Method: From February 2022 to April 2024, 120 children with Mycoplasma pneumoniae pneumonia from Xiamen Fifth Hospital were selected as the research subjects. They were randomly divided into an experimental group and a control group using a random number table method, with 60 cases in each group. The control group received conventional treatment, while the experimental group received lipid soluble vitamin adjuvant therapy in addition to the control group. The lung function [forced vital capacity (FVC), forced expiratory volume in one second (FEV1), peak expiratory flow rate (PEF)], serum inflammatory factors [interleukin-6 (IL-6), IL-10, tumor necrosis factor-α (TNF-α)], clinical indicators (wheezing, pulmonary rales, fever reduction, cough disappearance) of the two groups were compared before and after treatment. Time and length of hospital stay. Result: After treatment, FVC, FEV1, and PEF increased in both groups of patients, while IL-6, IL-10, and TNF-α decreased. The study group had higher FVC, FEV1, and PEF, and lower IL-6, IL-10, and TNF-α, with statistically significant differences (P<0.05). The recovery time of the study group patients was shorter than that of the control group, and the difference was statistically significant (P<0.05). Conclusion: Lipid soluble vitamins as adjuvant therapy can significantly improve lung function, reduce serum inflammatory cytokine levels, and shorten the relief time and hospitalization time of clinical symptoms in children with mycoplasma pneumonia.
  • Article
    WANG Jinyuan, YANG Xiaoliang, GAO Chongyan, SHAO Lanling, HE Yanmin.
    Chinese And Foreign Medical Research. 2025, 23(24): 12-15. https://doi.org/10.14033/j.cnki.cfmr.2025.24.004
    [Abstract] Objective: To analyze the efficacy of nonsteroidal anti-inflammatory drugs in the treatment of subacute thyroiditis and their impact on inflammatory indicators. Method: From August 2021 and August 2022, 100 patients with subacute thyroiditis admitted to Jinchang Central Hospital were randomly divided into two groups using a random number table method. The observation group received treatment with nonsteroidal anti-inflammatory drugs, while the control group received treatment with glucocorticoids, with 50 cases in each group. The treatment efficacy and changes in serum biomarkers between the two groups of patients were compared. Result: The clinical treatment efficacy of the observation group was higher than that of the control group, and the difference was statistically significant (P<0.05). There was no statistically significant difference in serum indicators such as C-reactive protein, erythrocyte sedimentation rate, free triiodothyronine, free thyroxine, and thyroid stimulating hormone between the two groups before treatment (P>0.05). After treatment, the observation group had higher levels of thyroid stimulating hormone than the control group, while the levels of other serum biomarkers such as C-reactive protein were lower than the control group, with statistical significance (P<0.05). The probability of adverse reactions in the observation group was lower than that in the control group, with statistical significance (P<0.05). The disappearance time of symptoms in the observation group was shorter than that in the control group, with statistical significance (P<0.05). Conclusion: The use of nonsteroidal anti-inflammatory drugs in the treatment of subacute thyroiditis can further enhance the therapeutic effect, effectively adjust abnormal serum indicators in the body, and improve patients, inflammatory indicators.
  • Clinical practice
    CHEN Zejia, WANG Wenqiang, YANG Yanhui, BAO Yuwang
    Chinese And Foreign Medical Research. 2025, 23(24): 16-18. https://doi.org/10.14033/j.cnki.cfmr.2025.24.005
    Objective: To observe the efficacy of tigecycline combined with cefoperazone sulbactam in the treatment of severe pneumonia caused by pan resistant Acinetobacter baumannii (PDR-AB). Method: Using a random number table method, 76 patients diagnosed with PDR-AB induced severe pneumonia from July 2023 to October 2024 were divided into two groups. The control group of 38 cases was treated with cefoperazone sulbactam, while the study group of 38 cases was treated with tigecycline in addition. The clinical efficacy, inflammatory factors, bacterial clearance rate, and adverse reactions were compared between two groups. Result: The total effective rate and bacterial clearance rate of the two groups were compared, and the study group had higher rates, with statistically significant differences (P<0.05). After treatment, the levels of CRP, WBC, and PCT in the study group significantly decreased and were lower than those in the control group, with statistical significance (P<0.05). There was no statistically significant difference in adverse reactions between the two groups (P>0.05). Conclusion: In the treatment of severe pneumonia caused by PDR-AB, the addition of tigecycline to cefoperazone sulbactam has better efficacy and bacterial clearance rate, can significantly improve the inflammatory status of patients, and has better safety.
  • Clinical practice
    CHEN Bixiang, ZHAO Qian, XU Ximei, CHEN Zhouna
    Chinese And Foreign Medical Research. 2025, 23(24): 19-21. https://doi.org/10.14033/j.cnki.cfmr.2025.24.006
    Objective: To investigate the effect of wrist and ankle needling combined with auricular pressure bean on the pain level and sleep quality of hepatocellular carcinoma patients after intervention. Method: 92 patients with hepatocellular carcinoma treated with interventional procedures in Zhangzhou City Hospital of Traditional Chinese Medicine, Fujian Province, were selected as the study subjects from December 2021 to October 2024, and were divided into the control group and the experimental group by the random number table method, with 46 cases in each group. The control group carried out conventional nursing intervention, and the experimental group carried out wrist and ankle needles combined with auricular pressure bean nursing intervention. Postoperative pain level, anxiety and depression and sleep quality were compared between the two groups. Result: After 7 d of care, the numerical pain method (NRS), Hamilton Anxiety Scale (HAMA), Hamilton Depression Scale (HAMD), and Pittsburgh Sleep Quality Index (PSQI) scores of the test group were lower than those of the control group, and the difference was statistically significant (P<0.05). Conclusion: Wrist and ankle acupuncture combined with auricular pressure bean care in hepatocellular carcinoma patients reduces post-interventional pain, improves anxiety and depression, and enhances sleep quality.
  • Clinical practice
    WANG Yulong
    Chinese And Foreign Medical Research. 2025, 23(24): 22-25. https://doi.org/10.14033/j.cnki.cfmr.2025.24.007
    Objective: To investigate the results of decompression and fusion internal fixation in patients with lumbar spinal stenosis (LSS) combined with Ⅰ-degree degenerative slip. Method: 138 LSS patients admitted to Guiyang Hospital of Guiyang Airline from June 2021 to June 2024 were selected as the study subjects, and were divided into the control group (n=69, simple decompression treatment) and the observation group (n=69, decompression and fusion internal fixation treatment) according to the treatment method. The operation time, intraoperative bleeding, visual analog scale (VAS), Japanese Orthopaedic Association Low Back Pain Disorder Rating Scale (JOA) score, imaging examinations (pelvic tilt angle, thoracic kyphosis angle, lumbar anterior kyphosis angle, lumbar spondylolisthesis degree, and intervertebral disc height), and complication rates were compared between the two groups. Result: The operation time, intraoperative bleeding, JOA score, pelvic tilt angle, thoracic kyphosis angle, lumbar anterior kyphosis angle, intervertebral disc height, and complication rate in the observation group were higher than those in the control group, and the difference was statistically significant (P<0.05). The VAS score and the degree of lumbar spondylolisthesis in the observation group were lower than those in the control group, and the difference was statistically significant (P<0.05). Conclusion: Compared with decompression alone, decompression and fusion internal fixation in patients with LSS combined with Ⅰ-degree degenerative spondylolisthesis can help to further improve postoperative JOA score, reduce the degree of lumbar spondylolisthesis, and improve lumbar spine anatomy and VAS score, but it will increase surgical trauma, which may in turn increase the rate of complications and increase the burden of treatment.
  • Clinical practice
    FAN Shiyao
    Chinese And Foreign Medical Research. 2025, 23(24): 26-29. https://doi.org/10.14033/j.cnki.cfmr.2025.24.008
    Objective: To investigate the effect of improving the function of the affected limbs after treating patients with hemiplegia with antelope horn soup combined with warm bile soup plus reduction combined with acupuncture. Method: 50 patients who underwent stroke hemiplegia treatment in Fuzhou Zhongde Hospital from July 2023 to July 2024 were selected as the study subjects, and were divided into the observation group and the control group using the random number lottery method, with 25 cases in each group. The control group was treated with acupuncture alone, and the observation group was treated with antelope horn soup combined with warm bile soup plus reduction combined with acupuncture. Improvement of transport function and blood rheology of the affected limbs and complication rate were compared between the two groups after treatment. Result: The upper limb and lower limb scores of the observation group were higher than those of the control group, the overall motor function scores were higher than those of the control group, the blood rheology indexes were lower than those of the control group, and the complication rates were lower than those of the control group, and the differences were statistically significant (P<0.05). Conclusion: The implementation of antelope horn soup combined with the addition and subtraction of warm gallbladder soup combined with acupuncture treatment is conducive to improving the function of the affected limbs in hemiplegic patients with stroke, optimizing their blood rheology data, and reducing the risk of complications.
  • Clinical practice
    CHEN Wanqiu, PAN Yao
    Chinese And Foreign Medical Research. 2025, 23(24): 29-32. https://doi.org/10.14033/j.cnki.cfmr.2025.24.009
    Objective: To investigate the efficacy of the self-proposed formula for activating blood circulation and removing blood stasis to prepare traditional Chinese medicine hot package in patients with chronic obstructive pulmonary disease (COPD). Method: 205 cases of COPD patients admitted to Bijie City Hospital of Traditional Chinese Medicine from June 2023 to June 2024 were assigned to control group (n=103) and observation group (n=102) with random numerical table. The control group was treated routinely, and the observation group was treated with the self-proposed formula for activating blood circulation and removing blood stasis by preparing traditional Chinese medicine hot package. The Chinese medicine symptom scores, lung function indexes, blood gas analysis indexes and adverse reactions of the two groups were compared. Result: The observation group had lower scores of chest expansion, distension like congestion, wheezing and coughing up, and dim complexion and higher lung function indexes than the control group after treatment, the observation group expressed higher PaO2 and lower PaCO2 than the control group, with statistically significant differences (P<0.05). The comparison of the incidence of adverse reactions in both groups showed no statistical difference (P>0.05). Conclusion: Self-proposed formula for activating blood circulation and removing blood stasis to prepare traditional Chinese medicine hot package can enhance the efficacy of COPD patients, improve pulmonary ventilation and gas exchange function, correct the abnormalities of blood gas analysis indexes, and promote the disappearance of disease symptoms, which is safe and reliable.
  • Clinical practice
    WEI Rong, YUAN Jianfeng, ZHANG Guangfeng
    Chinese And Foreign Medical Research. 2025, 23(24): 33-36. https://doi.org/10.14033/j.cnki.cfmr.2025.24.010
    Objective: To investigate the efficacy of elderly female patients with osteoporosis receiving deslumizumab injection in combination with basal therapy. Method: 80 cases of elderly female osteoporosis patients admitted to Lanzhou City Hospital of Traditional Chinese Medicine from January 2020 to January 2024 were selected as the study subjects, and were divided into the control group (40 cases, basic treatment) and the study group (40 cases, combined with deslumizumab injection on the basis of the control group) according to the method of randomized number table. Both groups were treated for a period of 1 year, and the treatment conditions of the two groups were compared and analyzed. Result: After treatment, the levels of bone density indexes in both groups increased, and the research group was higher, and the levels of all bone metabolism indexes decreased, and the research group was lower, and the difference was statistically significant (P<0.05). Before and after treatment, there was no statistically significant difference in the levels of various biochemical indicators between the two groups (P>0.05). Compared with the control group, the total effective rate of treatment in the study group was higher, and the difference was statistically significant (P<0.05). The difference in the incidence of adverse reactions between the two groups was not statistically significant (P>0.05). Conclusion: Elderly female osteoporosis patients who received disutilizumab injection combined with basal treatment showed improvement in their bone mineral density and bone metabolism indexes, with no abnormalities in biochemical indexes, and the therapeutic effect was improved with high safety.
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